利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

15 条记录 (耗时 0.017 秒)

    ISOLATED NANOCAPSULE POPULATIONS AND SURFACTANT-STABILIZED MICROCAPSULES AND NANOCAPSULES FOR DIAGNOSTIC IMAGING AND DRUG DELIVERY AND METHODS FOR THEIR PRODUCTION
    5.
    发明申请
    ISOLATED NANOCAPSULE POPULATIONS AND SURFACTANT-STABILIZED MICROCAPSULES AND NANOCAPSULES FOR DIAGNOSTIC IMAGING AND DRUG DELIVERY AND METHODS FOR THEIR PRODUCTION 审中-公开
    分离的纳诺卡普人口和表面活性剂稳定的微囊藻毒素和用于诊断成像和药物递送的纳米抗体及其生产方法

    公开(公告)号：US20080279783A1

    公开(公告)日：2008-11-13

    申请号：US11849759

    申请日：2007-09-04

    申请人： Margaret A. Wheatley ,  Brian E. Oeffinger ,  Nikhil Dhoot ,  Justin Lathia

    发明人： Margaret A. Wheatley ,  Brian E. Oeffinger ,  Nikhil Dhoot ,  Justin Lathia

    IPC分类号： A61K49/22 ,  A61K9/50

    CPC分类号： B82Y5/00 ,  A61K41/0028 ,  A61K47/62 ,  A61K47/6925 ,  A61K49/223

    摘要： A method for producing surfactant-stabilized microcapsules or nanocapsules including the steps of (a) preparing a suspension comprising a non-ionic sorbitan detergent and a salt in phosphate buffered saline; (b) adding to the suspension a nonionic polyoxyethylenesorbitan detergent to produce a solution; (c) heating while stirring the solution of step (b) to 55±5° C. and maintaining the temperature of the solution at 55±5° C. for several minutes; (d) allowing the solution to cool to room temperature; (e) autoclaving the solution; (f) creating surfactant-stabilized microbubbles and nanobubbles in the solution; and (g) collecting surfactant-stabilized nanocapsules and microcapsules formed from the microbubbles and nanobubbles.

    摘要翻译： 一种用于制备表面活性剂稳定的微胶囊或纳米胶囊的方法，包括以下步骤：（a）制备包含非离子脱水山梨醇洗涤剂和磷酸盐缓冲盐水中的盐的悬浮液; （b）向所述悬浮液中加入非离子聚氧乙烯脱水山梨糖醇清净剂以产生溶液; （c）将步骤（b）的溶液搅拌至55±5℃，同时将溶液的温度维持在55±5℃几分钟; （d）使溶液冷却至室温; （e）高压灭菌溶液; （f）在溶液中产生表面活性剂稳定的微泡和纳米气泡; 和（g）收集由微泡和纳米气泡形成的表面活性剂稳定的纳米胶囊和微胶囊。

    Solid Dosage Form of Wetted Heparin
    6.
    发明申请
    Solid Dosage Form of Wetted Heparin 有权
    润湿肝素的固体剂型

    公开(公告)号：US20070224262A1

    公开(公告)日：2007-09-27

    申请号：US11568749

    申请日：2005-05-06

    申请人： Shingai Majuru ,  Brahma Singh ,  Nikhil Dhoot

    发明人： Shingai Majuru ,  Brahma Singh ,  Nikhil Dhoot

    IPC分类号： A61K31/727

    CPC分类号： A61K9/4866 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1641 ,  A61K31/727

    摘要： The present invention relates to a solid pharmaceutical composition (such as a solid dosage form) comprising a delivery agent and wetted heparin. The inclusion of wetted heparin rather than un-wetted heparin in the solid pharmaceutical composition results in increased delivery of the heparin. Without being bound by any particular theory, applicants believe that because the polymer chain of the wetted heparin is already in an “open” form, while un-wetted heparin is not, less of the wetted heparin is broken down in the gastrointestinal tract and is more readily absorbed in the stomach.

    摘要翻译： 本发明涉及包含递送剂和湿润肝素的固体药物组合物（例如固体剂型）。 在固体药物组合物中包含湿润肝素而不是未润湿的肝素导致肝素的递送增加。 申请人不受任何特定理论的约束，认为因为浸润肝素的聚合物链已经是“开放”形式，而未润湿的肝素不是，较少的湿润肝素在胃肠道中被分解，并且是 更容易吸收在胃里。

    Solid dosage form of wetted heparin
    10.
    发明授权
    Solid dosage form of wetted heparin 有权
    浸湿肝素的固体剂型

    公开(公告)号：US08039018B2

    公开(公告)日：2011-10-18

    申请号：US11568749

    申请日：2005-05-06

    申请人： Shingai Majuru ,  Brahma Singh ,  Nikhil Dhoot

    发明人： Shingai Majuru ,  Brahma Singh ,  Nikhil Dhoot

    IPC分类号： A61K9/48 ,  A01N57/00

    CPC分类号： A61K9/4866 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1641 ,  A61K31/727

    摘要： The present invention relates to a solid pharmaceutical composition (such as a solid dosage form) comprising a delivery agent and wetted heparin. The inclusion of wetted heparin rather than un-wetted heparin in the solid pharmaceutical composition results in increased delivery of the heparin. Without being bound by any particular theory, applicants believe that because the polymer chain of the wetted heparin is already in an “open” form, while un-wetted heparin is not, less of the wetted heparin is broken down in the gastrointestinal tract and is more readily absorbed in the stomach.

    摘要翻译： 本发明涉及包含递送剂和湿润肝素的固体药物组合物（例如固体剂型）。 在固体药物组合物中包含湿润肝素而不是未润湿的肝素导致肝素的递送增加。 申请人不受任何特定理论的约束，认为因为浸润肝素的聚合物链已经是“开放”形式，而未润湿的肝素不是，较少的湿润肝素在胃肠道中被分解，并且是 更容易吸收在胃里。