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公开(公告)号:US20090131399A1
公开(公告)日:2009-05-21
申请号:US11886785
申请日:2006-03-29
申请人: Thomas Fuchss , Andreas Strub , Wolf-Rudiger Ulrich , Christian Hesslinger , Martin Lehner , Raimund Kulzer , Rainer Boer , Manfrid Eltze
发明人: Thomas Fuchss , Andreas Strub , Wolf-Rudiger Ulrich , Christian Hesslinger , Martin Lehner , Raimund Kulzer , Rainer Boer , Manfrid Eltze
IPC分类号: A61K31/397 , C07D223/02 , A61P29/00 , A61K31/55
CPC分类号: C07D471/04
摘要: The compounds of formula (I) in which R1, R11 and A have the meanings as given in the description are novel effective iNOS inhibitors.
摘要翻译: 其中R1,R11和A具有如本说明书中给出的含义的式(I)化合物是新的有效的iNOS抑制剂。
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公开(公告)号:US20100317650A1
公开(公告)日:2010-12-16
申请号:US12849571
申请日:2010-08-03
申请人: Thomas FUCHSS , Andreas STRUB , Wolf-Rüdiger ULRICH , Christian HESSLINGER , Martin LEHNER , Raimund Külzer , Rainer BOER , Manfrid ELTZE
发明人: Thomas FUCHSS , Andreas STRUB , Wolf-Rüdiger ULRICH , Christian HESSLINGER , Martin LEHNER , Raimund Külzer , Rainer BOER , Manfrid ELTZE
CPC分类号: C07D471/04
摘要: The compounds of formula (I) in which R1, R11 and A have the meanings as given in the description are novel effective iNOS inhibitors.
摘要翻译: 其中R1,R11和A具有如本说明书中给出的含义的式(I)化合物是新的有效的iNOS抑制剂。
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公开(公告)号:US20060184286A1
公开(公告)日:2006-08-17
申请号:US11319000
申请日:2005-12-27
IPC分类号: G05D11/00
CPC分类号: G21C5/00 , G21C7/00 , G21C21/00 , G21D3/001 , G21D2003/002 , G21Y2002/201 , G21Y2002/202 , G21Y2002/204 , G21Y2002/304 , G21Y2004/40 , Y02E30/39
摘要: In a computer modeling method for the core of a nuclear reactor the core is divided into a plurality of primary grids in the form of coarse mesh cells. A sub-section of the core relating to at least one grid is assigned to that grid. The sub-section includes that grid and a buffer zone that surrounds the grid horizontally and contains at least the grid that lies immediately adjacent to the first grid. The sub-section is sub-divided into a plurality of secondary grids—fine mesh cells—that are smaller than the primary grids. In a first computing step, a model of the core is calculated using a nodal calculation method, based on a respective dataset that is assigned to each primary grid. In a second computing step, a respective second dataset is assigned to each secondary grid of a sub-section and a model is then calculated for the sub-section, based on the dataset and the flows on the border of the sub-section that have been calculated in the first computing step.
摘要翻译: 在用于核反应堆的核心的计算机建模方法中,核心被分为多个粗网格细胞形式的主网格。 与至少一个网格相关的核心的子部分被分配给该网格。 该子部分包括网格和缓冲区,其横向包围网格,并且至少包含紧邻第一网格的网格。 该子部分被细分为多个次网格 - 细网格单元 - 小于一次网格。 在第一计算步骤中,基于分配给每个主网格的相应数据集,使用节点计算方法来计算核心的模型。 在第二计算步骤中,将相应的第二数据集分配给子部分的每个次级网格,然后基于数据集和具有所述子部分的子部分的边界上的流动来为子部分计算模型 在第一计算步骤中计算。
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公开(公告)号:US07790710B2
公开(公告)日:2010-09-07
申请号:US11886785
申请日:2006-03-29
申请人: Thomas Fuchss , Andreas Strub , Wolf-Rüdiger Ulrich , Christian Hesslinger , Martin Lehner , Raimund Külzer , Rainer Boer , Manfrid Eltze
发明人: Thomas Fuchss , Andreas Strub , Wolf-Rüdiger Ulrich , Christian Hesslinger , Martin Lehner , Raimund Külzer , Rainer Boer , Manfrid Eltze
IPC分类号: A01N43/00 , A61K31/55 , A01N43/46 , A01N43/90 , A61K31/519 , C07D413/00 , C07D415/00 , C07D417/00 , C07D419/00 , C07D513/02 , C07D515/02 , C07D403/02
CPC分类号: C07D471/04
摘要: The compounds of formula (I) in which R1, R11 and A have the meanings as given in the description are novel effective iNOS inhibitors.
摘要翻译: 其中R1,R11和A具有如本说明书中给出的含义的式(I)化合物是新的有效的iNOS抑制剂。
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