摘要:
The present invention is based, at least in part, on the identification of a novel active site on BCL-2 family polypeptide such as BAX, which when bound by a compound, modifies the activity of the BCL-2 family polypeptide.
摘要:
PROBLEM TO BE SOLVED: To provide an axial piston hydraulic rotating machine having high stability of a piston shoe.SOLUTION:A circular internal static pressure pocket 23 communicated with a filler opening 9A, an inner peripheral land portion 22 formed on the outer periphery of the internal static pressure pocket 23, an external static pressure pocket 24 formed on the outer periphery of the inner peripheral land portion 22, and an outer peripheral land portion 25 formed on the outer periphery of the external static pressure pocket 24 are formed on the sliding surface in contact a piston shoe 9 with the swash palate 10. The inner peripheral land portion 22 is annularly formed around the filler opening 9A. Oil passing grooves 27 through which the internal static pressure pocket 23 communicates with the external static pressure pocket 24 are formed in parts of the inner peripheral land portion 22 on straight lines, passing through the center of the filler opening 9A. The oil passing grooves 27 are inclined with respect to the straight line A-B passing through the center of the filler opening 9A. An inner wall surface and an outer wall surface of the inner peripheral land portion 22 are disposed on the straight lines that connect the center of the filler opening 9A to the center of the oil passing groove 27.
摘要:
The present invention provides a method for identifying a thermostable polymerase having altered fidelity. The method consists of generating a random population of polymerase mutants by mutating at least one amino acid residue of a thermostable polymerase and screening the population for one or more active polymerase mutants by genetic selection. For example, the invention provides a method for identifying a thermostable polymerase having altered fidelity by mutating at least one amino acid residue in an active site O-helix of a thermostable polymerase. The invention also provides thermostable polymerases and nucleic acids encoding thermostable polymerases having altered fidelity, for example, high fidelity polymerases and low fidelity polymerases. The invention additionally provides a method for identifying one or more mutations in a gene by amplifying the gene with a high fidelity polymerase. The invention further provides a method for accurately copying repetitive nucleotide sequences using a high fidelity polymerase mutant. The invention also provides a method for diagnosing a genetic disease using a high fidelity polymerase mutant. The invention further provides a method for randomly mutagenizing a gene by amplifying the gene using a low fidelity polymerase mutant.
摘要:
The present invention is based, at least in part, on the identification of a novel active site on BCL-2 family polypeptide such as BAX, which when bound by a compound, modifies the activity of the BCL-2 family polypeptide.
摘要:
To promote the digestion of an animal to thereby elevate the feed efficiency or prevent or ameliorate intestinal infections such as inflammatory intestinal injury of the animal, a combination of at least one fungus selected from Aspergillus sojae, Aspergillus tamarii, Aspergillus foetidus, Aspergillus niger, and Aspergillus oryzae with an acidic enzyme produced by the fungus is administered to the animal.
摘要:
A subframe structure for an automotive vehicle wherein a subframe is attached through a rubber mount to a vehicle body, suspension components are assembled onto the subframe so that the suspension components are held connected to the vehicle body through the subframe, and a detecting assembly capable of providing an output signal according to a load that acts between a subframe and a vehicle body is provided. A rubber mount for use in this subframe structure is also disclosed.
摘要:
A brake torque control device obtains inertia torque Tine based upon an equation of motion (Tine=Tw−Ft·Rt) about the rotation of a tire based upon a wheel torque Tw according to a brake torque exerted on the tire, road friction force Ft and a radius Rt of the tire. When the inertia torque Tine exceeds a predetermined reference value, road friction force Ft at this time is set as estimated maximum road friction force Fmax. The instructed brake torque is calculated under the condition that the value that is obtained by adding the predetermined value corresponding to the inertia torque Tine to the torque Fmax·Rt based upon this estimated maximum road friction force Fmax is set as an upper limit value of the instructed brake torque. This allows to clearly set, as one value, the target value of the instructed brake torque upon an ABS control, thereby being capable of more accurately executing the pressure-increasing control and pressure-reducing control of the brake fluid pressure.
摘要:
An environmentally-safe method for protecting plants is provided for reducing the use of chemically-synthesized pesticide. Specifically, an anti-microbial and/or anti-viral composition comprising a laccase, a cell of a laccase-producing microorganism or a treated product thereof, and one or more kinds of phenol derivatives each represented by the general formula (I) shown below or a salt of the phenol derivative is provided. Furthermore, a plant disease-preventing agent, seed-sterilizing agent, post-harvest agent, and nutrient solution-sterilizing agent, each containing the composition; and plant disease-preventing method, seed-sterilizing method, post-harvest-treatment method, and nutrient solution-sterilizing method in hydroponics and solid-medium hydroponics using each f the agents are provided. (in this formula, each of R1 to R5 independently represents hydrogen, an alkyl group having 1 to 6 carbon atoms, substituted or unsubstituted alkenyl group having 2 to 6 carbon atoms, alkoxy group having 1 to 6 carbon atoms, substituted or unsubstituted aryl group having 6 to 20 core carbon atoms, carboxyl group having 1 to 10 carbon atoms, carbonyl group having 1 to 10 carbon atoms, or halogen atom, and at least one of R1 to R5 is an alkenyl group having 1 to 10 carbon atoms; provided that at least one of R1 and R5 is not an alkoxy group).
摘要:
Herein disclosed a communications system according to the present invention comprises, a wireless microphone transmission apparatus for transmitting a radio microphone signal on a predetermined wireless microphone frequency channel carrying a voice signal and a tone signal; and a wireless receiving apparatus for receiving the radio microphone signal on the predetermined wireless microphone frequency channel carrying the voice signal and the tone signal transmitted by the wireless microphone transmission apparatus. The wireless receiving apparatus includes an integral computing unit for sequentially computing integrals of the signal levels of the tones of the tone signal at first predetermined time intervals and a data information computing unit for sequentially computing differences between two respective integrals of the signal levels of the tones of the tone signal, at respective second predetermined time intervals to acquire data information.
摘要:
A subframe structure for an automotive vehicle wherein a subframe is attached through a rubber mount to a vehicle body, suspension components are assembled onto the subframe so that the suspension components are held connected to the vehicle body through the subframe, and a detecting assembly capable of providing an output signal according to a load that acts between a subframe and a vehicle body is provided. A rubber mount for use in this subframe structure is also disclosed.