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公开(公告)号：US10676424B2
公开(公告)日：2020-06-09
申请号：US16133297
申请日：2018-09-17
申请人： Ming-Yu Ngai , Katarzyna N. Hojczyk
发明人： Ming-Yu Ngai , Katarzyna N. Hojczyk
IPC分类号： C07C233/25 , C07C259/06 , C07C259/10 , C07C269/06 , C07C273/18 , C07C231/14 , C07C253/30 , C07D213/75 , C07D213/76 , C07D347/00 , C07D239/47 , C07D239/91 , C07D473/40 , C07D263/57 , C07D209/08 , C07D215/40 , C07D401/04 , C07D471/04 , C07J43/00 , C07D417/04 , C07D405/04 , C07C231/12 , C07C233/33 , C07C233/54 , C07C233/80 , C07C233/81 , C07C255/60 , C07C255/58 , C07C271/38 , C07C275/34
摘要： The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: wherein A is an aryl or heteroaryl, each with or without substitution; and R1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl)2, —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl); —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising: (a) reacting a compound having the structure: with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:
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公开(公告)号：US20200262784A1
公开(公告)日：2020-08-20
申请号：US16868343
申请日：2020-05-06
申请人： Ming-Yu Ngai , Katarzyna N. Hojczyk
发明人： Ming-Yu Ngai , Katarzyna N. Hojczyk
IPC分类号： C07C233/25 , C07C275/34 , C07C271/38 , C07C255/58 , C07C255/60 , C07C233/81 , C07C233/80 , C07C233/54 , C07C233/33 , C07C231/12 , C07J43/00 , C07D471/04 , C07D401/04 , C07D215/40 , C07D209/08 , C07D263/57 , C07D473/40 , C07D239/91 , C07D239/47 , C07D347/00 , C07D213/76 , C07D213/75 , C07C253/30 , C07C231/14 , C07C273/18 , C07C269/06 , C07C259/10 , C07C259/06 , C07D405/04 , C07D417/04
摘要： The present invention provides a process of producing a trifluoromcthoxylated aryl or trifluoromothoxylated heteroaryl having the structure: wherein A is an aryl or heteroaryl, each with or without substitution; and R1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl)2, —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising: (a) reacting a compound having the structure: with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:
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公开(公告)号：US20190016670A1
公开(公告)日：2019-01-17
申请号：US16133297
申请日：2018-09-17
申请人： Ming-Yu Ngai , Katarzyna N. Hojczyk
发明人： Ming-Yu Ngai , Katarzyna N. Hojczyk
IPC分类号： C07C233/25 , C07D209/08 , C07J43/00 , C07D473/40 , C07D239/91 , C07D239/47 , C07D405/04 , C07D347/00 , C07D213/76 , C07D213/75 , C07C255/60 , C07C233/54 , C07C233/80 , C07C231/12 , C07C233/33 , C07C233/81 , C07D263/57 , C07D215/40 , C07D401/04 , C07D417/04 , C07D471/04 , C07C259/06 , C07C259/10 , C07C269/06 , C07C273/18 , C07C231/14 , C07C253/30 , C07C275/64 , C07C271/38 , C07C255/58 , C07C275/34
CPC分类号： C07C233/25 , C07C231/12 , C07C231/14 , C07C233/33 , C07C233/54 , C07C233/80 , C07C233/81 , C07C253/30 , C07C255/58 , C07C255/60 , C07C259/06 , C07C259/10 , C07C269/06 , C07C271/38 , C07C273/1809 , C07C273/1854 , C07C275/34 , C07D209/08 , C07D213/75 , C07D213/76 , C07D215/40 , C07D239/47 , C07D239/91 , C07D263/57 , C07D347/00 , C07D401/04 , C07D405/04 , C07D417/04 , C07D471/04 , C07D473/40 , C07J43/003 , C07C275/64
摘要： The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: wherein A is an aryl or heteroaryl, each with or without subsutitution; and R1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl)2, —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl); —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising: (a) reacting a compound having the structure: with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:
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公开(公告)号：US10118890B2
公开(公告)日：2018-11-06
申请号：US15516610
申请日：2015-10-09
申请人： Ming-Yu Ngai , Katarzyna N. Hojczyk
发明人： Ming-Yu Ngai , Katarzyna N. Hojczyk
IPC分类号： C07C233/25 , C07C259/06 , C07C259/10 , C07D239/91 , C07C231/12 , C07C255/60 , C07C253/30 , C07C233/33 , C07C233/80 , C07C233/54 , C07C233/81 , C07D215/40 , C07D209/08 , C07D213/75 , C07D401/04 , C07D473/40 , C07D213/76
摘要： The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: wherein A is an aryl or heteroaryl, each with or without subsutitution; and R1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl)2, —NH-(alkenyl), —NH-(alkynyl)—NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising: (a) reacting a compound having the structure: with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:
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公开(公告)号：US11724982B2
公开(公告)日：2023-08-15
申请号：US16868343
申请日：2020-05-06
申请人： Ming-Yu Ngai , Katarzyna N. Hojczyk
发明人： Ming-Yu Ngai , Katarzyna N. Hojczyk
IPC分类号： C07C233/25 , C07C259/06 , C07C259/10 , C07C269/06 , C07C273/18 , C07C231/14 , C07C253/30 , C07D213/75 , C07D213/76 , C07D347/00 , C07D239/47 , C07D239/91 , C07D473/40 , C07D263/57 , C07D209/08 , C07D215/40 , C07D401/04 , C07D471/04 , C07J43/00 , C07D417/04 , C07D405/04 , C07C231/12 , C07C233/33 , C07C233/54 , C07C233/80 , C07C233/81 , C07C255/60 , C07C255/58 , C07C271/38 , C07C275/34
CPC分类号： C07C233/25 , C07C231/12 , C07C231/14 , C07C233/33 , C07C233/54 , C07C233/80 , C07C233/81 , C07C253/30 , C07C255/58 , C07C255/60 , C07C259/06 , C07C259/10 , C07C269/06 , C07C271/38 , C07C273/1809 , C07C273/1854 , C07C275/34 , C07D209/08 , C07D213/75 , C07D213/76 , C07D215/40 , C07D239/47 , C07D239/91 , C07D263/57 , C07D347/00 , C07D401/04 , C07D405/04 , C07D417/04 , C07D471/04 , C07D473/40 , C07J43/003 , C07C273/1854 , C07C275/64 , C07C269/06 , C07C271/38 , C07C231/14 , C07C233/25 , C07C253/30 , C07C255/60 , C07C253/30 , C07C255/58 , C07C273/1809 , C07C275/34
摘要： The present invention provides a process of producing a trifluoromcthoxylated aryl or trifluoromothoxylated heteroaryl having the structure:
wherein
A is an aryl or heteroaryl, each with or without substitution; and
R1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl)2, —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising:
(a) reacting a compound having the structure:
with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure:
and
(b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:-
公开(公告)号：US20170298008A1
公开(公告)日：2017-10-19
申请号：US15516610
申请日：2015-10-09
申请人： Ming-Yu Ngai , Katarzyna N. Hojczyk
发明人： Ming-Yu Ngai , Katarzyna N. Hojczyk
IPC分类号： C07C233/25 , C07C231/12 , C07D239/91 , C07D215/40 , C07D213/76 , C07D213/75 , C07D209/08 , C07C259/10 , C07C259/06 , C07C255/60 , C07C253/30 , C07C233/81 , C07C233/80 , C07C233/54 , C07C233/33 , C07D401/04 , C07D473/40
CPC分类号： C07C233/25 , C07C231/12 , C07C231/14 , C07C233/33 , C07C233/54 , C07C233/80 , C07C233/81 , C07C253/30 , C07C255/60 , C07C259/06 , C07C259/10 , C07C269/06 , C07C273/1809 , C07C273/1854 , C07D209/08 , C07D213/75 , C07D213/76 , C07D215/40 , C07D239/47 , C07D239/91 , C07D263/57 , C07D347/00 , C07D401/04 , C07D405/04 , C07D417/04 , C07D471/04 , C07D473/40 , C07J43/003 , C07C275/64 , C07C271/38 , C07C255/58 , C07C275/34
摘要： The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: wherein A is an aryl or heteroaryl, each with or without subsutitution; and R1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl)7, —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising: (a) reacting a compound having the structure: with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:
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