公开(公告)号：US20100280507A1

公开(公告)日：2010-11-04

申请号：US12770572

申请日：2010-04-29

申请人： Alexei BABKIN ,  Peter LITTRUP ,  William NYDAM ,  Barron NYDAM

发明人： Alexei BABKIN ,  Peter LITTRUP ,  William NYDAM ,  Barron NYDAM

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2018/00214 ,  A61B2018/0212 ,  A61B2018/0262

摘要： A cryoablation system includes thermally insulated containers for holding liquid refrigerant. The containers are placed in a docking station that charges the containers with a liquid refrigerant at a cryogenic temperature suitable for carrying out a surgical procedure. The charged containers are detachably connectable with an inlet line of a cryoablation probe. When the cryoprobe is activated, the chilled liquid refrigerant is transported from a delivery container, through the cryoprobe, and to a recovery container. The recovery container is preferably identical in design to the delivery container. The refilled recovery container is then placed in the docking station to charge. In another embodiment, a cartridge includes a delivery container and recovery container combined as a single unit. Methods are also described.

摘要翻译： 冷冻消融系统包括用于保持液体制冷剂的隔热容器。 容器放置在对接站中，该对接站在适于执行外科手术的低温温度下用液体制冷剂对容器充电。 带电容器可与冷冻消融探针的入口管线可拆卸地连接。 当冷冻探针被激活时，冷冻的液体制冷剂从输送容器输送通过冷冻探针，并传送到回收容器。 回收容器的设计优选与输送容器相同。 然后将再填充的回收容器放置在对接站中以进行充电。 在另一个实施例中，盒包括作为单个单元组合的输送容器和回收容器。 还描述了方法。

公开(公告)号：US09095320B2

公开(公告)日：2015-08-04

申请号：US13246120

申请日：2011-09-27

申请人： Peter Littrup ,  Alexei Babkin ,  Barron Nydam ,  William Nydam

发明人： Peter Littrup ,  Alexei Babkin ,  Barron Nydam ,  William Nydam

IPC分类号： A61B18/20 ,  A61B18/02 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00589 ,  A61B2018/0212 ,  A61B2018/0268

摘要： A method for cryo-induced renal neuromodulation includes applying cryoenergy to neural fibers that contribute to renal function, or to vascular structures that contact, feed or perfuse the neural fibers. In one embodiment, cryoenergy is applied via a distal energy-delivering section of a flexible catheter. The distal section may include a plurality of microtubes for transporting a cryogen to the distal tip. The energy-delivering section contacts and extracts heat from the wall of the renal artery. In one embodiment, the distal energy-delivering section is radially expandable. The renal nerve is cooled to a degree such that nerve function is disrupted.

摘要翻译： 一种用于冷冻诱导的肾神经调节的方法包括向有助于肾功能的神经纤维应用冷冻能量，或将神经纤维接触，进食或灌注的血管结构应用。 在一个实施例中，通过柔性导管的远端能量输送部分施加低温能量。 远端部分可以包括多个用于将冷冻剂输送到远侧末端的微管。 能量输送部分从肾动脉的壁接触并提取热量。 在一个实施例中，远侧能量输送部分是可径向扩张的。 将肾神经冷却到使神经功能受到破坏的程度。

公开(公告)号：US20130345688A1

公开(公告)日：2013-12-26

申请号：US13980609

申请日：2011-08-26

申请人： Alexei Babkin ,  Peter Littrup ,  Barron Nydam ,  William Nydam

发明人： Alexei Babkin ,  Peter Littrup ,  Barron Nydam ,  William Nydam

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61M2025/1086 ,  A61M2025/1093

摘要： Cryoablation balloon catheters and methods are described herein. The cryoablation balloon catheter comprises a distal end section and an inflatable balloon member disposed along the distal end section for contacting a target tissue. The balloon member may be inflated with a thermally conductive liquid. One or more cooling microtubes are positioned within the balloon and a single phase liquid coolant is transported from a liquid source, through the microtubes to the distal section, and returned to a reservoir. Cryogenic energy is transferred from the microtubes, through the conductive liquid filling the balloon, through the wall of the balloon, and to the tissue. In a cryoablation balloon catheter, a plurality of flexible microtubes are adhered to a surface of the expandable balloon. Cryoenergy from the microtubes is directly transferred to the tissue.

摘要翻译： 本文描述了冷冻消融气囊导管和方法。 冷冻消融气囊导管包括远端部分和沿着远端部分设置的用于接触靶组织的可充气气囊部件。 球囊构件可以用导热液体充气。 一个或多个冷却微管定位在球囊内，并且单相液体冷却剂从液体源通过微管输送到远端部分，并返回到储存器。 低温能量从微管，通过填充气囊的导电液体通过球囊壁传递到组织。 在冷冻消融气囊导管中，多个柔性微管粘附到可膨胀气囊的表面。 来自微管的冷冻能量直接转移到组织。

公开(公告)号：US07499745B2

公开(公告)日：2009-03-03

申请号：US09794612

申请日：2001-02-27

申请人： Peter Littrup ,  Robert Duncan

发明人： Peter Littrup ,  Robert Duncan

IPC分类号： A61B5/05

CPC分类号： A61B5/4312 ,  A61B5/053 ,  A61B5/4869 ,  A61B5/6806 ,  G01N33/48728

摘要： A method and apparatus that use complex impedance measurements of tissue in human or animal bodies for the detection and characterization of medical pathologies is disclosed. An analysis of the complex impedance measurements is performed by a trained evaluation system that uses a nonlinear continuum model to analyze the resistive, capacitive, and inductive measurements collected from a plurality of sensing electrodes. The analysis of the impedance measurements results in the construction of a multidimensional space that defines the tissue characteristics, which the trained evaluation system uses to detect and characterize pathologies. The method and apparatus are sufficiently general to be applied to various types of human and animal tissues for the analysis of various types of medical pathologies.

摘要翻译： 公开了一种使用人体或动物体中的组织的复杂阻抗测量来检测和表征医学病症的方法和装置。 复杂阻抗测量的分析由经过训练的评估系统执行，该系统使用非线性连续模型来分析从多个感测电极收集的电阻，电容和感应测量。 阻抗测量的分析导致定义组织特征的多维空间的构造，训练的评估系统用于检测和表征病理学。 所述方法和装置足够普遍以适用于各种类型的人和动物组织用于分析各种类型的医学病理学。

公开(公告)号：US09408655B2

公开(公告)日：2016-08-09

申请号：US13980632

申请日：2011-10-27

申请人： Alexei Babkin ,  Peter Littrup ,  William Nydam

发明人： Alexei Babkin ,  Peter Littrup ,  William Nydam

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2018/0268

摘要： A cryoablation apparatus includes a distal energy delivery section to facilitate energy transfer to the tissue, resulting in faster achievement of tissue target temperatures. The energy delivery section includes a first heat exchange region and a second heat exchange region having a different heat exchange efficiency than the first heat exchange region. The first heat exchange region may comprise an increased surface area along a radial portion or length of the cryoprobe in contact with surrounding tissue. The heat exchange region may include ridges, texture, threads, and microtubes which serve to increase the thermal-contacting surface area and provide enhanced cryoenergy to the tissue.

摘要翻译： 冷冻消融装置包括远端能量输送部分，以促进能量转移到组织，从而更快地实现组织靶温度。 能量传递部分包括具有与第一热交换区域不同的热交换效率的第一热交换区域和第二热交换区域。 第一热交换区域可以包括沿着与周围组织接触的冷冻探针的径向部分或长度的增加的表面积。 热交换区域可以包括用于增加热接触表面面积的脊，纹理，螺纹和微管，并向组织提供增强的低温能。

公开(公告)号：US09402676B2

公开(公告)日：2016-08-02

申请号：US13980609

申请日：2011-08-26

申请人： Alexei Babkin ,  Peter Littrup ,  Barron Nydam ,  William Nydam

发明人： Alexei Babkin ,  Peter Littrup ,  Barron Nydam ,  William Nydam

IPC分类号： A61B18/02 ,  A61M25/10 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61M2025/1086 ,  A61M2025/1093

摘要： Cryoablation balloon catheters and methods are described herein. The cryoablation balloon catheter comprises a distal end section and an inflatable balloon member disposed along the distal end section for contacting a target tissue. The balloon member may be inflated with a thermally conductive liquid. One or more cooling microtubes are positioned within the balloon and a single phase liquid coolant is transported from a liquid source, through the microtubes to the distal section, and returned to a reservoir. Cryogenic energy is transferred from the microtubes, through the conductive liquid filling the balloon, through the wall of the balloon, and to the tissue. In a cryoablation balloon catheter, a plurality of flexible microtubes are adhered to a surface of the expandable balloon. Cryoenergy from the microtubes is directly transferred to the tissue.

摘要翻译： 本文描述了冷冻消融气囊导管和方法。 冷冻消融气囊导管包括远端部分和沿着远端部分设置的用于接触靶组织的可充气气囊部件。 球囊构件可以用导热液体充气。 一个或多个冷却微管定位在球囊内，并且单相液体冷却剂从液体源通过微管输送到远端部分，并返回到储存器。 低温能量从微管，通过填充气囊的导电液体通过球囊壁传递到组织。 在冷冻消融气囊导管中，多个柔性微管粘附到可膨胀气囊的表面。 来自微管的冷冻能量直接转移到组织。

公开(公告)号：US08888768B2

公开(公告)日：2014-11-18

申请号：US12770572

申请日：2010-04-29

申请人： Alexei Babkin ,  Peter Littrup ,  William Nydam ,  Barron Nydam

发明人： Alexei Babkin ,  Peter Littrup ,  William Nydam ,  Barron Nydam

IPC分类号： A61B18/02 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2018/00214 ,  A61B2018/0212 ,  A61B2018/0262

摘要： A cryoablation system includes thermally insulated containers for holding liquid refrigerant. The containers are placed in a docking station that charges the containers with a liquid refrigerant at a cryogenic temperature suitable for carrying out a surgical procedure. The charged containers are detachably connectable with an inlet line of a cryoablation probe. When the cryoprobe is activated, the chilled liquid refrigerant is transported from a delivery container, through the cryoprobe, and to a recovery container. The recovery container is preferably identical in design to the delivery container. The refilled recovery container is then placed in the docking station to charge. In another embodiment, a cartridge includes a delivery container and recovery container combined as a single unit. Methods are also described.

摘要翻译： 冷冻消融系统包括用于保持液体制冷剂的隔热容器。 容器放置在对接站中，该对接站在适于执行外科手术的低温温度下用液体制冷剂对容器充电。 带电容器可与冷冻消融探针的入口管线可拆卸地连接。 当冷冻探针被激活时，冷冻的液体制冷剂从输送容器输送通过冷冻探针，并传送到回收容器。 回收容器的设计优选与输送容器相同。 然后将再填充的回收容器放置在对接站中以进行充电。 在另一个实施例中，盒包括作为单个单元组合的输送容器和回收容器。 还描述了方法。

公开(公告)号：US20050033273A1

公开(公告)日：2005-02-10

申请号：US10941511

申请日：2004-09-14

申请人： Peter Littrup ,  Seth Stabinsky ,  Kevin Bladel ,  Lisa Zindel ,  Glenn Foy

发明人： Peter Littrup ,  Seth Stabinsky ,  Kevin Bladel ,  Lisa Zindel ,  Glenn Foy

IPC分类号： A61B17/00 ,  A61B18/00 ,  A61B18/02 ,  A61B19/00

CPC分类号： A61B18/02 ,  A61B2017/00084 ,  A61B2017/00132 ,  A61B2017/00199 ,  A61B2018/00041 ,  A61B2090/378

摘要： A cryosurgical system adapted for treatment of fibroadenomas within the breast of a patient. The system includes cryoprobes and a control system which operates the cryoprobes to accomplish freezing in two stages, including a high power freeze and a low power freeze.

摘要翻译： 适用于治疗患者乳房内纤维腺瘤的冷冻手术系统。 该系统包括冷冻探针和控制系统，其操作冷冻探针以两个阶段完成冷冻，包括高功率冻结和低功率冷冻。

公开(公告)号：US20130331829A1

公开(公告)日：2013-12-12

申请号：US13980632

申请日：2011-10-27

申请人： Alexei Babkin ,  Peter Littrup ,  William Nydam

发明人： Alexei Babkin ,  Peter Littrup ,  William Nydam

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2018/0268

摘要： A cryoablation apparatus includes a distal energy delivery section to facilitate energy transfer to the tissue, resulting in faster achievement of tissue target temperatures. The energy delivery section includes a first heat exchange region and a second heat exchange region having a different heat exchange efficiency than the first heat exchange region. The first heat exchange region may comprise an increased surface area along a radial portion or length of the cryoprobe in contact with surrounding tissue. The heat exchange region may include ridges, texture, threads, and microtubes which serve to increase the thermal-contacting surface area and provide enhanced cryoenergy to the tissue.

摘要翻译： 冷冻消融装置包括远端能量输送部分，以促进能量转移到组织，从而更快地实现组织靶温度。 能量传递部分包括具有与第一热交换区域不同的热交换效率的第一热交换区域和第二热交换区域。 第一热交换区域可以包括沿着与周围组织接触的冷冻探针的径向部分或长度的增加的表面积。 热交换区域可以包括用于增加热接触表面积并且向组织提供增强的低温能量的脊，纹理，螺纹和微管。

公开(公告)号：US20080119836A1

公开(公告)日：2008-05-22

申请号：US12018403

申请日：2008-01-23

申请人： PETER LITTRUP ,  ALEXEI BABKIN ,  ROBERT DUNCAN ,  PRAMOD KERKAR ,  SERGEY BOLDAREV

发明人： PETER LITTRUP ,  ALEXEI BABKIN ,  ROBERT DUNCAN ,  PRAMOD KERKAR ,  SERGEY BOLDAREV

IPC分类号： A61B18/18

CPC分类号： A61B18/02 ,  A61B18/0218 ,  A61B2018/00529 ,  A61B2018/00547 ,  A61B2018/00577 ,  A61B2018/0262

摘要： A gas-based cryotherapy probe is provided with a shaft having a closed distal end adapted for insertion into a body. A supply conduit is disposed longitudinally within the shaft for flowing gas towards the distal end, and a return conduit is disposed longitudinally within the shaft for flowing gas from the distal end. The gas is maintained at a lower pressure within the return conduit than in the supply conduit. A heat exchanger is disposed within the shaft in thermal communication with the supply conduit and return conduit to exchange heat from gas in the supply conduit to gas in the return conduit. A vacuum jacket is adapted to provide thermal isolation of the heat exchanger from the shaft.

摘要翻译： 基于气体的冷冻治疗探针设置有具有适于插入体内的封闭远端的轴。 供应管道纵向设置在轴内以使气体朝向远端流动，并且回流管道纵向设置在轴内以用于从远端流动气体。 气体在返回管道内比在供应管道中保持较低的压力。 热交换器设置在轴内，与供应管道和返回管道热连通，以将来自供应管道中的气体的热量与返回管道中的气体进行热交换。 真空夹套适于提供热交换器与轴的热隔离。