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1.发明申请公开(公告)号：US20120108497A1
公开(公告)日：2012-05-03
申请号：US13332430
申请日：2011-12-21
申请人： Nitzan PALDI , Gal Yarden
发明人： Nitzan PALDI , Gal Yarden
CPC分类号： A61K31/713 , C12N15/113 , C12N15/1131 , C12N2310/14 , C12N2770/22022
摘要： Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.
摘要翻译： 使用RNA干扰技术降低蜜蜂感染性疾病的易感性的组合物和方法，更具体地，通过喂养病原体特异性dsRNA，预防和治疗诸如以色列急性麻痹病毒（IAPV）的蜜蜂中的病毒感染。 此外，公开了多病原体特异性dsRNA。
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公开(公告)号：US20120053231A1
公开(公告)日：2012-03-01
申请号：US13318636
申请日：2010-05-05
申请人： Nitzan Paldi , Eitan Glick
发明人： Nitzan Paldi , Eitan Glick
IPC分类号： A61K31/7105 , A61P33/00 , A61P31/10 , C07H21/02
CPC分类号： C12N15/113 , A61D7/00 , A61K31/00 , A61K31/7088 , C12N2310/11 , C12N2310/14
摘要： Compositions and methods for reducing susceptibility and enhancing tolerance to Nosema disease (Nosemosis) using RNA interference technology, and more particularly, prevention and treatment of Nosema infections in honeybees by feeding of Nosema-specific dsRNA.
摘要翻译： 使用RNA干扰技术降低易感性和增加对Nosema病的耐受性的组合物和方法，更具体地，通过喂食Nosema特异性dsRNA来预防和治疗蜜蜂中的Nosema感染。
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3.发明授权Compositions for conferring tolerance to viral disease in social insects, and the use thereof 有权赋予社会昆虫病毒性疾病耐受性的组合物及其用途公开(公告)号：US08097712B2
公开(公告)日：2012-01-17
申请号：US12222949
申请日：2008-08-20
申请人： Nitzan Paldi , Gal Yarden
发明人： Nitzan Paldi , Gal Yarden
IPC分类号： C12N15/11 , C12N15/113 , C07H21/02
CPC分类号： A61K31/713 , C12N15/113 , C12N15/1131 , C12N2310/14 , C12N2770/22022
摘要： Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.
摘要翻译： 使用RNA干扰技术降低蜜蜂感染性疾病的易感性的组合物和方法，更具体地，通过喂养病原体特异性dsRNA，预防和治疗诸如以色列急性麻痹病毒（IAPV）的蜜蜂中的病毒感染。 此外，公开了多病原体特异性dsRNA。
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公开(公告)号：US08822426B2
公开(公告)日：2014-09-02
申请号：US13318636
申请日：2010-05-05
申请人： Nitzan Paldi , Eitan Glick
发明人： Nitzan Paldi , Eitan Glick
CPC分类号： C12N15/113 , A61D7/00 , A61K31/00 , A61K31/7088 , C12N2310/11 , C12N2310/14
摘要： Compositions and methods for reducing susceptibility and enhancing tolerance to Nosema disease (Nosemosis) using RNA interference technology, and more particularly, prevention and treatment of Nosema infections in honeybees by feeding of Nosema-specific dsRNA.
摘要翻译： 使用RNA干扰技术降低易感性和增加对Nosema病的耐受性的组合物和方法，更具体地，通过喂食Nosema特异性dsRNA来预防和治疗蜜蜂中的Nosema感染。
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5.发明申请Compositions for conferring tolerance to viral disease in social insects, and the use thereof 有权赋予社会昆虫病毒性疾病耐受性的组合物及其用途公开(公告)号：US20090118214A1
公开(公告)日：2009-05-07
申请号：US12222949
申请日：2008-08-20
申请人： Nitzan Paldi , Gal Yarden
发明人： Nitzan Paldi , Gal Yarden
IPC分类号： A61K31/713 , C07H21/02 , A61P31/12
CPC分类号： A61K31/713 , C12N15/113 , C12N15/1131 , C12N2310/14 , C12N2770/22022
摘要： Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.
摘要翻译： 使用RNA干扰技术降低对蜜蜂感染性疾病的敏感性的组合物和方法，更具体地，通过饲喂病原体特异性dsRNA来预防和治疗蜜蜂如以色列急性麻痹病毒（IAPV）中的病毒感染。 此外，公开了多病原体特异性dsRNA。
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6.发明申请Method of enhancing expression of exogenous polynucleotide sequences in plants 审中-公开增强植物中外源多核苷酸序列表达的方法公开(公告)号：US20060130180A1
公开(公告)日：2006-06-15
申请号：US10542551
申请日：2004-01-15
申请人： Nitzan Paldi , Herve Huet , Eri Govrin
发明人： Nitzan Paldi , Herve Huet , Eri Govrin
CPC分类号： C12N15/8257 , C12N15/8216 , C12N15/8218 , C12N2770/34011
摘要： A method of enhancing an expression of an exogenous polynucleotide sequence in a plant which includes administering to the plant a virus selected capable of suppressing gene silencing in the plant, thereby enhancing the expression of the transgene in the plant.
摘要翻译： 一种增强植物中外源多核苷酸序列表达的方法，其包括向植物施用能够抑制植物中基因沉默的选择的病毒，从而增强植物中转基因的表达。
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7.发明授权公开(公告)号：US08507457B2
公开(公告)日：2013-08-13
申请号：US13332430
申请日：2011-12-21
申请人： Nitzan Paldi , Gal Yarden
发明人： Nitzan Paldi , Gal Yarden
IPC分类号： C12N15/11 , C12N15/113 , C07H21/02
CPC分类号： A61K31/713 , C12N15/113 , C12N15/1131 , C12N2310/14 , C12N2770/22022
摘要： Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-specific dsRNA. Further, multiple-pathogen specific dsRNA is disclosed.
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8.发明申请Preventing and Curing Beneficial Insect Diseases Via Plant Transcribed Molecules 审中-公开通过植物转录的分子预防和治愈有益的昆虫疾病公开(公告)号：US20120157512A1
公开(公告)日：2012-06-21
申请号：US13391103
申请日：2010-08-22
申请人： Eyal Ben-Chanoch , Nitzan Paldi , Gal Yarden
发明人： Eyal Ben-Chanoch , Nitzan Paldi , Gal Yarden
IPC分类号： A61K31/7088 , C12N5/10 , C12N1/21 , A01H5/00 , A61K31/713 , A61P31/14 , A61P31/04 , A61P31/12 , A61P33/02 , A61P31/10 , A61P33/00 , C12N15/82 , A61P31/00
CPC分类号： C12N15/823 , C12N15/113 , C12N15/1131 , C12N2310/14
摘要： Methods and compositions for transforming plants to express polynucleotides capable of gene silencing gene expression in pathogens of beneficial insets such as IAPV, Nosema species and Varroa mites, and methods for using the transgenic plants for reducing infection and susceptibility of bees to Colony Collapse Disorder are provided.
摘要翻译： 提供用于转化植物以表达能够在诸如IAPV，Nosema种类和Varroa螨等有益插图的病原体中基因沉默基因表达的多核苷酸的方法和组合物，以及用于将转基因植物用于减少对Colony Collapse Disorder的感染和易感性的方法 。
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9.发明申请Virally infected plants as a source of insect reppellants/attractents 审中-公开病毒感染的植物作为昆虫reppellants /吸引人的来源公开(公告)号：US20050147632A1
公开(公告)日：2005-07-07
申请号：US10510753
申请日：2004-10-12
申请人： Nitzan Paldi , Eri Govkin , Herve Huet , Gai Yarden
发明人： Nitzan Paldi , Eri Govkin , Herve Huet , Gai Yarden
CPC分类号： G01N33/5097 , A01N63/00 , A01N65/38 , A61K36/00 , C12N15/8243 , C12N15/8286 , C12N2770/00011 , G01N30/02 , G01N2500/10 , Y02A40/162
摘要： A method of uncovering a putative insect repellent or attractant is provided. The method is effected by identifying volatiles differentially emitted from a plant infected with a virus and identifying at least one of the volatiles thereby uncovering the putative insect repellent or attractant.
摘要翻译： 提供了揭示推定的驱虫剂或引诱剂的方法。 该方法通过鉴定从感染病毒的植物差异发射的挥发物并鉴定至少一种挥发物，从而揭示推定的驱虫剂或引诱剂。
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