公开(公告)号：US1823686A

公开(公告)日：1931-09-15

申请号：US34304429

申请日：1929-02-27

申请人： PAUL HANKE

发明人： PAUL HANKE

IPC分类号： A61F13/12

CPC分类号： A61F13/12

公开(公告)号：US20130116138A1

公开(公告)日：2013-05-09

申请号：US13575834

申请日：2011-01-28

申请人： Thomas P. Binder ,  Aragula Gururaj Rao ,  Yasufumi Yamamoto ,  Paul Hanke

发明人： Thomas P. Binder ,  Aragula Gururaj Rao ,  Yasufumi Yamamoto ,  Paul Hanke

IPC分类号： C07K7/06 ,  C40B30/06

CPC分类号： C07K7/06 ,  C07K5/08 ,  C07K7/08 ,  C07K14/00

摘要： Described herein are small peptide domains and consensus sequences that bind small target molecules of industrial importance, e.g., metals such as nickel, β carotene, and isoflavones such as genistein. Also described are fusion proteins containing such binding domains fused to proteins or to peptide domains like GST or GBD that bind other ligands and can be used to immobilize the target binding domain on a support. One class of fusion proteins that is useful in industrial settings are fusions that contain concatemers of target binding domains, which increases the binding equivalents per molecule.

摘要翻译： 本文描述的是结合工业重要性的小靶分子的小肽结构域和共有序列，例如金属如镍，β-胡萝卜素和异黄酮如染料木素。 还描述了含有融合蛋白质或结合其他配体的肽结构域（如GST或GBD）的融合蛋白，并可用于将靶结合结构域固定在载体上。 在工业环境中有用的一类融合蛋白是融合靶结合域的融合物，这增加了每个分子的结合当量。

公开(公告)号：US20050221452A1

公开(公告)日：2005-10-06

申请号：US11136887

申请日：2005-05-25

申请人： Paul Hanke ,  Anthony Sinskey ,  Laura Willis ,  Stephane Guillouet

发明人： Paul Hanke ,  Anthony Sinskey ,  Laura Willis ,  Stephane Guillouet

IPC分类号： C12N1/21 ,  C12N9/00 ,  C12P13/08 ,  C07H21/04 ,  C12N9/88 ,  C12P13/20

CPC分类号： C12N9/93 ,  C12P13/08 ,  C12Y604/01001

摘要： The present invention relates to a mutated pyruvate carboxylase gene from Corynebacterium. The mutant pyruvate carboxylase gene encodes a pyruvate carboxylase enzyme which is resistant to feedback inhibition from aspartic acid. The present invention also relates to a method of replacing the wild-type pyruvate carboxylase gene in Corynebacterium with this feedback-resistant pyruvate carboxylase gene. The present invention further relates to methods of the production of amino acids, preferably lysine, comprising the use of this mutant pyruvate carboxylase enzyme in microorganisms.

摘要翻译： 本发明涉及来自棒状杆菌的突变型丙酮酸羧化酶基因。 突变体丙酮酸羧化酶基因编码丙酮酸羧化酶，其对天冬氨酸的反馈抑制具有抗性。 本发明还涉及用该反馈抗性丙酮酸羧化酶基因替代棒状杆菌中的野生型丙酮酸羧化酶基因的方法。 本发明还涉及生产氨基酸，优选赖氨酸的方法，其包括在微生物中使用该突变型丙酮酸羧化酶。

公开(公告)号：US1589173A

公开(公告)日：1926-06-15

申请号：US6579625

申请日：1925-10-30

申请人： PAUL HANKE

发明人： PAUL HANKE

IPC分类号： A61C13/07

CPC分类号： A61C13/0025

公开(公告)号：US20050042734A1

公开(公告)日：2005-02-24

申请号：US10671886

申请日：2003-09-29

申请人： Wuli Bao ,  Thomas Binder ,  Paul Hanke ,  Leif Solheim

发明人： Wuli Bao ,  Thomas Binder ,  Paul Hanke ,  Leif Solheim

IPC分类号： C12N9/10 ,  C07H5/06 ,  C12P19/26 ,  C12P19/28

CPC分类号： C12P19/26

摘要： Methods for cell-free production of glucosamine from starch, maltodextrin or glycogen or from fructose and a source of amino groups are disclosed. Also disclosed are cellular extracts comprising glucosamine-6-phosphate synthase activity, as well as a cellular extract comprising glucosamine-6-phosphate deaminase.

摘要翻译： 公开了从淀粉，麦芽糖糊精或糖原或果糖和氨基来源生产葡糖胺的无细胞方法。 还公开了包含葡糖胺-6-磷酸合酶活性的细胞提取物，以及包含葡糖胺-6-磷酸脱氨酶的细胞提取物。

公开(公告)号：US5140374A

公开(公告)日：1992-08-18

申请号：US776841

申请日：1991-10-15

申请人： David Jagielski ,  Wojciech Dabrowski ,  Paul Hanke

发明人： David Jagielski ,  Wojciech Dabrowski ,  Paul Hanke

IPC分类号： G03B21/11 ,  G03G15/22

CPC分类号： G03B21/118 ,  G03G15/223

摘要： A reader printer apparatus includes a modular housing formed by structural foam molding which includes an integrally formed means for carrying the various components of a reader printer apparatus. By providing an integrally formed carrying means, the need for a separate metal chassis and brackets is eliminated, thus reducing the number of parts required. Additionally, this allows the weight of the machine to be reduced to a value less than the seventy pound limit to enable the machine to be shipped by relatively less expensive small package carriers. The reader printer apparatus in accordance with the present invention includes a scanning assembly located relatively close to the object plane in order to reduce the overall size of the machine. Moreover, by locating adjacent scanning assembly adjacent to the object plane, the optical paths for the printing mode and the viewing mode are virtually independent, thus obviating the need for pivotally mounted viewing mirrors. The scanning assembly includes a pivotally mounted print mirror driven by a stepper motor synchronized to the speed of the print engine by a stepper motor, mechanically independent from the print engine. This reduces distortions in prints due to wear and voltage fluctuations relative to the print engine.

摘要翻译： 读取器打印机装置包括通过结构发泡成型形成的模块化壳体，其包括用于承载读取器打印机装置的各种部件的整体形成的装置。 通过提供整体形成的承载装置，消除了对单独的金属底盘和支架的需要，从而减少了所需的零件数量。 另外，这允许将机器的重量减小到小于七十磅的极限值，以使机器能够由相对较便宜的小型包装载体运输。 根据本发明的读取器打印机设备包括相对靠近物体平面的扫描组件，以减小机器的整体尺寸。 此外，通过将相邻的扫描组件邻近物平面定位，用于打印模式和观看模式的光路几乎是独立的，从而避免了对枢转安装的观察镜的需要。 扫描组件包括由步进电机驱动的可旋转地安装的打印反射镜，该步进马达与步进电机同步于打印引擎的速度，机械地独立于打印引擎。 这减少了相对于打印引擎的磨损和电压波动造成的打印失真。