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1.发明授权公开(公告)号：US06458763B1
公开(公告)日：2002-10-01
申请号：US09398330
申请日：1999-09-17
IPC分类号： A61K3800
CPC分类号： A61L27/227 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/604 , Y10S514/964
摘要： The present invention is directed to bioactive compositions that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in vivo. More particularly the present invention is directed to the use of compositions comprising an effective amount of bone sialoprotein to enhance the repair of damaged or diseased bone.
摘要翻译： 本发明涉及在损伤或患病组织与体内组合物接触时诱导损伤或患病结缔组织修复的生物活性组合物。 更具体地，本发明涉及使用包含有效量的骨唾液酸蛋白的组合物来增强受损或患病骨的修复。
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2.发明授权公开(公告)号：US06364912B1
公开(公告)日：2002-04-02
申请号：US09398333
申请日：1999-09-17
IPC分类号： A61F200
CPC分类号： A61K38/18 , A61L27/227 , A61L27/54 , A61L2300/236 , A61L2300/252 , A61L2300/414 , A61L2300/604 , Y10S623/908
摘要： Bioactive compositions that induce or enhance the repair of damaged or diseased connective tissues upon contact of the tissues with the compositions in vivo include an effective amount of pleiotrophin. A delivery vehicle is also included in the compositions. The compositions may be delivered to the repair sites by injection or by implantation.
摘要翻译： 在组织与体内组合物接触时诱导或增强受损或患病结缔组织修复的生物活性组合物包括有效量的多余营养素。 递送载体也包括在组合物中。 组合物可以通过注射或通过植入递送至修复部位。
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3.发明授权公开(公告)号：US06303138B1
公开(公告)日：2001-10-16
申请号：US09398494
申请日：1999-09-17
IPC分类号： A61F200
CPC分类号： A61L27/227 , A61L27/54 , A61L2300/236 , A61L2300/252 , A61L2300/414 , A61L2300/604
摘要： The present invention is directed to bioactive composition that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in vivo. More particularly the present invention is directed to the use of a composition comprising an effective amount of endothelin to enhance the repair of damaged or diseased bone and cartilage tissues.
摘要翻译： 本发明涉及在损伤或患病组织与体内组合物接触时诱导损伤或患病结缔组织修复的生物活性组合物。 更具体地，本发明涉及包含有效量的内皮素的组合物的用途，以增强受损或患病的骨和软骨组织的修复。
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4.发明授权Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration 失效从造血和非造血组织分离前体细胞及其在体内骨和软骨再生中的应用公开(公告)号：US06200606B1
公开(公告)日：2001-03-13
申请号：US08891952
申请日：1997-07-14
IPC分类号： A61K3512
CPC分类号： C12N5/0667 , A61K35/12 , A61K38/00 , A61K2035/124 , A61L27/3817 , A61L27/3821 , A61L27/3839 , A61L27/3847 , A61L27/3852 , C12N5/0663 , C12N2500/38 , C12N2501/39 , C12N2501/91
摘要： The present invention relates to the isolation of cartilage or bone precursor cells from hematopoietic and non-hematopoietic cells and their use in bone and cartilage regeneration procedures. The precursor cells are used for in vivo bone or cartilage repair by transplanting the cells, with or without a carrier material and without the need for in vitro culturing of the cells, to sites in the body requiring bone or cartilage repair.
摘要翻译： 本发明涉及从造血细胞和非造血细胞中分离软骨或骨前体细胞及其在骨和软骨再生过程中的用途。 前体细胞用于体内骨或软骨修复，通过移植具有或不具有载体材料的细胞，并且不需要体外培养细胞到体内需要骨或软骨修复的部位。
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