-
公开(公告)号:US20120070852A1
公开(公告)日:2012-03-22
申请号:US13132483
申请日:2009-12-01
申请人: Molly Stevens , James Eric Ghadiali
发明人: Molly Stevens , James Eric Ghadiali
CPC分类号: C12Q1/48 , C12Q1/485 , G01N33/542
摘要: The present invention relates to an assay for transferases. The assay comprises a first moiety comprising a transferase substrate and a second moiety capable of binding to the transferase substrate after it has been acted on by the transferase. One of the first and second moieties comprises a fluorophore and the other of the first and second moieties causes a change in fluorescence of the fluorophore. Thus, when the second moiety binds the transferase substrate after it has been acted on by the transferase, a change in fluorescence can be detected. The assay allows for agents that modulate the activity of the transferase to be screened.
摘要翻译: 本发明涉及转移酶的测定。 该测定法包括第一部分,其包含转移酶底物和在被转移酶作用之后能够结合转移酶底物的第二部分。 第一和第二部分之一包含荧光团,第一和第二部分中的另一部分引起荧光团的荧光变化。 因此,当第二部分在被转移酶作用后结合转移酶底物时,可以检测到荧光的变化。 该测定允许调节转移酶活性的试剂被筛选。
-
公开(公告)号:US20050079159A1
公开(公告)日:2005-04-14
申请号:US10480682
申请日:2002-06-13
申请人: Venkatram Shastri , Molly Stevens , Robert Langer
发明人: Venkatram Shastri , Molly Stevens , Robert Langer
IPC分类号: A01K67/027 , A61K31/70 , A61K35/12 , A61K45/00 , A61P43/00 , C12N5/00 , C12N5/02 , C12N5/077
CPC分类号: A01K67/0271 , A61K31/70 , A61K35/12 , C12N5/0068 , C12N5/0654 , C12N5/0655 , C12N2501/115 , C12N2501/15 , C12N2533/40 , C12N2533/74
摘要: The present invention relates to an in vivo method of promoting the growth of autologous tissue and its use to form corrective structures, including tissue that can be explanted to other locations in the animal. In particular, the invention relates to methods and systems for (a) the site-specific regeneration of tissue, and (b) the synthesis of neotissue for transplantation.
摘要翻译: 本发明涉及促进自体组织生长的体内方法及其用于形成矫正结构的用途,包括可移植到动物其他位置的组织。 特别地,本发明涉及用于(a)组织的位点特异性再生的方法和系统,和(b)用于移植的新组织的合成。
-
公开(公告)号:US20110123592A1
公开(公告)日:2011-05-26
申请号:US12994606
申请日:2009-05-27
申请人: Molly Stevens , Jose Sardinha , Erh-Hsuin Lim
发明人: Molly Stevens , Jose Sardinha , Erh-Hsuin Lim
CPC分类号: A61L27/54 , A61L27/227 , A61L27/38 , A61L2300/414
摘要: The invention relates to a biomaterial having a latent form of a growth factor immobilised thereon, and to a method of producing the biomaterial, comprising immobilising the latent form of the growth factor on the biomaterial. The biomaterial may be used in medicine, such as in tissue regeneration or repair.
摘要翻译: 本发明涉及具有固定在其上的生长因子的潜在形式的生物材料,以及生物材料的生产方法,包括将生长因子的潜在形式固定在生物材料上。 生物材料可用于医学中,例如在组织再生或修复中。
-
-