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公开(公告)号：US20120058943A1
公开(公告)日：2012-03-08
申请号：US13131295
申请日：2008-11-28
CPC分类号： A61K9/107 , A61K31/727 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2300/602 , C08B37/0075 , C08B37/0081 , C08J3/075 , C08J3/246 , C08J5/18 , C08J2305/10 , C08J2371/02 , C08L5/10
摘要： The invention relates to a bioactive hydrogel as a hybrid material of heparin and star-branched polyethylene glycol with functionalized end groups, wherein the heparin is bound directly by reaction of the carboxyl groups activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimides/N-hydroxysulfosuccinimide (EDC/s-NHS) with the terminal amino groups of the polyethylene glycol covalently by amide bonds.
摘要翻译： 本发明涉及作为具有官能化端基的肝素和星形支链聚乙二醇的混合材料的生物活性水凝胶，其中肝素通过与1-乙基-3-（3-二甲基氨基丙基）碳二亚胺活化的羧基反应而直接结合 / N-羟基磺基琥珀酰亚胺（EDC / s-NHS）与聚乙二醇的末端氨基通过酰胺键共价。
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公开(公告)号：US08859706B2
公开(公告)日：2014-10-14
申请号：US13131295
申请日：2008-11-28
IPC分类号： A61L33/08 , A61L33/10 , A61L33/12 , A61K38/18 , A61K47/42 , A61K47/36 , C08B37/10 , C08J5/18 , C08J3/075 , C08B37/00 , C08L5/10 , A61L27/54 , A61L27/52 , C08J3/24
CPC分类号： A61K9/107 , A61K31/727 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2300/602 , C08B37/0075 , C08B37/0081 , C08J3/075 , C08J3/246 , C08J5/18 , C08J2305/10 , C08J2371/02 , C08L5/10
摘要： The invention relates to a bioactive hydrogel as a hybrid material of heparin and star-branched polyethylene glycol with functionalized end groups, wherein the heparin is bound directly by reaction of the carboxyl groups activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimides/N-hydroxysulfosuccinimide (EDC/s-NHS) with the terminal amino groups of the polyethylene glycol covalently by amide bonds.
摘要翻译： 本发明涉及作为具有官能化端基的肝素和星形支链聚乙二醇的混合材料的生物活性水凝胶，其中肝素通过与1-乙基-3-（3-二甲基氨基丙基）碳二亚胺活化的羧基反应而直接结合 / N-羟基磺基琥珀酰亚胺（EDC / s-NHS）与聚乙二醇的末端氨基通过酰胺键共价。
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