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1.发明授权Optically active α-amino acid into which BSH is introduced and method for synthesizing the same 有权引入BSH的光学活性α-氨基酸及其合成方法公开(公告)号：US08431738B2
公开(公告)日：2013-04-30
申请号：US13055700
申请日：2009-07-23
IPC分类号： C07C61/12 , C07C323/53 , C07C319/20
摘要： Disclosed is the method for producing an optically active BSH amino acid, which comprises a step of reacting an optically active a-amino acid derivative having a halogen in a side chain with a cyanoethyl BSH compound represented by formula (1). An optically active BSH amino acid obtained by the method is also disclosed.
摘要翻译： 公开了光学活性BSH氨基酸的制造方法，其包括使侧链具有卤素的光学活性α-氨基酸衍生物与式（1）所示的氰乙基BSH化合物反应的工序。 还公开了通过该方法获得的光学活性的BSH氨基酸。
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2.发明申请OPTICALLY ACTIVE ALPHA-AMINO ACID INTO WHICH BSH IS INTRODUCED AND METHOD FOR SYNTHESIZING THE SAME 有权光学活性α-氨基酸进入其中的BSH及其合成方法公开(公告)号：US20110124914A1
公开(公告)日：2011-05-26
申请号：US13055700
申请日：2009-07-23
IPC分类号： C07F5/02
摘要： Disclosed is the method for producing an optically active BSH amino acid, which comprises a step of reacting an optically active a-amino acid derivative having a halogen in a side chain with a cyanoethyl BSH compound represented by formula (1). An optically active BSH amino acid obtained by the method is also disclosed.
摘要翻译： 公开了光学活性BSH氨基酸的制造方法，其包括使侧链具有卤素的光学活性α-氨基酸衍生物与式（1）所示的氰乙基BSH化合物反应的工序。 还公开了通过该方法获得的光学活性的BSH氨基酸。
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公开(公告)号：US20110184175A1
公开(公告)日：2011-07-28
申请号：US13055704
申请日：2009-07-23
IPC分类号： C07F5/02
CPC分类号： C07F5/027 , A61K41/0095
摘要： Disclosed is a method for producing a BSH derivative, which comprises a step of addition-reacting BSH with an α,β-unsaturated nitrile compound in the presence of a base. Various BSH derivatives obtained by the method are also disclosed.
摘要翻译： 公开了一种生产BSH衍生物的方法，其包括在碱存在下使BSH与α，β-不饱和腈化合物反应的步骤。 还公开了通过该方法获得的各种BSH衍生物。
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公开(公告)号：US08907128B2
公开(公告)日：2014-12-09
申请号：US13813697
申请日：2011-08-02
摘要： The purpose of the present invention is to provide a novel boron-containing compound utilizable in BNCT and so on and a process for preparing same. According to the process, a boron compounds having an amino acid skeleton containing cyclo-type rings or a pharmaceutically acceptable salt thereof is prepared, said boron compound being represented by general formula (I) [wherein l is an integer of 1 to 6; m is 0, 1, or 2; and n is 0, 1 or 2].
摘要翻译： 本发明的目的是提供一种可用于BNCT等的新型含硼化合物及其制备方法。 根据该方法，制备具有含有环型环的氨基酸骨架的硼化合物或其药学上可接受的盐，所述硼化合物由通式（I）表示[其中l为1〜6的整数; m为0,1或2; 和n为0,1或2]。
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5.发明授权Process for imparting water solubility or water dispersibility to hydrophobic cluster compound 有权赋予疏水性簇化合物水溶性或水分散性的方法公开(公告)号：US08907080B2
公开(公告)日：2014-12-09
申请号：US13511253
申请日：2010-11-26
申请人： Toshio Suzuki , Hideaki Ueda , Takeshi Nagasaki , Mitsunori Kirihata , Munenori Numata , Atsushi Ikeda
发明人： Toshio Suzuki , Hideaki Ueda , Takeshi Nagasaki , Mitsunori Kirihata , Munenori Numata , Atsushi Ikeda
CPC分类号： C01B31/0273 , B22F1/0062 , B22F1/0074 , B82Y30/00 , B82Y40/00 , C01B32/174 , C07F5/027 , C08B37/0057 , C08K3/02 , C08K3/041 , C08K3/045 , C08K3/06 , C08K3/08 , Y10S977/734 , Y10S977/742 , C08L5/00
摘要： Provided is a complex comprising a hydrophobic cluster compound and a β-1,3-1,6-D-glucan having a degree of branching (a ratio of β-1,6 linkages to β-1,3 linkages) of 50 to 100%.
摘要翻译： 提供了一种复合物，其包含疏水性簇化合物和具有支化度（＆bgr; -1,6键与＆bgr; -1,3键的比率）的＆lt; bgr。-1,3-1,6-D-葡聚糖 为50〜100％。
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公开(公告)号：US08865874B2
公开(公告)日：2014-10-21
申请号：US12280538
申请日：2006-10-05
申请人： Mitsunori Kirihata , Tomoyuki Asano , Kohki Uehara
发明人： Mitsunori Kirihata , Tomoyuki Asano , Kohki Uehara
CPC分类号： G01N33/5308 , C07F5/027 , C07K16/44 , G01N33/84 , G01N33/94
摘要： The present invention is a compound having a structure represented by the following formula (1): and an antibody to BSH obtained by using the compound as a hapten and using a complex of the hapten and a high-molecular compound as an antigen. By using the present invention, it becomes possible to provide a hapten compound for preparing an antibody recognizing BSH highly sensitively and highly selectively, an antibody to BSH, as well as a kit for measuring BSH and an immunological measuring method having high sensitivity and excellent in quantitative property using the antibody.
摘要翻译： 本发明是具有下述式（1）表示的结构的化合物和通过使用该化合物作为半抗原并使用半抗原和高分子化合物的复合物作为抗原而获得的BSH抗体。 通过使用本发明，可以提供一种半抗原化合物，用于制备高灵敏度，高度选择性地识别BSH的抗体，对BSH的抗体，以及用于测量BSH的试剂盒和具有高灵敏度和优异性的免疫测定方法 使用抗体的定量性质。
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公开(公告)号：US20130225861A1
公开(公告)日：2013-08-29
申请号：US13813697
申请日：2011-08-02
IPC分类号： C07F5/05
摘要： The purpose of the present invention is to provide a novel boron-containing compound utilizable in BNCT and so on and a process for preparing same. According to the process, a boron compounds having an amino acid skeleton containing cyclo-type rings or a pharmaceutically acceptable salt thereof is prepared, said boron compound being represented by general formula (I) [wherein l is an integer of 1 to 6; m is 0, 1, or 2; and n is 0, 1 or 2].
摘要翻译： 本发明的目的是提供一种可用于BNCT等的新型含硼化合物及其制备方法。 根据该方法，制备具有含有环型环的氨基酸骨架的硼化合物或其药学上可接受的盐，所述硼化合物由通式（I）表示[其中l为1〜6的整数; m为0,1或2; 和n为0,1或2]。
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8.发明申请PROCESS FOR IMPARTING WATER SOLUBILITY OR WATER DISPERSIBILITY TO HYDROPHOBIC CLUSTER COMPOUND 有权将水溶性或水分散性降低到疏水性聚合物化合物的方法公开(公告)号：US20120264931A1
公开(公告)日：2012-10-18
申请号：US13511253
申请日：2010-11-26
申请人： Toshio Suzuki , Hideaki Ueda , Takeshi Nagasaki , Mitsunori Kirihata , Munenori Numata , Atsushi Ikeda
发明人： Toshio Suzuki , Hideaki Ueda , Takeshi Nagasaki , Mitsunori Kirihata , Munenori Numata , Atsushi Ikeda
CPC分类号： C01B31/0273 , B22F1/0062 , B22F1/0074 , B82Y30/00 , B82Y40/00 , C01B32/174 , C07F5/027 , C08B37/0057 , C08K3/02 , C08K3/041 , C08K3/045 , C08K3/06 , C08K3/08 , Y10S977/734 , Y10S977/742 , C08L5/00
摘要： Provided is a complex comprising a hydrophobic cluster compound and a β-1,3-1,6-D-glucan having a degree of branching (a ratio of β-1,6 linkages to β-1,3 linkages) of 50 to 100%.
摘要翻译： 提供了一种复合物，其包含疏水性簇化合物和具有支化度（＆bgr; -1,6键与＆bgr; -1,3键的比率）的＆lt; bgr。-1,3-1,6-D-葡聚糖 为50〜100％。
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