公开(公告)号：US20220142609A1

公开(公告)日：2022-05-12

申请号：US17526798

申请日：2021-11-15

申请人： Gustavo Eduardo Abella ,  Ricardo Enrique Gayoso ,  Wayne State University ,  National Institutes of Health (NIH)

发明人： Lami Yeo ,  Roberto Romero ,  Gustavo Eduardo Abella ,  Ricardo Enrique Gayoso

IPC分类号： A61B8/08 ,  A61B8/00 ,  A61B8/14

摘要： A method and apparatus of examining fetal hearts includes obtaining ultrasound data of a fetal heart to generate fetal heart images, displaying different marked sample images of a fetal heart and at respective cardiac phases, each marking a different feature of a fetal heart at a respective marked location, and sequentially presenting one of the different marked sample images to a user along with one of the fetal heart images that is a similar view. As each of the different marked sample images is sequentially presented, a user is prompted to mark the different feature in a respective fetal heart image based on its marked location to create a plurality of marked fetal heart images, and a geometric model of the heart is generated based on the marked fetal heart images, from which fetal echocardiography views can be extracted. The fetal echocardiography views of the fetal heart are displayed.

公开(公告)号：US20220112179A1

公开(公告)日：2022-04-14

申请号：US17556147

申请日：2021-12-20

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education ,  National Institutes of Health, A component of the United States Department of Health and Human Servi ,  The Regents of the University of California

发明人： Donna M. Huryn ,  Peter Wipf ,  Matthew G. LaPorte ,  Raffaele Colombo ,  Marina Kovaliov ,  Chaemin Lim ,  Celeste Natalie Alverez ,  Zhizhou Yue ,  Lalith Palitha Samankumara ,  Alexander Julian Chatterley ,  Yongzhao Yan ,  Mary Liang ,  Neal J. Green ,  Eric T. Baldwin ,  William J. Moore ,  Michelle Arkin ,  R. Jeffrey Neitz ,  Kean-Hooi Ang ,  Clifford Bryant ,  Stacie Bulfer

IPC分类号： C07D405/14 ,  A61P35/00 ,  C07D401/10 ,  C07D413/14 ,  C07D401/14 ,  C07D417/14 ,  A61P25/28

摘要： The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.

公开(公告)号：US20220008060A1

公开(公告)日：2022-01-13

申请号：US17385230

申请日：2021-07-26

申请人： Muffin Incorporated ,  National Institutes of Health, an Agency of the Department of Health and Human Services

发明人： Shaun Davis Gittard ,  Gregory James Hardy ,  John C. Sigmon, JR. ,  Jeremy T. Newkirk ,  William J. Havel ,  Neal E. Fearnot ,  Toby Rogers ,  Kanishka Ratnayaka ,  Robert L. Lederman

IPC分类号： A61B17/02 ,  A61M25/00 ,  A61M25/10 ,  A61B90/00

摘要： Among other things, there is disclosed structure and methods for maintaining access to a location in the body while reducing or eliminating the potential for pulling an access device (e.g. a catheter) back through an opening. An introducer sheath includes a distal indented portion and a balloon, so that once placed in a desired location through tissue, the balloon can be inflated to anchor the sheath against retraction. In particular embodiments, structure and methods for accessing the pericardial cavity via the right atrial appendage are shown.

公开(公告)号：US20210068676A1

公开(公告)日：2021-03-11

申请号：US17046193

申请日：2019-05-17

申请人： The United States of America, Department of Health and Human Services, National Institutes of Health ,  Circle Cardiovascular Imaging Inc.

发明人： Li-Yueh HSU ,  Matthew JACOBS ,  Mitchel BENOVOY ,  Andrew ARAI

IPC分类号： A61B5/026 ,  A61B5/055 ,  G01R33/56 ,  G01R33/563

摘要： A computer-implemented method for automatically generating a fully quantitative myocardial blood flow map, comprising: receiving myocardial perfusion magnetic resonance imaging (MRI) images and arterial input function (AIF) MRI images; correcting a motion of a heart in the myocardial perfusion MRI images and the AIF MRI images, thereby obtaining motion corrected myocardial perfusion MRI images and motion corrected AIF images; correcting an intensity of the motion corrected myocardial perfusion MRI images and an intensity of the motion corrected AIF images, thereby obtaining surface coil intensity corrected MRI images and surface coil intensity corrected AIF images; using the surface coil intensity corrected MRI images and the surface coil intensity corrected AIF images, determining time-signal intensity characteristics and segmenting a left ventricle myocardial tissue region; and generating the myocardial blood flow map using the motion corrected myocardial perfusion MRI images, the left ventricle myocardial tissue region segmentation and the time-signal intensity characteristics.

公开(公告)号：US10654905B2

公开(公告)日：2020-05-19

申请号：US16175709

申请日：2018-10-30

申请人： The Board of Trustees of the Leland Stanford Junior University ,  United States Department of Health and Human Services, Office of Technology Transfer, National Institutes of Health

发明人： Christopher K. Garcia ,  Suman Mitra ,  Warren J. Leonard ,  Aaron M. Ring

IPC分类号： A61K38/20 ,  C07K14/55 ,  A61K38/00

摘要： Novel human interleukin-2 (IL-2) muteins or variants thereof are provided. In particular, provided are IL-2 muteins that have an increased binding capacity for IL-2Rβ receptor and a decreased binding capacity for IL-2Rγc receptor, as compared to wild-type IL-2. Such IL-2 muteins are useful, for example, as IL-2 partial agonist and antagonists in applications where reduction or inhibition of one or more IL-2 and/or IL-15 functions is useful (e.g., in the treatment of graft versus host disease (GVHD) and adult T cell leukemia). Also provided are nucleic acids encoding such IL-2 muteins, methods of making such IL-2 muteins, pharmaceutical compositions that include such IL-2 muteins and methods of treatment using such pharmaceutical compositions.

公开(公告)号：US10590074B2

公开(公告)日：2020-03-17

申请号：US15830244

申请日：2017-12-04

申请人： THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services, Office of Technology Transfer, National Institutes of Health

发明人： Amy Hauck Newman ,  Oluyomi M. Okunola-Bakare ,  Jianjing Cao

IPC分类号： C07C323/60 ,  A61K45/06 ,  A61K31/135 ,  C07C317/44 ,  C07C317/28 ,  C07C323/25 ,  C07D295/08 ,  C07D295/088 ,  C07D295/108 ,  C07D295/185

摘要： Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephrine (NE) reuptake via their respective transporters, DAT, SERT and NET. Also disclosed are methods for eliciting a wake-promoting or cognitive or attention enhancing effect and for treating substance use disorders, attention deficit (hyperactivity) disorder, depressive disorders, bipolar disorder or other neuropsychiatric disorders sleep disorders or cognitive impairment using the compounds.

公开(公告)号：US09911206B2

公开(公告)日：2018-03-06

申请号：US14994251

申请日：2016-01-13

申请人： Siemens Healthcare GmbH ,  National Institutes of Health (NIH)

发明人： Xiufeng Li ,  Gregory J. Metzger ,  Kamil Ugurbil ,  Dingxin Wang

IPC分类号： G06T11/00 ,  G01R33/563 ,  G01R33/561

CPC分类号： G06T11/003 ,  G01R33/5616 ,  G01R33/56366

摘要： A method for generating a perfusion weighted image using ASL with segmented acquisitions includes dividing an anatomical area of interest into slices and performing an EPI acquisition process using an MRI system to acquire a control image dataset representative of the slices. An ASL preparation process is performed using the MRI system to magnetically label protons in arterial blood water upstream from the anatomical area of interest. Following a first time period, a multi-band EPI acquisition process is performed using the MRI system to acquire a first labeled image dataset representative of a first subset of the slices. Following a second time period, another multi-band EPI acquisition process is performed using the MRI system to acquire a second labeled image dataset representative of a second subset of the slices. A perfusion weighted image is generated by subtracting the first and second labeled image dataset from the control image dataset.

公开(公告)号：US09896484B2

公开(公告)日：2018-02-20

申请号：US14887115

申请日：2015-10-19

申请人： The United States of America as Represented by the Secretary of the Department of Health and Human Services, National Institutes of Health, Office of Technology Transfer

发明人： Surender Khurana ,  Hana Golding

IPC分类号： C07K14/005 ,  A61K39/145 ,  G01N33/559 ,  G01N33/569 ,  A61K39/12 ,  C12N7/00 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/55566 ,  A61K2039/575 ,  C07K2319/21 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16152 ,  G01N33/559 ,  G01N33/56983 ,  G01N2333/11

摘要： The present invention includes influenza Hemagglutinin protein fragments that fold properly when expressed in bacteria.

公开(公告)号：US20170333494A1

公开(公告)日：2017-11-23

申请号：US15525329

申请日：2015-11-09

申请人： GlaxoSmithKline Intellectual Property Development Limited ,  National Institutes of Health

发明人： David A. WILFRET ,  Jesse Daniel KEICHER ,  Helene Fischer ROSENBERG

IPC分类号： A61K35/747 ,  A61M15/00 ,  A61K9/00 ,  A61K9/16

CPC分类号： A61K35/747 ,  A61K9/0043 ,  A61K9/0075 ,  A61K9/1617 ,  A61K9/1623 ,  A61M15/00 ,  A61M2202/064 ,  Y02A50/491

摘要： Aspects of the present invention are related to the use of Lactobacillus species in a composition for respiratory administration to prevent the pathogenic inflammatory sequelae of respiratory virus infections.

公开(公告)号：US09804171B2

公开(公告)日：2017-10-31

申请号：US15045146

申请日：2016-02-16

申请人： Moleculera Labs, Inc. ,  The Board of Regents of the University of Oklahoma ,  National Institutes of Health

发明人： Phina Madeleine Cunningham ,  Craig David Shimasaki ,  Susan E. Swedo ,  Christine Kirvan

IPC分类号： A61K38/00 ,  G01N33/53 ,  G01N33/68 ,  G01N33/564 ,  G01N33/569

CPC分类号： G01N33/686 ,  G01N33/564 ,  G01N33/56944 ,  G01N33/6854 ,  G01N33/6896 ,  G01N2333/315 ,  G01N2333/726 ,  G01N2333/912 ,  G01N2405/10 ,  G01N2469/20 ,  G01N2800/26 ,  G01N2800/28 ,  G01N2800/30 ,  G01N2800/38

摘要： The present invention provides a panel of at least five clinical analyses or tests (using serum samples) to determine the risk of pediatric acute-onset neuropsychiatric syndrome (PANS) and/or pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) in an individual. These include enzyme linked immunosorbent assays (ELISAs) to measure antibody titers against neuronal antigens present in the brain; the neuronal antigens include lysoganglioside, tubulin, dopamine receptor D1, dopamine receptor D2, serotonin receptor 5HT2A, and serotonin receptor 5HT2C. Antibody titers against at least four of these neuronal antigens are required in the present methods; preferably antibody tiers against all of these neuronal antigens are measured. A final assay is used to quantify calcium/calmodulin-dependent protein kinase activity using a neuronal cell line. The results of these analyses or tests are then combined using an algorithm to determine whether a PANS or PANDAS diagnosis is appropriate for the individual. Depending on the diagnosis, an appropriate treatment can be determined.