公开(公告)号：US11058707B2

公开(公告)日：2021-07-13

申请号：US16178712

申请日：2018-11-02

Applicant: Northeast Ohio Medical University

Inventor： Charles K. Thodeti

IPC: A61K31/7105 ,  A61K31/425 ,  A61K31/381 ,  A61P9/04 ,  A61P9/10 ,  A61K31/4439

Abstract: Methods useful for treating ischemic heart disease, reducing cardiac fibrosis, improving cardiac function, or increasing coronary angiogenesis are described.

公开(公告)号：US11028140B2

公开(公告)日：2021-06-08

申请号：US15512964

申请日：2015-09-22

Applicant: Northeast Ohio Medical University

Inventor： Fayez Safadi

IPC: C07K14/51 ,  A61K31/00 ,  A61K47/36 ,  A61K38/17 ,  A61K9/00 ,  A61L24/00 ,  A61L31/14 ,  A61L31/16 ,  A61L27/54 ,  A61L27/58 ,  A61L27/24 ,  A61K47/34 ,  A61F2/30

Abstract: A composition for enhancing bone tissue repair or regeneration is described. The composition includes osteoactivin or an active peptide fragment thereof and a biocompatible material. Osteogenic orthopedic devices including the osteoactivin-containing composition are also described. The devices and compositions can be used in methods for enhancing bone tissue repair or regeneration by contacting a site in need of bone repair or regeneration in a subject with the osteoactivin-containing composition.

公开(公告)号：US20240082357A1

公开(公告)日：2024-03-14

申请号：US18517957

申请日：2023-11-22

Applicant: SUMMA HEALTH ,  NORTHEAST OHIO MEDICAL UNIVERSITY

Inventor： Marc S. PENN ,  Maritza MAYORGA ,  Matthew KIEDROWSKI

IPC: A61K38/19 ,  A61K38/45 ,  C12N5/0775

CPC classification number: A61K38/195 ,  A61K38/45 ,  C12N5/0663 ,  C12Y207/11017

Abstract: Provided herein are methods to promote tissue healing, to treat tissue injury or to treat a condition related to tissue injury comprising administering to a subject in need thereof an effective amount of one or both of: a CAMKK1 polypeptide or an equivalent thereof; or an SDF-1 polypeptide or an equivalent thereof, in the presence of CXCR4 polypeptide expression, wherein the effective amount is an amount that induces exosome production, secretion and/or function in the subject. Recombinant stem cells are also provided that overexpress one or both of a CAMKK1 protein or polypeptide and/or an SDF-1 protein or polypeptides. The stem cells and products produced from them are useful to treat ischemic or inflammatory conditions as well as to promote tissue healing.

公开(公告)号：US20230093487A1

公开(公告)日：2023-03-23

申请号：US17739629

申请日：2022-05-09

Applicant: NORTHEAST OHIO MEDICAL UNIVERSITY

Inventor： William M. CHILIAN ,  Vahagn OHANYAN ,  Liya YIN

IPC: A61K31/519 ,  A61P9/08 ,  A61K9/00 ,  A61K31/353

Abstract: A method for treating or preventing heart failure involving blockage of small blood vessels is described. The method involves administering to a subject in need thereof a therapeutically effective amount of a vasodilator.

公开(公告)号：US20230038631A1

公开(公告)日：2023-02-09

申请号：US17723313

申请日：2022-04-18

Applicant: Northeast Ohio Medical University

Inventor： Alexander V. GALAZYUK

IPC: A61K31/196 ,  A61P27/16

Abstract: A method of treating tinnitus in a subject is described that includes administering a therapeutically effective amount of a group II metabotropic glutamate receptor (mGluR) agonist to the subject. A method of screening a subject having tinnitus for treatment with a group II mGluR agonist that includes testing the use of residual inhibition to suppress tinnitus in the subject, wherein suppression of tinnitus by residual inhibition indicates that a group II mGluR agonist would be effective for treating tinnitus in the subject, is also described.

公开(公告)号：US11554158B2

公开(公告)日：2023-01-17

申请号：US16093270

申请日：2017-04-13

Applicant: NORTHEAST OHIO MEDICAL UNIVERSITY

Inventor： Min-Ho Kim ,  Fayez Safadi ,  Bing Yu

IPC: A61K38/17 ,  A61K9/00 ,  A61P17/02 ,  A61K9/127 ,  A61L15/32

Abstract: A method for treating a skin wound of a subject is described. The method includes contacting the skin wound with a therapeutically effective amount of a wound healing composition comprising glycoprotein nonmelanoma clone B (GPNMB) protein, an active peptide fragment thereof, a GPNMB analog, a GPNMB potentiating agent, or a combination thereof.

公开(公告)号：US20210300980A1

公开(公告)日：2021-09-30

申请号：US17340405

申请日：2021-06-07

Applicant: Northeast Ohio Medical University

Inventor： Fayez Safadi

IPC: C07K14/51 ,  A61K38/17 ,  A61K9/00 ,  A61L24/00 ,  A61L31/14 ,  A61L31/16 ,  A61L27/54 ,  A61L27/58 ,  A61K47/36 ,  A61L27/24

Abstract: A composition for enhancing bone tissue repair or regeneration is described. The composition includes osteoactivin or an active peptide fragment thereof and a biocompatible material. Osteogenic orthopedic devices including the osteoactivin-containing composition are also described. The devices and compositions can be used in methods for enhancing bone tissue repair or regeneration by contacting a site in need of bone repair or regeneration in a subject with the osteoactivin-containing composition.

公开(公告)号：US20190201489A1

公开(公告)日：2019-07-04

申请号：US16314136

申请日：2017-06-28

Applicant: NORTHEAST OHIO MEDICAL UNIVERSITY

Inventor： Fayez SAFADI ,  Tariq HAQQI

IPC: A61K38/17 ,  C12N15/113 ,  A61K47/42 ,  A61P19/00 ,  A61K35/28 ,  A61K31/713

CPC classification number: A61K38/1774 ,  A61K31/713 ,  A61K35/28 ,  A61K47/42 ,  A61P19/00 ,  A61P19/04 ,  A61P19/06 ,  C07K2/00 ,  C12N15/113 ,  C12N2310/14

Abstract: In an aspect of the present application, compositions and methods are provided for preventing bone loss and/or stimulating bone healing in a subject in need thereof. Compositions can comprise a pharmaceutically acceptable carrier and a therapeutically effective amount of a zinc-finger CCHC domain-containing protein 6 (ZCCHC6) inhibitor. Methods can include administering a therapeutically effective amount of the ZCCHC6 inhibitor to the subject.

公开(公告)号：US11324748B2

公开(公告)日：2022-05-10

申请号：US16606451

申请日：2018-04-23

Applicant: NORTHEAST OHIO MEDICAL UNIVERSITY

Inventor： William M. Chilian ,  Vahagn Ohanyan ,  Liya Yin

IPC: A61K31/519 ,  A61P9/08 ,  A61K9/00 ,  A61K31/353

Abstract: A method for treating or preventing heart failure involving blockage of small blood vessels is described. The method involves administering to a subject in need thereof a therapeutically effective amount of a vasodilator.

公开(公告)号：US20140271903A1

公开(公告)日：2014-09-18

申请号：US13803585

申请日：2013-03-14

Applicant: NORTHEAST OHIO MEDICAL UNIVERSITY

Inventor： Vijaykumar Sutariya ,  Hiroshi Nakamura ,  Werner Geldenhuys

IPC: A61K47/34 ,  A61K9/51 ,  A61K31/4439

CPC classification number: A61K47/34 ,  A61K9/0048 ,  A61K9/06 ,  A61K9/5153 ,  A61K31/4439

Abstract: The present invention relates to a methods for extending the period of filtering bleb survival and/or providing for long term bleb survival following Glaucoma Filtration Surgery by delivering an ALK-5 inhibitor to a wound area (the surgical site) of a patient's eye. More particularly, the present invention relates to a method for the controlled delivery of an ALK-5 inhibitor to patient's eye using a thermo-sensitive polymer formulation, wherein the ALK-5 inhibitor is first contained in the polymer formulation at a temperature sufficient to maintain the formulation as a liquid and then applied to the eye wound opening, wherein the formulation turns to a gel. The use of the thermo-sensitive gel with ALK-5 inhibitor contained therein, provides for longer term bleb survival following Glaucoma Filtration Surgery (GFS) on a patient's eye. Thus, the present invention is particularly effective in inhibiting ocular fibrotic wound response following GFS.

Abstract translation: 本发明涉及通过将ALK-5抑制剂递送至患者眼睛的伤口区域（手术部位），延长滤泡存活时间和/或提供青光眼滤过手术后的长期生存的方法。 更具体地说，本发明涉及使用热敏聚合物制剂将ALK-5抑制剂控制递送到患者眼睛的方法，其中首先将ALK-5抑制剂以足以维持的温度包含在聚合物制剂中 该制剂作为液体，然后施加到眼睛伤口上，其中制剂变成凝胶。 含有其中含有ALK-5抑制剂的热敏凝胶的使用提供了在患者眼睛上的青光眼滤过手术（GFS）之后的更长期的泡状存活。 因此，本发明特别有效地抑制GFS后的眼纤维化伤口应答。