公开(公告)号：US07514546B2

公开(公告)日：2009-04-07

申请号：US11333859

申请日：2006-04-26

Applicant: Susan Mary Kingsman ,  Christopher R. Bebbington ,  Miles W. Carroll ,  Fiona M. Ellard ,  Kevin A. Myers

Inventor： Susan Mary Kingsman ,  Christopher R. Bebbington ,  Miles W. Carroll ,  Fiona M. Ellard ,  Kevin A. Myers

IPC: C07H21/04 ,  C12N15/00

CPC classification number: C07K16/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2319/00

Abstract: The use of an ScFv Ab (ScFv Ab) capable of recognizing a disease associated molecule (DAM) in the manufacture of a medicament for the prevention and/or treatment of a disease condition associated with a DAM is described. The ScFv Ab has therapeutic, diagnostic and prognostic applications.

Abstract translation: 描述了能够识别疾病相关分子（DAM）的ScFv Ab（ScFv Ab）在制备用于预防和/或治疗与DAM相关的疾病状况的药物中的用途。 ScFv Ab具有治疗，诊断和预后应用。

公开(公告)号：US06852703B1

公开(公告)日：2005-02-08

申请号：US09445375

申请日：1998-06-04

Applicant: Susan Mary Kingsman ,  Christopher Robert Bebbington ,  Fiona Margaret Ellard ,  Miles William Carroll ,  Kevin Alan Myers

Inventor： Susan Mary Kingsman ,  Christopher Robert Bebbington ,  Fiona Margaret Ellard ,  Miles William Carroll ,  Kevin Alan Myers

IPC: C12N15/09 ,  A61K35/76 ,  A61K39/02 ,  A61K39/395 ,  A61K48/00 ,  A61P35/00 ,  C07K14/47 ,  C07K14/485 ,  C07K14/705 ,  C07K16/30 ,  C12N15/87 ,  A61K35/00

CPC classification number: C07K16/40 ,  C07K14/485 ,  C07K14/70532 ,  C07K16/30 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30 ,  C12N15/87 ,  C12N2799/027

Abstract: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.

Abstract translation: 描述了包含编码感兴趣的产物（“POI”）的感兴趣的核苷酸序列（“NOI”）的载体。 NOI和/或POI能够识别肿瘤，使得在使用中载体能够将NOI和/或POI递送至肿瘤。

公开(公告)号：US06800281B2

公开(公告)日：2004-10-05

申请号：US10008610

申请日：2001-11-08

Applicant: Patrick Aebischer ,  Susan Mary Kingsman ,  Stuart Naylor ,  Nicholas Mazarakis

Inventor： Patrick Aebischer ,  Susan Mary Kingsman ,  Stuart Naylor ,  Nicholas Mazarakis

IPC: A61K4800

CPC classification number: C12N15/86 ,  A61K48/00 ,  C07K14/4756 ,  C12N2740/15043

Abstract: Disclosed and claimed are methods for treating or preventing neurodegenerative diseases, conditions or maladies or symptoms or physiology associated therewith, such as treating or preventing Parkinson's disease or symptoms or physiology associated therewith such as motor deficits or nigrostriatal degeneration; or, for inducing nigrostriatal regeneration. Advantageously, the methods involve administering a lentiviral vector that expresses GDNF, such as human GDNF, or a variant, homolog, analog or derivative thereof.

Abstract translation: 公开并要求保护的是用于治疗或预防神经变性疾病，病症或疾病或症状或与之相关的生理学的方法，例如治疗或预防帕金森病或与之相关的症状或生理学，例如运动缺陷或黑质纹状体变性; 或用于诱导黑质纹状体再生。 有利地，所述方法包括施用表达GDNF的慢病毒载体，例如人GDNF，或其变体，同系物，类似物或衍生物。

公开(公告)号：US06312682B1

公开(公告)日：2001-11-06

申请号：US09224014

申请日：1998-12-28

Applicant: Alan John Kingsman ,  Susan Mary Kingsman ,  Narry Kim ,  Kyriacos Mitrophanous

Inventor： Alan John Kingsman ,  Susan Mary Kingsman ,  Narry Kim ,  Kyriacos Mitrophanous

IPC: A61K4800

CPC classification number: C12N15/86 ,  A61K48/00 ,  C12N2740/16043 ,  C12N2740/16052

Abstract: Retroviral vector production systems for producing lentivirus-based vector particles which are capable of infecting and transducing non-dividing target cells, wherein one or more of the auxiliary genes such as vpr, vif, tat, and nef in the case of HIV-1 are absent from the system. The systems and resulting retrovirus vector particles have improved safety over existing systems and vectors.

Abstract translation: 用于产生能够感染和转导不分裂靶细胞的慢病毒载体颗粒的逆转录病毒载体生产系统，其中在HIV-1的情况下，一种或多种辅助基因如vpr，vif，tat和nef是 缺席系统。 系统和产生的逆转录病毒载体颗粒具有比现有系统和载体更好的安全性。

公开(公告)号：US06235522B1

公开(公告)日：2001-05-22

申请号：US09284011

申请日：1999-04-05

Applicant: Alan John Kingsman ,  Susan Mary Kingsman

Inventor： Alan John Kingsman ,  Susan Mary Kingsman

IPC: C12N1500

CPC classification number: C12N15/86 ,  A61K48/00 ,  C12N2740/16043 ,  C12N2740/16052 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/50 ,  C12N2830/60

Abstract: Retroviral vector particles capable of infecting and transducing non-dividing mammalian target cells, which vector particles may be based on letiviruses such as HIV and which have an RNA genome constructed so as to provide in the DNA provirus a non-lentiviral expression control element in the 5′LTR of the provirus.

Abstract translation: 能够感染和转导非分裂哺乳动物靶细胞的逆转录病毒载体颗粒，该载体颗粒可以基于诸如HIV之类的病毒性病毒，并且其具有构建的RNA基因，以便在DNA原病毒中提供非慢病毒表达控制元件 前病毒的5'LTR。

公开(公告)号：US20120213822A1

公开(公告)日：2012-08-23

申请号：US13401377

申请日：2012-02-21

Applicant: Richard Harrop ,  Michelle Kelleher ,  William Shingler ,  Susan Mary Kingsman ,  Miles William Carroll

Inventor： Richard Harrop ,  Michelle Kelleher ,  William Shingler ,  Susan Mary Kingsman ,  Miles William Carroll

IPC: A61K39/00 ,  A61P35/00

CPC classification number: A61K45/06 ,  A61K31/00 ,  A61K39/0011 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2300/00

Abstract: A method of treating or preventing disease, said method comprising administering to a subject, simultaneously, sequentially or separately, an antigen and a chemotherapeutic agent or agents comprising the steps of: administering the chemotherapeutic agent or agents, and administering an antigen up to 6 weeks after the chemotherapeutic agent.

Abstract translation: 一种治疗或预​​防疾病的方法，所述方法包括向对象同时，依次或分别施用抗原和化学治疗剂或试剂，所述方法包括以下步骤：施用所述化学治疗剂或试剂，并施用至多6周的抗原 化疗后。

公开(公告)号：US08133681B2

公开(公告)日：2012-03-13

申请号：US12052710

申请日：2008-03-20

Applicant: Richard Harrop ,  Michelle Kelleher ,  William Shingler ,  Susan Mary Kingsman ,  Miles William Carroll

Inventor： Richard Harrop ,  Michelle Kelleher ,  William Shingler ,  Susan Mary Kingsman ,  Miles William Carroll

IPC: G01N33/53 ,  A61K39/385

CPC classification number: A61K45/06 ,  A61K31/00 ,  A61K39/0011 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2300/00

Abstract: A method of treating or preventing disease, said method comprising administering to a subject, simultaneously, sequentially or separately, an antigen and a chemotherapeutic agent or agents comprising the steps of: administering the chemotherapeutic agent or agents, and administering an antigen up to 6 weeks after the chemotherapeutic agent.

Abstract translation: 一种治疗或预​​防疾病的方法，所述方法包括向对象同时，依次或分别施用抗原和化学治疗剂或试剂，所述方法包括以下步骤：施用所述化学治疗剂或试剂，并施用至多6周的抗原 化疗后。

公开(公告)号：US08084249B2

公开(公告)日：2011-12-27

申请号：US12714264

申请日：2010-02-26

Applicant: Susan Mary Kingsman ,  Christopher Robert Bebbington ,  Fiona Margaret Ellard ,  Miles William Carroll ,  Kevin Alan Myers

Inventor： Susan Mary Kingsman ,  Christopher Robert Bebbington ,  Fiona Margaret Ellard ,  Miles William Carroll ,  Kevin Alan Myers

IPC: C12N15/00

CPC classification number: C07K16/40 ,  C07K14/485 ,  C07K14/70532 ,  C07K16/30 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30 ,  C12N15/87 ,  C12N2799/027

Abstract: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.

Abstract translation: 描述了包含编码感兴趣的产物（“POI”）的感兴趣的核苷酸序列（“NOI”）的载体。 NOI和/或POI能够识别肿瘤，使得在使用中载体能够将NOI和/或POI递送至肿瘤。

公开(公告)号：US20100040539A1

公开(公告)日：2010-02-18

申请号：US12121621

申请日：2008-05-15

Applicant: Alan Kingsman ,  Susan Mary Kingsman ,  Christopher Robert Bebbington ,  Miles William Carroll ,  Fiona Margaret Ellard ,  Kevin Alan Myers

Inventor： Alan Kingsman ,  Susan Mary Kingsman ,  Christopher Robert Bebbington ,  Miles William Carroll ,  Fiona Margaret Ellard ,  Kevin Alan Myers

IPC: A61K51/00 ,  A61K39/395 ,  C12N9/96 ,  C12N5/02 ,  C07K16/00

CPC classification number: C07K16/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2319/00

Abstract: The use of an ScFv Ab (ScFv Ab) capable of recognising a disease associated molecule (DAM) in the manufacture of a medicament for the prevention and/or treatment of a disease condition associated with a DAM is described. The ScFv Ab has therapeutic, diagnostic and prognostic applications.

Abstract translation: 描述了能够识别疾病相关分子（DAM）的ScFv Ab（ScFv Ab）在制备用于预防和/或治疗与DAM有关的疾病状况的药物中的用途。 ScFv Ab具有治疗，诊断和预后应用。

公开(公告)号：US20080131400A1

公开(公告)日：2008-06-05

申请号：US11810007

申请日：2007-06-04

Applicant: Nicholas Mazarakis ,  Mimoun Azzouz ,  Susan Mary Kingsman

Inventor： Nicholas Mazarakis ,  Mimoun Azzouz ,  Susan Mary Kingsman

IPC: A61K35/76 ,  A61P25/00

CPC classification number: C12N15/86 ,  A01K2227/105 ,  A01K2267/0318 ,  A61K38/1709 ,  A61K38/1761 ,  A61K38/1796 ,  A61K38/185 ,  A61K38/1866 ,  A61K38/30 ,  A61K39/00 ,  A61K48/00 ,  A61K2121/00 ,  A61K2123/00 ,  C07K2319/00 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2799/027 ,  C12N2810/6054 ,  C12N2810/6081

Abstract: Provided is a method of treating motor neuron disease using a lentiviral vector system to transduce a target site, wherein the vector system is or comprises at least part of a rabies G envelope protein or a mutant, variant, homologue or fragment thereof, and a nucleotide of interest (NOI), and wherein the target site is at least part of the central nervous system.

Abstract translation: 提供了一种使用慢病毒载体系统治疗运动神经元疾病以转导靶位点的方法，其中载体系统是或包含狂犬病G包膜蛋白或突变体，变体，同源物或片段的至少一部分，以及核苷酸 感兴趣的（NOI），并且其中靶位点是中枢神经系统的至少一部分。