公开(公告)号：US5958416A

公开(公告)日：1999-09-28

申请号：US447154

申请日：1995-05-23

Applicant: Gary Birnbaum ,  Linda A. Kotilinek ,  Peter Erich Braun

Inventor： Gary Birnbaum ,  Linda A. Kotilinek ,  Peter Erich Braun

IPC: A61K38/00 ,  A61P37/00 ,  A61P37/02 ,  C07K14/35 ,  C07K14/47 ,  C12N9/16 ,  A61K39/02

CPC classification number: C07K14/35 ,  C07K14/4713 ,  C12N9/16 ,  A61K38/00 ,  Y10S514/885 ,  Y10S514/903

Abstract: The invention provides for peptides and methods of using peptides to block or inhibit a pathogenic autoimmune response to central nervous system components. One class of peptides are antigens derived from mycobacterial heat shock proteins and may immunologically cross-react with or are homologous to myelin components. The peptides can also be derived from myelin components such as 2',3' cyclic nucleotide phosphodiesterase and immunologically cross-react with and/or are homologous to mycobacterial heat shock proteins. A method of the invention involves administering a pharmaceutical composition including at least one peptide to an animal in an amount effective to block or inhibit a pathogenic autoimmune response to central nervous system components. The peptides are useful for the prevention, and treatment of autoimmune inflammatory central nervous system disease.

Abstract translation: 本发明提供了使用肽阻断或抑制对中枢神经系统组分的致病性自身免疫应答的肽和方法。 一类肽是来自分枝杆菌热休克蛋白的抗原，可与髓磷脂成分免疫交叉反应或与其同源。 肽还可以衍生自髓鞘组分如2'，3'环核苷酸磷酸二酯酶，并与分枝杆菌热休克蛋白免疫交叉反应和/或同源。 本发明的方法包括向动物施用包含至少一种肽的药物组合物，其量可有效阻断或抑制对中枢神经系统组分的致病性自身免疫应答。 该肽可用于预防和治疗自身免疫性中枢神经系统疾病。

公开(公告)号：US5714186A

公开(公告)日：1998-02-03

申请号：US581550

申请日：1996-01-04

Applicant: Stuart Justin Nash ,  Peter John Houzego ,  Timothy Michael Wood ,  Peter Erich Cox

Inventor： Stuart Justin Nash ,  Peter John Houzego ,  Timothy Michael Wood ,  Peter Erich Cox

IPC: B65B31/00 ,  B65D79/00 ,  B65D85/73 ,  B65D47/00 ,  B65D83/00

CPC classification number: B65D85/73 ,  B65B31/006 ,  Y10S220/906

Abstract: A device for generating a head on a beverage in a sealed can, when the can is opened, comprising a hollow capsule with first and second compartments communicating via tubes with apertures respective each on the opposite side of the capsule from the side of the chamber with which the tube communicates, and a ballast means for orientating the capsule in a position such that, as one chamber charges with liquid, the capsule is caused to rotate and trap a volume of air therein. The capsule may be cylindrical or more preferably spherical in external shape.

Abstract translation: PCT No.PCT / GB94 / 01660 Sec。 371日期1996年1月4日 102（e）日期1996年1月4日PCT PCT 1994年8月1日PCT公布。 公开号WO95 / 03983 日期1995年2月9日一种用于在罐被打开时在饮料上产生头部的装置，包括中空胶囊，其具有第一和第二隔室，所述第一和第二隔室通过管与所述胶囊的相对侧分别相通 管连通的室的一侧，以及用于使胶囊定向在使得当一个室与液体一起充电的位置时，使胶囊旋转并捕获一定体积的空气的压载装置。 胶囊可以是外形的圆柱形或更优选球形。

公开(公告)号：US5660867A

公开(公告)日：1997-08-26

申请号：US481527

申请日：1995-06-20

Applicant: Andrew John Reynolds ,  John David Skingsley ,  Stephen Michael Freshwater ,  John Kelshaw Conway ,  Peter Erich Cox ,  John Poley

Inventor： Andrew John Reynolds ,  John David Skingsley ,  Stephen Michael Freshwater ,  John Kelshaw Conway ,  Peter Erich Cox ,  John Poley

IPC: B65D79/00 ,  B65D85/73 ,  B65B31/00 ,  B65B17/00 ,  B65B25/00

CPC classification number: B65D85/73

Abstract: Devices are described for fitting into pressurized individually packaged beverages (typically canned beers, ales and stouts), by which gas at high pressure is stored within the package for jetting into the beverage as the package is opened to atmosphere. One embodiment comprises a length of tube (10) having a gas jetting orifice (14) which in use is submerged below the beverage in a pressurized can having a gaseous headspace, which can be used to charge the tube with gas during the passage of the filled can (16) along a conventional canning line, on which the can is inverted after filling which brings the orifice into the gaseous headspace. A more preferred design of device comprises a molded plastics capsule (34; 50;78) secured near the bottom of a can (20, 88) with an internal, preferably central, pipe (56; 62; 80) to provide a liquid seal to prevent loss of gas when the can is inverted from the upright position, and an airlock when the can is upright, to prevent beverage which has entered the capsule from leaving it when the can is opened to atmosphere. A further design of capsule (96) having a central internal pipe (98) and adapted to be pressurized solely by the ingress of beverage, which is fitted midway down the can (94) but which still only jets gas on opening, is also described.

Abstract translation: PCT No.PCT / GB93 / 02639 Sec。 371日期：1995年6月20日 102（e）1995年6月20日PCT 1993年12月23日PCT公布。 出版物WO94 / 14678 日期1994年7月7日描述适用于加压单独包装的饮料（通常是罐装啤酒，啤酒和烈酒），其中高压气体储存在包装内以便在包装被打开到大气中时喷射到饮料中。 一个实施例包括具有气体喷射孔（14）的一段长度的管（10），其在使用中浸没在具有气体顶部空间的加压罐内的饮料下方，该顶部空间可用于在通过期间用气体对气体进行充气 沿着传统的罐头线（16），罐体在填充之后被倒置，使得孔口进入气体顶部空间。 更优选的装置设计包括：模制塑料胶囊（34; 50; 78），其固定在具有内部，优选中心管（56; 62; 80）的罐（20,88）的底部附近，以提供液体密封 以防止当罐从直立位置反转时气体的损失，以及当罐直立时的气闸，以防止当罐被打开到大气时进入胶囊的饮料离开。 还描述了具有中心内部管道（98）并且适于仅通过饮料进入而加压的胶囊（96）的另一种设计，饮料进入中部位于罐（94）的中间，但仍然仅在开口处喷射气体， 。

公开(公告)号：US06600256B2

公开(公告)日：2003-07-29

申请号：US09811644

申请日：2001-03-19

Applicant: Edwin Van Lier ,  Godefridus Nicolaas Maria Verspaget ,  Petrus Jacobus Govardus Mies ,  Hans-Peter Erich Mews

Inventor： Edwin Van Lier ,  Godefridus Nicolaas Maria Verspaget ,  Petrus Jacobus Govardus Mies ,  Hans-Peter Erich Mews

IPC: H01J548

CPC classification number: H01K1/46 ,  H01J5/54

Abstract: The electric lamp has a light source (20) in an outer bulb (21). The light source (20) is secured in an envelope (1) by means of an insulator body (40) in which current connection conductors (43) are integrated and which is present in a lamp cap (10) of the reflector lamp. The lamp cap (10) is mechanically connected to a neck portion (5) of the envelope (1). The integrated insulator/current connector body (40, 43) enables electrical contacting, fixation, and mechanical adjustment of the light source (20) in the envelope (1).

Abstract translation: 电灯在外灯泡（21）中具有光源（20）。 光源（20）通过绝缘体（40）固定在封套（1）中，其中电流连接导体（43）被集成在一起，并且存在于反射灯的灯头（10）中。 灯头（10）机械地连接到外壳（1）的颈部（5）。 集成的绝缘体/电流连接器主体（40,43）能够使信封（1）中的光源（20）进行电接触，固定和机械调节。

公开(公告)号：US20090123397A1

公开(公告)日：2009-05-14

申请号：US11988670

申请日：2006-07-11

Applicant: Ken Seal ,  Peter Erich Hahn

Inventor： Ken Seal ,  Peter Erich Hahn

IPC: A01N43/56 ,  A01P1/00 ,  A61K8/49 ,  A61Q17/04 ,  C11D3/48 ,  C09D5/14 ,  C09D5/00 ,  C08K5/47 ,  C10L1/22 ,  C10M135/36

CPC classification number: A61Q17/005 ,  A61K8/345 ,  A61K8/49

Abstract: A microbiocidal composition comprising: a non-halogenated 2-alkyl-3-isothiazolone, and chlorphenesin and/or an alkane diol, wherein the alkyl group in the non-halogenated 2-alkyl-3-isothiazolone comprises 1 to 4 carbon atoms, the alkane diol comprises from 5 to 12 carbon atoms, and the hydroxyl groups of the alkane diol are vicinally substituted.

Abstract translation: 一种杀微生物组合物，其包含：非卤代2-烷基-3-异噻唑酮和氯苯醚和/或烷二醇，其中非卤代2-烷基-3-异噻唑酮中的烷基包含1至4个碳原子， 烷二醇包含5至12个碳原子，链烷二醇的羟基被相邻取代。

公开(公告)号：US6058965A

公开(公告)日：2000-05-09

申请号：US929017

申请日：1997-09-15

Applicant: Bernd Kujawaski ,  Peter Erich ,  Jean-Claude Zapata

Inventor： Bernd Kujawaski ,  Peter Erich ,  Jean-Claude Zapata

IPC: F16K27/02 ,  F16K51/00 ,  B23K20/12 ,  F16K27/10

CPC classification number: F16K51/00 ,  F16K27/0254 ,  Y10T29/49412 ,  Y10T29/49425 ,  Y10T29/49826 ,  Y10T29/53

Abstract: A flow-control valve has an outer housing assembly including an outer housing member, a tube fixed to the member and having an inner end remote from the member, and an end collar of high-alloy steel welded on the tube end. An inner housing member is formed of nonferrous metal with an inlet port and an outlet port and a valve seat between the ports. The end collar is seated in the inner housing member and a valve stem has an outer end at the outer housing member and an inner end projecting into the inner housing member and guided in the end collar, extending through the tube between the members, and carrying a valve body sealingly engageable with the seat. A connecting sleeve engaged around and fitted snugly to the end collar and inner member has an outer ring of high-alloy steel welded to the end collar and an inner ring of nonferrous metal, fixed integrally to the outer ring, and welded to the inner member.

Abstract translation: 流量控制阀具有外部壳体组件，其包括外部壳体构件，固定到构件并具有远离构件的内部端部的管和焊接在管端上的高合金钢的端部套环。 内壳构件由有色金属形成，具有入口和出口以及端口之间的阀座。 端部套环位于内部壳体构件中，并且阀杆在外部壳体构件处具有外端，并且内端突出到内部壳体构件中并且在端部轴环中被引导，在构件之间延伸穿过管，并且承载 阀体与阀座密封地接合。 连接套筒并且紧密地装配到端部套环和内部构件上，具有焊接到端部套环的高合金钢外圈和与所述外圈一体地固定的有色金属内圈，并且焊接到内部构件 。

公开(公告)号：US5874405A

公开(公告)日：1999-02-23

申请号：US368834

申请日：1994-12-16

Applicant: Gary Birnbaum ,  Linda K. Kotilinek ,  Peter Erich Braun

Inventor： Gary Birnbaum ,  Linda K. Kotilinek ,  Peter Erich Braun

IPC: A61K38/00 ,  A61P37/00 ,  A61P37/02 ,  C07K14/35 ,  C07K14/47 ,  C12N9/16

CPC classification number: C07K14/35 ,  C07K14/4713 ,  C12N9/16 ,  A61K38/00

Abstract: The invention provides for peptides and methods of using peptides to block or inhibit a pathogenic autoimmune response to central nervous system components. The peptides are antigens derived from mycobacterial heat shock proteins and that immunologically crossreact with or are homologous to myelin components. The peptides can also be derived from myelin components such as 2',3' cyclic nucleotide phosphodiesterase and that immunologically crossreact and/or are homologous to mycobacterial heat shock proteins. A method of the invention involves administering a pharmaceutical composition including at least one peptide to an animal in an amount effective to block or inhibit a pathogenic autoimmune response to central nervous system components. The peptides are useful for the prevention, and treatment of autoimmune inflammatory central nervous system disease.

Abstract translation: 本发明提供了使用肽阻断或抑制对中枢神经系统组分的致病性自身免疫应答的肽和方法。 肽是来自分枝杆菌热休克蛋白的抗原，并且与髓鞘成分免疫交叉或与髓鞘成分同源。 肽还可以衍生自髓鞘组分如2'，3'环核苷酸磷酸二酯酶，并且与免疫交叉反应和/或与分枝杆菌热休克蛋白同源。 本发明的方法包括向动物施用包含至少一种肽的药物组合物，其量可有效阻断或抑制对中枢神经系统组分的致病性自身免疫应答。 该肽可用于预防和治疗自身免疫性中枢神经系统疾病。

公开(公告)号：US5657749A

公开(公告)日：1997-08-19

申请号：US392741

申请日：1995-03-07

Applicant: Peter Erich Cox

Inventor： Peter Erich Cox

IPC: A61M15/00

CPC classification number: A61M15/0045 ,  A61M2202/064

Abstract: The invention relates to an inhalation device by which powdered material can be inhaled. A plurality of powder containers, each having a powder containing depression therein, may be individually fed to a use station which cooperates with an inhalation means. The inhalation means includes an outlet communicating with the open container by a passage, which passage has a wall means which cooperates with the powder containing depression to define a venturi.

Abstract translation: PCT No.PCT / EP93 / 02439 Sec。 371日期：1995年3月7日 102（e）1995年3月7日PCT PCT 1993年9月9日PCT公布。 出版物WO94 / 06497 日期：1994年3月31日本发明涉及吸入粉末状物质的吸入装置。 可以将多个粉末容器单独地供给到与吸入装置配合的使用站中，每个粉末容器均具有含有凹陷的粉末。 吸入装置包括通过通道与开口容器连通的出口，该通道具有与装有粉末的凹陷配合以限定文丘里管的壁装置。