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    Assay method
    2.
    发明授权
    Assay method 失效
    测定方法

    公开(公告)号：US07045280B2

    公开(公告)日：2006-05-16

    申请号：US10130368

    申请日：2000-12-05

    申请人： Paul Elvin ,  Philip Edwin Pinder

    发明人： Paul Elvin ,  Philip Edwin Pinder

    IPC分类号： C12Q1/00 ,  C12N9/72 ,  C07K14/00

    CPC分类号： C12Q1/37

    摘要： The present invention provides a method for the measurement of the activity of a plasminogen activator, such as urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) in a biological sample using an assay method characterized by the inclusion of an elastase inhibitor in the assay mixture. The invention also provides a diagnostic kit for the measurement of a plasminogen activator using said method and a method of determining the effective therapeutic dose of a plasminogen activator inhibitor using said method. Also provided is a method of preparing a pharmaceutical composition.

    摘要翻译： 本发明提供了一种使用测定方法测量生物样品中的纤溶酶原激活剂如尿激酶纤溶酶原激活物（uPA）或组织纤溶酶原激活物（tPA）的活性的方法，其特征在于将弹性蛋白酶抑制剂包含在 测定混合物。 本发明还提供了使用所述方法测量纤溶酶原激活物的诊断试剂盒，以及使用所述方法测定纤溶酶原激活物抑制剂的有效治疗剂量的方法。 还提供了制备药物组合物的方法。

    TARGETED BINDING AGENTS DIRECTED TO uPAR AND USES THEREOF
    3.
    发明申请
    TARGETED BINDING AGENTS DIRECTED TO uPAR AND USES THEREOF 失效
    指定的绑定代理人及其用途

    公开(公告)号：US20080152587A1

    公开(公告)日：2008-06-26

    申请号：US11733157

    申请日：2007-04-09

    申请人： Qing Zhou ,  Stephen Charles Emery ,  Paul Elvin

    发明人： Qing Zhou ,  Stephen Charles Emery ,  Paul Elvin

    IPC分类号： A61K51/00 ,  C07K16/00 ,  C07H21/02 ,  C12N15/66 ,  A61P35/00 ,  A61K39/00

    CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

    摘要： Targeted binding agents directed to the antigen uPAR and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen uPAR. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

    摘要翻译： 描述了针对抗原uPAR的靶向结合剂和这些抗体的用途。 特别是针对抗原uPAR的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

    TARGETED BINDING AGENTS DIRECTED TO UPAR AND USES THEREOF
    4.
    发明申请
    TARGETED BINDING AGENTS DIRECTED TO UPAR AND USES THEREOF 审中-公开
    指定的绑定代理指令及其使用

    公开(公告)号：US20120108797A1

    公开(公告)日：2012-05-03

    申请号：US13193167

    申请日：2011-07-28

    申请人： Paul Elvin ,  Stephen Charles Emery ,  Qing Zhou

    发明人： Paul Elvin ,  Stephen Charles Emery ,  Qing Zhou

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

    摘要： Targeted binding agents directed to the antigen uPAR and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen uPAR. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementary determine regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

    摘要翻译： 描述了针对抗原uPAR的靶向结合剂和这些抗体的用途。 特别是针对抗原uPAR的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

    Targeted binding agents directed to uPAR and uses thereof
    5.
    发明授权
    Targeted binding agents directed to uPAR and uses thereof 失效
    针对uPAR的靶向结合剂及其用途

    公开(公告)号：US08026344B2

    公开(公告)日：2011-09-27

    申请号：US11733157

    申请日：2007-04-09

    申请人： Qing Zhou ,  Stephen Charles Emery ,  Paul Elvin

    发明人： Qing Zhou ,  Stephen Charles Emery ,  Paul Elvin

    IPC分类号： C07K16/00 ,  C07K16/46 ,  C07K16/24 ,  A61K39/395

    CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

    摘要： Targeted binding agents directed to the antigen uPAR and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen uPAR. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

    摘要翻译： 描述了针对抗原uPAR的靶向结合剂和这些抗体的用途。 特别是针对抗原uPAR的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

    TARGETED BINDING AGENTS DIRECTED TO UPAR AND USES THEREOF
    7.
    发明申请
    TARGETED BINDING AGENTS DIRECTED TO UPAR AND USES THEREOF 审中-公开
    指定的绑定代理指令及其使用

    公开(公告)号：US20090123476A1

    公开(公告)日：2009-05-14

    申请号：US12296593

    申请日：2007-04-09

    申请人： Paul Elvin ,  Stephen Charles Emery ,  Qing Zhou

    发明人： Paul Elvin ,  Stephen Charles Emery ,  Qing Zhou

    IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K14/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12P21/04

    CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

    摘要： Targeted binding agents directed to the antigen uPAR and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen uPAR. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

    摘要翻译： 描述了针对抗原uPAR的靶向结合剂和这些抗体的用途。 特别是针对抗原uPAR的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

    Concrete wall form with flexible tie system
    8.
    发明申请
    Concrete wall form with flexible tie system 审中-公开
    混凝土墙体采用柔性扎带系统

    公开(公告)号：US20050218291A1

    公开(公告)日：2005-10-06

    申请号：US11127460

    申请日：2005-05-12

    申请人： Randy Musk ,  Edward Rahe ,  Paul Elvin

    发明人： Randy Musk ,  Edward Rahe ,  Paul Elvin

    IPC分类号： E04G17/04 ,  E04G17/06

    CPC分类号： E04G17/047 ,  E04G17/06 ,  E04G2017/0646

    摘要： A concrete wall form that can readily be used with different types of form ties systems to construct parallel form sections for receiving poured concrete. The form includes first and second tie rod engaging portions configured to receive first and second types of tie rods, respectively. In one aspect of the invention, the first tie rod engaging portion is configured to receive frangible tie rods in the form of elongate wires or flat strips. In another aspect of the invention, the second tie rod engaging portion is configured to receive tie rods having threaded bars that extend through tubes and between parallel wall form sections.

    摘要翻译： 一种混凝土墙体，可以容易地与不同类型的连接系统一起使用，以构建用于接收浇筑混凝土的平行形式段。 该形式包括分别接收第一和第二类型的拉杆的第一和第二拉杆接合部分。 在本发明的一个方面，第一拉杆接合部分构造成容纳呈细长线或扁平条形式的易碎拉杆。 在本发明的另一方面，第二拉杆接合部分构造成容纳具有延伸穿过管并且在平行壁形成部分之间的螺纹杆的拉杆。