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    Contrast agent for combined modality imaging and methods and systems thereof
    1.
    发明申请
    Contrast agent for combined modality imaging and methods and systems thereof 审中-公开
    组合形态成像的对比剂及其方法和系统

    公开(公告)号：US20050255044A1

    公开(公告)日：2005-11-17

    申请号：US10846062

    申请日：2004-05-14

    申请人： Stephen Lomnes ,  Egidijus Uzgiris ,  Floribertus Jansen ,  Pavel Fomitchov ,  Omayra De Jesus

    发明人： Stephen Lomnes ,  Egidijus Uzgiris ,  Floribertus Jansen ,  Pavel Fomitchov ,  Omayra De Jesus

    IPC分类号： A61B10/00 ,  A61B8/00 ,  A61K41/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/00

    CPC分类号： A61B5/0059 ,  A61K41/0028 ,  A61K49/0089

    摘要： In accordance with embodiments of the present technique, a combined modality imaging system includes a first imaging device of a first modality and a second imaging device of a second modality that is different from the first modality. The first and the second imaging devices are both adapted to interact with a contrast agent adapted to be received in a subject. The contrast agent includes an deformable particle that has a geometry that varies in response to an emission from the first imaging device. The deformable particle also includes a fluorescent component adapted to emit electromagnetic radiation that is detectable by the second imaging device and a quenching component separated from the fluorescent component at a distance based on the geometry and that which is adapted to absorb a portion of the electromagnetic radiation from the fluorescent component.

    摘要翻译： 根据本技术的实施例，组合模态成像系统包括第一模态的第一成像装置和与第一模态不同的第二模态的第二成像装置。 第一和第二成像装置都适于与适于被接收在受试者中的造影剂相互作用。 造影剂包括可变形颗粒，其具有响应于来自第一成像装置的发射而变化的几何形状。 可变形颗粒还包括适于发射可被第二成像装置检测的电磁辐射的荧光组件，以及基于该几何形状在一定距离处从荧光组件分离的淬火组分，以及适于吸收电磁辐射的一部分 从荧光成分。

    Method and system for ultrasonic tagging of fluorescence
    2.
    发明申请
    Method and system for ultrasonic tagging of fluorescence 审中-公开
    超声波标记荧光的方法和系统

    公开(公告)号：US20050107694A1

    公开(公告)日：2005-05-19

    申请号：US10714734

    申请日：2003-11-17

    申请人： Floribertus Jansen ,  Peter Lorraine ,  Stephen Lomnes ,  Pavel Fomitchov

    发明人： Floribertus Jansen ,  Peter Lorraine ,  Stephen Lomnes ,  Pavel Fomitchov

    IPC分类号： A61B5/00 ,  G01N21/17 ,  G01N21/47 ,  A61B6/00 ,  A61B8/00

    CPC分类号： G01N21/6456 ,  A61B5/0051 ,  A61B5/0091 ,  A61B5/4312 ,  A61K49/0017 ,  A61K49/0032 ,  A61K49/0034 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y20/00 ,  G01N21/1717 ,  G01N21/4795 ,  G01N2021/1729 ,  G01N2021/6439

    摘要： A method and system for localization of fluorescence in a scattering medium such as a biological tissue are provided. In comparison to other optical imaging techniques, this disclosure provides for improved spatial resolution, decreased computational time for reconstructions, and allows anatomical and functional imaging simultaneously. The method including the steps of illuminating the scattering medium with an excitation light to excite the fluorescence; modulating a portion of the emitted light from the fluorescence within the scattering medium using an ultrasonically induced variation of material properties of the scattering medium such as the refractive index; detecting the modulated optical signal at a surface of the scattering medium; and reconstructing a spatial distribution of the fluorescence in the scattering medium from the detected signal.

    摘要翻译： 提供了用于在诸如生物组织的散射介质中定位荧光的方法和系统。 与其他光学成像技术相比，本公开提供了改进的空间分辨率，减少重建的计算时间，并且同时允许解剖和功能成像。 该方法包括以激发光照射散射介质以激发荧光的步骤; 使用散射介质的材料性质如折射率的超声波诱导的变化来调制来自散射介质内的荧光的一部分发射光; 检测所述散射介质的表面处的调制光信号; 以及从所检测的信号重构散射介质中的荧光的空间分布。

    System and method for fiber optic bundle-based illumination for imaging system
    5.
    发明申请
    System and method for fiber optic bundle-based illumination for imaging system 有权
    用于成像系统的基于光纤束的照明的系统和方法

    公开(公告)号：US20070154153A1

    公开(公告)日：2007-07-05

    申请号：US11320675

    申请日：2005-12-30

    申请人： Pavel Fomitchov

    发明人： Pavel Fomitchov

    IPC分类号： G02B6/04

    CPC分类号： G02B6/06

    摘要： A system and method for fiber optic bundle-based illumination for an imaging system is disclosed. According to one embodiment of the present invention, the system includes a fiber optic bundle that comprising a plurality of optical fibers. Each optical fiber receives light from a light source. The system also includes a beam forming element that selects a mode of operation for the imaging system. The system further includes a beam deflecting device that deflects the light on a sample. According to one embodiment of the present invention, the method includes the steps of (1) selecting a mode of operation for the imaging system; (2) transmitting light from at least one light source through a fiber optic bundle, the fiber optic bundle comprising a plurality of optical fibers; (3) providing a beam forming element based on the selected mode of operation; and (4) deflecting the focused light on a sample.

    摘要翻译： 公开了一种用于成像系统的基于光纤束的照明的系统和方法。 根据本发明的一个实施例，该系统包括包括多个光纤的光纤束。 每个光纤接收来自光源的光。 该系统还包括选择成像系统的操作模式的波束形成元件。 该系统还包括使光在样品上偏转的光束偏转装置。 根据本发明的一个实施例，该方法包括以下步骤：（1）选择成像系统的操作模式; （2）从至少一个光源透过光纤束，所述光纤束包括多根光纤; （3）基于所选择的操作模式提供波束形成元件; 和（4）将聚焦光偏转到样品上。

    System and method to decrease probe size for improved laser ultrasound detection
    6.
    发明授权
    System and method to decrease probe size for improved laser ultrasound detection 失效
    减少探针尺寸的系统和方法，以改善激光超声检测

    公开(公告)号：US07576848B2

    公开(公告)日：2009-08-18

    申请号：US11018994

    申请日：2004-12-21

    申请人： Marc Dubois ,  Thomas E. Drake, Jr. ,  Pavel Fomitchov

    发明人： Marc Dubois ,  Thomas E. Drake, Jr. ,  Pavel Fomitchov

    IPC分类号： G01N21/00

    CPC分类号： G01N21/474 ,  G01N21/1702 ,  G01N29/2418

    摘要： The present invention provides a compact optical probe assembly that measures ultrasound in materials. The probe uses angle-terminated optical fiber to direct illumination laser light at the surface of a remote target. Ultrasonic displacements at the surface scatter the illumination laser light. Angle-terminated optical fibers collect phase modulated light and direct the phase modulated light to an optical processor to produce a signal representative of the ultrasonic surface displacements. The probe may also incorporate angle-terminated optical fibers to direct generation laser light to the surface of a remote target to generate ultrasonic surface displacements. Optional shared beam forming element(s) may optically act on the illumination laser and collected phase modulated light.

    摘要翻译： 本发明提供一种测量材料中的超声波的紧凑型光学探针组件。 探头使用角度端接的光纤将照明激光引导到远程目标的表面。 表面的超声波位移散射照明激光。 角度端接的光纤收集相位调制的光并将相位调制的光引导到光学处理器以产生代表超声表面位移的信号。 探针还可以包括角度端接的光纤以将生成的激光引导到远程目标的表面以产生超声表面位移。 可选的共享波束形成元件可以光学地作用于照明激光器和收集的相位调制光。

    SYSTEM AND METHOD FOR UTILIZING AN AUTOFOCUS FEATURE IN AN AUTOMATED MICROSCOPE
    7.
    发明申请
    SYSTEM AND METHOD FOR UTILIZING AN AUTOFOCUS FEATURE IN AN AUTOMATED MICROSCOPE 有权
    在自动显微镜中使用自动对焦特征的系统和方法

    公开(公告)号：US20070152130A1

    公开(公告)日：2007-07-05

    申请号：US11320676

    申请日：2005-12-30

    申请人： Pavel Fomitchov

    发明人： Pavel Fomitchov

    IPC分类号： G02B27/40

    CPC分类号： G02B21/245 ,  G02B7/36 ,  G02B21/006 ,  G02B21/244

    摘要： The invention relates to a method for adjusting focus in an automated microscope. The method may comprise the steps of: providing an optical detector for image acquisition, wherein the optical detector comprises an array of sensor pixels; designating a region of interest in the array of sensor pixels to emulate a confocal aperture; directing a light beam to illuminate an object according to a predefined pattern, thereby forming an image of the illuminated pattern at the optical detector, wherein the image of the illuminated pattern substantially overlaps the designated region of interest; detecting a light intensity from sensor pixels located within the designated region of interest; and adjusting a relative focal position of an objective lens based on the detected light intensity.

    摘要翻译： 本发明涉及一种用于在自动显微镜中调节焦点的方法。 该方法可以包括以下步骤：提供用于图像获取的光学检测器，其中所述光学检测器包括传感器像素阵列; 指定传感器像素阵列中的感兴趣区域以模拟共焦孔; 引导光束根据预定图案照射物体，从而在光学检测器处形成照明图案的图像，其中照射图案的图像基本上与指定的感兴趣区域重叠; 从位于所述指定的感兴趣区域内的传感器像素检测光强度; 以及基于检测到的光强度来调整物镜的相对焦点位置。

    Method and apparatus for imaging of tissue using multi-wavelength ultrasonic tagging of light
    9.
    发明申请
    Method and apparatus for imaging of tissue using multi-wavelength ultrasonic tagging of light 失效
    使用光的多波长超声波标签对组织成像的方法和装置

    公开(公告)号：US20050256403A1

    公开(公告)日：2005-11-17

    申请号：US10999752

    申请日：2004-11-30

    申请人： Pavel Fomitchov

    发明人： Pavel Fomitchov

    IPC分类号： A61B5/00 ,  A61B8/00 ,  A61B8/14

    CPC分类号： A61B5/0073 ,  A61B5/0097 ,  A61B8/14 ,  A61B2562/0238

    摘要： An imaging apparatus is disclosed. The imaging apparatus includes a source of electromagnetic radiation that is configured to emit electromagnetic radiation at two or more wavelengths through an imaging volume. The imaging apparatus also includes an ultrasound transducer that is configured to direct ultrasound waves through the imaging volume such that electromagnetic radiation passing through the imaging volume is modulated at the frequency of the ultrasound waves. The imaging apparatus further includes one or more electromagnetic radiation detectors that are configured to detect the modulated electromagnetic radiation from the imaging volume.

    摘要翻译： 公开了一种成像装置。 成像设备包括电磁辐射源，其被配置为通过成像体积发射两个或更多个波长的电磁辐射。 成像设备还包括超声波换能器，其被配置为将超声波引导通过成像体积，使得通过成像体积的电磁辐射以超声波的频率被调制。 成像装置还包括一个或多个电磁辐射检测器，其被配置为检测来自成像体积的经调制的电磁辐射。

    System and method to decrease probe size for improved laser ultrasound detection
    10.
    发明申请
    System and method to decrease probe size for improved laser ultrasound detection 失效

    公开(公告)号：US20060132804A1

    公开(公告)日：2006-06-22

    申请号：US11018994

    申请日：2004-12-21

    申请人： Marc Dubois ,  Thomas Drake ,  Pavel Fomitchov

    发明人： Marc Dubois ,  Thomas Drake ,  Pavel Fomitchov

    IPC分类号： G01B11/14

    CPC分类号： G01N21/474 ,  G01N21/1702 ,  G01N29/2418

    摘要： The present invention provides a compact optical probe assembly that measures ultrasound in materials. The probe uses angle-terminated optical fiber to direct illumination laser light at the surface of a remote target. Ultrasonic displacements at the surface scatter the illumination laser light. Angle-terminated optical fibers collect phase modulated light and direct the phase modulated light to an optical processor to produce a signal representative of the ultrasonic surface displacements. The probe may also incorporate angle-terminated optical fibers to direct generation laser light to the surface of a remote target to generate ultrasonic surface displacements. Optional shared beam forming element(s) may optically act on the illumination laser and collected phase modulated light.