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公开(公告)号：US07846434B2
公开(公告)日：2010-12-07
申请号：US12082497
申请日：2008-04-11
Applicant: Erik Stephen Espling , Peter Armstrong Thompson , Peter Robert Baum
Inventor： Erik Stephen Espling , Peter Armstrong Thompson , Peter Robert Baum
IPC: A61K39/395
CPC classification number: C07K16/30 , C07K16/00 , C07K16/2887 , C07K16/2896 , C07K2317/41 , C07K2317/622 , C07K2317/72 , C07K2317/732 , C07K2317/734
Abstract: Immunoglycoproteins, including antibodies, with improved ADCC and altered glycosylation patterns are provided. Also provided are cell culturing methods and media for producing such immunoglycoproteins, and therapeutic uses of such immunoglycoproteins.
Abstract translation: 提供了具有改善的ADCC和改变的糖基化模式的免疫糖蛋白，包括抗体。 还提供了用于产生这种免疫糖蛋白的细胞培养方法和培养基，以及这种免疫糖蛋白的治疗用途。
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公开(公告)号：US20130195850A1
公开(公告)日：2013-08-01
申请号：US13678128
申请日：2012-11-15
Applicant: Philip TAN , Sandy Alexander SIMON , Charles G. CERVENY , Christy Anne NILSSON , William BRADY , Jeffrey A. LEDBETTER , Martha Susan HAYDEN-LEDBETTER , Peter Armstrong THOMPSON , Cecile MORALES
Inventor： Philip TAN , Sandy Alexander SIMON , Charles G. CERVENY , Christy Anne NILSSON , William BRADY , Jeffrey A. LEDBETTER , Martha Susan HAYDEN-LEDBETTER , Peter Armstrong THOMPSON , Cecile MORALES
IPC: C07K16/46
CPC classification number: A61K39/39541 , A61K31/4184 , A61K38/16 , A61K39/39558 , A61K2039/505 , C07K16/2896 , C07K16/3061 , C07K16/461 , C07K2317/24 , C07K2317/50
Abstract: The present disclosure provides a humanized anti-CD37 small modular immunopharmaceutical (SMIP) molecule, as well as synergistic combination therapies of CD37-specific binding molecules (such as anti-CD37 SMIP proteins or antibodies) with bifunctional chemotherapeutics (such as bendamustine) that can be administered concurrently or sequentially, for use in treating or preventing B cell related autoimmune, inflammatory, or hyperproliferative diseases.
Abstract translation: 本公开内容提供人源化抗CD37小模块化免疫药物（SMIP）分子，以及CD37-特异性结合分子（例如抗CD37SMIP蛋白或抗体）与双功能化学治疗剂（例如苯达莫司汀）的协同组合疗法，其可以 同时或顺序施用，用于治疗或预防B细胞相关的自身免疫性，炎症性或过度增殖性疾病。
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公开(公告)号：US08409577B2
公开(公告)日：2013-04-02
申请号：US12304562
申请日：2007-06-12
Applicant: Peter Armstrong Thompson , Jeffrey A. Ledbetter , Martha Susan Hayden-Ledbetter , Laura Sue Grosmaire , Robert Bader , William Brady
Inventor： Peter Armstrong Thompson , Jeffrey A. Ledbetter , Martha Susan Hayden-Ledbetter , Laura Sue Grosmaire , Robert Bader , William Brady
CPC classification number: C07K16/28 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/2803 , C07K16/2809 , C07K16/2818 , C07K16/2827 , C07K16/2833 , C07K16/2851 , C07K16/2875 , C07K16/2878 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/46 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/52 , C07K2317/53 , C07K2317/622 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2319/30
Abstract: Multivalent binding peptides, including bi-specific binding peptides, having immunoglobulin effector function are provided, along with encoding nucleic acids, vectors and host cells as well as methods for making such peptides and methods for using such peptides to treat or prevent a variety of diseases, disorders or conditions, as well as to ameliorate at least one symptom associated with such a disease, disorder or condition.
Abstract translation: 提供具有免疫球蛋白效应子功能的多价结合肽，包括双特异性结合肽，以及编码核酸，载体和宿主细胞以及制备这些肽的方法和使用这些肽治疗或预防各种疾病的方法 ，疾病或病症，以及改善与这种疾病，病症或病症相关的至少一种症状。
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公开(公告)号：US20110177070A1
公开(公告)日：2011-07-21
申请号：US13001088
申请日：2009-07-02
Applicant: Alan Keith Lofquist , Peter Robert Baum , Peter Armstrong Thompson , Lynda Misher
Inventor： Alan Keith Lofquist , Peter Robert Baum , Peter Armstrong Thompson , Lynda Misher
CPC classification number: C07K14/715 , C07K14/71 , C07K14/7151 , C07K14/7155 , C07K16/22 , C07K16/24 , C07K2317/55 , C07K2319/30 , C07K2319/32 , C07K2319/74
Abstract: This disclosure provides a multi-target fusion protein composed of a TGF? antagonist domain and another binding domain antagonistic for a heterologous target (such as IL6, IL10, VEGF, TNF, HGF, TWEAK, IGF) or agonistic for a heterologous target (such as GITR). The multi-specific fusion protein may also include an intervening domain that separates the binding domains and allows for dimerization. This disclosure also provides polynucleotides encoding the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.
Abstract translation: 本公开提供了由TGFβ1组成的多靶融合蛋白， 拮抗剂结构域和对异源靶标（如IL6，IL10，VEGF，TNF，HGF，TWEAK，IGF）拮抗的另一结合结构域或对异源靶标（如GITR）的激动作用。 多特异性融合蛋白还可以包括分离结合域并允许二聚化的中间结构域。 本公开还提供了编码多特异融合蛋白的多核苷酸，融合蛋白的组合物，以及使用多特异性融合蛋白和组合物的方法。
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5.发明申请CD37 IMMUNOTHERAPEUTIC AND COMBINATION WITH BIFUNCTIONAL CHEMOTHERAPEUTIC THEREOF 有权CD37免疫组织化学与双功能化学疗法公开(公告)号：US20110171208A1
公开(公告)日：2011-07-14
申请号：US12678857
申请日：2009-04-11
Applicant: Philip Tan , Sandy Alexander Simon , Charles G. Cerveny , Christy Anne Nilsson , William Brady , Jeffrey A. Ledbetter , Martha Susan Hayden-Ledbetter , Peter Armstrong Thompson , Cecile Morales
Inventor： Philip Tan , Sandy Alexander Simon , Charles G. Cerveny , Christy Anne Nilsson , William Brady , Jeffrey A. Ledbetter , Martha Susan Hayden-Ledbetter , Peter Armstrong Thompson , Cecile Morales
IPC: A61K39/395 , C07K16/00 , A61P35/00
CPC classification number: A61K39/39541 , A61K31/4184 , A61K38/16 , A61K39/39558 , A61K2039/505 , C07K16/2896 , C07K16/3061 , C07K16/461 , C07K2317/24 , C07K2317/50
Abstract: The present disclosure provides a humanized anti-CD37 small modular immunopharmaceutical (SMIP) molecule, as well as synergistic combination therapies of CD37-specific binding molecules (such as anti-CD37 SMIP proteins or antibodies) with bifunctional chemotherapeutics (such as bendamustine) that can be administered concurrently or sequentially, for use in treating or preventing B cell related autoimmune, inflammatory, or hyperproliferative diseases.
Abstract translation: 本公开内容提供人源化抗CD37小模块化免疫药物（SMIP）分子，以及CD37-特异性结合分子（例如抗CD37SMIP蛋白或抗体）与双功能化学治疗剂（例如苯达莫司汀）的协同组合疗法，其可以 同时或顺序施用，用于治疗或预防B细胞相关的自身免疫性，炎症性或过度增殖性疾病。
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Patent Agency Ranking
公开(公告)号：US20110152173A1
公开(公告)日：2011-06-23
申请号：US13001087
申请日：2009-07-02
Applicant: Alan Keith Lofquist , Kendall Mark Mohler , Peter Robert Baum , Peter Armstrong Thompson , Lynda Misher
Inventor： Alan Keith Lofquist , Kendall Mark Mohler , Peter Robert Baum , Peter Armstrong Thompson , Lynda Misher
IPC: A61K38/02 , C07K19/00 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/02 , A61P35/00 , A61P19/02 , A61P11/06 , A61P17/06 , A61P25/28 , A61P29/00 , A61P11/00
CPC classification number: C07K14/7151 , C07K14/70575 , C07K14/715 , C07K2319/30 , C07K2319/32
Abstract: This disclosure provides a multi-target fusion protein composed of a TNF-α antagonist domain and another binding domain antagonistic for a heterologous target, such as IL6, RANKL, IL7, IL17A/F, TWEAK, CSF2, IGF1, IGF2 or BLyS/APRIL, or agonistic for a heterologous target, such as IL10. The multi-specific fusion protein may also include an intervening domain that separates the binding domains and allows for dimerization. This disclosure also provides polynucleotides encoding the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.
Abstract translation: 本公开提供了由TNF-α拮抗剂结构域和异源靶标拮抗的多靶融合蛋白，例如IL6，RANKL，IL7，IL17A / F，TWEAK，CSF2，IGF1，IGF2或BLyS / APRIL 或对异源靶标如IL10的激动剂。 多特异性融合蛋白还可以包括分离结合域并允许二聚化的中间结构域。 本公开还提供了编码多特异融合蛋白的多核苷酸，融合蛋白的组合物，以及使用多特异性融合蛋白和组合物的方法。
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公开(公告)号：US20140141022A1
公开(公告)日：2014-05-22
申请号：US13815721
申请日：2013-03-15
Applicant: PETER ARMSTRONG THOMPSON , JEFFREY A. LEDBETTER , MARTHA SUSAN HAYDEN-LEDBETTER , LAURA SUE GROSMAIRE , ROBERT BADER , WILLIAM BRADY
Inventor： PETER ARMSTRONG THOMPSON , JEFFREY A. LEDBETTER , MARTHA SUSAN HAYDEN-LEDBETTER , LAURA SUE GROSMAIRE , ROBERT BADER , WILLIAM BRADY
IPC: C07K16/18
CPC classification number: C07K16/28 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/2803 , C07K16/2809 , C07K16/2818 , C07K16/2827 , C07K16/2833 , C07K16/2851 , C07K16/2875 , C07K16/2878 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/46 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/52 , C07K2317/53 , C07K2317/622 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2319/30
Abstract: Multivalent binding peptides, including bi-specific binding peptides, having immunoglobulin effector function are provided, along with encoding nucleic acids, vectors and host cells as well as methods for making such peptides and methods for using such peptides to treat or prevent a variety of diseases, disorders or conditions, as well as to ameliorate at least one symptom associated with such a disease, disorder or condition.
Abstract translation: 提供具有免疫球蛋白效应子功能的多价结合肽，包括双特异性结合肽，以及编码核酸，载体和宿主细胞以及制备这些肽的方法和使用这些肽治疗或预防各种疾病的方法 ，疾病或病症，以及改善与这种疾病，病症或病症相关的至少一种症状。
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公开(公告)号：US20120034245A9
公开(公告)日：2012-02-09
申请号：US12304562
申请日：2007-06-12
Applicant: Peter Armstrong Thompson , Jeffrey A. Ledbetter , Martha Susan Hayden-Ledbetter , Laura Sue Grosmaire , Robert Bader , William Brady
Inventor： Peter Armstrong Thompson , Jeffrey A. Ledbetter , Martha Susan Hayden-Ledbetter , Laura Sue Grosmaire , Robert Bader , William Brady
IPC: A61K39/395 , C07K16/46 , C07H21/00 , C12N15/63 , C12N5/10 , A61P37/06 , A61P29/00 , A61P3/10 , A61P19/02 , A61P11/06 , A61P25/00 , A61P17/06 , C07K19/00 , A61P35/00
CPC classification number: C07K16/28 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/2803 , C07K16/2809 , C07K16/2818 , C07K16/2827 , C07K16/2833 , C07K16/2851 , C07K16/2875 , C07K16/2878 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/46 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/52 , C07K2317/53 , C07K2317/622 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2319/30
Abstract: Multivalent binding peptides, including bi-specific binding peptides, having immunoglobulin effector function are provided, along with encoding nucleic acids, vectors and host cells as well as methods for making such peptides and methods for using such peptides to treat or prevent a variety of diseases, disorders or conditions, as well as to ameliorate at least one symptom associated with such a disease, disorder or condition.
Abstract translation: 提供具有免疫球蛋白效应子功能的多价结合肽，包括双特异性结合肽，以及编码核酸，载体和宿主细胞以及制备这些肽的方法和使用这些肽治疗或预防各种疾病的方法 ，疾病或病症，以及改善与这种疾病，病症或病症相关的至少一种症状。
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公开(公告)号：US20110217302A1
公开(公告)日：2011-09-08
申请号：US13123509
申请日：2009-10-09
Applicant: Valerie Odegard , Catherine J. McMahan , Peter Robert Baum , Peter Armstrong Thompson , Philip Tan , John W. Blankenship , Sateesh Kumar Natarajan
Inventor： Valerie Odegard , Catherine J. McMahan , Peter Robert Baum , Peter Armstrong Thompson , Philip Tan , John W. Blankenship , Sateesh Kumar Natarajan
IPC: A61K39/395 , C12N15/63 , G01N33/566 , C07K19/00 , C07H21/00 , C07K16/46 , A61P37/06 , A61P11/06 , A61P3/10 , A61P19/02
CPC classification number: C07K16/2809 , A61K39/3955 , A61K2039/505 , C07K16/46 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/524 , C07K2317/622 , C07K2317/76 , C07K2319/00
Abstract: Single chain fusion proteins that specifically bind to a TCR complex or a component thereof, such as TCRα, TCRβ, or CD3ε, along with compositions and methods of use thereof are provided.
Abstract translation: 提供了特异性结合TCR复合物或其组分的单链融合蛋白，例如TCRα，TCR＆bgr，或CD3和egr，以及组合物及其使用方法。
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公开(公告)号：US20110158995A1
公开(公告)日：2011-06-30
申请号：US13056141
申请日：2009-07-28
Applicant: Philip Tan , Laura Sue Grosmaire , Peter Robert Baum , Peter Armstrong Thompson
Inventor： Philip Tan , Laura Sue Grosmaire , Peter Robert Baum , Peter Armstrong Thompson
IPC: A61K39/395 , C12P21/04 , C12N5/10 , C12N15/63 , C07K16/00 , C07H21/04 , A61P19/02 , A61P29/00 , A61P37/00
CPC classification number: C07K14/7056 , A61K2039/505 , C07K16/2803 , C07K16/2851 , C07K16/2896 , C07K2317/31 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2319/30 , C07K2319/32 , C07K2319/74
Abstract: This disclosure provides a multi-specific fusion protein composed of a CD72-ligand binding domain and another binding domain specific for a heterologous target, such as a B-cell specific protein. The multi-specific fusion protein may also include an intervening domain that separates the other domains. This disclosure also provides polynucleotides encoding the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.
Abstract translation: 本公开提供由CD72-配体结合结构域和异源靶特异性的另一结合结构域（例如B细胞特异性蛋白质）组成的多特异性融合蛋白。 多特异性融合蛋白还可以包括分隔其他结构域的中间结构域。 本公开还提供了编码多特异融合蛋白的多核苷酸，融合蛋白的组合物，以及使用多特异性融合蛋白和组合物的方法。
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