公开(公告)号：US09408655B2

公开(公告)日：2016-08-09

申请号：US13980632

申请日：2011-10-27

申请人： Alexei Babkin ,  Peter Littrup ,  William Nydam

发明人： Alexei Babkin ,  Peter Littrup ,  William Nydam

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2018/0268

摘要： A cryoablation apparatus includes a distal energy delivery section to facilitate energy transfer to the tissue, resulting in faster achievement of tissue target temperatures. The energy delivery section includes a first heat exchange region and a second heat exchange region having a different heat exchange efficiency than the first heat exchange region. The first heat exchange region may comprise an increased surface area along a radial portion or length of the cryoprobe in contact with surrounding tissue. The heat exchange region may include ridges, texture, threads, and microtubes which serve to increase the thermal-contacting surface area and provide enhanced cryoenergy to the tissue.

摘要翻译： 冷冻消融装置包括远端能量输送部分，以促进能量转移到组织，从而更快地实现组织靶温度。 能量传递部分包括具有与第一热交换区域不同的热交换效率的第一热交换区域和第二热交换区域。 第一热交换区域可以包括沿着与周围组织接触的冷冻探针的径向部分或长度的增加的表面积。 热交换区域可以包括用于增加热接触表面面积的脊，纹理，螺纹和微管，并向组织提供增强的低温能。

公开(公告)号：US09402676B2

公开(公告)日：2016-08-02

申请号：US13980609

申请日：2011-08-26

申请人： Alexei Babkin ,  Peter Littrup ,  Barron Nydam ,  William Nydam

发明人： Alexei Babkin ,  Peter Littrup ,  Barron Nydam ,  William Nydam

IPC分类号： A61B18/02 ,  A61M25/10 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61M2025/1086 ,  A61M2025/1093

摘要： Cryoablation balloon catheters and methods are described herein. The cryoablation balloon catheter comprises a distal end section and an inflatable balloon member disposed along the distal end section for contacting a target tissue. The balloon member may be inflated with a thermally conductive liquid. One or more cooling microtubes are positioned within the balloon and a single phase liquid coolant is transported from a liquid source, through the microtubes to the distal section, and returned to a reservoir. Cryogenic energy is transferred from the microtubes, through the conductive liquid filling the balloon, through the wall of the balloon, and to the tissue. In a cryoablation balloon catheter, a plurality of flexible microtubes are adhered to a surface of the expandable balloon. Cryoenergy from the microtubes is directly transferred to the tissue.

摘要翻译： 本文描述了冷冻消融气囊导管和方法。 冷冻消融气囊导管包括远端部分和沿着远端部分设置的用于接触靶组织的可充气气囊部件。 球囊构件可以用导热液体充气。 一个或多个冷却微管定位在球囊内，并且单相液体冷却剂从液体源通过微管输送到远端部分，并返回到储存器。 低温能量从微管，通过填充气囊的导电液体通过球囊壁传递到组织。 在冷冻消融气囊导管中，多个柔性微管粘附到可膨胀气囊的表面。 来自微管的冷冻能量直接转移到组织。

公开(公告)号：US08888768B2

公开(公告)日：2014-11-18

申请号：US12770572

申请日：2010-04-29

申请人： Alexei Babkin ,  Peter Littrup ,  William Nydam ,  Barron Nydam

发明人： Alexei Babkin ,  Peter Littrup ,  William Nydam ,  Barron Nydam

IPC分类号： A61B18/02 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2018/00214 ,  A61B2018/0212 ,  A61B2018/0262

摘要： A cryoablation system includes thermally insulated containers for holding liquid refrigerant. The containers are placed in a docking station that charges the containers with a liquid refrigerant at a cryogenic temperature suitable for carrying out a surgical procedure. The charged containers are detachably connectable with an inlet line of a cryoablation probe. When the cryoprobe is activated, the chilled liquid refrigerant is transported from a delivery container, through the cryoprobe, and to a recovery container. The recovery container is preferably identical in design to the delivery container. The refilled recovery container is then placed in the docking station to charge. In another embodiment, a cartridge includes a delivery container and recovery container combined as a single unit. Methods are also described.

摘要翻译： 冷冻消融系统包括用于保持液体制冷剂的隔热容器。 容器放置在对接站中，该对接站在适于执行外科手术的低温温度下用液体制冷剂对容器充电。 带电容器可与冷冻消融探针的入口管线可拆卸地连接。 当冷冻探针被激活时，冷冻的液体制冷剂从输送容器输送通过冷冻探针，并传送到回收容器。 回收容器的设计优选与输送容器相同。 然后将再填充的回收容器放置在对接站中以进行充电。 在另一个实施例中，盒包括作为单个单元组合的输送容器和回收容器。 还描述了方法。

公开(公告)号：US09095320B2

公开(公告)日：2015-08-04

申请号：US13246120

申请日：2011-09-27

申请人： Peter Littrup ,  Alexei Babkin ,  Barron Nydam ,  William Nydam

发明人： Peter Littrup ,  Alexei Babkin ,  Barron Nydam ,  William Nydam

IPC分类号： A61B18/20 ,  A61B18/02 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00589 ,  A61B2018/0212 ,  A61B2018/0268

摘要： A method for cryo-induced renal neuromodulation includes applying cryoenergy to neural fibers that contribute to renal function, or to vascular structures that contact, feed or perfuse the neural fibers. In one embodiment, cryoenergy is applied via a distal energy-delivering section of a flexible catheter. The distal section may include a plurality of microtubes for transporting a cryogen to the distal tip. The energy-delivering section contacts and extracts heat from the wall of the renal artery. In one embodiment, the distal energy-delivering section is radially expandable. The renal nerve is cooled to a degree such that nerve function is disrupted.

摘要翻译： 一种用于冷冻诱导的肾神经调节的方法包括向有助于肾功能的神经纤维应用冷冻能量，或将神经纤维接触，进食或灌注的血管结构应用。 在一个实施例中，通过柔性导管的远端能量输送部分施加低温能量。 远端部分可以包括多个用于将冷冻剂输送到远侧末端的微管。 能量输送部分从肾动脉的壁接触并提取热量。 在一个实施例中，远侧能量输送部分是可径向扩张的。 将肾神经冷却到使神经功能受到破坏的程度。

公开(公告)号：US20130345688A1

公开(公告)日：2013-12-26

申请号：US13980609

申请日：2011-08-26

申请人： Alexei Babkin ,  Peter Littrup ,  Barron Nydam ,  William Nydam

发明人： Alexei Babkin ,  Peter Littrup ,  Barron Nydam ,  William Nydam

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61M2025/1086 ,  A61M2025/1093

摘要： Cryoablation balloon catheters and methods are described herein. The cryoablation balloon catheter comprises a distal end section and an inflatable balloon member disposed along the distal end section for contacting a target tissue. The balloon member may be inflated with a thermally conductive liquid. One or more cooling microtubes are positioned within the balloon and a single phase liquid coolant is transported from a liquid source, through the microtubes to the distal section, and returned to a reservoir. Cryogenic energy is transferred from the microtubes, through the conductive liquid filling the balloon, through the wall of the balloon, and to the tissue. In a cryoablation balloon catheter, a plurality of flexible microtubes are adhered to a surface of the expandable balloon. Cryoenergy from the microtubes is directly transferred to the tissue.

摘要翻译： 本文描述了冷冻消融气囊导管和方法。 冷冻消融气囊导管包括远端部分和沿着远端部分设置的用于接触靶组织的可充气气囊部件。 球囊构件可以用导热液体充气。 一个或多个冷却微管定位在球囊内，并且单相液体冷却剂从液体源通过微管输送到远端部分，并返回到储存器。 低温能量从微管，通过填充气囊的导电液体通过球囊壁传递到组织。 在冷冻消融气囊导管中，多个柔性微管粘附到可膨胀气囊的表面。 来自微管的冷冻能量直接转移到组织。

公开(公告)号：US20130331829A1

公开(公告)日：2013-12-12

申请号：US13980632

申请日：2011-10-27

申请人： Alexei Babkin ,  Peter Littrup ,  William Nydam

发明人： Alexei Babkin ,  Peter Littrup ,  William Nydam

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2018/0268

摘要： A cryoablation apparatus includes a distal energy delivery section to facilitate energy transfer to the tissue, resulting in faster achievement of tissue target temperatures. The energy delivery section includes a first heat exchange region and a second heat exchange region having a different heat exchange efficiency than the first heat exchange region. The first heat exchange region may comprise an increased surface area along a radial portion or length of the cryoprobe in contact with surrounding tissue. The heat exchange region may include ridges, texture, threads, and microtubes which serve to increase the thermal-contacting surface area and provide enhanced cryoenergy to the tissue.

摘要翻译： 冷冻消融装置包括远端能量输送部分，以促进能量转移到组织，从而更快地实现组织靶温度。 能量传递部分包括具有与第一热交换区域不同的热交换效率的第一热交换区域和第二热交换区域。 第一热交换区域可以包括沿着与周围组织接触的冷冻探针的径向部分或长度的增加的表面积。 热交换区域可以包括用于增加热接触表面积并且向组织提供增强的低温能量的脊，纹理，螺纹和微管。

公开(公告)号：US20120253336A1

公开(公告)日：2012-10-04

申请号：US13246120

申请日：2011-09-27

申请人： Peter Littrup ,  Alexei Babkin ,  Barron Nydam ,  William Nydam

发明人： Peter Littrup ,  Alexei Babkin ,  Barron Nydam ,  William Nydam

IPC分类号： A61B18/20

CPC分类号： A61B18/02 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00589 ,  A61B2018/0212 ,  A61B2018/0268

摘要： A method for cryo-induced renal neuromodulation includes applying cryoenergy to neural fibers that contribute to renal function, or to vascular structures that contact, feed or perfuse the neural fibers. In one embodiment, cryoenergy is applied via a distal energy-delivering section of a flexible catheter. The distal section may include a plurality of microtubes for transporting a cryogen to the distal tip. The energy-delivering section contacts and extracts heat from the wall of the renal artery. In one embodiment, the distal energy-delivering section is radially expandable. The renal nerve is cooled to a degree such that nerve function is disrupted.

摘要翻译： 一种用于冷冻诱导的肾神经调节的方法包括向有助于肾功能的神经纤维应用冷冻能量，或将神经纤维接触，进食或灌注的血管结构应用。 在一个实施例中，通过柔性导管的远端能量输送部分施加低温能量。 远端部分可以包括多个用于将冷冻剂输送到远侧末端的微管。 能量输送部分从肾动脉的壁接触并提取热量。 在一个实施例中，远侧能量输送部分是可径向扩张的。 将肾神经冷却到使神经功能受到破坏的程度。

公开(公告)号：US08475441B2

公开(公告)日：2013-07-02

申请号：US12643919

申请日：2009-12-21

申请人： Alexei Babkin ,  Peter Littrup

发明人： Alexei Babkin ,  Peter Littrup

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B34/10 ,  A61B90/39 ,  A61B2017/00084 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00714 ,  A61B2018/00744 ,  A61B2018/00797 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/378

摘要： A system and method for use with at least one cryoprobe for the treatment of biological tissue controls the energy applied to the tissue. The invention receives live procedure data such as temperature information from locations along the pathway of the cryogenic liquids, and calculates a procedure signature or profile based on the procedure data. In one embodiment, volumetric isotherms are calculated. The procedure signature is compared to a planning signature based on previously acquired image data and estimates of the thermal gradients from models. The system and method are further configured to automatically regulate the application of power based on analysis of the planning data to the procedure data.

摘要翻译： 与用于治疗生物组织的至少一个冷冻探针一起使用的系统和方法控制施加到组织的能量。 本发明从沿着低温液体的路径的位置接收诸如温度信息的实时程序数据，并且基于过程数据计算过程签名或简档。 在一个实施例中，计算体积等温线。 将程序签名与基于先前获取的图像数据的计划签名和来自模型的热梯度的估计进行比较。 该系统和方法还被配置为基于对规划数据的分析来自动调节功率的应用程序数据。

公开(公告)号：US20100168725A1

公开(公告)日：2010-07-01

申请号：US12643919

申请日：2009-12-21

申请人： Alexei Babkin ,  Peter Littrup

发明人： Alexei Babkin ,  Peter Littrup

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B34/10 ,  A61B90/39 ,  A61B2017/00084 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00714 ,  A61B2018/00744 ,  A61B2018/00797 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/378

摘要： A system and method for use with at least one cryoprobe for the treatment of biological tissue controls the energy applied to the tissue. The invention receives live procedure data such as temperature information from locations along the pathway of the cryogenic liquids, and calculates a procedure signature or profile based on the procedure data. In one embodiment, volumetric isotherms are calculated. The procedure signature is compared to a planning signature based on previously acquired image data and estimates of the thermal gradients from models. The system and method are further configured to automatically regulate the application of power based on analysis of the planning data to the procedure data.

摘要翻译： 与用于治疗生物组织的至少一个冷冻探针一起使用的系统和方法控制施加到组织的能量。 本发明从沿着低温液体的路径的位置接收诸如温度信息的实时程序数据，并且基于过程数据计算过程签名或简档。 在一个实施例中，计算体积等温线。 将程序签名与基于先前获取的图像数据的计划签名和来自模型的热梯度的估计进行比较。 该系统和方法还被配置为基于对规划数据的分析来自动调节功率的应用程序数据。

公开(公告)号：US20060235375A1

公开(公告)日：2006-10-19

申请号：US11447356

申请日：2006-06-06

申请人： Peter Littrup ,  Alexei Babkin ,  Robert Duncan ,  Sergey Boldarev

发明人： Peter Littrup ,  Alexei Babkin ,  Robert Duncan ,  Sergey Boldarev

IPC分类号： A61B18/02

CPC分类号： F25D3/10 ,  A61B18/02 ,  A61B18/0218 ,  A61B2018/00017 ,  A61B2018/00023 ,  A61B2018/0262 ,  A61B2018/0293

摘要： A cryotherapy system is provided with multiple cryoprobes, each of which has a shaft with a closed distal end adapted for insertion into a body and conduits for flowing a cryogenic fluid through the shaft to reduce a temperature of the distal end. A source is provided for the cryogenic fluid, and flow-control metering valves are provided in fluid communication with the conduits and source of the cryogenic fluid. A compressor is provided in fluid communication with the conduits of the cryoprobes to define a self-contained fluid system. The flow-control metering valves and the compressor are controlled by a computer processor to provide the desired flows of the cryogenic fluid through the conduits of the self-contained fluid system.