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公开(公告)号：US09090561B2
公开(公告)日：2015-07-28
申请号：US13614838
申请日：2012-09-13
申请人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号： C07D471/04 , A61K31/4375 , C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12
CPC分类号： C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US20130018046A1
公开(公告)日：2013-01-17
申请号：US13614838
申请日：2012-09-13
申请人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号： A61K31/4439 , C07D403/12 , A61K31/506 , C07D401/12 , A61K31/496 , C07D471/04 , A61K31/4375 , C07D413/12 , A61K31/4725 , A61K31/502 , A61K31/497 , C07D498/04 , A61K31/5383 , A61K31/551 , A61K31/5377 , A61K31/53 , A61P35/00 , C07D401/14
CPC分类号： C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号：US08278307B2
公开(公告)日：2012-10-02
申请号：US12227130
申请日：2007-05-08
申请人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
发明人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
IPC分类号： A61K31/496 , A61K31/4178 , C07D403/12
CPC分类号： C07D231/12 , C07D233/64 , C07D233/90 , C07D277/40 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，以及其制备和用途。
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公开(公告)号：US08461167B2
公开(公告)日：2013-06-11
申请号：US12227002
申请日：2007-05-08
申请人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02
CPC分类号： C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号：US20130005738A1
公开(公告)日：2013-01-03
申请号：US13612067
申请日：2012-09-12
申请人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
发明人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
IPC分类号： C07D403/12 , A61P35/00 , C07D417/12 , A61K31/427 , A61K31/496 , A61K31/4178
CPC分类号： C07D231/12 , C07D233/64 , C07D233/90 , C07D277/40 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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![Substituted acetylenic imidazo[1,2-A]pyridine compounds as kinase inhibitors](/abs-image/US/2013/06/25/US08470851B2/abs.jpg.150x150.jpg)
6.发明授权Substituted acetylenic imidazo[1,2-A]pyridine compounds as kinase inhibitors 有权取代的炔属咪唑并[1,2-A]吡啶化合物作为激酶抑制剂公开(公告)号：US08470851B2
公开(公告)日：2013-06-25
申请号：US13357745
申请日：2012-01-25
申请人： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antoinette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
发明人： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antoinette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
IPC分类号： A61K31/44
CPC分类号： C07D471/04 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US20090176781A1
公开(公告)日：2009-07-09
申请号：US12227002
申请日：2007-05-08
申请人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zhu , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zhu , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号： A61K31/5377 , C07D401/14 , A61K31/4439 , A61K31/506 , C07D403/12 , C07D413/12 , A61P35/00
CPC分类号： C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US20090149471A1
公开(公告)日：2009-06-11
申请号：US12227130
申请日：2007-05-08
申请人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Matthew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi k. Sawyer , Jan Antoinette C. Romero
发明人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Matthew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi k. Sawyer , Jan Antoinette C. Romero
IPC分类号： A61K31/4178 , C07D403/12 , C07D417/12 , A61K31/427 , A61K31/4439 , A61K31/506 , A61P35/00 , A61K31/496
CPC分类号： C07D231/12 , C07D233/64 , C07D233/90 , C07D277/40 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，以及其制备和用途。
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公开(公告)号：US20120202776A1
公开(公告)日：2012-08-09
申请号：US12736910
申请日：2009-05-21
申请人： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlmann , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
发明人： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlmann , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
IPC分类号： A61K31/675 , C07F9/6512 , C07F9/6561 , A61P35/00 , C07F9/6509 , C07F9/6521 , C07F9/58 , C07F9/6558 , C07F9/6584
CPC分类号： C07F9/6533 , C07D239/48 , C07F9/58 , C07F9/650905 , C07F9/6512 , C07F9/6521 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
摘要： The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明的特征在于其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。
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公开(公告)号：US09012462B2
公开(公告)日：2015-04-21
申请号：US12736910
申请日：2009-05-21
申请人： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlman , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
发明人： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlman , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
IPC分类号： A61K31/506 , C07F9/30 , C07D239/48 , C07F9/6509 , C07F9/6512 , C07F9/6521 , C07F9/6558 , C07F9/6561 , C07F9/6568 , C07F9/6571
CPC分类号： C07F9/6533 , C07D239/48 , C07F9/58 , C07F9/650905 , C07F9/6512 , C07F9/6521 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
摘要： The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明的特征在于其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。
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