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    Campylobacter vaccine
    5.
    发明授权
    Campylobacter vaccine 失效
    弯曲杆菌疫苗

    公开(公告)号：US06790446B2

    公开(公告)日：2004-09-14

    申请号：US10192419

    申请日：2002-07-10

    申请人： Antonius Arnoldus Christiaan Jacobs ,  Johannes Franciscus van den Bosch ,  Petrus Johannes Maria Nuijten

    发明人： Antonius Arnoldus Christiaan Jacobs ,  Johannes Franciscus van den Bosch ,  Petrus Johannes Maria Nuijten

    IPC分类号： A61K3900

    CPC分类号： A61K39/105 ,  A61K2039/505 ,  A61K2039/5252 ,  C07K14/205 ,  C07K16/121 ,  Y02A50/47 ,  Y10S424/826

    摘要： The present invention relates to vaccines comprising antiserum raised against a flagellaless Campylobacter strain for the prevention of Campylobacter colonization in animals. The invention also relates to antigenic Campylobacter proteins visible in a Western blot of Campylobacter jejuni protein after incubation of said Western blot with antibodies against a flagellaless mutant of Campylobacter jejuni and not visible after incubation of said blot with antibodies against wild type Campylobacter jejuni, and to their use in vaccines and the manufacturing thereof. The invention further relates to vaccines comprising such proteins and antibodies against such proteins. The invention further relates to the use of such Campylobacter proteins and to antiserum and antibodies raised against Campylobacter antigens for the preparation of vaccines. Finally, the invention relates to methods for the preparation of such vaccines.

    摘要翻译： 本发明涉及包含抗鞭毛弯曲杆菌菌株产生的用于预防动物弯曲杆菌定植的抗血清的疫苗。 本发明还涉及在所述蛋白质印迹与抗空肠弯曲杆菌的无鞭毛虫突变体的抗体孵育后在空肠弯曲杆菌蛋白质的Western印迹中可见的抗原性弯曲杆菌蛋白质，并且在用野生型空肠弯曲杆菌抗体孵育后不可见， 它们在疫苗中的应用及其制造。 本发明还涉及包含这种蛋白质和针对这种蛋白质的抗体的疫苗。 本发明还涉及这种弯曲杆菌蛋白质的用途以及抗弯曲杆菌抗原产生的用于制备疫苗的抗血清和抗体。 最后，本发明涉及制备这种疫苗的方法。

    Pasteurella multocida vaccine
    10.
    发明授权
    Pasteurella multocida vaccine 失效
    巴氏杆菌多杀巴斯德疫苗

    公开(公告)号：US4999191A

    公开(公告)日：1991-03-12

    申请号：US190533

    申请日：1988-05-05

    申请人： John R. Glisson ,  Charles L. Hofacre

    发明人： John R. Glisson ,  Charles L. Hofacre

    IPC分类号： A61K39/102

    CPC分类号： A61K39/102 ,  Y10S424/826 ,  Y10S424/83

    摘要： Mutogenesis of the Clemson University (CU) vaccine strain of P. multocida with N-methyl-N-nitro-N-nitrosoguanidine resulted in temperature sensitive (TS) mutants which grew at 37.degree. C. but not 42.degree. C. Two mutants, PM#1 and PM#3, were found to provide turkeys with a level of protection against challenge with a virulent serotype 3 P. multocida strain (P-1059) comparable to the protection provided by the CU strain. Intravenous (IV) inoculation of PM#1, PM#3, and CU was used to determine differences in virulence. PM#1 and PM#3 resulted in lower mortality and lameness than the CU strain. Histopathological evaluation of spleens at 24, 48, and 72 hours post IV inoculation demonstrated that the CU strain induced 2 times more splenic necrosis than either PM#1 or PM#3.

    摘要翻译： 具有N-甲基-N-硝基-N-亚硝基胍的多杀巴氏杆菌克隆斯大学（CU）疫苗株的发生导致温度敏感（TS）突变体，其在37℃而不是42℃生长。两个突变体， 发现PM＃1和PM＃3为具有与CU菌株提供的保护相当的强毒血清型3 P.多球菌菌株（P-1059）提供了一定的防御水平的火鸡。 使用PM＃1，PM＃3和CU的静脉内（IV）接种来确定毒力的差异。 PM＃1和PM＃3导致比CU菌株更低的死亡率和跛行。 IV接种后24,48和72小时脾脏的组织病理学评估表明，CU菌株比PM＃1或PM＃3诱导2倍以上的脾坏死。