公开(公告)号：US09215995B2

公开(公告)日：2015-12-22

申请号：US13165061

申请日：2011-06-21

申请人： Rebecca K. Gottlieb ,  Chia-Hung Chiu ,  Meena Ramachandran ,  Nandita Dangui-Patel ,  Jefferson Rose ,  Ashwin K. Rao ,  Hsifu Wang ,  Ying Luo

发明人： Rebecca K. Gottlieb ,  Chia-Hung Chiu ,  Meena Ramachandran ,  Nandita Dangui-Patel ,  Jefferson Rose ,  Ashwin K. Rao ,  Hsifu Wang ,  Ying Luo

IPC分类号： A61B5/05 ,  A61B5/1486 ,  A61B5/145 ,  C12Q1/00 ,  A61B5/00 ,  G01N27/30

CPC分类号： A61B5/1486 ,  A61B5/0017 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/726 ,  C12Q1/001 ,  G01N27/307

摘要： Embodiments of the invention provide amperometric analyte sensors having multiple related structural elements (e.g. sensor arrays comprising a working, counter and reference electrode) and algorithms designed for use with such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.

摘要翻译： 本发明的实施例提供了具有多个相关结构元件（例如包括工作，计数器和参考电极的传感器阵列）和被设计用于这种传感器的算法的电流分析物传感器。 尽管可以在多种情况下使用创新的实施例，但是本发明的典型实施例包括用于糖尿病管理的葡萄糖传感器。

公开(公告)号：US20110319734A1

公开(公告)日：2011-12-29

申请号：US13165061

申请日：2011-06-21

申请人： Rebecca K. Gottlieb ,  Chia-Hung Chiu ,  Meena Ramachandran ,  Nandita Dangui-Patel ,  Jefferson Rose ,  Ashwin K. Rao ,  Hsifu Wang ,  Ying Luo

发明人： Rebecca K. Gottlieb ,  Chia-Hung Chiu ,  Meena Ramachandran ,  Nandita Dangui-Patel ,  Jefferson Rose ,  Ashwin K. Rao ,  Hsifu Wang ,  Ying Luo

IPC分类号： A61B5/145

CPC分类号： A61B5/1486 ,  A61B5/0017 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/726 ,  C12Q1/001 ,  G01N27/307

摘要： Embodiments of the invention provide amperometric analyte sensors having multiple related structural elements (e.g. sensor arrays comprising a working, counter and reference electrode) and algorithms designed for use with such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.

摘要翻译： 本发明的实施例提供了具有多个相关结构元件（例如包括工作，计数器和参考电极的传感器阵列）和被设计用于这种传感器的算法的电流分析物传感器。 尽管可以在多种情况下使用创新的实施例，但是本发明的典型实施例包括用于糖尿病管理的葡萄糖传感器。

公开(公告)号：US20050027177A1

公开(公告)日：2005-02-03

申请号：US10926319

申请日：2004-08-25

申请人： John Shin ,  Kris Holtzclaw ,  Nandita Dangui ,  Sami Kanderian ,  John Mastrototaro ,  Peter Hong

发明人： John Shin ,  Kris Holtzclaw ,  Nandita Dangui ,  Sami Kanderian ,  John Mastrototaro ,  Peter Hong

IPC分类号： G01N33/66 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1468 ,  A61B5/1486 ,  A61B5/1495

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/6848 ,  A61B5/6849 ,  A61M2005/1726 ,  G06F19/00

摘要： A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals. It also includes obtaining at least two reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals. Also included is calculating the calibration characteristics using the reference glucose values and the corresponding glucose monitor data to regress the obtained glucose monitor data. And calibrating the obtained glucose monitor data using the calibration characteristics is included. In preferred embodiments, the reference source is a blood glucose meter, and the at least two reference glucose values are obtained from blood tests. In additional embodiments, the calculation of the calibration characteristics is obtained using linear regression and in particular embodiments, least squares linear regression. Alternatively, the calculation of the calibration characteristics is obtained using non-linear regression.

摘要翻译： 校准葡萄糖监测数据的方法包括以预定间隔在一段时间内收集葡萄糖监测数据。 它还包括从参考源获得至少两个参考葡萄糖值，所述参考源在时间上对应于以预定间隔获得的葡萄糖监测数据。 还包括使用参考葡萄糖值和相应的葡萄糖监测数据计算校准特性以回归所获得的葡萄糖监测数据。 并且包括使用校准特性来校准所获得的葡萄糖监测数据。 在优选实施例中，参考源是血糖仪，并且从血液测试获得至少两个参考葡萄糖值。 在另外的实施例中，使用线性回归和特定实施例，最小二乘线性回归来获得校准特性的计算。 或者，使用非线性回归获得校准特性的计算。

公开(公告)号：US08543354B2

公开(公告)日：2013-09-24

申请号：US12914969

申请日：2010-10-28

申请人： Ying Luo ,  Rebecca K. Gottlieb ,  Meena Ramachandran ,  Chia-Hung Chiu ,  Nandita Dangui-Patel ,  Michael Kremliovsky ,  Jefferson Rose

发明人： Ying Luo ,  Rebecca K. Gottlieb ,  Meena Ramachandran ,  Chia-Hung Chiu ,  Nandita Dangui-Patel ,  Michael Kremliovsky ,  Jefferson Rose

IPC分类号： G06F17/18

CPC分类号： G01N33/66 ,  A61B5/0017 ,  A61B5/002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/6849 ,  A61B5/7207

摘要： Disclosed are methods, apparatuses, etc. for glucose sensor signal stability analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to assess an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time. A reliability of the at least one sensor signal to respond to the blood glucose level of the patient may be assessed based at least partly on the at least one metric assessing an underlying trend. Other example embodiments are disclosed herein.

公开(公告)号：US20110320166A1

公开(公告)日：2011-12-29

申请号：US12914969

申请日：2010-10-28

申请人： Ying Luo ,  Rebecca K. Gottlieb ,  Meena Ramachandran ,  Chia-Hung Chiu ,  Nandita Dangui-Patel ,  Michael Kremliovsky ,  Jefferson Rose

发明人： Ying Luo ,  Rebecca K. Gottlieb ,  Meena Ramachandran ,  Chia-Hung Chiu ,  Nandita Dangui-Patel ,  Michael Kremliovsky ,  Jefferson Rose

IPC分类号： G06F19/00 ,  G06F17/18

CPC分类号： G01N33/66 ,  A61B5/0017 ,  A61B5/002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/6849 ,  A61B5/7207

摘要： Disclosed are methods, apparatuses, etc. for glucose sensor signal stability analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to assess an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time. A reliability of the at least one sensor signal to respond to the blood glucose level of the patient may be assessed based at least partly on the at least one metric assessing an underlying trend. Other example embodiments are disclosed herein.

摘要翻译： 公开了用于葡萄糖传感器信号稳定性分析的方法，装置等。 在某些示例性实施例中，可以获得响应于患者的血糖水平的至少一个传感器信号的一系列样本。 至少部分地基于一系列样本，可以确定至少一个度量以评估至少一个传感器信号对患者随着时间的血糖水平的响应性的变化的潜在趋势。 可以至少部分地基于评估潜在趋势的至少一个度量来评估至少一个传感器信号对患者的血糖水平的响应的可靠性。 本文公开了其它示例性实施例。