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公开(公告)号:US09216229B2
公开(公告)日:2015-12-22
申请号:US13904432
申请日:2013-05-29
申请人: Alan Daniel Brown , Brian Robert Champion , Clare Lees , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
发明人: Alan Daniel Brown , Brian Robert Champion , Clare Lees , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
IPC分类号: A61K38/04 , A61K47/48 , A61K39/00 , A61K39/395
CPC分类号: A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译: 本发明涉及提供新型免疫原,其包含抗原性IgE肽,优选与免疫原性载体连接以预防,治疗或减轻IgE介导的病症。 本发明还涉及这些药物的生产方法,免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号:US08889144B2
公开(公告)日:2014-11-18
申请号:US12872645
申请日:2010-08-31
申请人: Brian Robert Champion , Leonard Gabriel Contillo, Jr. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
发明人: Brian Robert Champion , Leonard Gabriel Contillo, Jr. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
CPC分类号: A61K39/0005 , C12N9/6424 , C12Y304/21061
摘要: The present invention relates to the provision of immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译: 本发明涉及提供免疫原,其包含与免疫原性载体连接的抗原性PCSK9肽,用于预防,治疗或缓解PCSK9介导的病症。 本发明还涉及这些药物的生产方法,免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号:US20110052621A1
公开(公告)日:2011-03-03
申请号:US12872645
申请日:2010-08-31
申请人: Brian Robert Champion , Leonard Gabriel Contillo, JR. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
发明人: Brian Robert Champion , Leonard Gabriel Contillo, JR. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
CPC分类号: A61K39/0005 , C12N9/6424 , C12Y304/21061
摘要: The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译: 本发明涉及提供包含与免疫原性载体连接的抗原性PCSK9肽以预防,治疗或缓解PCSK9介导的病症的新型免疫原。 本发明还涉及这些药物的生产方法,免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号:US20100158933A1
公开(公告)日:2010-06-24
申请号:US12634336
申请日:2009-12-09
申请人: ALAN DANIEL BROWN , BRIAN ROBERT CHAMPION , CLARE CHRISTY , DAVID PAUL GERVAIS , LYN HOWARD JONES , ANNE MARIA KRISTINA KJERRSTROM , DAVID CAMERON PRYDE , LEE RICHARD ROBERTS , DAVID MICHAEL WYATT
发明人: ALAN DANIEL BROWN , BRIAN ROBERT CHAMPION , CLARE CHRISTY , DAVID PAUL GERVAIS , LYN HOWARD JONES , ANNE MARIA KRISTINA KJERRSTROM , DAVID CAMERON PRYDE , LEE RICHARD ROBERTS , DAVID MICHAEL WYATT
CPC分类号: A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译: 本发明涉及提供新型免疫原,其包含抗原性IgE肽,优选与免疫原性载体连接以预防,治疗或减轻IgE介导的病症。 本发明还涉及这些药物的生产方法,免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号:US07643528B2
公开(公告)日:2010-01-05
申请号:US11973671
申请日:2007-10-10
申请人: William N. Partlo , Alexander I. Ershov , German Rylov , Igor V. Fomenkov , Daniel J. W. Brown , Christian J. Wittak , Rajasekhar M. Rao , Robert A. Bergstedt , John Fitzgerald , Richard L. Sandstrom , Vladimir B. Fleurov , Robert N. Jacques , Ed Danielewicz , Robin Swain , Edward Arriola , Michael Wyatt , Walter Crosby
发明人: William N. Partlo , Alexander I. Ershov , German Rylov , Igor V. Fomenkov , Daniel J. W. Brown , Christian J. Wittak , Rajasekhar M. Rao , Robert A. Bergstedt , John Fitzgerald , Richard L. Sandstrom , Vladimir B. Fleurov , Robert N. Jacques , Ed Danielewicz , Robin Swain , Edward Arriola , Michael Wyatt , Walter Crosby
IPC分类号: H01S3/22
CPC分类号: H01S3/0057 , G03F7/70341 , G03F7/70583
摘要: An apparatus and method which may comprise a pulsed gas discharge laser which may comprise a seed laser portion; an amplifier portion receiving the seed laser output and amplifying the optical intensity of each seed pulse; a pulse stretcher which may comprise: a first beam splitter operatively connected with the first delay path and a second pulse stretcher operatively connected with the second delay path; a first optical delay path tower containing the first beam splitter; a second optical delay path tower containing the second beam splitter; one of the first and second optical delay paths may comprise: a plurality of mirrors defining the respective optical delay path including mirrors located in the first tower and in the second tower; the other of the first and second optical delay paths may comprise: a plurality of mirrors defining the respective optical delay path including mirrors only in one of the first tower and the second tower.
摘要翻译: 一种可包括可包括种子激光器部分的脉冲气体放电激光器的装置和方法; 接收种子激光输出并放大每个种子脉冲的光强度的放大器部分; 脉冲展开器,其可以包括:与第一延迟路径可操作地连接的第一分束器和与第二延迟路径可操作地连接的第二脉冲展开器; 包含第一分束器的第一光学延迟路径塔; 包含第二分束器的第二光学延迟路径塔; 第一和第二光学延迟路径中的一个可以包括:多个反射镜,其限定相应的光学延迟路径,包括位于第一塔架和第二塔架中的反射镜; 第一和第二光学延迟路径中的另一个可以包括:多个反射镜限定相应的光学延迟路径,其仅包括在第一塔架和第二塔架之一中的镜子。
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公开(公告)号:US09204522B2
公开(公告)日:2015-12-01
申请号:US14055678
申请日:2013-10-16
申请人: Michael Wyatt
发明人: Michael Wyatt
CPC分类号: H05B37/029 , H04L41/12 , H05B37/0254
摘要: A format for controlling information between multiple masters and clients uses each of a plurality of ports over a specified line, where the specified line can be ethernet, and where the ports can be opened and closed, and where the ports are calculated based on the number assigned to the console, a console multiplier, and at least one increment that represents the kind of information where there are multiple kinds of information.
摘要翻译: 用于控制多个主机和客户端之间的信息的格式使用指定行上的多个端口中的每个端口,其中指定的线路可以是以太网,以及哪些端口可以被打开和关闭,以及哪些端口基于数量计算 分配给控制台,控制台乘数和至少一个增量,表示存在多种信息的信息种类。
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公开(公告)号:US20150098957A1
公开(公告)日:2015-04-09
申请号:US14508977
申请日:2014-10-07
申请人: Brian Robert Champion , Leonard Gabriel Contillo, JR. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
发明人: Brian Robert Champion , Leonard Gabriel Contillo, JR. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
CPC分类号: A61K39/0005 , C12N9/6424 , C12Y304/21061
摘要: The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译: 本发明涉及提供包含与免疫原性载体连接的抗原性PCSK9肽以预防,治疗或缓解PCSK9介导的病症的新型免疫原。 本发明还涉及这些药物的生产方法,免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号:US20140111117A1
公开(公告)日:2014-04-24
申请号:US14055678
申请日:2013-10-16
申请人: Michael Wyatt
发明人: Michael Wyatt
IPC分类号: H05B37/02
CPC分类号: H05B37/029 , H04L41/12 , H05B37/0254
摘要: A format for controlling information between multiple masters and clients uses each of a plurality of ports over a specified line, where the specified line can be ethernet, and where the ports can be opened and closed, and where the ports are calculated based on the number assigned to the console, a console multiplier, and at least one increment that represents the kind of information where there are multiple kinds of information.
摘要翻译: 用于控制多个主机和客户端之间的信息的格式使用指定行上的多个端口中的每个端口,其中指定的线路可以是以太网,以及哪些端口可以被打开和关闭,以及哪些端口基于数量计算 分配给控制台,控制台乘数和至少一个增量,表示存在多种信息的信息种类。
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公开(公告)号:US20140017239A1
公开(公告)日:2014-01-16
申请号:US13904432
申请日:2013-05-29
申请人: Alan Daniel Brown , Brian Robert Champion , Clare Christy , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
发明人: Alan Daniel Brown , Brian Robert Champion , Clare Christy , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
IPC分类号: A61K47/48 , A61K39/395
CPC分类号: A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译: 本发明涉及提供新型免疫原,其包含抗原性IgE肽,优选与免疫原性载体连接以预防,治疗或减轻IgE介导的病症。 本发明还涉及这些药物的生产方法,免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号:US20120294848A1
公开(公告)日:2012-11-22
申请号:US13564103
申请日:2012-08-01
申请人: Alan Daniel Brown , Brian Robert Champion , Clare Christy , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
发明人: Alan Daniel Brown , Brian Robert Champion , Clare Christy , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
IPC分类号: C07K17/00 , A61K39/395 , A61P37/02 , C07K16/00
CPC分类号: A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译: 本发明涉及提供新型免疫原,其包含抗原性IgE肽,优选与免疫原性载体连接以预防,治疗或减轻IgE介导的病症。 本发明还涉及这些药物的生产方法,免疫原性组合物及其药物合成及其在药物中的用途。
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