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    Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
    1.
    发明授权
    Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system 有权

    公开(公告)号：US10351620B2

    公开(公告)日：2019-07-16

    申请号：US15629123

    申请日：2017-06-21

    Applicant: Moses Rodriguez ,  David J. Miller ,  Larry R. Pease

    Inventor： Moses Rodriguez ,  David J. Miller ,  Larry R. Pease

    IPC: C07K14/705 ,  C07K16/18 ,  C12Q1/6876 ,  A61K38/00 ,  A61K39/00

    Abstract: Antibodies, particularly human antibodies, are disclosed having activity in treatment of demyelinating diseases and diseases of the central nervous system. Neuromodulatory agents are provided comprising a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, and active fragments, monomers and combinations thereof having one or more of the following characteristics: capable of inducing remyelination; binding to neural tissue; promoting Ca++ signaling with oligodendrocytes; and promoting cellular proliferation of glial cells. Amino acid and DNA sequences of exemplary antibodies are disclosed. Methods are described for treating demyelinating diseases, and diseases of the central nervous system, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, and active fragments thereof. The invention extends to the use of antibodies and fragments in diagnostic and therapeutic applications, including screening assays.

    Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
    4.
    发明申请
    Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system 有权
    人IgM抗体及其诊断和治疗用途，特别是在中枢神经系统中

    公开(公告)号：US20090274690A1

    公开(公告)日：2009-11-05

    申请号：US12313515

    申请日：2008-11-20

    Applicant: Moses Rodriguez ,  David J. Miller ,  Larry R. Pease

    Inventor： Moses Rodriguez ,  David J. Miller ,  Larry R. Pease

    IPC: A61K39/395 ,  A61P25/00

    CPC classification number: A61K38/00 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/77 ,  C12Q1/6876 ,  Y02A50/473

    Abstract: Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. The neuromodulatory agent has one or more of the following characteristics: it is capable of inducing remyelination; binding to neural tissue; promoting Ca−− signaling with oligodendrocytes; and promoting cellular proliferation of glial cells. Amino acid and DNA sequences of exemplary antibodies are disclosed. Methods are described for treating demyelinating diseases, and diseases of the central nervous system of humans and domestic animals, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in diagnostic and therapeutic applications, including screening assays for the discovery of additional antibodies that bind to cells of the nervous system, particularly oligodendrocytes.

    Abstract translation: 公开了抗体，特别是人抗体，其表现出治疗脱髓鞘疾病以及中枢神经系统的病毒，细菌或特发性起源的其它疾病，包括由脊髓损伤引起的神经功能障碍的活性。 阐述神经调节剂，其包括并且包含选自能够结合中枢神经系统结构或细胞的抗体，肽类似物，半抗原，其活性片段，其激动剂，其模拟物，其单体 及其组合。 神经调节剂具有以下一个或多个特征：它能够诱导髓鞘再生; 结合神经组织; 促进少突胶质细胞的Ca-信号传导; 并促进神经胶质细胞的细胞增殖。 公开了示例性抗体的氨基酸和DNA序列。 描述了使用多克隆IgM抗体和人单克隆抗体sHIgm22（LYM22），sHIgm46（LYM46）ebvHIgM MSI19D10，CB2bG8，AKJR4，CB2iE12，CB2iE7等治疗脱髓鞘疾病和人和家畜的中枢神经系统疾病的方法， MSI19E5和MSI10E10，其活性片段等。 本发明还延伸到使用人类抗体，片段，肽衍生物和类似材料，以及它们在诊断和治疗应用中的用途，包括用于发现结合神经系统细胞，特别是少突胶质细胞的其它抗体的筛选测定。

    Suppression of demyelination by interleukin-6
    6.
    发明授权
    Suppression of demyelination by interleukin-6 失效
    白介素-6抑制脱髓鞘

    公开(公告)号：US5863529A

    公开(公告)日：1999-01-26

    申请号：US530654

    申请日：1995-09-20

    Applicant: Moses Rodriguez

    Inventor： Moses Rodriguez

    IPC: A61K38/20

    CPC classification number: A61K38/204

    Abstract: A method of suppressing demyelination of the central nervous system is disclosed. The method comprises administering a therapeutically effective amount of Interleukin-6 or an analog thereof to a mammal. Methods of treating multiple sclerosis and a related article of manufacture are also disclosed.

    Abstract translation: 公开了抑制中枢神经系统脱髓鞘的方法。 该方法包括向哺乳动物施用治疗有效量的白细胞介素-6或其类似物。 还公开了治疗多发性硬化症和相关制品的方法。

    HUMAN ANTIBODIES AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF FOR THE TREATMENT OF NEUROLOGICAL DISEASE
    10.
    发明申请
    HUMAN ANTIBODIES AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF FOR THE TREATMENT OF NEUROLOGICAL DISEASE 审中-公开
    用于治疗神经病的人体抗体及其诊断和治疗用途

    公开(公告)号：US20130280167A1

    公开(公告)日：2013-10-24

    申请号：US13880415

    申请日：2011-10-19

    Applicant: Moses Rodriguez ,  Arthur E. Warrington ,  Larry R. Pease

    Inventor： Moses Rodriguez ,  Arthur E. Warrington ,  Larry R. Pease

    IPC: A61K39/395

    CPC classification number: A61K39/39541 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/74 ,  C07K2317/94

    Abstract: Specific binding members, particularly human antibodies, particularly recombinant antibodies, and fragments thereof, which are capable of binding to and recognizing neurons in the CNS and eliciting responses in CNS neurons are provided. The antibodies are useful for neuroprotection and in the diagnosis and treatment of conditions associated with nerve damage, injury or degeneration and neurodegenerative disease. The antibodies, variable regions or CDR domain sequences thereof, and fragments thereof of the invention may also be used in therapy in combination with chemotherapeutics, immune modulators, or neuroactive agents and/or with other antibodies or fragments thereof. Antibodies are exemplified by the antibodies IgM12 and IgM42 whose sequences are provided herein.

    Abstract translation: 提供了能够结合并识别CNS中的神经元并引起CNS神经元中的反应的特异性结合成员，特别是人抗体，特别是重组抗体及其片段。 该抗体可用于神经保护和用于诊断和治疗与神经损伤，损伤或变性和神经变性疾病相关的病症。 本发明的抗体，可变区或CDR结构域序列及其片段也可用于与化学治疗剂，免疫调节剂或神经活性剂和/或与其它抗体或其片段组合的治疗中。 抗体以本文提供其序列的抗体IgM12和IgM42为例。

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