公开(公告)号：US20100331415A1

公开(公告)日：2010-12-30

申请号：US12734657

申请日：2008-11-18

申请人： Rudolf Krumbholz ,  Karin Krumbholz ,  Christine Krumbholz ,  Norbert Schirra ,  Peter Lembke

发明人： Rudolf Krumbholz ,  Karin Krumbholz ,  Christine Krumbholz ,  Norbert Schirra ,  Peter Lembke

IPC分类号： A61K31/20 ,  C07C57/03 ,  A61P29/00

CPC分类号： A61K45/06 ,  A61K31/202 ,  A61K2300/00

摘要： The invention relates to the use of omega-3-fatty acid(s) in means for pain relief. The means preferably comprise highly unsaturated omega-3-fatty acid(s) that contain, above all, EPA and/or DHA. Preferably, the omega-3-fatty acid is administered in a high dose of more than 2 g, in particular more than 3 to 4 g, for pain relief.

摘要翻译： 本发明涉及ω-3-脂肪酸在减轻疼痛的手段中的用途。 该方法优选包含高度不饱和的ω-3-脂肪酸，其最重要地包含EPA和/或DHA。 优选地，ω-3-脂肪酸以大于2g，特别是大于3至4g的高剂量施用以缓解疼痛。

公开(公告)号：US06234464B1

公开(公告)日：2001-05-22

申请号：US09348379

申请日：1999-07-07

申请人： Rudolf Krumbholz ,  Alf Lamprecht ,  Claus-Michael Lehr ,  Ulrich Schäfer ,  Norbert Schirra ,  Manfred Treitz

发明人： Rudolf Krumbholz ,  Alf Lamprecht ,  Claus-Michael Lehr ,  Ulrich Schäfer ,  Norbert Schirra ,  Manfred Treitz

IPC分类号： B01J1302

CPC分类号： B01J13/06 ,  A23P10/30 ,  Y10T428/2984

摘要： A microencapsulated unsaturated fatty acid or fatty acid compound or mixture of fatty acids and/or fatty acid compounds, and particularly an omega-3-fatty acid or omega-6-fatty acid or an ethyl ester or a glyceride thereof or a mixture of such fatty acids and/or fatty acid compounds. Fatty acid compounds are understood to include derivatives. Particles of the compounds are provided with capsule walls composed of two layers. The inner layer is composed of gelatin A, gelatine B. casein or an alginate, or of a derivative or salt of one of these polymers. The outer layer is composed of gelatin B, gum arabic, pectin or chitosan or a derivative or salt of one of these polymers.

摘要翻译： 微胶囊化的不饱和脂肪酸或脂肪酸化合物或脂肪酸和/或脂肪酸化合物的混合物，特别是ω-3-脂肪酸或ω-6-脂肪酸或其乙酯或其甘油酯或其混合物 脂肪酸和/或脂肪酸化合物。 脂肪酸化合物被理解为包括衍生物。 化合物的颗粒具有由两层组成的胶囊壁。 内层由明胶A，明胶B.酪蛋白或藻酸盐，或这些聚合物之一的衍生物或盐组成。 外层由明胶B，阿拉伯胶，果胶或壳聚糖或这些聚合物之一的衍生物或盐组成。

公开(公告)号：US20110015418A1

公开(公告)日：2011-01-20

申请号：US12305942

申请日：2007-06-19

申请人： Rudolf Krumbholz ,  Peter Lembke ,  Norbert Schirra

发明人： Rudolf Krumbholz ,  Peter Lembke ,  Norbert Schirra

IPC分类号： C11B3/10

CPC分类号： G01N30/28 ,  B01D15/161 ,  B01D15/163 ,  B01D15/40 ,  B01J20/286 ,  G01N30/02 ,  G01N30/32 ,  G01N30/8658 ,  G01N30/8689 ,  G01N2030/3076

摘要： Method for improving the performance of a preparative batchwise Super Critical Fluid Chromatographic separation for the recovery of a target fatty acid or derivative thereof, or of a group of target fatty acids or of derivatives thereof from a mixture, characterized in that the said Super Critical Fluid Chromatographic separation employs a chromatographic column charged with a stationary phase chosen from the group consisting of aluminium oxide or aluminium oxides, titanium oxide or titanium oxides, silica gel or silica gels, amino propyl modified silica gels, diol modified silica gels, phenyl modified silica gels and “reversed phase” phases, the former in turn chosen from the group consisting of RP 18, RP8 and RP3, and in that the said Super Critical Fluid Chromatographic Separation further employs a mobile phase chosen from the group consisting of ethylene, propane, ammonia, dinitrogen dioxide and CO2, wherein in the said method, during the run of the said mixture on the chromatographic column, a pressure and/or temperature gradient is applied to the chromatographic column during the elution of the target fatty acid or derivative thereof.

摘要翻译： 用于改进用于从混合物中回收目标脂肪酸或其衍生物或一组目标脂肪酸或其衍生物的制备型间歇超临界流体色谱分离的性能的方法，其特征在于所述超临界流体 色谱分离采用带有选自氧化铝或氧化铝，氧化钛或氧化钛，硅胶或硅胶，氨基丙基改性硅胶，二醇改性硅胶，苯基改性硅胶的固定相的色谱柱 和“反相”相，前者又选自RP 18，RP 8和RP 3组成，并且所述超临界流体色谱分离还采用选自乙烯，丙烷，氨的流动相 ，二氧化氮和二氧化碳，其中在所述方法中，在所述混合物在色谱上运行期间 图示柱中，在目标脂肪酸或其衍生物洗脱期间，将色谱柱施加压力和/或温度梯度。

公开(公告)号：US08063235B2

公开(公告)日：2011-11-22

申请号：US12305942

申请日：2007-06-19

申请人： Rudolf Krumbholz ,  Peter Lembke ,  Norbert Schirra

发明人： Rudolf Krumbholz ,  Peter Lembke ,  Norbert Schirra

IPC分类号： C11B7/00 ,  C11B3/10

CPC分类号： G01N30/28 ,  B01D15/161 ,  B01D15/163 ,  B01D15/40 ,  B01J20/286 ,  G01N30/02 ,  G01N30/32 ,  G01N30/8658 ,  G01N30/8689 ,  G01N2030/3076

摘要： Method for improving the performance of a preparative batchwise Super Critical Fluid Chromatographic separation for the recovery of a target fatty acid or derivative thereof, or of a group of target fatty acids or of derivatives thereof from a mixture, characterized in that the said Super Critical Fluid Chromatographic separation employs a chromatographic column charged with a stationary phase chosen from the group consisting of aluminium oxide or aluminium oxides, titanium oxide or titanium oxides, silica gel or silica gels, amino propyl modified silica gels, diol modified silica gels, phenyl modified silica gels and “reversed phase” phases, the former in turn chosen from the group consisting of RP18, RP8 and RP3, and in that the said Super Critical Fluid Chromatographic Separation further employs a mobile phase chosen from the group consisting of ethylene, propane, ammonia, dinitrogen dioxide and CO2, wherein in the said method, during the run of the said mixture on the chromatographic column, a pressure and/or temperature gradient is applied to the chromatographic column during the elution of the target fatty acid or derivative thereof.

摘要翻译： 用于改进用于从混合物中回收目标脂肪酸或其衍生物或一组目标脂肪酸或其衍生物的制备型间歇超临界流体色谱分离的性能的方法，其特征在于所述超临界流体 色谱分离采用带有选自氧化铝或氧化铝，氧化钛或氧化钛，硅胶或硅胶，氨基丙基改性硅胶，二醇改性硅胶，苯基改性硅胶的固定相的色谱柱 和“反相”相，前者反过来选自RP18，RP8和RP3组成，并且所述超临界流体色谱分离还采用选自乙烯，丙烷，氨， 二氧化氮和二氧化碳，其中在所述方法中，在所述混合物在色谱柱上运行期间 在目标脂肪酸或其衍生物洗脱期间，将色谱柱施加压力和/或温度梯度至色谱柱。