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公开(公告)号：US20100317650A1
公开(公告)日：2010-12-16
申请号：US12849571
申请日：2010-08-03
申请人： Thomas FUCHSS , Andreas STRUB , Wolf-Rüdiger ULRICH , Christian HESSLINGER , Martin LEHNER , Raimund Külzer , Rainer BOER , Manfrid ELTZE
发明人： Thomas FUCHSS , Andreas STRUB , Wolf-Rüdiger ULRICH , Christian HESSLINGER , Martin LEHNER , Raimund Külzer , Rainer BOER , Manfrid ELTZE
CPC分类号： C07D471/04
摘要： The compounds of formula (I) in which R1, R11 and A have the meanings as given in the description are novel effective iNOS inhibitors.
摘要翻译： 其中R1，R11和A具有如本说明书中给出的含义的式（I）化合物是新的有效的iNOS抑制剂。
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2.发明申请NOVEL N-SUBSTITUTED TETRAHYDROISOQUINOLINE/ISOINDOLINE HYDROXAMIC ACID COMPOUNDS 失效新型N-取代的四氢喹啉啉/异辛醇羟基酸化合物公开(公告)号：US20110201643A1
公开(公告)日：2011-08-18
申请号：US12921821
申请日：2009-03-12
IPC分类号： A61K31/4725 , C07D401/02 , C07D217/06 , A61K31/472 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61P19/00 , A61P37/06 , A61P29/00 , A61P9/00 , A61P31/18 , A61P25/28 , A61P11/00
CPC分类号： C07D217/06 , C07D401/06 , C07D401/12 , C07D405/06
摘要： Compounds of a certain formula (I) wherein R1, R2, R3, X, Y, r, s, t, u and v have the meanings as defined in the specification, and the salts, solvates and hydrates thereof are novel effective HDAC 6 inhibitors.
摘要翻译： 其中R1，R2，R3，X，Y，r，s，t，u和v具有本说明书中定义的含义的某种式（I）的化合物及其盐，溶剂化物和水合物是新的有效的HDAC 6 抑制剂。
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公开(公告)号：US20090131399A1
公开(公告)日：2009-05-21
申请号：US11886785
申请日：2006-03-29
申请人： Thomas Fuchss , Andreas Strub , Wolf-Rudiger Ulrich , Christian Hesslinger , Martin Lehner , Raimund Kulzer , Rainer Boer , Manfrid Eltze
发明人： Thomas Fuchss , Andreas Strub , Wolf-Rudiger Ulrich , Christian Hesslinger , Martin Lehner , Raimund Kulzer , Rainer Boer , Manfrid Eltze
IPC分类号： A61K31/397 , C07D223/02 , A61P29/00 , A61K31/55
CPC分类号： C07D471/04
摘要： The compounds of formula (I) in which R1, R11 and A have the meanings as given in the description are novel effective iNOS inhibitors.
摘要翻译： 其中R1，R11和A具有如本说明书中给出的含义的式（I）化合物是新的有效的iNOS抑制剂。
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![3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives](/abs-image/US/2015/04/28/US09018175B2/abs.jpg.150x150.jpg)
4.发明授权3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives 有权3,4,4a，10b-四氢-1H-噻喃并[4,3-c]异喹啉衍生物公开(公告)号：US09018175B2
公开(公告)日：2015-04-28
申请号：US13515214
申请日：2010-12-15
申请人： Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
发明人： Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
IPC分类号： A61K31/56 , A61K31/519 , A61K31/5585 , C07D495/04 , C07D519/00
CPC分类号： C07D519/00
摘要： The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
摘要翻译： 其中A，R1，R2，R3和R5具有如说明书中给出的含义的式（1）化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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![NOVEL 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO[4,3-C] ISOQUINOLINE COMPOUNDS](/abs-image/US/2014/04/24/US20140113877A1/abs.jpg.150x150.jpg)
5.发明申请NOVEL 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO[4,3-C] ISOQUINOLINE COMPOUNDS 审中-公开新的3,4,4A，10B-四氢-1H-苯并[4,3-C]异喹啉化合物公开(公告)号：US20140113877A1
公开(公告)日：2014-04-24
申请号：US14124446
申请日：2012-06-12
申请人： Dieter Flockerzi , Alexander Mann , Thomas Stengel , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Clemens Braun , Ewald Benediktus , Andreas Pahl , Raimund Kuelzer , Degenhard Marx
发明人： Dieter Flockerzi , Alexander Mann , Thomas Stengel , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Clemens Braun , Ewald Benediktus , Andreas Pahl , Raimund Kuelzer , Degenhard Marx
IPC分类号： C07D519/00 , A61K45/06 , A61K31/519
CPC分类号： C07D519/00 , A61K31/519 , A61K45/06 , C07D495/04
摘要： The compounds of formula (1) in which A, X, R1, R2, R3 and R7 have the meanings as given in the description, are novel effective inhibitors of type 4 and type 5 phosphodiesterase.
摘要翻译： 其中A，X，R1，R2，R3和R7具有说明书中给出的含义的式（1）化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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6.发明授权N-substituted tetrahydroisoquinoline/isoindoline hydroxamic acid compounds 失效N-取代四氢异喹啉/异二氢吲哚异羟肟酸化合物公开(公告)号：US08575193B2
公开(公告)日：2013-11-05
申请号：US12921821
申请日：2009-03-12
IPC分类号： C07D217/06 , C07D401/02 , A61K31/472
CPC分类号： C07D217/06 , C07D401/06 , C07D401/12 , C07D405/06
摘要： Compounds of a certain formula (I) wherein R1, R2, R3, X, Y, r, s, t, u and v have the meanings as defined in the specification, and the salts, solvates and hydrates thereof are novel effective HDAC 6 inhibitors.
摘要翻译： 其中R1，R2，R3，X，Y，r，s，t，u和v具有本说明书中定义的含义的某种式（I）的化合物及其盐，溶剂化物和水合物是新的有效的HDAC 6 抑制剂。
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公开(公告)号：US20070049599A1
公开(公告)日：2007-03-01
申请号：US10576712
申请日：2004-10-29
IPC分类号： A61K31/525
CPC分类号： A61K45/06 , A61K31/195 , A61K31/198 , A61K31/519 , A61K2300/00
摘要： The invention describes the use of Tetrahydrobiopterin (BH4) or derivatives thereof for the treatment of COPD. In a preferred embodiment, BH4 or derivates thereof are combined with arginine or derivatives thereof.
摘要翻译： 本发明描述了四氢生物蝶呤（BH4）或其衍生物用于治疗COPD的用途。 在优选的实施方案中，BH4或其衍生物与精氨酸或其衍生物组合。
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公开(公告)号：US20140112945A1
公开(公告)日：2014-04-24
申请号：US14125187
申请日：2012-06-12
申请人： Thomas Stengel , Thomas Maier , Alexander Mann , Josef Stadlwieser , Dieter Flockerzi , Andreas Pahl , Ewald Benediktus , Manuela Hessmann , Tobias Kanacher , Ragna Hussong , Christof Zitt , Hans Christof Holst , Rolf-Peter Hummel , Martin Viertelhaus , Hermann Tenor , Torsten Dunkern , Armin Hatzelmann , Christian Hesslinger
发明人： Thomas Stengel , Thomas Maier , Alexander Mann , Josef Stadlwieser , Dieter Flockerzi , Andreas Pahl , Ewald Benediktus , Manuela Hessmann , Tobias Kanacher , Ragna Hussong , Christof Zitt , Hans Christof Holst , Rolf-Peter Hummel , Martin Viertelhaus , Hermann Tenor , Torsten Dunkern , Armin Hatzelmann , Christian Hesslinger
IPC分类号： A61K31/519 , A61K45/06 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06
摘要： The compounds of formula (1) in which R1, R7, R8, R9, R10, R17, R18, R19, R20 and m have the meanings as given in the description, are novel effective inhibitors of type 4 and type 5 phosphodiesterase.
摘要翻译： 其中R1，R7，R8，R9，R10，R17，R18，R19，R20和m具有如说明书中给出的含义的式（1）化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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![3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4,3-c] ISOQUINOLINE DERIVATIVES](/abs-image/US/2012/11/15/US20120289474A1/abs.jpg.150x150.jpg)
9.发明申请3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4,3-c] ISOQUINOLINE DERIVATIVES 有权3,4,4A，10B-TETRAHYDRO-1H-噻吩并[4,3-c]异喹啉衍生物公开(公告)号：US20120289474A1
公开(公告)日：2012-11-15
申请号：US13515214
申请日：2010-12-15
申请人： Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
发明人： Dieter Flockerzi , Thomas Stengel , Alexander Mann , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Thomas Maier , Hermann Tenor , Clemens Braun , Raimund Külzer , Degenhard Marx
IPC分类号： A61K31/519 , A61K31/56 , A61K31/5585 , A61K31/59 , A61K31/7048 , A61P9/12 , A61P31/00 , A61P7/02 , A61P7/10 , A61P11/00 , A61P11/06 , A61P11/08 , C07D495/04 , A61P37/06
CPC分类号： C07D519/00
摘要： The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
摘要翻译： 其中A，R1，R2，R3和R5具有如说明书中给出的含义的式（1）化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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公开(公告)号：US07790710B2
公开(公告)日：2010-09-07
申请号：US11886785
申请日：2006-03-29
申请人： Thomas Fuchss , Andreas Strub , Wolf-Rüdiger Ulrich , Christian Hesslinger , Martin Lehner , Raimund Külzer , Rainer Boer , Manfrid Eltze
发明人： Thomas Fuchss , Andreas Strub , Wolf-Rüdiger Ulrich , Christian Hesslinger , Martin Lehner , Raimund Külzer , Rainer Boer , Manfrid Eltze
IPC分类号： A01N43/00 , A61K31/55 , A01N43/46 , A01N43/90 , A61K31/519 , C07D413/00 , C07D415/00 , C07D417/00 , C07D419/00 , C07D513/02 , C07D515/02 , C07D403/02
CPC分类号： C07D471/04
摘要： The compounds of formula (I) in which R1, R11 and A have the meanings as given in the description are novel effective iNOS inhibitors.
摘要翻译： 其中R1，R11和A具有如本说明书中给出的含义的式（I）化合物是新的有效的iNOS抑制剂。
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