公开(公告)号：US20050255044A1

公开(公告)日：2005-11-17

申请号：US10846062

申请日：2004-05-14

申请人： Stephen Lomnes ,  Egidijus Uzgiris ,  Floribertus Jansen ,  Pavel Fomitchov ,  Omayra De Jesus

发明人： Stephen Lomnes ,  Egidijus Uzgiris ,  Floribertus Jansen ,  Pavel Fomitchov ,  Omayra De Jesus

IPC分类号： A61B10/00 ,  A61B8/00 ,  A61K41/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/00

CPC分类号： A61B5/0059 ,  A61K41/0028 ,  A61K49/0089

摘要： In accordance with embodiments of the present technique, a combined modality imaging system includes a first imaging device of a first modality and a second imaging device of a second modality that is different from the first modality. The first and the second imaging devices are both adapted to interact with a contrast agent adapted to be received in a subject. The contrast agent includes an deformable particle that has a geometry that varies in response to an emission from the first imaging device. The deformable particle also includes a fluorescent component adapted to emit electromagnetic radiation that is detectable by the second imaging device and a quenching component separated from the fluorescent component at a distance based on the geometry and that which is adapted to absorb a portion of the electromagnetic radiation from the fluorescent component.

摘要翻译： 根据本技术的实施例，组合模态成像系统包括第一模态的第一成像装置和与第一模态不同的第二模态的第二成像装置。 第一和第二成像装置都适于与适于被接收在受试者中的造影剂相互作用。 造影剂包括可变形颗粒，其具有响应于来自第一成像装置的发射而变化的几何形状。 可变形颗粒还包括适于发射可被第二成像装置检测的电磁辐射的荧光组件，以及基于该几何形状在一定距离处从荧光组件分离的淬火组分，以及适于吸收电磁辐射的一部分 从荧光成分。

公开(公告)号：US20070238088A1

公开(公告)日：2007-10-11

申请号：US11392133

申请日：2006-03-29

申请人： Slawomir Rubinsztajn ,  David Demoulpied ,  Omayra de Jesus ,  Gregory Goddard ,  James Van Alstine ,  Jan Larsson ,  Mohan Amaratunga ,  Nicolas Thevenin

发明人： Slawomir Rubinsztajn ,  David Demoulpied ,  Omayra de Jesus ,  Gregory Goddard ,  James Van Alstine ,  Jan Larsson ,  Mohan Amaratunga ,  Nicolas Thevenin

IPC分类号： C12N5/08 ,  C12Q1/00 ,  C04B14/04

CPC分类号： C09C1/3081 ,  B01D2221/10 ,  B01J13/003 ,  B01J13/0034 ,  B01J13/0047 ,  B82Y30/00 ,  C01P2004/62 ,  C01P2004/64

摘要： Disclosed are hydrophilic functionalized silica compositions that are stable and do not show significant pH increases upon heat sterilization. Also provided are methods to make hydrophilic functionalized silica compositions by reacting acidic silica particles with hydrophilic organosilanes. Further provided are methods of separating components in a mixture using hydrophilic functionalized silica compositions.

摘要翻译： 公开了稳定的并且在加热灭菌时不显示显着的pH增加的亲水性官能化二氧化硅组合物。 还提供了通过使酸性二氧化硅颗粒与亲水性有机硅烷反应来制备亲水性官能化二氧化硅组合物的方法。 还提供了使用亲水性官能化二氧化硅组合物分离混合物中的组分的方法。