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50 条记录 (耗时 0.049 秒)

    Dispensing device
    1.
    发明授权
    Dispensing device 有权

    公开(公告)号：US11116917B2

    公开(公告)日：2021-09-14

    申请号：US16183364

    申请日：2018-11-07

    申请人： PFIZER LIMITED

    发明人： Peter J. Houzego ,  John Kelshaw Conway ,  Martin Douglas Pearl ,  Andrew Mark Bryant

    IPC分类号： A61M15/00 ,  G06M1/24 ,  B65D83/06 ,  B65D83/04

    摘要： A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.

    (4-phenylimidazol-2-yl) ethylamine derivatives useful as sodium channel modulators
    5.
    发明授权
    (4-phenylimidazol-2-yl) ethylamine derivatives useful as sodium channel modulators 有权
    （4-苯基咪唑-2-基）乙胺衍生物，其用作钠通道调节剂

    公开(公告)号：US09079878B2

    公开(公告)日：2015-07-14

    申请号：US14351893

    申请日：2012-10-15

    申请人： Pfizer Limited

    发明人： Sharanjeet Kaur Bagal ,  Mark Ian Kemp ,  Duncan Charles Miller ,  Yoshihisa Murata

    IPC分类号： A61K31/4178 ,  C07D405/06

    CPC分类号： C07D405/06 ,  A61K31/4178

    摘要： The present invention is directed to imidazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new imidazole NaV1.8 modulators of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description. NaV1.8 modulators are useful in the treatment of a wide range of disorders, particularly pain.

    摘要翻译： 本发明涉及咪唑衍生物，其在医药中的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。 更具体地，本发明涉及式（I）的新的咪唑NaV1.8调节剂：或其药学上可接受的盐，其中R 1，R 2，R 3，R 4和R 5如说明书中所定义。 NaV1.8调节剂可用于治疗各种疾病，特别是疼痛。

    Chemical Compounds
    7.
    发明申请
    Chemical Compounds 审中-公开

    公开(公告)号：US20150105396A1

    公开(公告)日：2015-04-16

    申请号：US14576796

    申请日：2014-12-19

    申请人： Pfizer Limited

    发明人： Kiyoyuki Omoto ,  Robert McKenzie Owen ,  David Cameron Pryde ,  Christine Ann Louise Watson ,  Mifune Takeuchi

    IPC分类号： C07D487/04 ,  A61K31/5025

    摘要： The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.

    Chemical compounds
    8.
    发明授权
    Chemical compounds 有权
    化合物

    公开(公告)号：US08952008B2

    公开(公告)日：2015-02-10

    申请号：US14103960

    申请日：2013-12-12

    申请人： Pfizer Limited

    发明人： Kiyoyuki Omoto ,  Robert McKenzie Owen ,  David Cameron Pryde ,  Christine Ann Louise Watson ,  Mifune Takeuchi

    IPC分类号： A01N43/58 ,  A61K31/495 ,  C07D487/00

    CPC分类号： C07D487/04 ,  A61K31/5025 ,  A61K45/06

    摘要： The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.

    摘要翻译： 本发明涉及咪唑并哒嗪衍生物。 更具体地说，本发明涉及式（I）的4-（联苯-3-基）-7H-咪唑并[4,5-c]哒嗪衍生物及其药学上可接受的盐，其中R1，R2，R3，R4和R5 如说明书中所定义。 本发明的咪唑并哒嗪衍生物调节GABA A受体的活性。 它们可用于治疗许多病症，包括疼痛。