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1.发明申请公开(公告)号：US20140147867A1
公开(公告)日：2014-05-29
申请号：US13990393
申请日：2011-11-25
申请人： William D. Arnold , Christelle Jost , Brian Noland , Jonathan Gary , Joseph Buechler , Vance Wong , Scott Harold Rongey , Uday Kumar Veeramallu , Kelline Marie Rodems
发明人： William D. Arnold , Christelle Jost , Brian Noland , Jonathan Gary , Joseph Buechler , Vance Wong , Scott Harold Rongey , Uday Kumar Veeramallu , Kelline Marie Rodems
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/325 , G01N2800/60
摘要： The present invention relates in part to diagnosing the occurrence of heart failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The present invention further relates in part to assigning an outcome risk (e.g., worsening cardiac function or a mortality risk, a risk of rehospitalization) to a subject. The methods comprise performing one or more assays that detect one or more biomarkers selected from the group consisting of WAP4C, ESAM, LTBR, Mesothelin, and Syndecan-1 performed on a body fluid sample obtained from a subject, and assigning diagnosis or risk based, at least in part, on the result(s) obtained thereby.
摘要翻译： 本发明部分地涉及诊断心力衰竭的发生，特别是在表现出利钠肽的正常体液水平的受试者中。 本发明还部分地涉及将受试者的结局风险（例如恶化心脏功能或死亡风险，再住院风险）分配给患者。 所述方法包括进行一种或多种测定，所述测定法检测在从受试者获得的体液样品上进行的选自由WAP4C，ESAM，LTBR，间皮素和Syndecan-1组成的组中的一种或多种生物标志物，以及分配诊断或风险， 至少部分地取决于由此获得的结果。
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2.发明授权Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes 有权用于全身炎症反应综合征的诊断和/或预后的方法和组合物公开(公告)号：US08221995B2
公开(公告)日：2012-07-17
申请号：US12663841
申请日：2008-06-27
申请人： Seok-Won Lee , Kelline M. Rodems , David W. Oelschlager , Uday Kumar Veeramallu , Joseph A. Buechler , Paul H. McPherson
发明人： Seok-Won Lee , Kelline M. Rodems , David W. Oelschlager , Uday Kumar Veeramallu , Joseph A. Buechler , Paul H. McPherson
IPC分类号： G01N33/00
CPC分类号： G01N33/6893 , G01N2333/521 , G01N2800/26 , G01N2800/50 , G01N2800/56
摘要： The present invention relates to methods and compositions for diagnosing SIRS, sepsis, severe sepsis, septic shock, or MODS in a subject, or assigning a prognostic risk for one or more clinical outcomes for a subject suffering from SIRS, sepsis, severe sepsis, septic shock, or MODS, the method comprising performing an immunoassay for CCL23 splice variant.
摘要翻译： 本发明涉及用于诊断受试者的SIRS，败血症，严重败血症，败血性休克或MODS的方法和组合物，或为患有SIRS，败血症，严重败血症，败血症的受试者分配一种或多种临床结果的预后风险 休克或MODS，所述方法包括对CCL23剪接变体进行免疫测定。
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公开(公告)号：US07977068B2
公开(公告)日：2011-07-12
申请号：US12020482
申请日：2008-01-25
申请人： Jeff Gray , Joe Buechler , Uday Kumar Veeramallu
发明人： Jeff Gray , Joe Buechler , Uday Kumar Veeramallu
CPC分类号： C07K16/00 , C07K2317/55 , C07K2319/02 , C07K2319/50 , C07K2319/75 , C12N15/625
摘要： The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.
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公开(公告)号：US5656421A
公开(公告)日：1997-08-12
申请号：US654034
申请日：1991-02-12
CPC分类号： C12M25/10 , C12M23/58 , C12M29/02 , C12M41/00 , C12M41/12 , C12M41/26 , C12M41/32 , C12M41/48
摘要： A unique hollow fiber multiple bioreactor system and method for the propagation of cells and the production of various cell propagation products is described. Simultaneous fluid flow through lumens of hollow fibers in bioreactors is maintained constant across multiple bioreactors so production is maintained essentially constant. The system and method include use of a flow block holder which allows a dissolved oxygen probe to be calibrated at the same pressure as the media in the bioreactor system.
摘要翻译： 描述了独特的中空纤维多重生物反应器系统和用于细胞繁殖和各种细胞繁殖产物的生产的方法。 通过生物反应器中的中空纤维流的同时流体流动在多个生物反应器上保持恒定，因此生产维持基本恒定。 该系统和方法包括使用允许在与生物反应器系统中的介质相同的压力下校准溶解氧探针的流动块支架。
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5.发明授权Latent protein C assays and their uses for diagnosis and/or prognosis in systemic inflammatory response syndromes 有权潜伏蛋白C测定及其在全身炎症反应综合征中的诊断和/或预后的用途公开(公告)号：US07655428B2
公开(公告)日：2010-02-02
申请号：US11614836
申请日：2006-12-21
IPC分类号： G01N21/00 , G01N21/64 , G01N21/75 , G01N21/76 , G01N25/18 , G01N33/00 , A61K39/00 , A61K39/395 , A61K39/44
CPC分类号： C07K16/36 , C07K16/40 , G01N33/573 , G01N33/6893 , G01N33/86 , G01N2333/96461 , G01N2800/26
摘要： The present invention relates to methods and compositions for measuring latent protein C in test samples, particularly patient samples. The methods and compositions described are sensitive for latent protein C, relative to activated protein C.
摘要翻译： 本发明涉及用于测量试验样品，特别是患者样品中潜伏蛋白C的方法和组合物。 所述方法和组合物相对于活化的蛋白C对潜伏蛋白C敏感。
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6.发明申请METHODS AND COMPOSITIONS FOR DIAGNOSIS AND/OR PROGNOSIS IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROMES 审中-公开用于系统性炎症反应综合征诊断和/或预防的方法和组合物公开(公告)号：US20090004755A1
公开(公告)日：2009-01-01
申请号：US11770608
申请日：2007-06-28
申请人： Seok-Won Lee , Kelline M. Rodems , David W. Oelschlager , Uday Kumar Veeramallu , Joseph A. Buechler , Paul H. McPherson
发明人： Seok-Won Lee , Kelline M. Rodems , David W. Oelschlager , Uday Kumar Veeramallu , Joseph A. Buechler , Paul H. McPherson
IPC分类号： G01N33/566
CPC分类号： G01N33/6893 , G01N2333/521 , G01N2800/50 , G01N2800/56
摘要： The present invention relates to methods and compositions for diagnosing SIRS, sepsis, severe sepsis, septic shock, or MODS in a subject, or assigning a prognostic risk for one or more clinical outcomes for a subject suffering from SIRS, sepsis, severe sepsis, septic shock, or MODS, the method comprising performing an immunoassay for CCL23 splice variant.
摘要翻译： 本发明涉及用于诊断受试者的SIRS，败血症，严重败血症，败血性休克或MODS的方法和组合物，或为患有SIRS，败血症，严重败血症，败血症的受试者分配一种或多种临床结果的预后风险 休克或MODS，所述方法包括对CCL23剪接变体进行免疫测定。
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公开(公告)号：US07396661B2
公开(公告)日：2008-07-08
申请号：US10367169
申请日：2003-02-13
申请人： Jeff Gray , Joe Buechler , Uday Kumar Veeramallu
发明人： Jeff Gray , Joe Buechler , Uday Kumar Veeramallu
CPC分类号： C07K16/00 , C07K2317/55 , C07K2319/02 , C07K2319/50 , C07K2319/75 , C12N15/625
摘要： The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.
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8.发明授权公开(公告)号：US08795975B2
公开(公告)日：2014-08-05
申请号：US13990393
申请日：2011-11-25
申请人： William D. Arnold , Christelle Jost , Brian Noland , Jonathan Gary , Joseph Buechler , Vance Wong , Scott Harold Rongey , Uday Kumar Veeramallu , Kelline Marie Rodems
发明人： William D. Arnold , Christelle Jost , Brian Noland , Jonathan Gary , Joseph Buechler , Vance Wong , Scott Harold Rongey , Uday Kumar Veeramallu , Kelline Marie Rodems
CPC分类号： G01N33/6893 , G01N2800/325 , G01N2800/60
摘要： The present invention relates in part to diagnosing the occurrence of heart failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The present invention further relates in part to assigning an outcome risk (e.g., worsening cardiac function or a mortality risk, a risk of rehospitalization) to a subject. The methods comprise performing one or more assays that detect one or more biomarkers selected from the group consisting of WAP4C, ESAM, LTBR, Mesothelin, and Syndecan-1 performed on a body fluid sample obtained from a subject, and assigning diagnosis or risk based, at least in part, on the result(s) obtained thereby.
摘要翻译： 本发明部分地涉及诊断心力衰竭的发生，特别是在表现出利钠肽的正常体液水平的受试者中。 本发明还部分地涉及将受试者的结局风险（例如恶化心脏功能或死亡风险，再住院风险）分配给患者。 所述方法包括进行一种或多种测定，所述测定法检测在从受试者获得的体液样品上进行的选自由WAP4C，ESAM，LTBR，间皮素和Syndecan-1组成的组中的一种或多种生物标志物，以及分配诊断或风险， 至少部分地取决于由此获得的结果。
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公开(公告)号：US08476040B2
公开(公告)日：2013-07-02
申请号：US13112600
申请日：2011-05-20
申请人： Jeff Gray , Joe Buechler , Uday Kumar Veeramallu
发明人： Jeff Gray , Joe Buechler , Uday Kumar Veeramallu
CPC分类号： C07K16/00 , C07K2317/55 , C07K2319/02 , C07K2319/50 , C07K2319/75 , C12N15/625
摘要： The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.
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10.发明授权公开(公告)号：US07972811B2
公开(公告)日：2011-07-05
申请号：US12021098
申请日：2008-01-28
申请人： Jeff Gray , Joe Buechler , Uday Kumar Veeramallu
发明人： Jeff Gray , Joe Buechler , Uday Kumar Veeramallu
CPC分类号： C07K16/00 , C07K2317/55 , C07K2319/02 , C07K2319/50 , C07K2319/75 , C12N15/625
摘要： The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.
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