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    Methods and compositions for monitoring and risk prediction in cardiorenal syndrome
    1.
    发明授权
    Methods and compositions for monitoring and risk prediction in cardiorenal syndrome 有权
    心脏综合征监测和风险预测的方法和组成

    公开(公告)号：US07985560B2

    公开(公告)日：2011-07-26

    申请号：US12909654

    申请日：2010-10-21

    申请人： Gunars Valkirs ,  Paul H. McPherson

    发明人： Gunars Valkirs ,  Paul H. McPherson

    IPC分类号： G01N1/00 ,  G01N33/53

    CPC分类号： G01N33/6893 ,  G01N33/74 ,  G01N2333/58 ,  G01N2800/347

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to monitor cardiorenal syndrome using assays that detect NGAL, preferably together with assays that detect natriuretic peptides such as BNP. Such methods and compositions can provide early indications of a deterioration in cardiorenal syndrome status, including prognosis regarding mortality and worsening renal function.

    摘要翻译： 本发明涉及用于受试者的治疗方案的监测，诊断，预后和测定的方法和组合物。 特别地，本发明涉及选择用于使用检测NGAL的测定法监测心肾综合征的方法和组合物，优选与检测利尿钠肽如BNP的测定法一起使用。 这些方法和组合物可以提供心脏综合征状态恶化的早期迹象，包括关于死亡率和恶化的肾功能的预后。

    Methods and Compositions for Diagnosis and Prognosis of Renal Artery Stenosis
    2.
    发明申请
    Methods and Compositions for Diagnosis and Prognosis of Renal Artery Stenosis 有权
    肾动脉狭窄的诊断和预后的方法和组成

    公开(公告)号：US20100086944A1

    公开(公告)日：2010-04-08

    申请号：US12513499

    申请日：2007-11-14

    申请人： Gunars Valkirs ,  Paul H. McPherson

    发明人： Gunars Valkirs ,  Paul H. McPherson

    IPC分类号： G01N33/573 ,  C12Q1/34

    CPC分类号： G01N33/6893 ,  G01N2800/323 ,  G01N2800/347

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects in the context of renal artery stenosis (RAS). In particular, the invention relates to using assays that detect NGAL, their use to diagnose RAS in subjects suffering from hypertension, and their use in prognosis, particularly of mortality and worsening renal function.

    摘要翻译： 本发明涉及用于在肾动脉狭窄（RAS）背景下的受试者的治疗方案的监测，诊断，预后和测定的方法和组合物。 特别地，本发明涉及使用检测NGAL的测定法，它们在患有高血压的受试者中诊断RAS的用途，以及它们在预后中的用途，特别是在死亡率和恶化的肾功能方面的用途。

    Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
    3.
    发明授权
    Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays 失效
    测定肌钙蛋白I和T的方法以及肌钙蛋白I和T的复合物以及免疫测定中使用的抗体选择

    公开(公告)号：US07604946B2

    公开(公告)日：2009-10-20

    申请号：US10850954

    申请日：2004-05-21

    申请人： Kenneth F. Buechler ,  Paul H. McPherson

    发明人： Kenneth F. Buechler ,  Paul H. McPherson

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6887 ,  Y10S435/961 ,  Y10S435/962 ,  Y10S435/971 ,  Y10S435/973 ,  Y10S436/811 ,  Y10S436/819

    摘要： Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in various conformations in the blood, the ratios of the monomeric troponin I an T and the binary and ternary complexes, as well as which form of troponin present in the blood, may be related to the metabolic state of the heart. Disclosed is a system to determine the presence of a troponin form or a group of troponin forms in a sample of whole blood, serum or plasma.Disclosed is a stabilized composition of troponin; the stabilized composition can comprise a stabilized composition of troponin I, wherein the troponin I is oxidized, the troponin I can be unbound or the troponin I can be in a complex.Disclosed is a method for improving the recovery of troponin I or T from a surface used in immunoassaysAlso disclosed are antibodies which recognize, unbound troponin forms, the forms of troponin in binary complexes, the ternary complex of troponin I, T and C, and the conformations of troponin I having intramolecularly oxidized and reduced cysteines.

    摘要翻译： 用于检测和定量体液中肌钙蛋白I和肌钙蛋白T的测定系统和专用抗体作为心肌梗死的指标。 由于肌钙蛋白I和T存在于血液中的各种构象中，单体肌钙蛋白I与T和二元和三元复合物的比例以及存在于血液中的肌钙蛋白形式可能与代谢状态有关 心。 公开了一种确定全血，血清或血浆样品中肌钙蛋白形式或一组肌钙蛋白形式存在的系统。 公开了稳定的肌钙蛋白的组合物; 稳定的组合物可以包含肌钙蛋白I的稳定化组合物，其中肌钙蛋白I被氧化，肌钙蛋白I可以是未结合的，或者肌钙蛋白I可以在复合物中。 公开了一种从免疫测定中使用的表面改善肌钙蛋白I或T的回收方法。还公开了识别未结合的肌钙蛋白形式的抗体，二元复合物中肌钙蛋白的形式，肌钙蛋白I，T和C的三元复合物，以及 具有分子内氧化和还原半胱氨酸的肌钙蛋白I的构象。

    Methods And Compositions For Monitoring And Risk Prediction In Cardiorenal Syndrome
    5.
    发明申请
    Methods And Compositions For Monitoring And Risk Prediction In Cardiorenal Syndrome 有权
    心脏综合征监测和风险预测的方法和组成

    公开(公告)号：US20080254485A1

    公开(公告)日：2008-10-16

    申请号：US11940111

    申请日：2007-11-14

    申请人： Gunars Valkirs ,  Paul H. McPherson

    发明人： Gunars Valkirs ,  Paul H. McPherson

    IPC分类号： G01N33/573

    CPC分类号： G01N33/6893 ,  G01N33/74 ,  G01N2333/58 ,  G01N2800/347

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to monitor cardiorenal syndrome using assays that detect NGAL, preferably together with assays that detect natriuretic peptides such as BNP. Such methods and compositions can provide early indications of a deterioration in cardiorenal syndrome status, including prognosis regarding mortality and worsening renal function.

    摘要翻译： 本发明涉及用于受试者的治疗方案的监测，诊断，预后和测定的方法和组合物。 特别地，本发明涉及选择用于使用检测NGAL的测定法监测心肾综合征的方法和组合物，优选与检测利尿钠肽如BNP的测定法一起使用。 这些方法和组合物可以提供心脏综合征状态恶化的早期迹象，包括关于死亡率和恶化的肾功能的预后。

    Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
    7.
    发明授权
    Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays 失效
    测定肌钙蛋白I和T的方法以及肌钙蛋白I和T的复合物以及免疫测定中使用的抗体选择

    公开(公告)号：US08114612B2

    公开(公告)日：2012-02-14

    申请号：US12986893

    申请日：2011-01-07

    申请人： Kenneth F. Buechler ,  Paul H. McPherson

    发明人： Kenneth F. Buechler ,  Paul H. McPherson

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6887 ,  Y10S435/961 ,  Y10S435/962 ,  Y10S435/971 ,  Y10S435/973 ,  Y10S436/811 ,  Y10S436/819

    摘要： Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction are disclosed. Troponin I and T exist in various conformations and the ratios of monomeric troponin I and T and the binary and ternary complexes, as well as which form of troponin present in the blood, may be related to the metabolic state of the heart. Disclosed are systems to determine the presence of a troponin form or a group of troponin forms in whole blood, serum or plasma samples.Disclosed is a method for improving the recovery of troponin I or T from a surface used in immunoassays.Also disclosed are antibodies which recognize unbound troponin forms, the forms of troponin in binary complexes, the ternary complex of troponin I, T and C, and the conformations of troponin I having intramolecularly oxidized and reduced cysteines.

    摘要翻译： 公开了用于检测和定量体液中肌钙蛋白I和肌钙蛋白T作为心肌梗死指标的测定系统和专用抗体。 肌钙蛋白I和T以各种构象存在，单体肌钙蛋白I和T与二元和三元复合物的比例以及存在于血液中的肌钙蛋白形式可能与心脏的代谢状态有关。 公开了确定全血，血清或血浆样品中肌钙蛋白形式或一组肌钙蛋白形式存在的系统。 公开了一种用于从免疫测定中使用的表面改善肌钙蛋白I或T的恢复的方法。 还公开了识别未结合的肌钙蛋白形式，二元复合物中的肌钙蛋白的形式，肌钙蛋白I，T和C的三元复合物以及具有分子内氧化和还原的半胱氨酸的肌钙蛋白I的构象的抗体。

    Immunoassay fluorometer
    10.
    发明授权
    Immunoassay fluorometer 失效
    免疫测定荧光计

    公开(公告)号：US06830731B1

    公开(公告)日：2004-12-14

    申请号：US09003090

    申请日：1998-01-05

    申请人： Kenneth F. Buechler ,  Joseph M Anderberg ,  Paul H. McPherson

    发明人： Kenneth F. Buechler ,  Joseph M Anderberg ,  Paul H. McPherson

    IPC分类号： G01N2164

    CPC分类号： G01N21/645 ,  Y10T436/112499 ,  Y10T436/115831

    摘要： A fluorometer for sensing the fluorescence of a sample utilizes an optical energy source for exciting a sample to be tested and an optical energy detector for detecting the emitted energy from the excited sample. Drive electronics are used for positioning the sample with respect to the optical components allowing a plurality of sample regions to be tested. A processor is utilized to control the operation of the test in accordance with test instructions and for processing the emitted energy detected from the sample to determine test results. A ROM chip socket accepts a plurality of ROM chips, wherein each ROM chip stores test data sets for one or more test types to be performed. ROM chips can be swapped to allow the fluorometer to be configured and reconfigured to perform a plurality of different tests. A communications interface facilitates the sharing of test information between the fluorometer and external entities.

    摘要翻译： 用于感测样品的荧光的荧光计利用用于激发待测试样品的光能源和用于检测来自激发样品的发射能量的光能检测器。 驱动电子器件用于相对于光学部件定位样品，允许测试多个样品区域。 使用处理器来根据测试指令来控制测试的操作，并且用于处理从样品检测到的发射能量以确定测试结果。 ROM芯片插座接受多个ROM芯片，其中每个ROM芯片存储要执行的一种或多种测试类型的测试数据集。 可以交换ROM芯片以允许荧光计被配置和重新配置以执行多个不同的测试。 通信接口有助于在荧光计和外部实体之间共享测试信息。