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6 条记录 (耗时 0.012 秒)

    SINGLE VESSEL PRODUCTION OF BUTANOL FROM BIOMASS USING ENGINEERED THERMOPHILIC MICROORGANISMS
    1.
    发明申请
    SINGLE VESSEL PRODUCTION OF BUTANOL FROM BIOMASS USING ENGINEERED THERMOPHILIC MICROORGANISMS 失效
    使用工程化热生物微生物从生物量生产丁醇的单一容器

    公开(公告)号：US20140057327A1

    公开(公告)日：2014-02-27

    申请号：US13592103

    申请日：2012-08-22

    申请人： Omar Bagasra ,  Kamal Chowdhury ,  Verlie A. Tisdale ,  George E. Miller, III ,  Rebecca Bullard-Dillard

    发明人： Omar Bagasra ,  Kamal Chowdhury ,  Verlie A. Tisdale ,  George E. Miller, III ,  Rebecca Bullard-Dillard

    IPC分类号： C12N1/21 ,  C12N15/03 ,  C12P5/02 ,  C12P7/16 ,  C12P7/04 ,  C12P7/08

    CPC分类号： C12R1/145 ,  C12P7/16 ,  C12P2203/00 ,  Y02E50/10 ,  Y02E50/343

    摘要： The present invention relates to the production of biofuels by utilizing efficient biomass digestion and fermentation by a new thermophilic microorganism generated after fusion of two different bacteria Clostridium thermocellum and C. acetobutylicum and properly mutating the fused bacteria to produce biofuels and other economically important chemicals in a single vessel from lignocellulosic derived renewable biomass. All the necessary biochemical digestions and fermentation are carried out by this single thermophilic microorganism in one single vessel eliminating the need for multiple step digestion and fermentation processes, requiring multiple chambers. It also significantly reduces the rate limiting steps where increasing accumulation of alcohol, butanol and other substances become toxic to the very bacteria that produce these biofuels. The single vessel is incubated at high temperatures (45° C. or above) to eliminate the need for periodic stoppage and restarting of the process.

    摘要翻译： 本发明涉及通过利用两种不同细菌热纤维梭菌和丙酮丁醇梭菌融合后产生的新的嗜热微生物利用有效的生物质消化和发酵来生产生物燃料，并适当地突变融合细菌以在其中生产生物燃料和其它经济上重要的化学物质 来自木质纤维素衍生的可再生生物质的单一容器。 所有必要的生物化学消化和发酵都是通过这种单一嗜热微生物在一个单一的容器中进行的，消除了对需要多个室的多步骤消化和发酵过程的需要。 它还显着降低了速率限制步骤，其中增加的酒精，丁醇和其他物质的积累对生产这些生物燃料的细菌变得有毒。 将单个容器在高温（45℃或更高）下孵育，以消除对该过程的周期性停止和重新启动的需要。

    miRNA TRIPLEX FORMATIONS FOR THE DOWNREGULATION OF VIRAL REPLICATION
    2.
    发明申请
    miRNA TRIPLEX FORMATIONS FOR THE DOWNREGULATION OF VIRAL REPLICATION 失效
    用于下调病毒复制的miRNA三聚体形式

    公开(公告)号：US20100048675A1

    公开(公告)日：2010-02-25

    申请号：US12512090

    申请日：2009-07-30

    申请人： Omar Bagasra

    发明人： Omar Bagasra

    IPC分类号： A61K31/7088 ,  C07H21/02 ,  C07H21/04 ,  C12N15/63 ,  C12N5/02

    CPC分类号： A61K31/7088 ,  C12N15/1132 ,  C12N2310/141 ,  C12N2310/531

    摘要： As discovered herein, using miRNAs having high homology with both HIV-1 and a co-infecting virus such as HHV-6, HHV-7, or GVB-C, one can inhibit viral replication, more particularly HIV-1 replication using such mutually homologous miRNAs that give rise to the creation of stable triplex formations effective in the downregulation and/or inhibition of viral replication.

    摘要翻译： 如本文所发现的，使用与HIV-1和共感染病毒如HHV-6，HHV-7或GVB-C具有高同源性的miRNA可以抑制病毒复制，更特别的是使用这种相互作用的HIV-1复制 同源miRNA产生在病毒复制的下调和/或抑制中有效的稳定三链体形成的产生。

    Single vessel production of butanol from biomass using engineered thermophilic microorganisms
    4.
    发明授权
    Single vessel production of butanol from biomass using engineered thermophilic microorganisms 失效
    使用工程化的嗜热微生物从生物质单体生产丁醇

    公开(公告)号：US08669082B1

    公开(公告)日：2014-03-11

    申请号：US13592103

    申请日：2012-08-22

    申请人： Omar Bagasra ,  Kamal Chowdhury ,  Verlie A. Tisdal ,  George E. Miller, III ,  Rebecca Bullard-Dillard

    发明人： Omar Bagasra ,  Kamal Chowdhury ,  Verlie A. Tisdal ,  George E. Miller, III ,  Rebecca Bullard-Dillard

    IPC分类号： C12N1/20 ,  C12P7/16 ,  C12N15/00

    CPC分类号： C12R1/145 ,  C12P7/16 ,  C12P2203/00 ,  Y02E50/10 ,  Y02E50/343

    摘要： The present invention relates to the production of biofuels by utilizing efficient biomass digestion and fermentation by a new thermophilic microorganism generated after fusion of two different bacteria Clostridium thermocellum and C. acetobutylicum and properly mutating the fused bacteria to produce biofuels and other economically important chemicals in a single vessel from lignocellulosic derived renewable biomass. All the necessary biochemical digestions and fermentation are carried out by this single thermophilic microorganism in one single vessel eliminating the need for multiple step digestion and fermentation processes, requiring multiple chambers. It also significantly reduces the rate limiting steps where increasing accumulation of alcohol, butanol and other substances become toxic to the very bacteria that produce these biofuels. The single vessel is incubated at high temperatures (45° C. or above) to eliminate the need for periodic stoppage and restarting of the process.

    摘要翻译： 本发明涉及通过利用两种不同细菌热纤维梭菌和丙酮丁醇梭菌融合后产生的新的嗜热微生物利用有效的生物质消化和发酵来生产生物燃料，并适当地突变融合细菌以在其中生产生物燃料和其它经济上重要的化学物质 来自木质纤维素衍生的可再生生物质的单一容器。 所有必要的生物化学消化和发酵都是通过这种单一嗜热微生物在一个单一的容器中进行的，消除了对需要多个室的多步骤消化和发酵过程的需要。 它还显着降低了速率限制步骤，其中增加的酒精，丁醇和其他物质的积累对生产这些生物燃料的细菌变得有毒。 将单个容器在高温（45℃或更高）下孵育，以消除对该过程的周期性停止和重新启动的需要。

    miRNA triplex formations for the downregulation of viral replication
    5.
    发明授权
    miRNA triplex formations for the downregulation of viral replication 失效
    用于下调病毒复制的miRNA三重结构

    公开(公告)号：US08323891B2

    公开(公告)日：2012-12-04

    申请号：US12512090

    申请日：2009-07-30

    申请人： Omar Bagasra

    发明人： Omar Bagasra

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N5/00 ,  C12N15/11

    CPC分类号： A61K31/7088 ,  C12N15/1132 ,  C12N2310/141 ,  C12N2310/531

    摘要： As discovered herein, using miRNAs having high homology with both HIV-1 and a co-infecting virus such as HHV-6, HHV-7, or GVB-C, one can inhibit viral replication, more particularly HIV-1 replication using such mutually homologous miRNAs that give rise to the creation of stable triplex formations effective in the downregulation and/or inhibition of viral replication.

    摘要翻译： 如本文所发现的，使用与HIV-1和共感染病毒如HHV-6，HHV-7或GVB-C具有高同源性的miRNA可以抑制病毒复制，更特别的是使用这种相互作用的HIV-1复制 同源miRNA产生在病毒复制的下调和/或抑制中有效的稳定三链体形成的产生。