公开(公告)号：US5055261A

公开(公告)日：1991-10-08

申请号：US270849

申请日：1988-11-14

申请人： Mirza A. Khoja ,  Frank W. Wogoman

发明人： Mirza A. Khoja ,  Frank W. Wogoman

IPC分类号： B65G25/02 ,  G01N1/28 ,  G01N35/00

CPC分类号： B65G25/02 ,  G01N21/8483 ,  G01N35/00029 ,  G01N1/2813 ,  G01N2035/00039 ,  G01N2035/00118

摘要： A multiple reagent test strip-reading instrument having rails extending from a loading area to one or more reading station platforms and then to a waste receptacle, a reciprocating blotter arm which contacts individual reagent strips sequentially placed transversely on the rails in the loading area, moving individual strips along the rails to an indexing strip advancing mechanism which intermittently advances the strips along the rails in spaced parallel relation, and after each advance, allows the strips to dwell for a predetermined time period; individual test strips being thereby sequentially delivered to reading position on the reading station platform where, during the dwell period, they are read by reflectance photometry. After reading, the strips are moved to the waste receptacle. Means is provided for insuring that each test strip is delivered to reading position in registration with the read head of the photometer, and means is also provided for pressing each test strip flat against the reading station platform. The indexing mechanism employs a strip advancing member provided with parallel rows of equally spaced upstanding pegs or fingers, there being guiding and drive means for imparting movement to said member along a vertical orbital path having a generally circular extent and also having a rectilinear extent parallel with the rails, said pegs intersecting the plane of the reagent strips on the rails when said member moves forwardly along said rectilinear extent and being withdrawn from said plane when said member moves rearwardly along said circular extent.

摘要翻译： 一种多试剂测试条读取仪器，具有从装载区域延伸到一个或多个阅读站平台，然后到废物容器的轨道，一个往复式吸墨纸臂，其接触各个试剂条，其横向地放置在装载区域中的轨道上，移动 沿着轨道的单独条带到分段条带前进机构，其间隔地沿着轨道以间隔开的平行关系推进条带，并且在每个前进之后允许条带停留预定时间段; 单独的测试条由此顺序地传送到阅读台平台上的读取位置，在停留时段期间，它们通过反射光度测量被读取。 阅读后，将条移动到废物容器。 提供了用于确保每个测试条被传送到与光度计的读取头对准的读取位置的装置，并且还提供用于将每个测试条平放在读取台平台上的装置。 分度机构采用设置有平行的等间距直立的钉或手指的条带推进构件，存在引导和驱动装置，用于沿着具有大致圆形范围的垂直轨道路径向所述构件施加运动，并且还具有与 所述轨道，当所述构件沿着所述直线范围向前移动时，所述栓与试剂条的平面相交，并且当所述构件沿着所述圆形范围向后移动时从所述平面撤回。

公开(公告)号：US4820491A

公开(公告)日：1989-04-11

申请号：US32607

申请日：1987-04-01

申请人： Mirza A. Khoja ,  Frank W. Wogoman

发明人： Mirza A. Khoja ,  Frank W. Wogoman

IPC分类号： G01N33/52 ,  B65G25/02 ,  G01N1/28 ,  G01N21/75 ,  G01N21/78 ,  G01N35/00

CPC分类号： G01N35/00029 ,  B65G25/02 ,  G01N21/8483 ,  G01N1/2813 ,  G01N2035/00039 ,  G01N2035/00118 ,  Y10T436/112499 ,  Y10T436/113332

摘要： A multiple reagent test strip-reading instrument having rails extending from a loading area to one or more reading station platforms and then to a waste receptacle, a reciprocating blotter arm which contacts individual reagent strips sequentially placed transversely on the rails in the loading area, moving individual strips along the rails to an indexing strip advancing mechanism which intermittently advances the strips along the rails in spaced parallel relation, and after each advance, allows the strips to dwell for a predetermined time period; individual test strips being thereby sequentially delivered to reading position on the reading station platform where, during the dwell period, they are read by reflectance photometry. After reading, the strips are moved to the waste receptacle. Means is provided for insuring that each test strip is delivered to reading position in registration with the read head of the photometer, and means is also provided for pressing each test strip flat against the reading station platform. The indexing mechanism employs a strip advancing member provided with parallel rows of equally spaced upstanding pegs or fingers, there being guiding and drive means for imparting movement to said member along a vertical orbital path having a generally circular extent and also having a rectilinear extent parallel with the rails, said pegs intersecting the plane of the reagent strips on the rails when said member moves forwardly along said rectilinear extent and being withdrawn from said plane when said member moves rearwardly along said circular extent.

摘要翻译： 一种多试剂测试条读取仪器，具有从装载区域延伸到一个或多个阅读站平台，然后到废物容器的轨道，一个往复式吸墨纸臂，其接触各个试剂条，其横向地放置在装载区域中的轨道上，移动 沿着轨道的单独条带到分段条带前进机构，其间隔地沿着轨道以间隔开的平行关系推进条带，并且在每个前进之后允许条带停留预定时间段; 单独的测试条由此顺序地传送到阅读台平台上的读取位置，在停留时段期间，它们通过反射光度测量被读取。 阅读后，将条移动到废物容器。 提供了用于确保每个测试条被传送到与光度计的读取头对准的读取位置的装置，并且还提供用于将每个测试条平放在读取台平台上的装置。 分度机构采用设置有平行的等间距直立的钉或手指的条带推进构件，存在引导和驱动装置，用于沿着具有大致圆形范围的垂直轨道路径向所述构件施加运动，并且还具有与 所述轨道，当所述构件沿着所述直线范围向前移动时，所述栓与试剂条的平面相交，并且当所述构件沿着所述圆形范围向后移动时从所述平面撤回。

公开(公告)号：US4689202A

公开(公告)日：1987-08-25

申请号：US649363

申请日：1984-09-11

申请人： Mirza A. Khoja ,  Frank W. Wogoman

发明人： Mirza A. Khoja ,  Frank W. Wogoman

IPC分类号： G01N33/52 ,  B65G25/02 ,  G01N1/28 ,  G01N21/75 ,  G01N21/78 ,  G01N35/00 ,  G01N21/13 ,  G01N35/04

CPC分类号： G01N35/00029 ,  B65G25/02 ,  G01N21/8483 ,  G01N1/2813 ,  G01N2035/00039 ,  G01N2035/00118 ,  Y10T436/112499 ,  Y10T436/113332

摘要： A multiple reagent test strip-reading instrument having rails extending from a loading area to one or more reading station platforms and then to a waste receptacle, a reciprocating blotter arm which contacts individual reagent strips sequentially placed transversely on the rails in the loading area, moving individual strips along the rails to an indexing strip advancing mechanism which intermittently advances the strips along the rails in spaced parallel relation, and after each advance, allows the strips to dwell for a predetermined time period; individual test strips being thereby sequentially delivered to reading position on the reading station platform where, during the dwell period, they are read by reflectance photometry. After reading, the strips are moved to the waste receptacle. Means is provided for insuring that each test strip is delivered to reading position in registration with the read head of the photometer, and means is also provided for pressing each test strip flat against the reading station platform. The indexing mechanism employs a strip advancing member provided with parallel rows of equally spaced upstanding pegs or fingers, there being guiding and drive means for imparting movement to said member along a vertical orbital path having a generally circular extent and also having a rectilinear extent parallel with the rails, said pegs intersecting the plane of the reagent strips on the rails when said member moves forwardly along said rectilinear extent and being withdrawn from said plane when said member moves rearwardly along said circular extent.

公开(公告)号：US4127231A

公开(公告)日：1978-11-28

申请号：US850622

申请日：1977-11-11

申请人： Mirza A. Khoja ,  Louis F. Gutierrez ,  John T. Perone

发明人： Mirza A. Khoja ,  Louis F. Gutierrez ,  John T. Perone

IPC分类号： B04B5/04 ,  B04B13/00

CPC分类号： B04B5/0442 ,  Y10S128/03

摘要： The support arm is used in an apparatus for the centrifugal liquid processing of whole blood wherein whole blood is withdrawn from a donor and passed through a flexible tubing of a fluid system of the apparatus into a bowl thereof where the blood is centrifuged to separate the same into at least three components. One component which is to be collected is withdrawn through a flexible tubing at a fixed rate of volumetric displacement while the other two components are withdrawn through flexible tubings at variable rates of volumetric displacement. The other two components are recombined and returned to the donor. The withdrawal of the one component is optically monitored to determine whether or not either one of the other components is being mixed with the one component. The support arm is positioned above the bowl for guiding the tubings to the bowl in a first position and is pivotal horizontally to a second position where the bowl can be easily removed. A releasable latch member holds the arm in the first position and mounts an optical sensing system for monitoring the withdrawal of the one component through a light transmissive portion of the flexible tubing, through which the one component is being withdrawn.

摘要翻译： 支撑臂用于全血离心液体处理的装置中，其中全血从供体中取出并通过装置的流体系统的柔性管进入其中离心分离血液的碗中 进入至少三个组件。 要收集的一个组分通过柔性管以固定的体积位移速率被抽出，而另外两个组分通过柔性管以可变的体积位移速率被抽出。 另外两个组分被重组并返回给供体。 光学地监测一个组分的抽出，以确定其它组分中的任一个是否与一个组分混合。 所述支撑臂位于所述碗的上方，用于在第一位置将所述管引导到所述碗，并且可水平地枢转到第二位置，在所述第二位置，所述碗可以容易地移除。 可释放的闩锁构件将臂保持在第一位置并且安装光学感测系统，用于监测一个部件通过柔性管道的透光部分的抽出，通过该柔性管道的一个部件被抽出。

公开(公告)号：US4132349A

公开(公告)日：1979-01-02

申请号：US850621

申请日：1977-11-11

申请人： Mirza A. Khoja ,  Louis F. Gutierrez ,  John T. Perone

发明人： Mirza A. Khoja ,  Louis F. Gutierrez ,  John T. Perone

IPC分类号： B04B5/04 ,  B04B9/08

CPC分类号： B04B9/08 ,  B04B5/0442 ,  Y10T74/19102

摘要： The rotor drive assembly is utilized in driving a rotor assembly in an apparatus for centrifugal liquid processing of whole blood wherein whole blood is withdrawn from a donor, passed into a bowl held by the rotor assembly and the blood is centrifuged to separate the same into at least three components within the bowl. One component which is to be collected is withdrawn at a fixed rate of volumetric displacement while the other two components are withdrawn at variable rates of volumetric displacement. The other two components are recombined and returned to the donor. The withdrawal of the one component is optically monitored to determine whether or not either one of the other components is being mixed with the one component. The rotor drive assembly includes a unitary vertical drive shaft having a lower rotatable collar, an intermediate fixed collar and an upper rotatable collar mounted thereon. Two idler pulleys depend from the fixed collar and an idler shaft is rotatably journaled in the fixed collar and has upper and lower pulleys. The lower pulley, the idler pulley and the first collar form planetary drive means driven by a first continuous belt. A second continuous belt engages the upper pulley and the third collar. Also, passage means extend from the center of the upper portion of the drive shaft downwardly and then outwardly through the fixed collar for passing flexible, blood component carrying tubings to the bowl.

摘要翻译： 转子驱动组件用于驱动用于全血离心液体处理的设备中的转子组件，其中全血从供体中取出，通过转子组件保持的碗中，并将血液离心以将其分离成 碗内至少有三个部件。 要收集的一个组分以固定的体积位移速率取出，而另外两个组分以可变的体积位移速率取出。 另外两个组分被重组并返回给供体。 光学地监测一个组分的抽出，以确定其它组分中的任一个是否与一个组分混合。 转子驱动组件包括具有下部可旋转轴环的单一垂直驱动轴，中间固定轴环和安装在其上的上部可旋转轴环。 两个空转轮从固定轴环上取下，而惰轮轴可旋转地轴颈固定在固定的轴环上并具有上和下滑轮。 下滑轮，惰轮和第一轴环形成由第一连续带驱动的行星驱动装置。 第二连续带接合上滑轮和第三轴环。 此外，通道装置从驱动轴的上部的中心向下延伸，然后向外延伸穿过固定的环，用于将柔性的血液成分输送管道传递到碗。

公开(公告)号：US3986442A

公开(公告)日：1976-10-19

申请号：US620991

申请日：1975-10-09

申请人： Mirza A. Khoja ,  George M. Coker, Jr.

发明人： Mirza A. Khoja ,  George M. Coker, Jr.

IPC分类号： B04B5/04 ,  B04B9/08 ,  F16H1/28 ,  F16H7/00

CPC分类号： B04B5/0442 ,  B04B9/08 ,  B04B2005/0492

摘要： A drive system for a centrifugal liquid processing apparatus or the like wherein a rotor assembly having a container for receiving a liquid to be processed by centrifugation is rotatably mounted on a rotor drive assembly, which in turn is rotatably mounted to a stationary base. Liquid communication is maintained with the container during rotation of the rotor by means of a flexible umbilical cable which extends from the container to a location external to the apparatus by way of a passageway provided in the support shaft of the rotor assembly and a guide sleeve carried on and rotatably mounted to the rotor drive assembly. The rotor assembly is rotatably driven in the same direction as the rotor drive assembly with a speed ratio of 2:1 and the guide sleeve is rotatably driven in the opposite direction with a speed equal to that of the rotor drive assembly to prevent the umbilical cable from becoming twisted during operation of the apparatus. This is accomplished by a novel drive arrangement which includes a planetary drive gear on the rotor drive assembly which is rotatably coupled to the rotor and guide sleeve by means of a single drive belt.

摘要翻译： 一种用于离心液体处理设备等的驱动系统，其中具有用于接收待离心处理液体的容器的转子组件可旋转地安装在转子驱动组件上，转子驱动组件又可旋转地安装在固定基座上。 通过柔性脐带缆在转子旋转期间与容器一起保持液体连通，柔性脐带缆线通过设置在转子组件的支撑轴中的通道从容器延伸到设备外部的位置，以及承载的导向套筒 并且可旋转地安装到转子驱动组件。 转子组件以与转子驱动组件相同的方向以2:1的速度比可旋转地驱动，并且引导套筒以相当于转子驱动组件的速度的相反方向可旋转地驱动，以防止脐带缆 在设备的操作期间变得扭曲。 这是通过一种新颖的驱动装置实现的，其包括在转子驱动组件上的行星驱动齿轮，其通过单个驱动带可旋转地联接到转子和引导套筒。

公开(公告)号：US4223672A

公开(公告)日：1980-09-23

申请号：US10232

申请日：1979-02-08

申请人： David S. Terman ,  Herbert M. Cullis ,  Mirza A. Khoja ,  Michael R. Sullivan

发明人： David S. Terman ,  Herbert M. Cullis ,  Mirza A. Khoja ,  Michael R. Sullivan

IPC分类号： A61M1/34 ,  A61M1/36 ,  A61M5/00 ,  B01D35/00

CPC分类号： A61M1/3472 ,  A61M1/3486 ,  A61M1/3693

摘要： The apparatus includes a peristaltic pump for withdrawing whole blood from a patient, a device for centrifuging the blood to separate plasma from the whole blood, a plasma treatment chamber for receiving the plasma, a vehicle positioned within the chamber and having an immuno-adsorbent agent fixed thereon to interact and bond with an immunological reactant carried by the plasma that is passed through the chamber for removing the immunological reactant from the plasma, tubing connected to recombine the substantially immunological reactant free plasma with the remainder of the whole blood and a peristaltic pump for returning the recombined whole blood to the patient. According to the present invention the plasma treatment chamber has a variable volume so that the chamber can be used for treating sequentially different quantities of plasma.

摘要翻译： 该装置包括用于从患者中取出全血的蠕动泵，用于离心血液以将血浆与全血分离的装置，用于接收等离子体的等离子体处理室，位于室内的车辆并具有免疫吸附剂 固定在其上以与由等离子体携带的免疫反应物相互作用并结合，所述免疫反应物通过所述腔室以从血浆中除去免疫反应物，所述管连接以将基本上免疫的反应物无血浆与剩余的全血和蠕动泵 用于将重组的全血返回给患者。 根据本发明，等离子体处理室具有可变的体积，使得室可以用于顺序地处理不同量的等离子体。