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6 条记录 (耗时 0.014 秒)

    Process for the preparation of accelerated release formulations using compressed fluids
    1.
    发明授权
    Process for the preparation of accelerated release formulations using compressed fluids 有权
    使用压缩流体制备加速释放制剂的方法

    公开(公告)号：US06913779B2

    公开(公告)日：2005-07-05

    申请号：US10221704

    申请日：2001-03-07

    申请人： Italo Colombo ,  Paolo Pallado

    发明人： Italo Colombo ,  Paolo Pallado

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K31/18 ,  A61K31/343 ,  A61K31/522 ,  A61K31/5415 ,  A61K31/55 ,  A61K31/57 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/40 ,  B05D3/00

    CPC分类号： A61K9/146 ,  A61K9/1635 ,  A61K9/1694

    摘要： The following description refers to a process for the impregnation of cross-linked polymers with an active ingredient. The process is based on the used of compressed fluids, in particular CO2, with antisolvent effect, and involves the steps of impregnating the polymer with an active ingredient solution, adding a compressed fluid until precipitation of the active ingredient caused by the compressed fluid antisolvent effect, removing the solvent and the compressed fluid. The process allows to obtain accelerated release pharmaceutical formulations that, compared with the formulations already known, contain larger quantities of amorphous or nanocrystalline active ingredient.

    摘要翻译： 以下描述涉及用活性成分浸渍交联聚合物的方法。 该方法基于使用具有抗溶剂作用的压缩流体，特别是CO 2 2，并且包括用活性成分溶液浸渍聚合物的步骤，加入压缩流体直至活性物质沉淀 成分由压缩液引起反作用，除去溶剂和压缩液。 该方法允许获得加速释放药物制剂，其与已知的制剂相比含有较大量的无定形或纳米晶体活性成分。

    Nanosheres comprising a biocompatible polysaccharide
    3.
    发明授权
    Nanosheres comprising a biocompatible polysaccharide 失效
    包含生物相容性多糖的纳米球

    公开(公告)号：US06214384B1

    公开(公告)日：2001-04-10

    申请号：US08938288

    申请日：1997-09-26

    申请人： Paolo Pallado ,  Luca Benedetti ,  Lanfranco Callegaro

    发明人： Paolo Pallado ,  Luca Benedetti ,  Lanfranco Callegaro

    IPC分类号： A61K919

    CPC分类号： A61K9/5161

    摘要： Microspheres, having a size lower than 1&mgr; and comprising a biocompatible polysaccharidic polymer, are prepared with a process comprising the precipitation of polymer induced by means of a supercritical antisolvent (SAS). These microspheres are used as vehicling agents or carriers in the preparation of pharmaceutical compositions administrable by oral, nasal, pulmonary, vaginal or rectal route. These microspheres can also be advantageously used as vehicling agent or carriers in the preparation of pharmaceutical compositions for the treatment of human diseases associated with genic defects, for the preparation of diagnostics and in the agro-alimentary industry.

    摘要翻译： 使用包含通过超临界反溶剂（SAS）诱导的聚合物沉淀的方法制备具有小于1mu并且包含生物相容性多糖聚合物的微球。 这些微球用作制剂中可以通过口服，鼻，肺，阴道或直肠途径给药的药物组合物的载体或载体。 这些微球体还可以有利地用作制备用于治疗与基因缺陷相关的人类疾病，用于制备诊断学和在农业食品工业中的药物组合物的载体剂或载体。

    Method and apparatus for removing substances from solid matrix with energy saving
    4.
    发明申请
    Method and apparatus for removing substances from solid matrix with energy saving 审中-公开
    节能除去固体基体物质的方法和装置

    公开(公告)号：US20050257809A1

    公开(公告)日：2005-11-24

    申请号：US10523915

    申请日：2002-08-06

    申请人： Fortunato Fedegari ,  Andrea Scullino ,  Paolo Pallado

    发明人： Fortunato Fedegari ,  Andrea Scullino ,  Paolo Pallado

    IPC分类号： B01D11/02 ,  B08B7/00 ,  B09B3/00 ,  B08B7/04 ,  B08B3/04

    CPC分类号： B09B3/0058 ,  B01D11/0203 ,  B01D11/0296 ,  B08B7/0021

    摘要： A method and apparatus for washing solid matrices such as swarf from machining operations, bottles or other containers, contaminated with lubricating oils or similar substances, are described. The method is implemented with liquid CO2 which dissolves the organic substances and is then separated therefrom by evaporation; the evaporated CO2 is then compressed and condensed in order to recommence the cycle. An advantage of the method and apparatus is that some of the heat supplied to the CO2 for its evaporation and some of that removed for its condensation are obtained by providing for an exchange of heat between the evaporator and the condenser of the system.

    摘要翻译： 描述了用于从加工操作，瓶子或其他容器中洗涤固体基质如切屑的方法和装置，被润滑油或类似物质污染。 该方法用溶解有机物质的液体CO 2实现，然后通过蒸发与其分离; 然后将蒸发的CO 2 2压缩并冷凝以重新开始循环。 该方法和装置的优点在于，通过在蒸发器和蒸发器之间提供热量来获得供应到CO 2的蒸发器的一些热量，以及用于其蒸发而被去除的一些热量 冷凝器系统。

    Nanosheres comprising a biocompatible polysaccharide
    6.
    发明授权
    Nanosheres comprising a biocompatible polysaccharide 失效
    包含生物相容性多糖的纳米球

    公开(公告)号：US06541035B1

    公开(公告)日：2003-04-01

    申请号：US09558801

    申请日：2000-04-26

    申请人： Paolo Pallado ,  Luca Benedetti ,  Lanfranco Callegaro

    发明人： Paolo Pallado ,  Luca Benedetti ,  Lanfranco Callegaro

    IPC分类号： A61K916

    CPC分类号： A61K9/5161

    摘要： Microspheres, having a size lower than 1&mgr; and comprising a biocompatible polysaccharidic polymer, are prepared with a process comprising the precipitation of polymer induced by means of a supercritical antisolvent (SAS). These microspheres are used as vehicling agents or carriers in the preparation of pharmaceutical compositions administrable by oral, nasal, pulmonary, vaginal or rectal route. These microspheres can also be advantageously used as vehicling agent or carriers in the preparation of pharmaceutical compositions for the treatment of human diseases associated with genic defects, for the preparation of diagnostics and in the agro-alimentary industry.

    摘要翻译： 使用包含通过超临界反溶剂（SAS）诱导的聚合物沉淀的方法制备具有小于1mu并且包含生物相容性多糖聚合物的微球。 这些微球用作制剂中可以通过口服，鼻，肺，阴道或直肠途径给药的药物组合物的载体或载体。 这些微球体还可以有利地用作制备用于治疗与基因缺陷相关的人类疾病，用于制备诊断学和在农业食品工业中的药物组合物的载体剂或载体。