公开(公告)号：US20070053934A1

公开(公告)日：2007-03-08

申请号：US11510493

申请日：2006-08-25

申请人： Neville Kallenbach ,  Daniel Malamud ,  Zhigang Liu ,  William Abrams ,  Paramjit Arora

发明人： Neville Kallenbach ,  Daniel Malamud ,  Zhigang Liu ,  William Abrams ,  Paramjit Arora

IPC分类号： A61K31/70 ,  A61K39/12 ,  A01N43/04

CPC分类号： C12N7/00 ,  A61K38/1709 ,  A61K47/58 ,  A61K47/595 ,  C07K14/47 ,  C07K14/4723 ,  C07K14/705 ,  C12N2740/16061

摘要： The invention is directed to compositions comprising polyvalent complexes containing a biocompatible polymer backbone to which is attached a plurality of monomeric anti-microbial peptides and to methods for using such complexes to stabilize anti-microbial peptides for treating or preventing a disease or condition resulting from infection with a microbe. Multivalent derivatives of existing antimicrobial peptides in which several peptides are covalently linked have been investigated. The resulting construct may contain up to 30 or more units, and exhibits a significant enhancement of anti-microbial effect relative to the free peptides: on the order of a ten fold improvement in effectiveness, suggesting that higher multimerization can indeed lead to more effective agents. The invention is also directed to the use of such complexes for delivery of anti-viral peptides, in particular, peptides and peptide fragments obtained from salivary agglutinin protein (gp-340) for use in treating or preventing infection with HIV.

摘要翻译： 本发明涉及包含含有多个单体抗微生物肽的生物相容性聚合物骨架的多价复合物的组合物，以及使用这些复合物来稳定抗微生物肽以治疗或预防感染引起的疾病或病症的方法 用微生物。 已经研究了几种肽共价连接的现有抗微生物肽的多价衍生物。 所得构建体可以含有多达30个或更多个单元，并且相对于游离肽显示出显着增强的抗微生物效应：有效性提高十倍，这表明更高的多聚化确实会导致更有效的试剂 。 本发明还涉及这种复合物用于递送抗病毒肽，特别是从用于治疗或预防HIV感染的唾液凝集素蛋白（gp-340）获得的肽和肽片段的用途。