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    NOVEL ACTIVES AGAINST PROSTATE CARCINOMA
    1.
    发明申请
    NOVEL ACTIVES AGAINST PROSTATE CARCINOMA 审中-公开
    对前瞻性癌症的新兴活动

    公开(公告)号：US20090326056A1

    公开(公告)日：2009-12-31

    申请号：US12299825

    申请日：2007-05-15

    申请人： Regina Goralczyk ,  Ulrich Siler ,  Karin Wertz

    发明人： Regina Goralczyk ,  Ulrich Siler ,  Karin Wertz

    IPC分类号： A61K31/352

    CPC分类号： A61K31/01 ,  A61K31/353 ,  A61K31/355 ,  A61K2300/00

    摘要： The present invention relates to the use of a composition comprising lycopene and genistein in the prevention and coadjuvant treatment of prostate carcinoma. The present invention is also directed to the use of a composition comprising lycopene and epigallocatechin gallate in the prevention and coadjuvant treatment of prostate carcinoma. More specifically, the present invention relates to the use of one of these compositions in the primary prevention (i.e., the prophylactic supplementation of healthy subjects) of the onset of prostate carcinoma, in the coadjuvant treatment (i.e. the supplementation accompanying a running therapy of prostate carcinoma) and in the secondary prevention (i.e., the supplementation after a successful therapy for the prevention of relapse) of prostate carcinoma. Furthermore, the present invention is also directed to the reduction/decrease of the PSA plasma level in the blood of subjects to whom either a composition comprising lycopene and genistein or to whom either a composition comprising lycopene and epigallocatechin gallate are administered. Further compounds that may preferably also be present in the composition of the present invention are vitamin E, resveratrol and polyunsaturated fatty acid (derivative)s.

    摘要翻译： 本发明涉及包含番茄红素和染料木素的组合物在预防和辅助治疗前列腺癌中的用途。 本发明还涉及包含番茄红素和表没食子儿茶素没食子酸酯的组合物在预防和辅助治疗前列腺癌中的用途。 更具体地说，本发明涉及这些组合物中的一种在辅助治疗中的一级预防（即健康受试者的预防性补充）前列腺癌发作的用途（即伴随前列腺的运行治疗的补充） 癌症）和前列腺癌的二次预防（即成功治疗预防复发后的补充）。 此外，本发明还涉及给予包含番茄红素和染料木素的组合物或包含番茄红素和表没食子儿茶素没食子酸酯的组合物的受试者的血液中PSA血浆水平的降低/降低。 还可以存在于本发明组合物中的其它化合物是维生素E，白藜芦醇和多不饱和脂肪酸（衍生物）。

    Novel use of lycopene
    2.
    发明申请
    Novel use of lycopene 审中-公开
    小说使用番茄红素

    公开(公告)号：US20060069151A1

    公开(公告)日：2006-03-30

    申请号：US10537452

    申请日：2003-12-04

    申请人： Luca Barella ,  Regina Goralczyk ,  Ulrich Siler ,  Karin Wertz

    发明人： Luca Barella ,  Regina Goralczyk ,  Ulrich Siler ,  Karin Wertz

    IPC分类号： A61K31/375 ,  A61K31/355 ,  A61K31/353 ,  A61K31/015

    CPC分类号： A61K31/355 ,  A61K31/01 ,  A61K31/375 ,  A61K2300/00

    摘要： Lycopene can be used in the primary prevention and incidence risk reduction of non-cancerous symptoms and/or pathologies (i.e., the prophylactic supplementation of the healthy subjects), in the treatment or the coadjuvant treatment of non-can-cerous symptoms and/or pathologies (i.e. the supplementation as therapy or accompanying a running therapy) and in the secondary prevention of non-cancerous symptoms and/or pahtologies (i.e., the supplementation after a successful therapy for the prevention of the relapse), which are associated with, favored by or caused by androgen signalling or which are sensitive to a reduction of androgen signalling.

    摘要翻译： 番茄红素可用于非癌症症状和/或非癌症症状的治疗或辅助治疗中非癌症症状和/或病态（即健康受试者的预防性补充）的一级预防和发病风险降低 病理学（即作为治疗或伴随运行疗法的补充剂）和二次预防非癌症症状和/或睑炎（即，成功治疗以后用于预防复发的补充剂）与青睐相关 由雄激素信号传导或由其引起，或对雄激素信号传导的降低敏感。

    Novel Use of Organic Compounds
    4.
    发明申请
    Novel Use of Organic Compounds 审中-公开
    有机化合物的新用途

    公开(公告)号：US20080199413A1

    公开(公告)日：2008-08-21

    申请号：US11995178

    申请日：2006-07-13

    申请人： Regina Goralczyk ,  Karin Wertz

    发明人： Regina Goralczyk ,  Karin Wertz

    IPC分类号： A61Q17/04 ,  A61K31/121 ,  A61K31/015 ,  A61K31/341 ,  A61K31/35 ,  A61K31/045 ,  A61K31/355 ,  A61K31/05 ,  A61K31/01 ,  A61P17/00 ,  A61P3/02

    CPC分类号： A61K8/34 ,  A23K20/111 ,  A23K20/174 ,  A23K20/179 ,  A23L2/58 ,  A23L7/126 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/31 ,  A61K8/345 ,  A61K8/355 ,  A61K31/01 ,  A61K31/045 ,  A61K31/07 ,  A61K31/122 ,  A61Q19/08 ,  A23V2200/318 ,  A23V2250/211 ,  A23V2250/314 ,  A23V2250/712

    摘要： The present invention is directed to the use of a compound selected from the group consisting of β-carotene, lutein, lycopene and β-cryptoxanthin, and mixtures thereof and combinations thereof with CoQ-10 for maintaining the energy metabolism, the energy flow and/or the energy production in skin or of skin of animals including humans, for maintaining the respiratory function of the skin of animals including humans, for energizing the skin, maintaining and supporting the radiance and natural glow of the skin of animals including humans and for promoting a healthy appearance of the skin of animals including humans for preventing UV-A radiation-induced mtDNA mutagenesis in skin of animals including humans, as well as for the manufacture of a composition, preferably an orally applicable composition, for these uses and the corresponding methods. The present invention is further directed to the use of a compound selected from the group consisting of β-carotene, lutein, lycopene and β-cryptoxanthin, and mixtures thereof and combinations thereof with CoQ-10 in sunscreens as well as daily care products to improve their photoprotective potential, as well as to their use as effective micronutrients for skin maintenance. Furthermore the present invention is directed to compositions, preferably orally applicable compositions, comprising a certain amount of at least one compound selected from the group consisting of β-carotene, lutein, lycopene and β-cryptoxanthin and mixtures thereof and combinations thereof with CoQ-10 as active ingredient, characterized in that the amount is effective for such uses as mentioned above.

    摘要翻译： 本发明涉及选自β-胡萝卜素，叶黄素，番茄红素和β-隐黄质及其混合物的化合物及其与CoQ-10的组合的用途，用于维持能量代谢，能量流和/ 或包括人类在内的动物的皮肤或皮肤的能量产生，以维持包括人在内的动物的皮肤的呼吸功能，激发皮肤，维持和支持动物包括人的皮肤的光泽和自然发光，并促进 包括人在内的动物包括人的皮肤的健康外观，用于防止包括人在内的动物的皮肤中的UV-A辐射诱导的mtDNA诱变，以及用于制造用于这些用途的组合物，优选口服适用的组合物和相应的方法 。 本发明进一步涉及选自β-胡萝卜素，叶黄素，番茄红素和β-隐黄质及其混合物的化合物及其与CoQ-10在防晒剂中的组合以及日常护理产品的使用的改进 它们的光保护潜力，以及它们作为有效的微量营养素用于皮肤维持。 此外，本发明涉及包含一定量至少一种选自β-胡萝卜素，叶黄素，番茄红素和β-隐黄质及其混合物的组合物，优选口服适用的组合物，以及它们与CoQ-10的组合 作为活性成分，其特征在于该量对于上述用途是有效的。

    Treatment, prevention, and modulation of aging of the skin
    5.
    发明申请
    Treatment, prevention, and modulation of aging of the skin 审中-公开
    治疗，预防和调节皮肤老化

    公开(公告)号：US20070148106A1

    公开(公告)日：2007-06-28

    申请号：US11454376

    申请日：2006-06-15

    申请人： Karin Wertz ,  Regina Goralczyk

    发明人： Karin Wertz ,  Regina Goralczyk

    IPC分类号： A61K8/31

    CPC分类号： A61Q19/08 ,  A61K8/31 ,  A61K8/678

    摘要： Methods to treat, prevent, and modulate aging of the skin are provided. More particularly, methods are provided for treating or preventing non-light induced skin aging in an organism and for reducing the basal MMP-10 expression in unirradiated cells of an organism and/or reducing the basal MMP-1 RNA transcription and protein translation in unirradiated cells of an organism, which include administering an effective amount of β-carotene, a precursor of β-carotene, a derivative of β-carotene, a salt of β-carotene, or a combination thereof to an organism in need thereof. Also provided are compositions for treating and preventing non-light induced aging of the skin. In addition, methods for modulating UV-A induced RNA transcription and polypeptide translation of a matrix metalloprotease (MMP) and treating or ameliorating UVA-induced photoaging by administering to an organism in need thereof an effective amount of a composition comprising β-carotene, a precursor of β-carotene, a derivative of β-carotene, a salt of β-carotene, or a combination thereof are provided. Compositions for modulating the effect of UVA-induced RNA transcription and polypeptide translation of a matrix metalloprotease (MMP) are also provided.

    摘要翻译： 提供了治疗，预防和调节皮肤老化的方法。 更具体地，提供了用于治疗或预防生物体中非光诱导的皮肤老化并降低生物体未照射的细胞中的基础MMP-10表达和/或减少未照射的基础MMP-1 RNA转录和蛋白质翻译的方法 生物体的细胞，其包括向有需要的生物体施用有效量的β-胡萝卜素，β-胡萝卜素的前体，β-胡萝卜素的衍生物，β-胡萝卜素的盐或其组合。 还提供了用于治疗和预防非光诱导的皮肤老化的组合物。 另外，用于调节UV-A诱导的RNA转录和基质金属蛋白酶（MMP）的多肽翻译的方法以及通过向有需要的生物体施用有效量的包含β-胡萝卜素的组合物来治疗或改善UVA诱导的光老化， 提供β-胡萝卜素的前体，β-胡萝卜素的衍生物，β-胡萝卜素的盐或其组合。 还提供了用于调节UVA诱导的RNA转录和基质金属蛋白酶（MMP）的多肽翻译的作用的组合物。

    Beta-carotene modulation of gene expression
    6.
    发明申请
    Beta-carotene modulation of gene expression 审中-公开
    β-胡萝卜素调控基因表达

    公开(公告)号：US20070031356A1

    公开(公告)日：2007-02-08

    申请号：US11479232

    申请日：2006-06-30

    申请人： Petra Buchwald Hunziker ,  Regina Goralczyk ,  Willi Hunziker ,  Martin Neeb ,  Georges Riss ,  Nicole Seifert ,  Guido Steiner ,  Karin Wertz

    发明人： Petra Buchwald Hunziker ,  Regina Goralczyk ,  Willi Hunziker ,  Martin Neeb ,  Georges Riss ,  Nicole Seifert ,  Guido Steiner ,  Karin Wertz

    IPC分类号： A61K8/49 ,  C12Q1/68

    CPC分类号： A61Q19/08 ,  A61K8/31 ,  A61Q19/04

    摘要： Methods and compositions—particularly compositions containing β-carotene—for modulating the expression of genes that effect or influence cellular health or protect against cellular damage, e.g., skin aging, are provided. More particularly, a method is provided for screening for a compound that modulates an effect of UV irradiation on eukaryotic cells. Methods and compositions for ameliorating the effects of non-UV radiation induced skin aging and for modulating UVA-induced gene expression on skin aging are also provided. Further provided are methods and compositions for enhancing UVA-induced tanning of the skin, for promoting cell differentiation in UVA-irradiated cells of an organism, and for modulating stress-induced induction of a gene in an organism.

    摘要翻译： 提供了方法和组合物，特别是含有β-胡萝卜素的组合物，用于调节影响或影响细胞健康或防止细胞损伤（例如皮肤衰老）的基因的表达。 更具体地，提供了一种筛选调节UV照射对真核细胞的影响的化合物的方法。 还提供了用于改善非UV辐射诱导的皮肤老化和调节UVA诱导的基因表达对皮肤老化的影响的方法和组合物。 还提供了用于增强UVA诱导的皮肤鞣制，促进生物体的UVA照射的细胞中的细胞分化和调节应激诱导的生物体中基因的诱导的方法和组合物。

    NOVEL USE OF COMPOUNDS AND COMBINATIONS OF COMPOUNDS FOR IMPROVING THE PHYSICAL APPEARANCE
    8.
    发明申请
    NOVEL USE OF COMPOUNDS AND COMBINATIONS OF COMPOUNDS FOR IMPROVING THE PHYSICAL APPEARANCE 审中-公开
    化合物的新用途和化合物的组合改善物理外观

    公开(公告)号：US20100015262A1

    公开(公告)日：2010-01-21

    申请号：US12295408

    申请日：2007-04-02

    申请人： Regina Goralczyk ,  Joseph Schwager ,  Karin Wertz

    发明人： Regina Goralczyk ,  Joseph Schwager ,  Karin Wertz

    IPC分类号： A61K36/73 ,  A61K31/352 ,  A61K31/047 ,  A61K31/20 ,  A61K31/05 ,  A61K31/197 ,  A61P17/00 ,  A61P3/00

    CPC分类号： A61K8/31 ,  A21D2/36 ,  A23C9/13 ,  A23C9/1322 ,  A23L33/30 ,  A61K8/345 ,  A61K8/347 ,  A61K8/361 ,  A61K8/498 ,  A61K8/97 ,  A61K2800/92 ,  A61Q19/06

    摘要： The present invention is directed inter alia to the use of at least one compound selected from the group consisting of (−)-epigallocatechin gallate, resveratrol, eicosapentaenoic acid, docosahexaenioic acid, rose hip extract/concentrate, hydroxytyrosol, lycopene, lutein, β-cryptoxanthin, zeaxanithin and derivatives thereof, for the treatment of cellulite, for the prevention of the development of mild cellulite, for the prevention of the progression of mild cellulite to severe cellulite, for smoothening the micro relief of the skin, for maintaining or increasing the tensile properties of the skin, and/or for reducing the fat mass and the circumference at the hips and thighs, as well as to the corresponding cosmetic and medical methods.

    摘要翻译： 本发明特别涉及使用至少一种选自（ - ） - 表没食子儿茶素没食子酸酯，白藜芦醇，二十碳五烯酸，二十二碳六烯酸，玫瑰果提取物/浓缩物，羟基酪醇，番茄红素，叶黄素，β- 隐黄质，玉米黄素及其衍生物，用于治疗脂肪团，用于防止轻度脂肪团的发育，用于防止轻度脂肪团进入严重脂肪团的进展，以平滑皮肤的微小浮雕，维持或增加 皮肤的拉伸性能和/或用于降低臀部和大腿处的脂肪量和周长，以及相应的美容和医疗方法。