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    FLEA ALLANTOINASE PROTEINS AND USES THEREOF
    1.
    发明申请
    FLEA ALLANTOINASE PROTEINS AND USES THEREOF 审中-公开
    FLEA ALLANTOINASE蛋白及其用途

    公开(公告)号：US20090042230A1

    公开(公告)日：2009-02-12

    申请号：US12051564

    申请日：2008-03-19

    申请人： PATRICK J. GAINES ,  NANCY WISNEWSKI

    发明人： PATRICK J. GAINES ,  NANCY WISNEWSKI

    IPC分类号： C12Q1/37 ,  C12N9/80

    CPC分类号： C07K14/4359 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C12N2799/021

    摘要： The present invention relates to flea allantoinase proteins; to flea allantoinase nucleic acid molecules, including those that encode such flea allantoinase proteins; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit flea allantoinase activity, as well as the use of such therapeutic compositions to treat animals.

    摘要翻译： 本发明涉及跳蚤尿囊素蛋白; 包括那些编码这种跳蚤尿囊素酶蛋白质的尿蛋白酶核酸分子; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这种抑制性化合物的治疗组合物，特别是那些特异性抑制跳蚤尿囊炎活性的化合物，以及使用这些治疗组合物来治疗动物。

    Flea peritrophin nucleic acid molecules, proteins and uses thereof
    2.
    发明授权
    Flea peritrophin nucleic acid molecules, proteins and uses thereof 失效
    跳蚤培养蛋白核酸分子，蛋白质及其用途

    公开(公告)号：US07247447B2

    公开(公告)日：2007-07-24

    申请号：US10401324

    申请日：2003-03-27

    申请人： Patrick J. Gaines ,  Nancy Wisnewski

    发明人： Patrick J. Gaines ,  Nancy Wisnewski

    IPC分类号： C12P21/02 ,  C12N15/00 ,  C12N15/12

    CPC分类号： C07K14/4359 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C12N2799/021

    摘要： The present invention relates to flea peritrophin proteins; to flea peritrophin nucleic acid molecules, including those that encode such flea peritrophin proteins; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain and use such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit flea peritrophin activity, as well as the use of such therapeutic compositions to treat animals.

    摘要翻译： 本发明涉及跳蚤培养蛋白; 跳蚤培养蛋白核酸分子，包括编码这种跳蚤培养蛋白的蛋白质; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。 本发明还包括获得和使用这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这种抑制性化合物，特别是那些特异性抑制跳蚤营养不良蛋白活性的化合物的治疗组合物，以及这些治疗组合物用于治疗动物的用途。

    Flea peritrophin nucleic acid molecules
    4.
    发明授权
    Flea peritrophin nucleic acid molecules 失效
    跳蚤培养蛋白核酸分子

    公开(公告)号：US07662622B2

    公开(公告)日：2010-02-16

    申请号：US11778533

    申请日：2007-07-16

    申请人： Patrick J. Gaines ,  Nancy Wisnewski

    发明人： Patrick J. Gaines ,  Nancy Wisnewski

    IPC分类号： C12N15/00 ,  C12N15/12

    CPC分类号： C07K14/4359 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C12N2799/021

    摘要： The present invention relates to flea peritrophin proteins; to flea peritrophin nucleic acid molecules, including those that encode such flea peritrophin proteins; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain and use such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit flea peritrophin activity, as well as the use of such therapeutic compositions to treat animals.

    摘要翻译： 本发明涉及跳蚤培养蛋白; 跳蚤培养蛋白核酸分子，包括编码这种跳蚤培养蛋白的蛋白质; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。 本发明还包括获得和使用这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这种抑制性化合物，特别是那些特异性抑制跳蚤营养不良蛋白活性的化合物的治疗组合物，以及这些治疗组合物用于治疗动物的用途。

    FLEA HEAD, NERVE CORD, HINDGUT AND MALPIGHIAN TUBULE NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF
    5.
    发明申请
    FLEA HEAD, NERVE CORD, HINDGUT AND MALPIGHIAN TUBULE NUCLEIC ACID MOLECULES, PROTEINS AND USES THEREOF 审中-公开
    FLEA头，神经线，HINDGUT和MALPIGHIAN管核核酸分子，蛋白质及其用途

    公开(公告)号：US20090186008A1

    公开(公告)日：2009-07-23

    申请号：US12034516

    申请日：2008-02-20

    申请人： KEVIN S. BRANDT ,  PATRICK J. GAINES ,  DAN T. STINCHCOMB ,  NANCY WISNEWSKI

    发明人： KEVIN S. BRANDT ,  PATRICK J. GAINES ,  DAN T. STINCHCOMB ,  NANCY WISNEWSKI

    IPC分类号： A61K38/43 ,  C07H21/04 ,  C12N15/52 ,  C12N9/00 ,  C07K16/40 ,  C12Q1/25

    CPC分类号： C07K14/4359 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C12N2799/021

    摘要： The present invention relates to flea head, nerve cord, hindgut and Malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule proteins; to antibodies raised against such flea head, nerve cord, hindgut and Malpighian tubule proteins; and to compounds that inhibit flea head, nerve cord, hindgut and Malpighian tubule protein activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising proteins, nucleic acid molecules, or protective compounds derived from proteins of the present invention as well as the use of such therapeutic compositions to protect animals from flea infestation. Also included in the present invention is the use of flea head, nerve cord, hindgut and Malpighian tubule proteins to derive inhibitory compounds.

    摘要翻译： 本发明涉及跳蚤头，神经根，后肠和马鞭状小管蛋白; 跳蚤头，神经线，后肠和马鞭状小管核酸分子，包括编码这种跳蚤头，神经线，后肠和马鞭状小管蛋白的那些; 针对这种跳蚤头，神经线，后肠和马鞭状小管蛋白质产生的抗体; 以及抑制跳蚤头，神经丝，后肠和马鞭状小管蛋白活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含衍生自本发明蛋白质的蛋白质，核酸分子或保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。 本发明还包括使用跳蚤头，神经根，后肠和马鞭状小管蛋白来衍生抑制性化合物。

    Flea head, nerve cord, hindgut and malpighian tubule proteins
    6.
    发明授权
    Flea head, nerve cord, hindgut and malpighian tubule proteins 失效
    跳蚤头，神经线，后肠和小血管小管蛋白

    公开(公告)号：US07348410B2

    公开(公告)日：2008-03-25

    申请号：US10978245

    申请日：2004-10-29

    申请人： Patrick J. Gaines ,  Nancy Wisnewski

    发明人： Patrick J. Gaines ,  Nancy Wisnewski

    IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  G01N33/53

    CPC分类号： C07K14/4359 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C12N2799/021

    摘要： The present invention relates to flea head, nerve cord, hindgut and Malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule proteins; to antibodies raised against such flea head, nerve cord, hindgut and Malpighian tubule proteins; and to compounds that inhibit flea head, nerve cord, hindgut and Malpighian tubule protein activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising proteins, nucleic acid molecules, or protective compounds derived from proteins of the present invention as well as the use of such therapeutic compositions to protect animals from flea infestation. Also included in the present invention is the use of flea head, nerve cord, hindgut and Malpighian tubule proteins to derive inhibitory compounds.

    摘要翻译： 本发明涉及跳蚤头，神经根，后肠和马鞭状小管蛋白; 跳蚤头，神经线，后肠和马鞭状小管核酸分子，包括编码这种跳蚤头，神经线，后肠和马鞭状小管蛋白的那些; 针对这种跳蚤头，神经线，后肠和马鞭状小管蛋白质产生的抗体; 以及抑制跳蚤头，神经丝，后肠和马鞭状小管蛋白活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含衍生自本发明蛋白质的蛋白质，核酸分子或保护性化合物的治疗组合物，以及这些治疗组合物用于保护动物免于跳蚤侵染的治疗组合物。 本发明还包括使用跳蚤头，神经根，后肠和马鞭状小管蛋白来衍生抑制性化合物。

    Flea protease proteins, nucleic acid molecules, and uses thereof
    7.
    发明授权
    Flea protease proteins, nucleic acid molecules, and uses thereof 失效
    跳蚤蛋白酶蛋白质，核酸分子及其用途

    公开(公告)号：US06204010B1

    公开(公告)日：2001-03-20

    申请号：US09032215

    申请日：1998-02-27

    申请人： Gary L. Stiegler ,  Patrick J. Gaines

    发明人： Gary L. Stiegler ,  Patrick J. Gaines

    IPC分类号： C12N1512

    CPC分类号： C12N9/6408 ,  A61K35/00 ,  A61K39/00 ,  C07K16/40 ,  C12N9/48 ,  C12N9/641 ,  C12N9/6424 ,  C12N9/6472

    摘要： The present invention relates to flea serine protease proteins; to flea serine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.

    摘要翻译： 本发明涉及跳蚤丝氨酸蛋白酶蛋白质; 到跳蚤丝氨酸蛋白酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。

    Flea protease proteins, nucleic acid molecules, and uses thereof
    8.
    发明授权
    Flea protease proteins, nucleic acid molecules, and uses thereof 失效
    跳蚤蛋白酶蛋白质，核酸分子及其用途

    公开(公告)号：US06210920B1

    公开(公告)日：2001-04-03

    申请号：US08749699

    申请日：1996-11-15

    申请人： Shirley Wu Hunter ,  Gary L. Stiegler ,  Patrick J. Gaines

    发明人： Shirley Wu Hunter ,  Gary L. Stiegler ,  Patrick J. Gaines

    IPC分类号： C12P2106

    CPC分类号： C12N9/6408 ,  A61K35/00 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4359 ,  C07K14/4742 ,  C07K16/18 ,  C07K16/40 ,  C07K2319/00 ,  C12N9/48 ,  C12N9/641 ,  C12N9/6424 ,  C12N9/6472 ,  Y10S530/858

    摘要： The present invention relates to flea serine protease proteins and flea cysteine protease proteins; to flea serine protease and cysteine protease nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or cysteine protease activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.

    摘要翻译： 本发明涉及跳蚤丝氨酸蛋白酶蛋白和跳蚤半胱氨酸蛋白酶蛋白; 跳蚤丝氨酸蛋白酶和半胱氨酸蛋白酶核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制跳蚤丝氨酸蛋白酶和/或半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物以及这种治疗组合物用于保护宿主动物免于跳蚤侵染的用途。

    Flea allantoinase proteins and uses thereof
    9.
    发明授权
    Flea allantoinase proteins and uses thereof 失效
    跳蚤尿囊素蛋白及其用途

    公开(公告)号：US06905682B2

    公开(公告)日：2005-06-14

    申请号：US10180165

    申请日：2002-06-25

    申请人： Patrick J. Gaines ,  Nancy Wisnewski

    发明人： Patrick J. Gaines ,  Nancy Wisnewski

    IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/435 ,  A61K38/46 ,  C07H21/04 ,  C12N1/20 ,  C12N9/14 ,  C12N15/00

    CPC分类号： C07K14/4359 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C12N2799/021

    摘要： The present invention relates to flea allantoinase proteins; to flea allantoinase nucleic acid molecules, including those that encode such flea allantoinase proteins; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit flea allantoinase activity, as well as the use of such therapeutic compositions to treat animals.

    摘要翻译： 本发明涉及跳蚤尿囊素蛋白; 包括那些编码这种跳蚤尿囊素酶蛋白质的尿蛋白酶核酸分子; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这种抑制性化合物的治疗组合物，特别是那些特异性抑制跳蚤尿囊炎活性的化合物，以及使用这些治疗组合物来治疗动物。

    Flea allantoinase nucleic acid molecules, proteins and uses thereof
    10.
    发明授权
    Flea allantoinase nucleic acid molecules, proteins and uses thereof 有权
    蚕丝尿蛋白酶核酸分子，蛋白质及其用途

    公开(公告)号：US06469152B2

    公开(公告)日：2002-10-22

    申请号：US09894698

    申请日：2001-06-28

    申请人： Patrick J. Gaines ,  Nancy Wisnewski

    发明人： Patrick J. Gaines ,  Nancy Wisnewski

    IPC分类号： C07H2102

    CPC分类号： C07K14/4359 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C12N2799/021

    摘要： The present invention relates to flea allantoinase proteins; to flea allantoinase nucleic acid molecules, including those that encode such flea allantoinase proteins; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The present invention also includes therapeutic compositions comprising such inhibitory compounds, particularly those that specifically inhibit flea allantoinase activity, as well as the use of such therapeutic compositions to treat animals.

    摘要翻译： 本发明涉及跳蚤尿囊素蛋白; 包括那些编码这种跳蚤尿囊素酶蛋白质的尿蛋白酶核酸分子; 针对这种蛋白质产生的抗体; 以及抑制这些蛋白质活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这种抑制性化合物的治疗组合物，特别是那些特异性抑制跳蚤尿囊炎活性的化合物，以及使用这些治疗组合物来治疗动物。