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1.发明申请METHOD FOR PREPARING AND ANALYZING CELLS HAVING CHROMOSOMAL ABNORMALITIES 审中-公开用于制备和分析具有染色体异常的细胞的方法公开(公告)号：US20100240062A1
公开(公告)日：2010-09-23
申请号：US12790346
申请日：2010-05-28
CPC分类号： C12Q1/6841
摘要： The present invention provides methods for preparing cells with highly condensed chromosomes, such as sperm, and methods for detecting and quantifying specific cellular target molecules in intact cells. Specifically, methods are provided for detecting chromosomes and chromosomal abnormalities, including aneuploidy, in intact cells using fluorescence in situ hybridization of cells in suspension, such as sperm cells.
摘要翻译： 本发明提供了制备具有高浓度染色体的细胞如精子的方法，以及用于检测和定量完整细胞中特异性细胞靶分子的方法。 具体地，提供了使用荧光原位杂交细胞悬浮液（如精子细胞）来检测完整细胞中染色体和染色体异常（包括非整倍体）的方法。
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公开(公告)号：US08953866B2
公开(公告)日：2015-02-10
申请号：US13460682
申请日：2012-04-30
申请人： Thaddeus C. George , David A. Basiji , Brian E. Hall , William E. Ortyn , Michael J. Seo , Philip J. Morrissey , Cathleen A. Zimmerman
发明人： Thaddeus C. George , David A. Basiji , Brian E. Hall , William E. Ortyn , Michael J. Seo , Philip J. Morrissey , Cathleen A. Zimmerman
CPC分类号： G01N21/53 , G01N15/14 , G01N15/1475 , G01N21/6428 , G01N21/645 , G01N21/6456 , G01N2021/6423 , G01N2021/6439 , G01N2021/6482
摘要： Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.
摘要翻译： 提供了用于确定和分析小物体（诸如识别不同细胞状态的细胞）的光度和形态特征的方法。 特别地，提供了用于鉴定凋亡细胞的方法，并且用于区分经历细胞凋亡的细胞与坏死。
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公开(公告)号：US20110280467A1
公开(公告)日：2011-11-17
申请号：US13191270
申请日：2011-07-26
申请人： Thaddeus C. George , David A. Basiji , Brian E. Hall , William E. Ortyn , Michael J. Seo , Philip J. Morrissey , Cathleen A. Zimmerman
发明人： Thaddeus C. George , David A. Basiji , Brian E. Hall , William E. Ortyn , Michael J. Seo , Philip J. Morrissey , Cathleen A. Zimmerman
IPC分类号： G06K9/00
CPC分类号： G06K9/00127 , G01N15/1475 , G01N21/47 , G01N21/645 , G01N21/6456 , G01N2021/6423 , G01N2021/6439 , G01N2021/6482 , G06K9/00147
摘要： Provided are methods for determining and analyzing photometric and morphogenic features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.
摘要翻译： 提供了用于确定和分析小物体（例如，识别不同细胞状态的细胞）的光度和形态特征的方法。 特别地，提供了用于鉴定凋亡细胞的方法，并且用于区分经历细胞凋亡的细胞与坏死。
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公开(公告)号：US20120100532A1
公开(公告)日：2012-04-26
申请号：US13302941
申请日：2011-11-22
申请人： Thaddeus C. George , David A. Basiji , Brian E. Hall , William E. Ortyn , Michael J. Seo , Philip J. Morrissey , Cathleen A. Zimmerman
发明人： Thaddeus C. George , David A. Basiji , Brian E. Hall , William E. Ortyn , Michael J. Seo , Philip J. Morrissey , Cathleen A. Zimmerman
CPC分类号： G06K9/00127 , G01N15/1475 , G01N21/47 , G01N21/645 , G01N21/6456 , G01N2021/6423 , G01N2021/6439 , G01N2021/6482 , G06K9/00147
摘要： Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.
摘要翻译： 提供了用于确定和分析小物体（诸如识别不同细胞状态的细胞）的光度和形态特征的方法。 特别地，提供了用于鉴定凋亡细胞的方法，并且用于区分经历细胞凋亡的细胞与坏死。
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公开(公告)号：US20080240539A1
公开(公告)日：2008-10-02
申请号：US10593016
申请日：2005-03-16
申请人： Thaddeus C. George , David A. Basiji , Brian E. Hall , William E. Ortyn , Michael J. Seo , Philip J. Morrissey , Cathleen A. Zimmerman
发明人： Thaddeus C. George , David A. Basiji , Brian E. Hall , William E. Ortyn , Michael J. Seo , Philip J. Morrissey , Cathleen A. Zimmerman
CPC分类号： G06K9/00127 , G01N15/1475 , G01N21/47 , G01N21/645 , G01N21/6456 , G01N2021/6423 , G01N2021/6439 , G01N2021/6482 , G06K9/00147
摘要： Provided are methods for determining and analyzing photometric and morphogenic features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.
摘要翻译： 提供了用于确定和分析小物体（例如，识别不同细胞状态的细胞）的光度和形态特征的方法。 特别地，提供了用于鉴定凋亡细胞的方法，并且用于区分经历细胞凋亡的细胞与坏死。
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6.发明申请METHODS FOR PREPARING AND ANALYZING CELLS HAVING CHROMOSOMAL ABNORMALITIES 审中-公开用于制备和分析具有染色体异常的细胞的方法公开(公告)号：US20080138816A1
公开(公告)日：2008-06-12
申请号：US11838138
申请日：2007-08-13
CPC分类号： B82Y5/00 , B82Y15/00 , C12Q1/6841 , C12Q2565/619
摘要： The present invention provides methods for preparing cells with highly condensed chromosomes, such as sperm, and methods for detecting and quantifying specific cellular target molecules in intact cells. Specifically, methods are provided for detecting chromosomes and chromosomal abnormalities, including aneuploidy, in intact cells using fluorescence in situ hybridization of cells in suspension, such as sperm cells.
摘要翻译： 本发明提供了制备具有高浓度染色体的细胞如精子的方法，以及用于检测和定量完整细胞中特异性细胞靶分子的方法。 具体地，提供了使用荧光原位杂交细胞悬浮液（如精子细胞）来检测完整细胞中染色体和染色体异常（包括非整倍体）的方法。
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公开(公告)号：US20120328177A1
公开(公告)日：2012-12-27
申请号：US13460682
申请日：2012-04-30
申请人： Thaddeus C. George , David A. Basiji , Brian E. Hall , William E. Ortyn , Michael J. Seo , Philip J. Morrissey , Cathleen A. Zimmerman
发明人： Thaddeus C. George , David A. Basiji , Brian E. Hall , William E. Ortyn , Michael J. Seo , Philip J. Morrissey , Cathleen A. Zimmerman
IPC分类号： G06K9/62
CPC分类号： G01N21/53 , G01N15/14 , G01N15/1475 , G01N21/6428 , G01N21/645 , G01N21/6456 , G01N2021/6423 , G01N2021/6439 , G01N2021/6482
摘要： Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.
摘要翻译： 提供了用于确定和分析小物体（诸如识别不同细胞状态的细胞）的光度和形态特征的方法。 特别地，提供了用于鉴定凋亡细胞的方法，并且用于区分经历细胞凋亡的细胞与坏死。
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公开(公告)号：US08103080B2
公开(公告)日：2012-01-24
申请号：US10593016
申请日：2005-03-16
申请人： Thaddeus C George , David A Basiji , Brian E Hall , William E Ortyn , Michael J Seo , Philip J Morrissey , Cathleen A Zimmerman
发明人： Thaddeus C George , David A Basiji , Brian E Hall , William E Ortyn , Michael J Seo , Philip J Morrissey , Cathleen A Zimmerman
IPC分类号： G06K9/00
CPC分类号： G06K9/00127 , G01N15/1475 , G01N21/47 , G01N21/645 , G01N21/6456 , G01N2021/6423 , G01N2021/6439 , G01N2021/6482 , G06K9/00147
摘要： Provided are methods for determining and analyzing photometric and morphogenic features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.
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9.发明授权Treatment of bacterial diseases with granulocyte-macrophage colony stimulating factor 失效用粒细胞巨噬细胞集落刺激因子治疗细菌性疾病
公开(公告)号：US5162111A
公开(公告)日：1992-11-10
申请号：US892123
申请日：1986-07-30
IPC分类号： A61K38/00 , A61P31/04 , C07K14/535
CPC分类号： C07K14/535 , A61K38/00 , Y10S930/145
摘要： Subjects suffering from infectious diseases are treated by direct administration of therapeutically-effective quantities of granulocyte-macrophage colony stimulating factor employed by itself or in conjunction with an antibiotic or a sulfonamide or other immunologically effective therapeutic agents. Homogeneous granulocyte-macrophage colony stimulating factor for use in treatment in bacterial diseases is prepared by recombinant DNA techniques and then purified to homogeneity by reverse phase high-performance liquid chromatography so that it may be safely administered to subject's suffering from infectious diseases.
摘要翻译： 患有感染性疾病的受试者通过直接施用治疗有效量的粒细胞 - 巨噬细胞集落刺激因子来治疗，所述粒细胞 - 巨噬细胞集落刺激因子本身或与抗生素或磺酰胺或其他免疫学上有效的治疗剂一起使用。 通过重组DNA技术制备用于细菌性疾病治疗的均匀粒细胞 - 巨噬细胞集落刺激因子，然后通过反相高效液相色谱纯化至均匀，从而可以安全地施用受试者感染性疾病。
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