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    DEPOT COMPOSITIONS WITH MULTIPLE DRUG RELEASE RATE CONTROLS AND USES THEREOF
    1.
    发明申请
    DEPOT COMPOSITIONS WITH MULTIPLE DRUG RELEASE RATE CONTROLS AND USES THEREOF 审中-公开
    具有多种药物释放速率控制的DEPOT组合物及其用途

    公开(公告)号：US20070196415A1

    公开(公告)日：2007-08-23

    申请号：US11553925

    申请日：2006-10-27

    申请人： Guohua Chen ,  Lothar Kleiner ,  Paul Houston ,  Jeremy Wright

    发明人： Guohua Chen ,  Lothar Kleiner ,  Paul Houston ,  Jeremy Wright

    IPC分类号： A61F2/02

    CPC分类号： A61K47/34 ,  A61K9/0024 ,  A61K9/143 ,  A61K9/145 ,  A61K9/146 ,  A61K9/19 ,  A61K47/10 ,  A61K47/14

    摘要： Injectable depot compositions with dual mechanisms of release rate control are provided for sustained beneficial agent delivery in a patient. The composition includes bioerodible particles and an injectable depot vehicle containing a bioerodible polymer in an organic solvent, for forming a bioerodible depot implant after administration to the patient. The bioerodible particles are dispersed in the depot vehicle and contain a beneficial agent and a release rate controlling agent retarding the release of the beneficial agent from the bioerodible particles and from the depot implant.

    摘要翻译： 提供具有释放速率控制的双重机制的可注射储库组合物，用于在患者中持续的有益药物递送。 该组合物包括生物可腐蚀颗粒和在有机溶剂中含有生物可腐蚀聚合物的可注射贮存载体，用于在给予患者之后形成生物可浸润的储库植入物。 生物可腐蚀颗粒分散在贮存载体中并含有有益剂和释放速率控制剂，其阻止有益剂从生物可侵蚀颗粒和贮存植入物的释放。

    Implantable elastomeric depot compositions and uses thereof
    2.
    发明申请
    Implantable elastomeric depot compositions and uses thereof 审中-公开
    可植入弹性体贮库组合物及其用途

    公开(公告)号：US20050079202A1

    公开(公告)日：2005-04-14

    申请号：US10857609

    申请日：2004-05-28

    申请人： Guohua Chen ,  Paul Houston ,  Lothar Kleiner ,  Aruna Nathan ,  Joel Rosenblatt

    发明人： Guohua Chen ,  Paul Houston ,  Lothar Kleiner ,  Aruna Nathan ,  Joel Rosenblatt

    IPC分类号： A61F2/00 ,  A61K9/00

    CPC分类号： A61K9/0024

    摘要： Methods and compositions for systemically or locally administering a beneficial agent to a subject are described, and include, for example, implantable elastomeric depot compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible, elastomeric polymer, a biocompatible solvent having low water miscibility that forms an elastomeric viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

    摘要翻译： 描述了用于向受试者全身或局部施用有益剂的方法和组合物，并且包括例如可植入的弹性体贮库组合物，其可以注射到期望的位置并且可以在延长的持续时间内提供有益剂的受控释放 时间。 组合物包括生物相容的弹性体聚合物，具有低水混溶性的生物相容性溶剂，其与聚合物形成弹性体粘性凝胶并限制植入物吸收水分，以及有益剂。

    SULFATED POLYSACCHARIDES AND USES THEREOF IN MEDICAL TREATMENT
    3.
    发明申请
    SULFATED POLYSACCHARIDES AND USES THEREOF IN MEDICAL TREATMENT 审中-公开
    硫化多糖及其在医疗中的应用

    公开(公告)号：US20090227537A1

    公开(公告)日：2009-09-10

    申请号：US12465106

    申请日：2009-05-13

    申请人： MICHAEL WILLIAM GRADY ,  Laura Sinclair ,  Paul Houston ,  Peter John Doyle

    发明人： MICHAEL WILLIAM GRADY ,  Laura Sinclair ,  Paul Houston ,  Peter John Doyle

    IPC分类号： A61K31/717 ,  A61K31/715 ,  A61P17/02

    CPC分类号： C08B15/00 ,  A61K31/715 ,  C08B37/0084

    摘要： The invention provides sulfated oxidised regenerated cellulose compounds, sulfated alginates, and the salts and hydrates thereof. The compounds are obtained by sulfation of oxidised regenerated cellulose with sulfur trioxide. The invention also provides pharmaceutical compositions comprising the compounds, in particular compositions for the treatment of medical conditions mediated by a matrix metalloproteinases and anticoagulant pharmaceutical compositions.

    摘要翻译： 本发明提供硫酸化氧化再生纤维素化合物，硫酸化藻酸盐及其盐和水合物。 通过氧化再生纤维素与三氧化硫的硫酸化获得化合物。 本发明还提供药物组合物，其包含化合物，特别是用于治疗由基质金属蛋白酶和抗凝血药物组合物介导的医学病症的组合物。

    Gas turbine engine airfoils having increased fatigue strength
    7.
    发明授权
    Gas turbine engine airfoils having increased fatigue strength 失效
    燃气涡轮发动机翼型具有增加的疲劳强度

    公开(公告)号：US6095755A

    公开(公告)日：2000-08-01

    申请号：US755842

    申请日：1996-11-26

    申请人： David Paul Houston

    发明人： David Paul Houston

    IPC分类号： F01D5/14 ,  C23C4/00 ,  F01D5/28 ,  F04D29/38

    CPC分类号： F01D5/288 ,  C23C4/01 ,  Y02T50/67 ,  Y02T50/673

    摘要： An airfoil having improved fatigue strength is disclosed. The airfoil comprises a tip, a root section, a platform, and an airfoil section located between the tip and the platform. The airfoil section has a leading edge and a trailing edge. A metallic coating is located along the leading edge and the trailing edge excluding a portion of the leading edge and the trailing edge located near the platform.

    摘要翻译： 公开了具有改善的疲劳强度的翼型。 翼型件包括尖端，根部，平台和位于尖端和平台之间的翼型部分。 翼型部分具有前缘和后缘。 金属涂层沿着前缘和后缘定位，不包括位于平台附近的前缘和后缘的一部分。

    Injectable multimodal polymer depot compositions and uses thereof
    8.
    发明授权
    Injectable multimodal polymer depot compositions and uses thereof 失效
    可注射多峰聚合物储库组合物及其用途

    公开(公告)号：US08501215B2

    公开(公告)日：2013-08-06

    申请号：US10628984

    申请日：2003-07-28

    申请人： Guohua Chen ,  Paul Houston ,  Lothar Kleiner ,  Jeremy Wright

    发明人： Guohua Chen ,  Paul Houston ,  Lothar Kleiner ,  Jeremy Wright

    IPC分类号： A61F2/00 ,  A61F13/00 ,  A61K9/14

    CPC分类号： A61K47/34 ,  A61K9/0024 ,  A61K9/2013 ,  A61K47/12 ,  A61K47/14

    摘要： Injectable depot compositions are provided that include a polymer matrix having a plurality of bioerodible, biocompatible polymers wherein each polymer of the plurality of polymers has a specified average molecular weight, and the polymer matrix has a broad molecular weight distribution of the plurality of polymers; a solvent having a miscibility in water of less than or equal to 7 wt % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith; and a beneficial agent. The compositions have substantially improved shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.

    摘要翻译： 提供了可注射的储库组合物，其包括具有多个生物可腐蚀的生物相容性聚合物的聚合物基质，其中所述多种聚合物中的每种聚合物具有指定的平均分子量，并且所述聚合物基质具有所述多种聚合物的宽分子量分布; 在25℃下在水中具有小于或等于7重量％的混溶性的溶剂，其量有效塑化聚合物并与其形成凝胶; 和有益的代理人。 组合物具有显着改善的剪切稀化行为和降低的注射力，使组合物通过注射容易地植入患者体表下方。

    IMPLANTABLE ELASTOMERIC CAPROLACTONE DEPOT COMPOSITIONS AND USES THEREOF
    9.
    发明申请
    IMPLANTABLE ELASTOMERIC CAPROLACTONE DEPOT COMPOSITIONS AND USES THEREOF 审中-公开
    可植入式弹性体夹心剂组合物及其用途

    公开(公告)号：US20070184084A1

    公开(公告)日：2007-08-09

    申请号：US11554540

    申请日：2006-10-30

    申请人： Guohua Chen ,  Lothar Kleiner ,  Paul Houston ,  Aruna Nathan ,  Joel Rosenblatt

    发明人： Guohua Chen ,  Lothar Kleiner ,  Paul Houston ,  Aruna Nathan ,  Joel Rosenblatt

    IPC分类号： A61K48/00 ,  A61K38/16 ,  A61K38/17 ,  A61K31/715 ,  A61K38/43 ,  A61K31/56

    CPC分类号： A61K9/0024

    摘要： Methods and compositions for systemically or locally administering a beneficial agent to a subject are described, and include, for example, implantable elastomeric depot compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible, elastomeric caprolactone copolymer, a biocompatible solvent having low water miscibility that forms an elastomeric viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

    摘要翻译： 描述了用于向受试者全身或局部施用有益剂的方法和组合物，并且包括例如可植入的弹性体贮库组合物，其可以注射到期望的位置并且可以在延长的持续时间内提供有益剂的受控释放 时间。 组合物包括生物相容的弹性体己内酯共聚物，具有低水混溶性的生物相容性溶剂，其与聚合物形成弹性粘性凝胶并限制植入物吸收水分，以及有益剂。