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    REAL TIME SELF-ADJUSTING CALIBRATION ALGORITHM
    2.
    发明申请
    REAL TIME SELF-ADJUSTING CALIBRATION ALGORITHM 审中-公开
    实时自调整校准算法

    公开(公告)号：US20090005666A1

    公开(公告)日：2009-01-01

    申请号：US12179536

    申请日：2008-07-24

    申请人： John J. Shin ,  Nandita N. Patel ,  Sami Kanderian, JR. ,  Lu Wang ,  Richard Yoon

    发明人： John J. Shin ,  Nandita N. Patel ,  Sami Kanderian, JR. ,  Lu Wang ,  Richard Yoon

    IPC分类号： A61B5/00

    CPC分类号： A61B5/6849 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/6848 ,  A61B2560/0223 ,  A61M2005/1726 ,  G06F19/00

    摘要： A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals. It also includes obtaining at least two reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals. Also included is calculating the calibration characteristics using the reference glucose values and corresponding glucose monitor data to regress the obtained glucose monitor data. And, calibrating the obtained glucose monitor data using the calibration characteristics is included. In preferred embodiments, the reference source is a blood glucose meter, and the at least two reference glucose values are obtained from blood tests. In additional embodiments, calculation of the calibration characteristics includes linear regression and, in particular embodiments, least squares linear regression. Alternatively, calculation of the calibration characteristics includes non-linear regression. Data integrity may be verified and the data may be filtered.

    摘要翻译： 校准葡萄糖监测数据的方法包括以预定间隔在一段时间内收集葡萄糖监测数据。 它还包括从参考源获得至少两个参考葡萄糖值，所述参考源在时间上对应于以预定间隔获得的葡萄糖监测数据。 还包括使用参考葡萄糖值和相应的葡萄糖监测数据计算校准特性以回收所获得的葡萄糖监测数据。 并且包括使用校准特性来校准所获得的葡萄糖监测数据。 在优选实施例中，参考源是血糖仪，并且从血液测试获得至少两个参考葡萄糖值。 在另外的实施例中，校准特性的计算包括线性回归，并且在特定实施例中包括最小二乘线性回归。 或者，校准特性的计算包括非线性回归。 可以验证数据完整性，并且可以对数据进行过滤。

    High-resolution melting analysis
    4.
    发明授权
    High-resolution melting analysis 有权
    高分辨率熔解分析

    公开(公告)号：US08606529B2

    公开(公告)日：2013-12-10

    申请号：US13429911

    申请日：2012-03-26

    申请人： Deborah Boles ,  Kenton C. Hasson ,  Sami Kanderian

    发明人： Deborah Boles ,  Kenton C. Hasson ,  Sami Kanderian

    IPC分类号： G06F19/00

    CPC分类号： G06F19/24 ,  B01L7/52 ,  C12Q1/6816 ,  G06F19/18 ,  G06F19/20 ,  C12Q2527/107 ,  C12Q2537/165 ,  C12Q2539/101

    摘要： The application relates to methods and systems for analysis of dissociation behavior of nucleic acids and identification of nucleic acids. In one aspect, methods and systems are disclosed for identifying a nucleic acid in a sample including an unknown nucleic acid and for detecting a single nucleotide polymorphism in a nucleic acid in a sample. Methods and systems are also disclosed for identification of a nucleic acid in a biological sample including at least one unknown nucleic acid by fitting denaturation data including measurements of a quantifiable physical change of the sample at a plurality of independent sample property points to a function to determine an intrinsic physical value and to obtain an estimated physical change function, and identifying the nucleic acid in the biological sample by comparing the intrinsic physical value for at least one unknown nucleic acid to an intrinsic physical value for a known nucleic acid.

    摘要翻译： 该申请涉及用于分析核酸的解离行为和核酸鉴定的方法和系统。 在一个方面，公开了用于鉴定样品中的核酸的方法和系统，所述样品包括未知核酸并用于检测样品中核酸中的单核苷酸多态性。 还公开了用于通过将包含多个独立样品特性点的样品的可量化物理变化的测量的变性数据拟合到确定的多个独立样品特性点的功能来鉴定包含至少一种未知核酸的生物样品中的核酸的方法和系统 内在物理价值，并获得估计的物理变化功能，以及通过将至少一种未知核酸的固有物理值与已知核酸的固有物理值进行比较来鉴定生物样品中的核酸。

    System and method for genotype analysis and enhanced monte carlo simulation method to estimate misclassification rate in automated genotyping
    5.
    发明授权
    System and method for genotype analysis and enhanced monte carlo simulation method to estimate misclassification rate in automated genotyping 有权
    用于基因型分析和增强蒙特卡罗模拟方法的系统和方法，用于估计自动基因分型中的错误分类率

    公开(公告)号：US08483972B2

    公开(公告)日：2013-07-09

    申请号：US13172104

    申请日：2011-06-29

    申请人： Sami Kanderian

    发明人： Sami Kanderian

    IPC分类号： G06F19/00 ,  G06F15/00

    CPC分类号： G06F19/18 ,  C12Q1/6827 ,  G06F19/24 ,  C12Q2527/107 ,  C12Q2537/165

    摘要： The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids. The present invention includes methods and systems for analyzing dynamic profiles of genotypes of nucleic acids, including the steps of using a computer, including a processor and a memory, to convert dynamic profiles of known genotypes of a nucleic acid to multi-dimensional data points, wherein the dynamic profiles each comprise measurements of a signal representing a physical change of a nucleic acid containing the known genotype relative to an independent variable; using the computer to reduce the multi-dimensional data points into reduced-dimensional data points; and generating a plot of the reduced-dimensional data points for each genotype. The present invention also relates to methods and systems for calculating error statistics for an assay for identifying a genotype in a biological sample using an enhanced Monte Carlo simulation method to generate a set of N random data points for each known genotype within a class of known genotypes, where each set of N random data points has the same mean data point and covariance matrix as a data set for each of the known genotypes.

    摘要翻译： 本发明涉及用于分析核酸解离行为的方法和系统。 本发明包括用于分析核酸基因型的动态谱的方法和系统，包括使用包括处理器和存储器的计算机将核酸的已知基因型的动态谱转化为多维数据点的步骤， 其中所述动态分布图包括相对于独立变量表示含有已知基因型的核酸的物理变化的信号的测量值; 使用计算机将多维数据点减少为维数据点; 并且生成针对每个基因型的缩小维数据点的图。 本发明还涉及用于使用增强的蒙特卡洛模拟方法来计算生物样品中基因型的测定的误差统计的方法和系统，以生成一组已知基因型内的每个已知基因型的一组N个随机数据点 ，其中每组N个随机数据点具有与每个已知基因型的数据集相同的平均数据点和协方差矩阵。

    High-resolution melting analysis
    6.
    发明授权
    High-resolution melting analysis 有权
    高分辨率熔解分析

    公开(公告)号：US08145433B2

    公开(公告)日：2012-03-27

    申请号：US12258098

    申请日：2008-10-24

    申请人： Deborah Boles ,  Kenton C. Hasson ,  Sami Kanderian

    发明人： Deborah Boles ,  Kenton C. Hasson ,  Sami Kanderian

    IPC分类号： G06F19/00

    CPC分类号： G06F19/24 ,  B01L7/52 ,  C12Q1/6816 ,  G06F19/18 ,  G06F19/20 ,  C12Q2527/107 ,  C12Q2537/165 ,  C12Q2539/101

    摘要： The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. In one aspect, methods and systems are disclosed for identifying a nucleic acid in a sample including an unknown nucleic acid and for detecting a single nucleotide polymorphism in a nucleic acid in a sample. In another aspect, methods and systems are disclosed for identification of a nucleic acid in a biological sample including at least one unknown nucleic acid by fitting denaturation data including measurements of a quantifiable physical change of the sample at a plurality of independent sample property points to a function to determine an intrinsic physical value and to obtain an estimated physical change function, and identifying the nucleic acid in the biological sample by comparing the intrinsic physical value for at least one unknown nucleic acid to an intrinsic physical value for a known nucleic acid.

    摘要翻译： 本发明涉及用于分析核酸的解离行为和核酸鉴定的方法和系统。 在一个方面，公开了用于鉴定样品中的核酸的方法和系统，所述样品包括未知核酸并用于检测样品中核酸中的单核苷酸多态性。 在另一方面，公开了用于通过拟合变性数据来包括至少一种未知核酸的生物样品中的核酸的鉴定的方法和系统，所述变性数据包括在多个独立样本特性点处的样品的可量化物理变化的测量值 用于确定固有物理值并获得估计的物理变化功能，以及通过将至少一种未知核酸的固有物理值与已知核酸的固有物理值进行比较来鉴定生物样品中的核酸。

    Rapid method of pattern recognition, machine learning, and automated genotype classification through correlation analysis of dynamic signals
    8.
    发明授权
    Rapid method of pattern recognition, machine learning, and automated genotype classification through correlation analysis of dynamic signals 有权
    通过动态信号的相关分析，模式识别，机器学习和自动化基因型分类的快速方法

    公开(公告)号：US08412466B2

    公开(公告)日：2013-04-02

    申请号：US12759415

    申请日：2010-04-13

    申请人： Sami Kanderian

    发明人： Sami Kanderian

    IPC分类号： G06F19/00 ,  G06F15/00 ,  C12Q1/68

    CPC分类号： G06F19/22 ,  C12Q1/6827 ,  G06F19/24 ,  C12Q2527/101 ,  C12Q2527/107 ,  C12Q2537/165

    摘要： The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of determining whether a genotype is present in a biological sample. This includes methods and systems for determining whether a genotype is present in a biological sample, through generating a dynamic profile an unknown genotype, correlating the dynamic profile to an average profile for a known genotype to generate a correlation value, and determining whether the correlation value falls within an acceptable threshold to determine if the unknown genotype is the known genotype. The present invention also relates to methods and systems for generating a training set to allow a machine to recognize a known genotype from within a class of known genotypes. The training set generated by these methods and systems may be used to assist in identification of unknown genotypes.

    摘要翻译： 本发明涉及用于分析核酸解离行为的方法和系统以及确定基因型是否存在于生物样品中的鉴定。 这包括用于通过生成未知基因型的动态分布来确定基因型是否存在于生物样品中的方法和系统，将动态分布与已知基因型的平均分布相关联以产生相关值，以及确定相关值 落在可接受的阈值内，以确定未知的基因型是否是已知的基因型。 本发明还涉及用于产生训练集以允许机器从一类已知基因型中识别已知基因型的方法和系统。 由这些方法和系统产生的训练集可用于帮助识别未知基因型。

    Real time self-adjusting calibration algorithm
    9.
    发明授权
    Real time self-adjusting calibration algorithm 有权
    实时自调整校准算法

    公开(公告)号：US07890295B2

    公开(公告)日：2011-02-15

    申请号：US10750978

    申请日：2003-12-31

    申请人： John J. Shin ,  Nandita N. Patel ,  Sami Kanderian, Jr. ,  Lu Wang ,  Richard Yoon

    发明人： John J. Shin ,  Nandita N. Patel ,  Sami Kanderian, Jr. ,  Lu Wang ,  Richard Yoon

    IPC分类号： G06F11/30

    CPC分类号： A61B5/6849 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/6848 ,  A61B2560/0223 ,  A61M2005/1726 ,  G06F19/00

    摘要： A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals. It also includes obtaining at least two reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals. Also included is calculating the calibration characteristics using the reference glucose values and corresponding glucose monitor data to regress the obtained glucose monitor data. And, calibrating the obtained glucose monitor data using the calibration characteristics is included. In preferred embodiments, the reference source is a blood glucose meter, and the at least two reference glucose values are obtained from blood tests. In additional embodiments, calculation of the calibration characteristics includes linear regression and, in particular embodiments, least squares linear regression. Alternatively, calculation of the calibration characteristics includes non-linear regression. Data integrity may be verified and the data may be filtered.

    摘要翻译： 校准葡萄糖监测数据的方法包括以预定间隔在一段时间内收集葡萄糖监测数据。 它还包括从参考源获得至少两个参考葡萄糖值，所述参考源在时间上对应于以预定间隔获得的葡萄糖监测数据。 还包括使用参考葡萄糖值和相应的葡萄糖监测数据计算校准特性以回收所获得的葡萄糖监测数据。 并且包括使用校准特性来校准所获得的葡萄糖监测数据。 在优选实施例中，参考源是血糖仪，并且从血液测试获得至少两个参考葡萄糖值。 在另外的实施例中，校准特性的计算包括线性回归，并且在特定实施例中包括最小二乘线性回归。 或者，校准特性的计算包括非线性回归。 可以验证数据完整性，并且可以对数据进行过滤。

    Virtual patient software system for educating and treating individuals with diabetes
    10.
    发明申请
    Virtual patient software system for educating and treating individuals with diabetes 审中-公开
    用于教育和治疗糖尿病患者的虚拟病人软件系统

    公开(公告)号：US20060272652A1

    公开(公告)日：2006-12-07

    申请号：US11145485

    申请日：2005-06-03

    申请人： David Stocker ,  Sami Kanderian ,  Gabriel Cortina ,  Tamir Nitzan ,  Jon Plummer ,  Garry Steil ,  John Mastrototaro

    发明人： David Stocker ,  Sami Kanderian ,  Gabriel Cortina ,  Tamir Nitzan ,  Jon Plummer ,  Garry Steil ,  John Mastrototaro

    IPC分类号： A61B19/00

    CPC分类号： G16H50/50

    摘要： A system to assist an individual in developing a therapy in diabetes treatment of a patient includes a user interface control module, a simulation engine, a charting and display module. The user interface control module receives an input related to the patient and captures a current time of the simulation. The simulation engine receives the input, generates a plurality of blood glucose readings for the patient up to the current time of the simulation based on the input, and to transfers the plurality of blood glucose readings. The charting and display module receives the plurality of blood glucose readings and display the plurality of blood glucose readings. The simulation engine receives patient parameters from a patient parameter library based on a selected patient model.

    摘要翻译： 帮助个体开发患者糖尿病治疗的治疗系统包括用户界面控制模块，模拟引擎，图表和显示模块。 用户界面控制模块接收与患者相关的输入并捕获模拟的当前时间。 模拟引擎接收输入，基于输入，生成直到模拟的当前时间的患者的多个血糖读数，并传送多个血糖读数。 制图和显示模块接收多个血糖读数并显示多个血糖读数。 模拟引擎基于所选择的患者模型从患者参数库接收患者参数。