公开(公告)号：US20220186167A1

公开(公告)日：2022-06-16

申请号：US17561389

申请日：2021-12-23

申请人： OLOGY BIOSERVICES, INC.

发明人： Eric VELA ,  April GREEN ,  Dalton BERRIE

IPC分类号： C12M1/06 ,  C12N5/073 ,  C12N5/071 ,  C12M1/24 ,  C12M1/00 ,  C12M1/12 ,  C12M1/42 ,  C12M3/00

摘要： Disclosed is a process for growing adherent cells in a containment box of a multi-parallel bioreactor, including: seeding the adherent cells on a carrier held in a culture dish; transferring the adherent cells on the carrier to a containment box of the multi-parallel bioreactor; and growing the adherent cells at a containment box while agitating the media at an impeller speed between 200 rpm to a 1200 rpm.

公开(公告)号：US20230002739A1

公开(公告)日：2023-01-05

申请号：US17748664

申请日：2022-05-19

申请人： OLOGY BIOSERVICES, INC.

发明人： Perry NEWTON ,  Dalton BERRIE ,  Tyler GROW ,  Sheldon DOXILLY ,  Christopher J. MONTOYA ,  Sara Jane TERPENING ,  Eric VELA

IPC分类号： C12N7/00 ,  C12M1/12 ,  C12M1/34

摘要： The invention relates to a method of increasing the yield of virus, virus particles, or viral vectors from host cells in a bioreactor. The invention provides a reproducible and robust method and system of determining and controlling the optimal time of infection of host cells using a correlation of process air parameters including Air flow, O2 flow, and respective trends thereof resulting in increased virus yield.

公开(公告)号：US20220098555A1

公开(公告)日：2022-03-31

申请号：US17310390

申请日：2020-02-14

申请人： OLOGY BIOSERVICES, INC.

发明人： ERIC VELA

IPC分类号： C12N7/00 ,  C12M1/12 ,  C12M1/34

摘要： The invention relates to a method of increasing the yield of virus, virus particles, or viral vectors from host cells in a fixed-bed bioreactor by specifically modifying the dissolved oxygen levels in the media.

公开(公告)号：US20180298327A1

公开(公告)日：2018-10-18

申请号：US16018435

申请日：2018-06-26

申请人： OLOGY BIOSERVICES, INC.

发明人： MANFRED REITER ,  WOLFGANG MUNDT ,  SIMONE FEIGL ,  SIMONE VON FIRCKS

IPC分类号： C12N5/073 ,  C12R1/91 ,  C12N7/00 ,  C12N15/01

摘要： The present invention relates to a method for production of continuous cell lines comprising providing living cells of an animal or a human, irradiating said cells with UV light, proliferating said cells and selecting multiplying cells as cells of a continuous cell line.

公开(公告)号：US20200345828A1

公开(公告)日：2020-11-05

申请号：US16877015

申请日：2020-05-18

申请人： OLOGY BIOSERVICES, INC.

发明人： RON COBB ,  MICHAEL SPRINGER ,  YAWEI NI

IPC分类号： A61K39/12 ,  A61K39/00 ,  A61K39/295 ,  A61K9/00 ,  A61K9/16 ,  A61K9/19

摘要： A dry powder norovirus vaccine is provided, which comprises at least two norovirus antigens representing different genogroups. The vaccine may be produced by formulation with a mixture of different antigens or combination of monovalent powders with each containing one antigen. The formulated vaccine is suitable for mucosal administration and soluble in aqueous solutions for parenteral administration. A method of immunization is also provided, which comprises at least one administration of the vaccine via mucosal and/or parental route. The immunization may have multiple administrations of the vaccine, i.e., one or more immunizations via a mucosal route followed by one or more immunizations via a parenteral route or vice versa, to maximize both mucosal and systemic immune responses and protection against norovirus infections.

公开(公告)号：US10329583B2

公开(公告)日：2019-06-25

申请号：US15289106

申请日：2016-10-07

申请人： Ology Bioservices, Inc.

发明人： Falko-Günter Falkner ,  Birgit Schafer ,  P Noel Barrett ,  Thomas R. Kreil ,  Hartmut Ehrlich ,  Annett Hessel

IPC分类号： A61K39/12 ,  C12N15/86 ,  A61K39/145 ,  A61K39/285 ,  C12N7/00 ,  C12N15/62 ,  A61K39/00

摘要： The present invention relates to recombinant viral vectors and methods of using the recombinant viral vectors to induce an immune response to influenza A viruses. The invention provides recombinant viral vectors based, for example, on the non-replicating modified vaccinia virus Ankara. When administered according to methods of the invention, the recombinant viral vectors are designed to be cross-protective and induce heterosubtypic immunity to influenza A viruses.

公开(公告)号：US20180243397A1

公开(公告)日：2018-08-30

申请号：US15754807

申请日：2016-08-26

申请人： Ron COBB ,  Michael SPRINGER ,  Yawei NI ,  OLOGY BIOSERVICES, INC.

发明人： RON COBB ,  MICHAEL SPRINGER ,  YAWEI NI

IPC分类号： A61K39/12 ,  A61K9/00 ,  A61K9/19 ,  A61K9/16

CPC分类号： A61K39/12 ,  A61K9/0095 ,  A61K9/1694 ,  A61K9/19 ,  A61K39/00 ,  A61K39/295 ,  A61K2039/5258 ,  A61K2039/541 ,  A61K2039/55583 ,  A61K2039/70 ,  C12N2770/16023 ,  C12N2770/16034 ,  C12N2770/16071

摘要： A dry powder norovirus vaccine is provided, which comprises at least two norovirus antigens representing different genogroups. The vaccine may be produced by formulation with a mixture of different antigens or combination of monovalent powders with each containing one antigen. The formulated vaccine is suitable for mucosal administration and soluble in aqueous solutions for parenteral administration. A method of immunization is also provided, which comprises at least one administration of the vaccine via mucosal and/or parental route. The immunization may have multiple administrations of the vaccine, i.e., one or more immunizations via a mucosal route followed by one or more immunizations via a parenteral route or vice versa, to maximize both mucosal and systemic immune responses and protection against norovirus infections.