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6 条记录 (耗时 0.012 秒)

    Salmonella vaccine
    2.
    发明授权
    Salmonella vaccine 有权
    沙门氏菌疫苗

    公开(公告)号：US07045122B2

    公开(公告)日：2006-05-16

    申请号：US10432102

    申请日：2001-11-15

    申请人： Petrus Johannes Maria Nuijten ,  Maarten Hendrik Witvliet

    发明人： Petrus Johannes Maria Nuijten ,  Maarten Hendrik Witvliet

    IPC分类号： A01N63/00 ,  A61K39/00 ,  A61K39/02 ,  A61K39/112

    CPC分类号： C12R1/42 ,  A61K39/0275 ,  A61K2039/522 ,  Y02A50/482

    摘要： The present invention relates to live attenuated Salmonella strains comprising a first attenuating mutation, that are not capable of making functional RecA. The invention also relates to these bacteria for use in vaccines. Furthermore, the invention relates to vaccines based upon these bacteria, to the use of such bacteria in the manufacture of vaccines and to methods for the preparation of such vaccines.

    摘要翻译： 本发明涉及不能制备功能性RecA的包含第一减毒突变的活减毒沙门氏菌菌株。 本发明还涉及用于疫苗的这些细菌。 此外，本发明涉及基于这些细菌的疫苗，这种细菌在制备疫苗中的用途以及制备这种疫苗的方法。

    Campylobacter vaccine
    4.
    发明授权
    Campylobacter vaccine 失效
    弯曲杆菌疫苗

    公开(公告)号：US06787137B1

    公开(公告)日：2004-09-07

    申请号：US09544683

    申请日：2000-04-07

    申请人： Antonius Arnoldus Christiaan Jacobs ,  Johannes Franciscus van den Bosch ,  Petrus Johannes Maria Nuijten

    发明人： Antonius Arnoldus Christiaan Jacobs ,  Johannes Franciscus van den Bosch ,  Petrus Johannes Maria Nuijten

    IPC分类号： A61K39395

    CPC分类号： A61K39/105 ,  A61K2039/505 ,  A61K2039/5252 ,  C07K14/205 ,  C07K16/121 ,  Y02A50/47 ,  Y10S424/826

    摘要： The present invention relates to vaccines comprising antiserum raised against a flagellaless Campylobacter strain for the prevention of Campylobacter colonisation in animals. The invention also relates to antigenic Campylobacter proteins visible in a Western blot of Campylobacter jejuni protein after incubation of said Western blot with antibodies against a flagellaless mutant of Campylobacter jejuni and not visible after incubation of said blot with antibodies against wild type Campylobacter jejuni, and to their use in vaccines and the manufacturing thereof. The invention further relates to vaccines comprising such proteins and antibodies against such proteins. The invention further relates to the use of such Campylobacter proteins and to antiserum and antibodies raised against Campylobacter antigens for the preparation of vaccines. Finally, the invention relates to methods for the preparation of such vaccines.

    摘要翻译： 本发明涉及包含抗鞭毛弯曲杆菌菌株产生的用于预防动物弯曲杆菌定植的抗血清的疫苗。 本发明还涉及在所述蛋白质印迹与抗空肠弯曲杆菌的无鞭毛虫突变体的抗体孵育后在空肠弯曲杆菌蛋白质的Western印迹中可见的抗原性弯曲杆菌蛋白质，并且在用野生型空肠弯曲杆菌抗体孵育后不可见， 它们在疫苗中的应用及其制造。 本发明还涉及包含这种蛋白质和针对这种蛋白质的抗体的疫苗。 本发明还涉及这种弯曲杆菌蛋白质的用途以及抗弯曲杆菌抗原产生的用于制备疫苗的抗血清和抗体。 最后，本发明涉及制备这种疫苗的方法。

    Campylobacter vaccine
    5.
    发明授权
    Campylobacter vaccine 失效
    弯曲杆菌疫苗

    公开(公告)号：US06790446B2

    公开(公告)日：2004-09-14

    申请号：US10192419

    申请日：2002-07-10

    申请人： Antonius Arnoldus Christiaan Jacobs ,  Johannes Franciscus van den Bosch ,  Petrus Johannes Maria Nuijten

    发明人： Antonius Arnoldus Christiaan Jacobs ,  Johannes Franciscus van den Bosch ,  Petrus Johannes Maria Nuijten

    IPC分类号： A61K3900

    CPC分类号： A61K39/105 ,  A61K2039/505 ,  A61K2039/5252 ,  C07K14/205 ,  C07K16/121 ,  Y02A50/47 ,  Y10S424/826

    摘要： The present invention relates to vaccines comprising antiserum raised against a flagellaless Campylobacter strain for the prevention of Campylobacter colonization in animals. The invention also relates to antigenic Campylobacter proteins visible in a Western blot of Campylobacter jejuni protein after incubation of said Western blot with antibodies against a flagellaless mutant of Campylobacter jejuni and not visible after incubation of said blot with antibodies against wild type Campylobacter jejuni, and to their use in vaccines and the manufacturing thereof. The invention further relates to vaccines comprising such proteins and antibodies against such proteins. The invention further relates to the use of such Campylobacter proteins and to antiserum and antibodies raised against Campylobacter antigens for the preparation of vaccines. Finally, the invention relates to methods for the preparation of such vaccines.

    摘要翻译： 本发明涉及包含抗鞭毛弯曲杆菌菌株产生的用于预防动物弯曲杆菌定植的抗血清的疫苗。 本发明还涉及在所述蛋白质印迹与抗空肠弯曲杆菌的无鞭毛虫突变体的抗体孵育后在空肠弯曲杆菌蛋白质的Western印迹中可见的抗原性弯曲杆菌蛋白质，并且在用野生型空肠弯曲杆菌抗体孵育后不可见， 它们在疫苗中的应用及其制造。 本发明还涉及包含这种蛋白质和针对这种蛋白质的抗体的疫苗。 本发明还涉及这种弯曲杆菌蛋白质的用途以及抗弯曲杆菌抗原产生的用于制备疫苗的抗血清和抗体。 最后，本发明涉及制备这种疫苗的方法。

    Streptococcus uberis protein, nucleic acid sequence encoding the same and its use in a mastitis vaccine
    6.
    发明授权
    Streptococcus uberis protein, nucleic acid sequence encoding the same and its use in a mastitis vaccine 失效
    乳房链球菌蛋白，编码相同的核酸序列及其在乳腺炎疫苗中的应用

    公开(公告)号：US07601804B2

    公开(公告)日：2009-10-13

    申请号：US10524198

    申请日：2003-08-06

    申请人： Petrus Johannes Maria Nuijten ,  Selma Marianne Hensen

    发明人： Petrus Johannes Maria Nuijten ,  Selma Marianne Hensen

    IPC分类号： C07K1/00 ,  G01N33/569

    CPC分类号： C07K14/315 ,  A61K39/00

    摘要： The present invention relates to nucleic acid sequences encoding a 22.5 kD Streptococcus uberis protein and to parts of such nucleic acid sequences that encode an immunogenic fragment of such proteins, and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to a 22.5 kD Streptococcus uberis protein and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, proteins or immunogenic parts thereof and antibodies against such proteins or immunogenic parts thereof. Also, the invention relates to the use of said proteins in vaccines and for the manufacture of vaccines. Moreover, the invention relates to the use of said nucleic acid sequences, proteins or antibodies for diagnostic or vaccination purposes. Finally the invention relates to diagnostic kits comprising such a nucleic acid, protein or antibodies against such protein.

    摘要翻译： 本发明涉及编码22.5kD乳房链球菌蛋白质的核酸序列和编码这种蛋白质的免疫原性片段的这些核酸序列的部分，以及DNA片段，重组DNA分子，活重组载体和包含该核酸的宿主细胞 酸序列或其部分。 本发明还涉及由这样的序列编码的22.5kD乳房链球菌蛋白及其免疫原性部分。 此外，本发明涉及包含此类核酸序列及其部分的DNA疫苗，DNA片段，重组DNA分子，活重组载体和包含此类核酸序列或其部分的宿主细胞，蛋白质或其免疫原性部分和针对此类蛋白质的抗体 或其免疫原性部分。 此外，本发明涉及所述蛋白质在疫苗中的用途以及制造疫苗。 此外，本发明涉及用于诊断或疫苗接种目的的所述核酸序列，蛋白质或抗体的用途。 最后，本发明涉及包含这种核酸，蛋白质或抗这种蛋白质的抗体的诊断试剂盒。