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公开(公告)号：US20200217085A1
公开(公告)日：2020-07-09
申请号：US16645435
申请日：2018-09-06
摘要： This invention relates to a deck board (1) and more particularly, to a reduced material deck board (1). In accordance with this invention there is provided a deck board (1) comprising an operatively upper board section (4) having at least one operatively downwardly depending support leg (5) terminating in at least one flange (7), an underside of the flange (7) having a concave surface.
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公开(公告)号：US20150283261A1
公开(公告)日：2015-10-08
申请号：US13435688
申请日：2012-03-30
CPC分类号： A61K47/48484 , A61K47/6829 , A61K47/6849
摘要： The present invention provides methods and reagents for directing the selective targeting and entry of bacterial toxins to mammalian cells. Methods include the step of contacting a cell with a bacterial toxin or toxic bioactive fragment thereof associated with an antibody or ligand that is specific to a target on the cell, wherein the antibody or ligand selectively binds the target on the cell and the bacterial toxin or fragment thereof is internalized and enters the cell. The invention further encompasses compositions and kits to carry out the methods.
摘要翻译： 本发明提供了用于将细菌毒素选择性靶向和进入哺乳动物细胞的方法和试剂。 方法包括使细胞与细胞毒素或其与细胞上的靶特异性的抗体或配体相关的毒性生物活性片段接触的步骤，其中抗体或配体选择性地结合细胞上的靶标和细菌毒素或 其片段被内化并进入细胞。 本发明还包括用于实施所述方法的组合物和试剂盒。
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公开(公告)号：US20060107602A1
公开(公告)日：2006-05-25
申请号：US10532891
申请日：2003-10-29
CPC分类号： E21B10/567 , B01J3/062 , B01J3/065 , B01J2203/063 , B01J2203/066
摘要： A composite material comprises a plurality of cores of material selected from the group comprising carbides, nitrides, carbonitrides, cemented carbides, cemented nitrides, cemented carbonitrides and mixtures thereof, dispersed in a matrix. The matrix comprises the components for making an ultra-hard material, such as diamond or cBN abrasive particles, and a suitable binder. The ultra-hard material is polycrystalline in nature and is typically PCD or PcBN. The cores are typically provided as individual particles or in the form of granules. The granules may be further coated with a second coating, which may be a similar material to that of the cores or of an ultra-hard material of a different grade to that of the first coating. The composite material typically takes on a honeycomb structure of a hard material and cores within the pores of the honeycomb structure bonded to the honeycomb structure. The pores of the honeycomb structure may be ordered or random. A method of producing the composite material and a method of producing a tool component incorporating such a material are also provided.
摘要翻译： 复合材料包括分散在基质中的多种选自碳化物，氮化物，碳氮化物，硬质合金，粘结氮化物，粘结碳氮化物及其混合物的材料芯。 基质包括用于制造超硬材料的组分，例如金刚石或cBN研磨剂颗粒，以及合适的粘合剂。 超硬材料本质上是多晶的，通常是PCD或PcBN。 核心通常提供为单个颗粒或颗粒形式。 颗粒可以进一步涂覆第二涂层，其可以是与芯的类似材料或与第一涂层不同等级的超硬材料的材料。 复合材料通常在与蜂窝结构体结合的蜂窝结构体的孔内具有硬质材料的蜂窝结构和芯。 蜂窝结构的孔可以是有序的或随机的。 还提供了一种生产该复合材料的方法和一种制造包含这种材料的工具部件的方法。
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公开(公告)号：US20060099895A1
公开(公告)日：2006-05-11
申请号：US10533269
申请日：2003-09-12
申请人： Klaus Tank , Raymond Chapman , Roy Achilles
发明人： Klaus Tank , Raymond Chapman , Roy Achilles
IPC分类号： B26D1/12
CPC分类号： E21B10/5676 , E21B29/06 , Y10T407/19
摘要： A tool insert comprises a substrate (10) having a support surface and a support ring extending laterally from the support surface. The support ring is sized to define a recess (14) within the confines thereof and a shelf about the periphery thereof. A layer (12) of ultra-hard abrasive material is located within the recess and bonded to the substrate and the support ring (16), and presents a primary cutting edge (22) for the tool insert. A protective layer (18) is bonded to the shelf about the support ring so as to protect the primary cutting edge. The protective layer provides a secondary cutting edge (20) for the tool insert, the depth of the protective layer being selected so as to be sufficient to protect the primary cutting edge whilst cutting, milling or drilling through a first substance but to expose the primary cutting edge upon encountering a second substance.
摘要翻译： 工具插入件包括具有支撑表面的基底（10）和从支撑表面横向延伸的支撑环。 支撑环的尺寸被设计成在其范围内限定凹部（14），并且围绕其周边形成搁板。 超硬研磨材料层（12）位于凹槽内，并与衬底和支撑环（16）结合，并提供用于工具插入件的主切削刃（22）。 保护层（18）围绕支撑环结合到搁板上以便保护主切削刃。 保护层提供用于工具插入件的辅助切割边缘（20），保护层的深度被选择为足以保护主切削刃，同时切割，铣削或钻孔通过第一物质，但暴露于初级 在遇到第二物质时切割边缘。
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公开(公告)号：US20220268032A1
公开(公告)日：2022-08-25
申请号：US17744370
申请日：2022-05-13
摘要： This invention relates to a deck board and more particularly, to a reduced material deck board. In accordance with this invention there is provided a deck board comprising an operatively upper board section having at least one operatively downwardly depending support leg terminating in at least one flange, an underside of the flange having a concave surface.
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公开(公告)号：US20060144621A1
公开(公告)日：2006-07-06
申请号：US10533046
申请日：2003-09-12
申请人： Klaus Tank , Raymond Chapman , Roy Achilles
发明人： Klaus Tank , Raymond Chapman , Roy Achilles
IPC分类号： E21B7/04
CPC分类号： E21B10/5676 , E21B29/06
摘要： A tool insert comprises a substrate (40), a layer of ultra-hard abrasive material (52) bonded to the substrate and presenting a primary cutting edge (54) for the tool insert, and a protective layer (56) bonded to the ultra-hard abrasive material so as to protect the primary cutting edge thereof. The protective layer provides a secondary cutting edge (58) for the tool insert, the depth of the protective layer being selected so as to be sufficient to protect the primary cutting edge whilst cutting, milling or drilling a window through a first substance, such as a casing or lining of a borehole or shaft, but to expose the primary cutting edge upon encountering a second substance, such as a rockbed. The invention extends to a method of drilling a horizontal or angled hole in a sub-terranean rock formation using a rotary drill string and bit incorporating a tool insert of the invention.
摘要翻译： 工具插入件包括基底（40），结合到基底的超硬研磨材料层（52），并且呈现用于刀具插入件的主切削刃（54）以及粘合到超硬质材料的保护层（56） 硬磨料，以保护其主切削刃。 保护层提供用于工具插入件的辅助切割边缘（58），保护层的深度被选择为足以保护主切削刃，同时通过第一物质切割，铣削或钻孔，例如 钻孔或轴的套管或衬套，但是在遇到第二物质（例如岩石）时露出主切割刃。 本发明延伸到使用旋转钻柱和包含本发明的工具插入件的钻头钻入地下岩层中的水平或倾斜孔的方法。
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7.发明授权Mobile wireless communications device with elastomeric sealing membrane covering switch and related methods 有权具有弹性密封膜覆盖开关的移动无线通信设备及相关方法公开(公告)号：US08160657B2
公开(公告)日：2012-04-17
申请号：US12508732
申请日：2009-07-24
申请人： Richard Perriello , Daniel Rice , Raymond Chapman
发明人： Richard Perriello , Daniel Rice , Raymond Chapman
CPC分类号： H04M1/23 , H01H13/06 , H01H2223/002 , H04M1/18
摘要： A mobile wireless communications device may include a housing having an opening therein and an inwardly extending housing ring adjacent the opening, and a switch carried by the housing and being aligned with the opening. The mobile wireless communications device may further include a backing member within the housing adjacent the opening, and an elastomeric switch membrane comprising a body covering the switch, and a flange coupled to the body and compressed between the backing member and the housing ring to define a seal therewith. The flange may include a flange base, and a pair of flange rings extending inwardly from the flange base and defining a valley therebetween aligned with the housing ring. In another embodiment, the flange may include a flange base and a first flange ring on a first surface thereof, and a pair of second flange rings on a second surface of the flange base and defining a valley therebetween aligned with the first flange ring.
摘要翻译： 移动无线通信设备可以包括其中具有开口的壳体和邻近开口的向内延伸的壳体环，以及由壳体承载并与开口对准的开关。 移动无线通信设备还可以包括邻近开口的壳体内的背衬构件，以及包括覆盖开关的主体的弹性开关膜，以及耦合到主体并在背衬构件和壳体环之间被压缩以限定一个 密封。 凸缘可以包括凸缘基部和从凸缘基部向内延伸并在其间限定与壳体环对齐的一对凸缘环。 在另一个实施例中，凸缘可以在其第一表面上包括凸缘基座和第一凸缘环，以及在凸缘基座的第二表面上的一对第二凸缘环，并且在其间限定与第一凸缘环对齐的凹部。
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公开(公告)号：US09623117B2
公开(公告)日：2017-04-18
申请号：US13435688
申请日：2012-03-30
CPC分类号： A61K47/48484 , A61K47/6829 , A61K47/6849
摘要： The present invention provides methods and reagents for directing the selective targeting and entry of bacterial toxins to mammalian cells. Methods include the step of contacting a cell with a bacterial toxin or toxic bioactive fragment thereof associated with an antibody or ligand that is specific to a target on the cell, wherein the antibody or ligand selectively binds the target on the cell and the bacterial toxin or fragment thereof is internalized and enters the cell. The invention further encompasses compositions and kits to carry out the methods.
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公开(公告)号：US08617573B2
公开(公告)日：2013-12-31
申请号：US13281501
申请日：2011-10-26
申请人： Edwin Raymond Chapman , Min Dong
发明人： Edwin Raymond Chapman , Min Dong
IPC分类号： A61K39/00 , A61K39/38 , A61K39/02 , A61K39/08 , A61K38/00 , A61K38/16 , A61K38/10 , A61P25/00 , A61P3/04
CPC分类号： C07H21/02 , C07H21/04 , C07K14/70571
摘要： It is disclosed here that synaptotagmin I (syt I) and synaptotagmin II (syt II) are the cellular receptors for botulinum neurotoxin B (BoNT/B) that mediate the cellular entry and toxicity of BoNT/B. The BoNT/B binding domains of syt I and II are also disclosed. While syt I needs gangliosides for BoNT/B binding, syt II can bind to BoNT/B in the absence of gangliosides. Various nucleic acids and polypeptides that relate to the BoNT/B binding domain of syt I or II are disclosed. Further disclosed are methods of reducing BoNT/B toxicity, methods of identifying agents that can block the binding between BoNT/B and syt I or II, methods of identifying agents that can bind to the BoNT/B binding domain of syt I or II, methods of detecting BoNT/B or Clostridium botulinum and kits for use thereof.
摘要翻译： 这里公开了突触结合蛋白I（syt I）和突触结合蛋白II（syt II）是介导BoNT / B的细胞进入和毒性的肉毒杆菌神经毒素B（BoNT / B）的细胞受体。 还公开了syt I和II的BoNT / B结合结构域。 虽然syt我需要用于BoNT / B结合的神经节苷脂，但是在不存在神经节苷脂的情况下，syt II可以结合BoNT / B。 公开了与syt I或II的BoNT / B结合结构域相关的各种核酸和多肽。 还公开了降低BoNT / B毒性的方法，鉴定可以阻断BoNT / B和syt I或II之间的结合的试剂的方法，鉴定可结合syt I或II的BoNT / B结合结构域的试剂的方法， 检测BoNT / B或肉毒杆菌的方法及其使用的试剂盒。
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公开(公告)号：US20120082672A1
公开(公告)日：2012-04-05
申请号：US13281501
申请日：2011-10-26
申请人： Edwin Raymond Chapman , Min Dong
发明人： Edwin Raymond Chapman , Min Dong
IPC分类号： A61K39/395 , C07K14/47 , G01N33/566 , G01N33/577 , A61K38/17 , A61P25/00
CPC分类号： C07H21/02 , C07H21/04 , C07K14/70571
摘要： It is disclosed here that synaptotagmin I (syt I) and synaptotagmin II (syt II) are the cellular receptors for botulinum neurotoxin B (BoNT/B) that mediate the cellular entry and toxicity of BoNT/B. The BoNT/B binding domains of syt I and II are also disclosed. While syt I needs gangliosides for BoNT/B binding, syt II can bind to BoNT/B in the absence of gangliosides. Various nucleic acids and polypeptides that relate to the BoNT/B binding domain of syt I or II are disclosed. Further disclosed are methods of reducing BoNT/B toxicity, methods of identifying agents that can block the binding between BoNT/B and syt I or II, methods of identifying agents that can bind to the BoNT/B binding domain of syt I or II, methods of detecting BoNT/B or Clostridium botulinum and kits for use thereof.
摘要翻译： 这里公开了突触结合蛋白I（syt I）和突触结合蛋白II（syt II）是介导BoNT / B的细胞进入和毒性的肉毒杆菌神经毒素B（BoNT / B）的细胞受体。 还公开了syt I和II的BoNT / B结合结构域。 虽然syt我需要用于BoNT / B结合的神经节苷脂，但是在不存在神经节苷脂的情况下，syt II可以结合BoNT / B。 公开了与syt I或II的BoNT / B结合结构域相关的各种核酸和多肽。 还公开了降低BoNT / B毒性的方法，鉴定可以阻断BoNT / B和syt I或II之间的结合的试剂的方法，鉴定可结合syt I或II的BoNT / B结合结构域的试剂的方法， 检测BoNT / B或肉毒杆菌的方法及其使用的试剂盒。
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