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公开(公告)号：US20090137495A1
公开(公告)日：2009-05-28
申请号：US12249186
申请日：2008-10-10
申请人： Shawn D. Britt , Lech Andrzej Ciszewski , Jiping Fu , Subramanian Karur , Yugang Liu , Peichao Lu , David Thomas Parker , Mahavir Prashad , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng
发明人： Shawn D. Britt , Lech Andrzej Ciszewski , Jiping Fu , Subramanian Karur , Yugang Liu , Peichao Lu , David Thomas Parker , Mahavir Prashad , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng
IPC分类号： A61K38/07 , C07K5/113 , C07D498/04 , C07D207/08 , A61P31/12
CPC分类号： C07D401/12 , C07D403/12 , C07K5/0812 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。
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公开(公告)号：US08008263B2
公开(公告)日：2011-08-30
申请号：US12249186
申请日：2008-10-10
申请人： Shawn D. Britt , Lech Andrzej Ciszewski , Jiping Fu , Subramanian Karur , Yugang Liu , Peichao Lu , David Thomas Parker , Mahavir Prashad , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng
发明人： Shawn D. Britt , Lech Andrzej Ciszewski , Jiping Fu , Subramanian Karur , Yugang Liu , Peichao Lu , David Thomas Parker , Mahavir Prashad , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng
CPC分类号： C07D401/12 , C07D403/12 , C07K5/0812 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。
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公开(公告)号：US20080045530A1
公开(公告)日：2008-02-21
申请号：US11697889
申请日：2007-04-09
申请人： Trixi Brandl , Shawn Britt , Sylvain Cottens , Claus Ehrhardt , Jiping Fu , Subramanian Karur , Hongju Li , Peichao Lu , David Parker , Michael Patane , Branko Radetich , Prakash Raman , Stefan Randl , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Ritesh Tichkule , Yanyi Zhu
发明人： Trixi Brandl , Shawn Britt , Sylvain Cottens , Claus Ehrhardt , Jiping Fu , Subramanian Karur , Hongju Li , Peichao Lu , David Parker , Michael Patane , Branko Radetich , Prakash Raman , Stefan Randl , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Ritesh Tichkule , Yanyi Zhu
IPC分类号： A61K31/195 , A61K31/40 , A61K31/421 , A61K31/445 , A61K31/47 , A61K31/4965 , A61K31/497 , A61K31/5375 , A61P31/12 , C07D207/00 , C07D217/00 , C07D241/02
CPC分类号： C07D403/12 , C07D207/08 , C07D217/04 , C07D241/04 , C07D401/14 , C07D405/14 , C07D407/12 , C07D413/04 , C07D413/12 , C07D413/14
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。
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公开(公告)号：US20120015907A1
公开(公告)日：2012-01-19
申请号：US13089764
申请日：2011-04-19
申请人： David BARNES , Rajiv CHOPRA , Scott Louis COHEN , Jiping FU , Mitsunori Kato , Peichao LU , Mohindra SEEPERSAUD , Wei ZHANG
发明人： David BARNES , Rajiv CHOPRA , Scott Louis COHEN , Jiping FU , Mitsunori Kato , Peichao LU , Mohindra SEEPERSAUD , Wei ZHANG
IPC分类号： A61K31/4355 , C07D413/14 , A61K31/5377 , C07D405/14 , A61K31/496 , C07D417/14 , A61K31/541 , A61K31/675 , C07D491/14 , A61K31/55 , C07D498/14 , A61P31/14 , A61P1/16 , A61P35/00 , A61P7/00 , A61P37/04 , C07D491/048
CPC分类号： C07D491/147 , C07D491/048
摘要： The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US20090197856A1
公开(公告)日：2009-08-06
申请号：US12339460
申请日：2008-12-19
申请人： Salvador G. Alvarez , Janos Botyanszki , Joseph de los Angeles , Jiping Fu , Roger Fujimoto , Joshua Michael Gralapp , Ronald Conrad Griffith , Peichao Lu , Son Minh Pham , Christopher Don Roberts , Franz Ulrich Schmitz , Mohindra Seepersaud , Ruben Tommasi , Adam Christopher Villa , Sompong Wattanasin , Aregahagn Yifru , Rui Zheng , Xiaoling Zheng
发明人： Salvador G. Alvarez , Janos Botyanszki , Joseph de los Angeles , Jiping Fu , Roger Fujimoto , Joshua Michael Gralapp , Ronald Conrad Griffith , Peichao Lu , Son Minh Pham , Christopher Don Roberts , Franz Ulrich Schmitz , Mohindra Seepersaud , Ruben Tommasi , Adam Christopher Villa , Sompong Wattanasin , Aregahagn Yifru , Rui Zheng , Xiaoling Zheng
IPC分类号： A61K31/407 , C07D487/14 , A61K31/454 , A61K31/5377 , A61K31/551 , A61K31/5355 , A61K31/496 , A61K31/541 , A61K31/437 , A61P31/12
CPC分类号： C07D471/22 , C07D487/14 , C07D487/22
摘要： Provided are compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds and compositions are useful for treating viral infections caused by the Flaviviridae family of viruses.
摘要翻译： 提供式（I）的化合物或其药学上可接受的盐或溶剂化物。 化合物和组合物可用于治疗由黄病毒科病毒引起的病毒感染。
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公开(公告)号：US20140134132A1
公开(公告)日：2014-05-15
申请号：US14037644
申请日：2013-09-26
申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中本文定义的变量R1，R2，R3，R4，R5和AB是非免疫抑制性亲环蛋白结合的mPTP阻断剂，因此可用于预防或治疗疾病或 疾病如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。
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公开(公告)号：US08324239B2
公开(公告)日：2012-12-04
申请号：US13089764
申请日：2011-04-19
申请人： David Barnes , Rajiv Chopra , Scott Louis Cohen , Jiping Fu , Mitsunori Kato , Peichao Lu , Mohindra Seepersaud , Wei Zhang
发明人： David Barnes , Rajiv Chopra , Scott Louis Cohen , Jiping Fu , Mitsunori Kato , Peichao Lu , Mohindra Seepersaud , Wei Zhang
IPC分类号： A61K31/4355 , C07D491/048
CPC分类号： C07D491/147 , C07D491/048
摘要： The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20110275819A1
公开(公告)日：2011-11-10
申请号：US13185683
申请日：2011-07-19
申请人： Shawn D. BRITT , Lech Andrzej CISZEWSKI , Jiping FU , Subramanian KARUR , Yugang LIU , Peichao LU , David Thomas PARKER , Mahavir PRASHAD , Prakash RAMAN , Pascal RIGOLLIER , Mohindra SEEPERSAUD , Aregahegn YIFRU , Rui ZHENG
发明人： Shawn D. BRITT , Lech Andrzej CISZEWSKI , Jiping FU , Subramanian KARUR , Yugang LIU , Peichao LU , David Thomas PARKER , Mahavir PRASHAD , Prakash RAMAN , Pascal RIGOLLIER , Mohindra SEEPERSAUD , Aregahegn YIFRU , Rui ZHENG
IPC分类号： C07D401/12 , C07D403/12 , C07D209/54
CPC分类号： C07D401/12 , C07D403/12 , C07K5/0812 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
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公开(公告)号：US20150306172A1
公开(公告)日：2015-10-29
申请号：US14717872
申请日：2015-05-20
申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中R1，R2，R3，R4，R5和AB如本文所定义，其为非免疫抑制性，亲环蛋白结合，mPTP阻断剂，因此可用于预防或治疗疾病或病症 例如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。
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公开(公告)号：US09072696B2
公开(公告)日：2015-07-07
申请号：US14037644
申请日：2013-09-26
申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中本文定义的变量R1，R2，R3，R4，R5和AB是非免疫抑制性亲环蛋白结合的mPTP阻断剂，因此可用于预防或治疗疾病或 疾病如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。
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