摘要:
Compounds of the formula (I): in which R1, R2, R3, R′3 and R4 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, the pharmaceutical compositions comprising them, and the processes for the preparation of these compounds.
摘要:
Precompression pump intended to dispense selectively a product contained in a container, said pump comprising a pump chamber (3) having an inlet valve (4), a piston (1) sliding in a first cylinder (2), a differential piston (5) forming an outlet valve of said pump chamber (3) and sliding in a second cylinder (11) between a closing position and an opening position of the pump chamber (3), said pump comprising also a pusher (6) provided with a dispensing orifice (7), said pusher element (6) being movable between a rest position and a pump actuation position, the pump being characterized in that said first and second cylinders (2 and 11) are directly formed by first and second respective internal walls of said pusher (6), the latter delimiting partially said pump chamber (3), the pump being also characterized in that it comprises only one spring (15) bearing on one side on a portion of the pusher (6) and on the other side on a portion of the differential piston (5), said spring (15) acting on the one hand as a return spring for the pusher (6) towards its rest position and on the other hand as a precompression spring for the differential piston (5).
摘要:
A pushbutton for actuating a device for dispensing or spraying a fluid substance includes a hollow body 1 having an outlet end 2 in which an outlet orifice 3 is formed, the outlet end including an inside surface 2a which is not perpendicular to the axis 1a of the body. An adjustment member 10 is rotatably received in the body of the pushbutton, and includes a shutter 19 provided with a front surface 19a that is complementary in shape to the inside surface of the outlet end. The shutter is urged towards the outlet end by a resilient tongue 18. The rotation of the adjustment member and shutter varies the outlet flow rate from the pushbutton.
摘要:
Part (14) of stem (4) which extends through opening (31) of lower basket (12) is provided with ribs (17) for having an easier passage of material, either during initial filling or during normal use. The lower part of valve body (1) is provided with openings (19), the number of which is different from the number of ribs (17).
摘要:
Compounds of the formula (1) in which R1, R2,X, Y and Z are as defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and the pharmaceutical compositions comprising them.
摘要:
The invention relates to compounds of the formula I: and to the pharmaceutically acceptable salts thereof, to processes for the preparation of them and to pharmaceutical compositions comprising them, which are useful especially for the treatment and prevention of dyslipidaemia, atherosclerosis and diabetes.
摘要:
A device mountable on a material container for dispensing fluid or pasty material therefrom is disclosed. The device comprises a first pump (10) for selectively dispensing the material from the container through an outlet (31), said first pump being mountable on the container by means of an attachment member (11), and a manual actuation member (30) movable between an inoperative position and an actuated position. The device further comprises a second pump (20) for dispensing compressed air at the same time as the material is dispensed. The second pump comprises two elements (21, 22), i.e. a plunger (21) and a pump cylinder (22) slidably housing the plunger (21), and is designed to feed a flow of compressed air to the outlet (31) in order to spray the material. One of said two elements (21, 22) of said second pump (20) is secured to said attachment member (11) of the first pump (10), whereas the other of said two elements (21, 22) is secured to the actuation member (30).
摘要:
A pushbutton for use with a spray device for mixing a primary substance with a predetermined quantity of a secondary substance stored in such a manner as to be sheltered from the air. The pushbutton is constituted by a first piece (2) which is moveable relative to a second piece (1) containing the emission channel (11) of the pushbutton. The first piece (2) includes containers (22) advantageously disposed like rounds in the cylinder of a revolver. Each container (22) contains the desired quantity of the secondary substance and is hermetically closed by a membrane (23). When the user actuates the pushbutton, a suitable resilient piece (3) and suitable connection pieces (15, 25) ensure that the user automatically displaces the first piece (2) in such a manner that the membrane (23) of one of the containers (22) is pierced and the corresponding dose of secondary substance is delivered into the emission channel (11) so as to be sprayed out together with the main substance.
摘要:
Compounds of the formula (1) in which R1, R2, X, Y and Z are as defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and the pharmaceutical compositions comprising them.
摘要:
The invention concerns a benzodiazepin derivative of formula (I) and their use for treating dyslipidemia, atherosclerosis, diabetes and its complications.