利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.008 秒)

    Process for the preparation of high-purity gamma- and alpha-cyclodextrins
    5.
    发明授权
    Process for the preparation of high-purity gamma- and alpha-cyclodextrins 失效
    制备高纯度γ-和α-环糊精的方法

    公开(公告)号：US4835105A

    公开(公告)日：1989-05-30

    申请号：US71577

    申请日：1987-07-09

    申请人： Gabor Seres ,  Miklos Jarai ,  Sandor Piukovich ,  Maria Szigetvari nee Gabanyi ,  Jozsef Szejtli

    发明人： Gabor Seres ,  Miklos Jarai ,  Sandor Piukovich ,  Maria Szigetvari nee Gabanyi ,  Jozsef Szejtli

    IPC分类号： C12P19/18 ,  C08B37/16

    CPC分类号： C08B37/0012

    摘要： The invention relates to a process for the preparation of high-purity gamma- and alpha-cyclodextrin starting from a starch substrate of low reducing capacity, partially hydrolysed with alpha-amylase. According to the invention a starch substrate of low reducing capacity partially hydrolysed with alpha-amylase is converted with cyclodextrin glucosyl transferase, after the addition of an aliphatic ketone of the formula R.sub.1 COR.sub.2, in which R.sub.1 and R.sub.2 stand for a straight or branched chained alkyl group having from 1 to 6 carbon atoms, and/or a phenol derivative of the formula R.sub.3 R.sub.4 PheOH, wherein R.sub.3 and R.sub.4 are hydrogen, alkyl having from 1 to 4 carbon atoms, or R.sub.3 and R.sub.4 together form phenyl group, Phe stand for phenyl group, OH is hydroxyl and/or a benzene derivative of the formula R.sub.5 R.sub.6 Phe, wherein R.sub.5 and R.sub.6 are hydrogen, alkyl having from 1 to 4 carbon atoms, or R.sub.5 and R.sub.6 together form phenyl group, Phe is phenyl, as a precipitating agent, and if desired, alpha- and/or gamma-cyclodextrin is isolated from the conversion mixture in a crude form, or after further purification, in a pure form.

    摘要翻译： 本发明涉及从低还原能力的淀粉底物开始制备高纯度γ-和α-环糊精的方法，其部分用α-淀粉酶水解。 根据本发明，在加入式R 1 COR 2的脂族酮后，用环糊精葡糖基转移酶转化用α-淀粉酶部分水解的低还原能力的淀粉底物，其中R 1和R 2表示直链或支链链烷基 具有1至6个碳原子，和/或式R3R4PheOH的酚衍生物，其中R3和R4是氢，具有1至4个碳原子的烷基，或R3和R4一起形成苯基，Phe代表苯基， OH是羟基和/或式R 5 R 6 Phe的苯衍生物，其中R 5和R 6是氢，具有1至4个碳原子的烷基或R 5和R 6一起形成苯基，Phe是苯基，作为沉淀剂，如果 所需的α-和/或γ-环糊精以粗制形式从转化混合物中分离，或在进一步纯化后以纯形式分离。