公开(公告)号：US20100233154A1

公开(公告)日：2010-09-16

申请号：US12575267

申请日：2009-10-07

申请人： Paul Elvin ,  Chadwick King ,  Palaniswami Rathanaswami

发明人： Paul Elvin ,  Chadwick King ,  Palaniswami Rathanaswami

IPC分类号： A61K39/395 ,  C07K16/40 ,  C07K16/00 ,  C07H21/04 ,  A61P35/00 ,  A61P9/10 ,  A61P19/02 ,  C12N15/63 ,  C12N5/07

CPC分类号： C12N9/99 ,  C07K16/40 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： The invention relates to targeted binding agents that specifically bind to heparanase and inhibit the biological activity of heparanase and uses of such agents. More specifically the invention relates to fully human monoclonal antibodies directed to that specifically bind to heparanase and uses of these antibodies. Aspects of the invention also relate to hybridomas or other cell lines expressing such antibodies. The disclosed targeted binding agents and antibodies are useful as diagnostics and for the treatment of diseases associated with the activity and/or overexpression of heparanase.

摘要翻译： 本发明涉及特异性结合肝素酶并抑制乙酰肝素酶的生物学活性的靶向结合剂及其用途。 更具体地，本发明涉及针对特异性结合肝素酶的完全人单克隆抗体以及这些抗体的用途。 本发明的方面还涉及表达这种抗体的杂交瘤或其它细胞系。 所公开的靶向结合剂和抗体可用作诊断和治疗与肝素酶的活性和/或过表达相关的疾病。

公开(公告)号：US20050053608A1

公开(公告)日：2005-03-10

申请号：US10877773

申请日：2004-06-25

申请人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal Kang ,  Chadwick King ,  Scott Klakamp ,  Qiaojuan Su

发明人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal Kang ,  Chadwick King ,  Scott Klakamp ,  Qiaojuan Su

IPC分类号： A61K39/395 ,  A61K47/48 ,  C07K16/22 ,  C07K16/28 ,  C07K17/00 ,  C12N20060101 ,  C12N5/06 ,  G01N33/53

CPC分类号： C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6897 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2317/92 ,  Y10S435/81

摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

公开(公告)号：US20050059087A1

公开(公告)日：2005-03-17

申请号：US10877774

申请日：2004-06-25

申请人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal Kang ,  Chadwick King ,  Scott Klakamp ,  Qiaojuan Su

发明人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal Kang ,  Chadwick King ,  Scott Klakamp ,  Qiaojuan Su

IPC分类号： A61K39/395 ,  A61K47/48 ,  C07K16/22 ,  C07K16/28 ,  C07K17/00 ,  C12N20060101 ,  C12N5/06 ,  G01N33/53

CPC分类号： C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6897 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2317/92 ,  Y10S435/81

摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

摘要翻译： 本发明涉及新型抗体，特别是针对表皮生长因子受体的缺失突变体的抗体，特别涉及III型缺失突变体EGFRvIII的抗体。 本发明还涉及针对表皮生长因子受体，特别是EGFRvIII的缺失突变体的人单克隆抗体。 还提供了这种抗体的诊断和治疗制剂及其免疫偶联物。

公开(公告)号：US20060171884A1

公开(公告)日：2006-08-03

申请号：US11303608

申请日：2005-12-16

申请人： Ian Foltz ,  Chadwick King ,  Peter Ling ,  Jaspal Kang ,  Kathy Manchulenko ,  Francine Chen ,  Caroline Scatena ,  Bruce Keyt ,  Edwin Madison ,  Wayne Godfrey ,  Stanislaw Morkowski ,  Jennifer Richardson

发明人： Ian Foltz ,  Chadwick King ,  Peter Ling ,  Jaspal Kang ,  Kathy Manchulenko ,  Francine Chen ,  Caroline Scatena ,  Bruce Keyt ,  Edwin Madison ,  Wayne Godfrey ,  Stanislaw Morkowski ,  Jennifer Richardson

IPC分类号： A61K51/00 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C12N5/06

CPC分类号： C07K16/40 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57492 ,  G01N2500/04

摘要： Binding proteins, such as fully human monoclonal antibodies and fragments thereof, directed to the antigen Matriptase and uses of such binding proteins are disclosed. Nucleotide sequences encoding, and amino acid sequences comprising heavy and light chain immunoglobulin molecules capable of binding to Matriptase are also disclosed. The invention also discloses cell lines expressing such immunoglobulin molecules and monoclonal antibodies to Matriptase. The antibodies can be used to detect, prevent, and treat diseases such as cancer.

公开(公告)号：US07572444B2

公开(公告)日：2009-08-11

申请号：US11303608

申请日：2005-12-16

申请人： Ian Foltz ,  Chadwick King ,  Peter Koon Bong Ling ,  Jaspal Singh Kang ,  Kathy Manchulenko ,  Francine Chen ,  Caroline Darne Scatena ,  Bruce A. Keyt ,  Edwin Madison ,  Wayne R. Godfrey ,  Stanislaw K. Morkowski ,  Jennifer H. Richardson

发明人： Ian Foltz ,  Chadwick King ,  Peter Koon Bong Ling ,  Jaspal Singh Kang ,  Kathy Manchulenko ,  Francine Chen ,  Caroline Darne Scatena ,  Bruce A. Keyt ,  Edwin Madison ,  Wayne R. Godfrey ,  Stanislaw K. Morkowski ,  Jennifer H. Richardson

IPC分类号： A61K39/395 ,  A61K51/00 ,  C07H21/04 ,  C12N5/06 ,  C12P21/06

CPC分类号： C07K16/40 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57492 ,  G01N2500/04

摘要： Binding proteins, such as fully human monoclonal antibodies and fragments thereof, directed to the antigen Matriptase and uses of such binding proteins are disclosed. Nucleotide sequences encoding, and amino acid sequences comprising heavy and light chain immunoglobulin molecules capable of binding to Matriptase are also disclosed. The invention also discloses cell lines expressing such immunoglobulin molecules and monoclonal antibodies to Matriptase. The antibodies can be used to detect, prevent, and treat diseases such as cancer.

摘要翻译： 公开了涉及抗原Matriptase的结合蛋白，例如完全人单克隆抗体及其片段，以及这些结合蛋白的用途。 还公开了编码和包含能够结合Matriptase的重链和轻链免疫球蛋白分子的氨基酸序列的核苷酸序列。 本发明还公开了表达这种免疫球蛋白分子的细胞系和对Matriptase的单克隆抗体。 抗体可用于检测，预防和治疗诸如癌症的疾病。

公开(公告)号：US20060062783A1

公开(公告)日：2006-03-23

申请号：US10956008

申请日：2004-09-30

申请人： Lorin Roskos ,  Ian Foltz ,  Chadwick King ,  Gregory Bell

发明人： Lorin Roskos ,  Ian Foltz ,  Chadwick King ,  Gregory Bell

IPC分类号： A61K39/395

CPC分类号： C07K16/26 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： Embodiments of the invention described herein relate to antibodies directed to the antigen parathyroid hormone (PTH) and uses of such antibodies. In particular, in some embodiments, there are provided fully human monoclonal antibodies directed to the antigen PTH. In further embodiments, nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided.

摘要翻译： 本文描述的本发明的实施方案涉及针对抗原甲状旁腺激素（PTH）的抗体和这种抗体的用途。 特别地，在一些实施方案中，提供针对抗原PTH的完全人单克隆抗体。 在另外的实施方案中，编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于横跨框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。

公开(公告)号：US07288253B2

公开(公告)日：2007-10-30

申请号：US10638265

申请日：2003-08-08

申请人： Lorin Roskos ,  Ian Foltz ,  Chadwick King

发明人： Lorin Roskos ,  Ian Foltz ,  Chadwick King

IPC分类号： A61K39/395 ,  A61K39/00 ,  A01N37/18

CPC分类号： C07K16/26 ,  A01K2217/075 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

摘要： Embodiments of the invention described herein relate to antibodies directed to the antigen parathyroid hormone (PTH) and uses of such antibodies. In particular, in some embodiments, there are provided fully human monoclonal antibodies directed to the antigen PTH. In further embodiments, nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided.

摘要翻译： 本文描述的本发明的实施方案涉及针对抗原甲状旁腺激素（PTH）的抗体和这种抗体的用途。 特别地，在一些实施方案中，提供针对抗原PTH的完全人单克隆抗体。 在另外的实施方案中，编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于横跨框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。

公开(公告)号：US07318925B2

公开(公告)日：2008-01-15

申请号：US10956008

申请日：2004-09-30

申请人： Lorin Roskos ,  Ian Foltz ,  Chadwick King ,  Gregory Bell

发明人： Lorin Roskos ,  Ian Foltz ,  Chadwick King ,  Gregory Bell

IPC分类号： C07K16/18 ,  C07K16/26

CPC分类号： C07K16/26 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： Embodiments of the invention described herein relate to antibodies directed to the antigen parathyroid hormone (PTH) and uses of such antibodies. In particular, in some embodiments, there are provided fully human monoclonal antibodies directed to the antigen PTH. In further embodiments, nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided.

摘要翻译： 本文描述的本发明的实施方案涉及针对抗原甲状旁腺激素（PTH）的抗体和这种抗体的用途。 特别地，在一些实施方案中，提供针对抗原PTH的完全人单克隆抗体。 在另外的实施方案中，编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于横跨框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。

公开(公告)号：US20050031614A1

公开(公告)日：2005-02-10

申请号：US10638265

申请日：2003-08-08

申请人： Lorin Roskos ,  Ian Foltz ,  Chadwick King

发明人： Lorin Roskos ,  Ian Foltz ,  Chadwick King

IPC分类号： C07K16/26 ,  A61K39/395

CPC分类号： C07K16/26 ,  A01K2217/075 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

摘要： Embodiments of the invention described herein relate to antibodies directed to the antigen parathyroid hormone (PTH) and uses of such antibodies. In particular, in some embodiments, there are provided fully human monoclonal antibodies directed to the antigen PTH. In further embodiments, nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided.

摘要翻译： 本文描述的本发明的实施方案涉及针对抗原甲状旁腺激素（PTH）的抗体和这种抗体的用途。 特别地，在一些实施方案中，提供针对抗原PTH的完全人单克隆抗体。 在另外的实施方案中，编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。