公开(公告)号：US20070098720A1

公开(公告)日：2007-05-03

申请号：US11613409

申请日：2006-12-20

Applicant: David Thomas ,  Mark de Boer ,  Pieter Res ,  Peter Simons

Inventor： David Thomas ,  Mark de Boer ,  Pieter Res ,  Peter Simons

IPC: A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C07K16/28

CPC classification number: A61K39/39541 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/2878 ,  C07K2317/31 ,  A61K2300/00

Abstract: Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.

Abstract translation: 公开了可以结合并刺激专业和非专业人抗原呈递细胞（“APC”）的激动剂抗CD40分子，包括单克隆抗体，增强CD40L对CD40阳性细胞的刺激作用和/或诱导表型成熟 的单核细胞来源的树突状细胞。 提供了几种这样的单克隆抗体，并且生产它们的细胞系已经保藏在美国典型培养物保藏中心。

公开(公告)号：US07232659B1

公开(公告)日：2007-06-19

申请号：US10771853

申请日：2004-02-04

Applicant: Larry A. Sklar ,  Eric R. Prossnitz ,  Peter Simons ,  Anna Waller ,  Daniel Cimino ,  Sean Biggs

Inventor： Larry A. Sklar ,  Eric R. Prossnitz ,  Peter Simons ,  Anna Waller ,  Daniel Cimino ,  Sean Biggs

IPC: G01N33/53 ,  G01N33/566 ,  G01N27/00 ,  G01N21/76 ,  C07N1/00

CPC classification number: G01N33/74 ,  G01N33/537 ,  Y10T436/13

Abstract: The present invention relates generally to molecular assemblies, more particularly to an assay for the detection of G-protein coupled receptor (GPCR) molecular assemblies and bead-based detection of ligand-GPCR complexes and to methods for identifying compounds as agonists, partial agonists or antagonists of the binding of G-protein coupled receptors to G-protein and for use of these compounds in the treatment of conditions or disease states in a mammalian subject or patient, including humans, where G-protein coupled receptor binding to G-protein is implicated.

Abstract translation: 本发明一般涉及分子组装，更具体地涉及用于检测G蛋白偶联受体（GPCR）分子组装和基于珠子的配体-GPCR复合物的检测方法，以及鉴定化合物作为激动剂，部分激动剂或 G蛋白偶联受体与G蛋白结合的拮抗剂，以及这些化合物用于治疗哺乳动物受试者或患者（包括人）中的条件或疾病状态的用途，其中G蛋白偶联受体结合G蛋白是 牵连

公开(公告)号：US06576316B2

公开(公告)日：2003-06-10

申请号：US09891723

申请日：2001-06-26

Applicant: Jan-Peter Simons ,  Hans-Eckard Weitsch ,  Fred-Roderich Pohl

Inventor： Jan-Peter Simons ,  Hans-Eckard Weitsch ,  Fred-Roderich Pohl

IPC: B32B1504

CPC classification number: B32B15/08 ,  C09J7/28 ,  F16F9/306 ,  Y10T428/14 ,  Y10T428/1438 ,  Y10T428/1443 ,  Y10T428/1457 ,  Y10T428/1471 ,  Y10T428/2804 ,  Y10T428/2839 ,  Y10T428/2848 ,  Y10T428/31678

Abstract: A metal strip, more particularly a metal strip for producing vibration damping moldings, is provided with a layer of adhesive viscoelastic plastics and permits coiling and comprises an anti-adhesive film-type coating. In a method of producing a metal strip, the metal strip is preferably degreased, preferably stretched, possibly pretreated and coated one-sided with an adhesive viscoelastic plastics. In addition, an anti-adhesive film is applied to the metal strip.

Abstract translation: 金属带，更具体地，用于制造振动阻尼模制品的金属带，设置有粘合剂粘弹性塑料层并且允许卷绕并且包括抗粘合膜型涂层。在制造金属带的方法中，金属带 优选脱脂，优选拉伸，可能预处理并用粘合剂粘弹性塑料单面涂覆。 此外，将抗粘剂膜施加到金属条上。

公开(公告)号：US4027046A

公开(公告)日：1977-05-31

申请号：US549119

申请日：1975-02-11

Applicant: Benno Bohm ,  Hermann Genth ,  Peter Schober ,  Peter Simons

Inventor： Benno Bohm ,  Hermann Genth ,  Peter Schober ,  Peter Simons

IPC: A23L2/80 ,  C12H1/044 ,  C12H1/048 ,  A23B7/00 ,  C12G1/00 ,  C12G1/02

CPC classification number: C12H1/0408 ,  A23L2/80

Abstract: In the fining of a protein-containing beverage such as a fruit juice or a grape or fruit wine or a must therefor in unfermented, partially fermented or fermented form, wherein silica sol is added to said beverage, and the deposit formed is separated off, the improvement which comprises adding an aluminate-modified silica sol to said beverage, whereby the protein removing and flocculation occurs more readily than with unmodified silica sol. The aluminate is preferably added in the form of sodium aluminate. Optionally gelatin is also added.

Abstract translation: 在含蛋白质的饮料如果汁或葡萄或​​水果酒的澄清中，或者是以未发酵的，部分发酵的或发酵的形式进行澄清，其中将硅溶胶加入到所述饮料中，形成的沉积物被分离出来， 其改进包括向所述饮料中加入铝酸盐改性的二氧化硅溶胶，由此与未改性的二氧化硅溶胶相比，更容易发生蛋白质去除和絮凝。 铝酸盐优选以铝酸钠的形式加入。 也可加入明胶。