公开(公告)号：US06927570B2

公开(公告)日：2005-08-09

申请号：US10625720

申请日：2003-07-22

Applicant: Michael Bancroft Simmonds ,  Kurt Gordon Jensen ,  Jost Hermann Diederichs ,  Randall Christopher Black

Inventor： Michael Bancroft Simmonds ,  Kurt Gordon Jensen ,  Jost Hermann Diederichs ,  Randall Christopher Black

IPC: G01N33/483 ,  G01N27/72 ,  G01N33/487 ,  G01N33/543 ,  G01N33/553 ,  G01N35/00 ,  G01R33/12 ,  G01N27/74

CPC classification number: B82Y15/00 ,  B82Y25/00 ,  G01N27/745 ,  G01N35/0098 ,  G01R33/12 ,  Y10S977/773 ,  Y10S977/838 ,  Y10S977/96

Abstract: An apparatus is provided for quantitatively measuring samples whose amount or other characteristic quality is to be determined. The samples are arranged in a predefined pattern and are excited in a magnetic field. The magnetizations of the magnetic particles are thereby caused to oscillate at the excitation frequency in the manner of a dipole to create their own fields. These fields are inductively coupled to at least one substantially flat sensor such as sensing coils fabricated in a gradiometer configuration.

Abstract translation: 提供了用于定量测量其量或其他特征质量的样品的装置。 样品以预定图案排列并在磁场中激发。 因此磁性粒子的磁化以激励频率以偶极子的方式振荡以产生它们自己的场。 这些场感应耦合到至少一个基本平坦的传感器，例如以梯度计配置制造的感测线圈。

公开(公告)号：US06597176B2

公开(公告)日：2003-07-22

申请号：US09911934

申请日：2001-07-23

Applicant: Michael Bancroft Simmonds ,  Kurt Gordon Jensen ,  Jost Hermann Diederichs ,  Randall Christopher Black

Inventor： Michael Bancroft Simmonds ,  Kurt Gordon Jensen ,  Jost Hermann Diederichs ,  Randall Christopher Black

IPC: G01N1506

CPC classification number: B82Y15/00 ,  B82Y25/00 ,  G01N27/745 ,  G01N35/0098 ,  G01R33/12 ,  Y10S977/773 ,  Y10S977/838 ,  Y10S977/96

Abstract: An apparatus is provided for quantitatively determining amounts and identities of substances whithin patterns of magnetic particles, such as within lateral flow membranes, microfludic systems, and the like. Magnetic particles are complexed with substances to be determined and are excited in an oscillating magnetic field. The magnetizations of the magnetic particles are thereby caused to oscillate at the excitation frequency to create their own fields. These fields are inductively coupled to at least one sensor such as sensing coils fabricated in a gradiometer configuration. The output signals from the sensing coils are appropriately amplified and processed to provide useful output indications.

Abstract translation: 提供了一种设备，用于定量测定在诸如侧流膜，微流体系统等之间的磁性颗粒图案中的物质的量和身份。 磁性颗粒与待确定的物质复合并在振荡磁场中被激发。 因此磁性颗粒的磁化在激发频率下振荡以产生它们自己的磁场。 这些场感应耦合到至少一个传感器，例如以梯度计配置制造的感测线圈。 来自感测线圈的输出信号被适当地放大和处理以提供有用的输出指示。

公开(公告)号：US06483303B2

公开(公告)日：2002-11-19

申请号：US09911939

申请日：2001-07-23

Applicant: Michael Bancroft Simmonds ,  Kurt Gordon Jensen ,  Jost Hermann Diederichs ,  Randall Christopher Black

Inventor： Michael Bancroft Simmonds ,  Kurt Gordon Jensen ,  Jost Hermann Diederichs ,  Randall Christopher Black

IPC: G01N2772

CPC classification number: B82Y15/00 ,  B82Y25/00 ,  G01N27/745 ,  G01N35/0098 ,  G01R33/12 ,  Y10S977/773 ,  Y10S977/838 ,  Y10S977/96

Abstract: An apparatus is provided for quantitatively measuring groups of magnetic particles. The particles are complexed with substances to be determined and are excited in a magnetic field. The magnetizations of the magnetic particles are thereby caused to oscillate at the excitation frequency in the manner of a dipole to create their own fields. These fields are inductively coupled to at least one sensor such as sensing coils fabricated in a gradiometer configuration. The output signals from the sensing coils are appropriately amplified and processed to provide useful output indications.

Abstract translation: 提供了用于定量测量磁性颗粒组的装置。 颗粒与待确定的物质络合并在磁场中被激发。 因此磁性粒子的磁化以激励频率以偶极子的方式振荡以产生它们自己的场。 这些场感应耦合到至少一个传感器，例如以梯度计配置制造的感测线圈。 来自感测线圈的输出信号被适当地放大和处理以提供有用的输出指示。

公开(公告)号：US06437563B1

公开(公告)日：2002-08-20

申请号：US09451660

申请日：1999-11-30

Applicant: Michael Bancroft Simmonds ,  Kurt Gordon Jensen ,  Jost Hermann Diederichs ,  Randall Christopher Black

Inventor： Michael Bancroft Simmonds ,  Kurt Gordon Jensen ,  Jost Hermann Diederichs ,  Randall Christopher Black

IPC: G01N2772

CPC classification number: B82Y15/00 ,  B82Y25/00 ,  G01N27/745 ,  G01N35/0098 ,  G01R33/12 ,  Y10S977/773 ,  Y10S977/838 ,  Y10S977/96

Abstract: An apparatus is provided for quantitatively measuring combinations of magnetic particles combined with analytes whose amount or other characteristic quality is to be determined. The magnetic particles are complexed with the analytes to be determined and are excited in a magnetic field. The magnetizations of the magnetic particles are thereby caused to oscillate at the excitation frequency in the manner of a dipole to create their own fields. These fields are inductively coupled to at least one sensor such as sensing coils fabricated in a gradiometer configuration. The output signals from the sensing coils are appropriately amplified and processed to provide useful output indications.

Abstract translation: 提供了一种设备，用于定量测量与要测定其量或其他特征质量的分析物组合的磁性颗粒的组合。 磁性颗粒与要测定的分析物复合，并在磁场中被激发。 因此磁性粒子的磁化以激励频率以偶极子的方式振荡以产生它们自己的场。 这些场感应耦合到至少一个传感器，例如以梯度计配置制造的感测线圈。 来自感测线圈的输出信号被适当地放大和处理以提供有用的输出指示。

公开(公告)号：US5894220A

公开(公告)日：1999-04-13

申请号：US600168

申请日：1996-02-12

Applicant: Frederick Charles Wellstood ,  Yonggyu Gim ,  Randall Christopher Black ,  Steven M. Green

Inventor： Frederick Charles Wellstood ,  Yonggyu Gim ,  Randall Christopher Black ,  Steven M. Green

IPC: G01N27/82 ,  G01R27/26 ,  G01R33/10 ,  G01R33/035 ,  G01J5/00 ,  G01N27/72 ,  G01R31/00

CPC classification number: G01R33/10 ,  G01N27/82 ,  G01R27/2623 ,  Y10S505/842 ,  Y10S505/846 ,  Y10S505/849

Abstract: A cryogenic apparatus for microscopy of physical properties of an object including a thin, stiff, transparent substrate or window within the outer wall of the vacuum space of a dewar and a cryogenic sensor within the vacuum space and spaced very close distances to the window. This construction allows for positioning a sample for measurement outside of the vacuum space, at room temperature or higher and for microscopy of physical properties of the sample by monitoring the output from the cryogenic sensor as it is scanned along the surface of the sample.

Abstract translation: 用于显微镜物镜的低温装置，包括在真空空间内的杜瓦瓶和低温传感器的真空空间的外壁内的薄的，刚性的，透明的基底或窗口，并且与窗口间隔非常近的距离。 这种结构允许在室温或更高温度下将用于测量的样品定位在室温或更高温度下，并且通过在沿着样品的表面扫描时监测来自低温传感器的输出来显示样品的物理性质。