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    Connectors for bifurcated stent
    2.
    发明授权
    Connectors for bifurcated stent 有权
    分支支架连接器

    公开(公告)号：US08343211B2

    公开(公告)日：2013-01-01

    申请号：US11300033

    申请日：2005-12-14

    申请人： Daniel Gregorich ,  Michael P. Meyer ,  Richard C. Tooley ,  Shawn Sorenson

    发明人： Daniel Gregorich ,  Michael P. Meyer ,  Richard C. Tooley ,  Shawn Sorenson

    IPC分类号： A61F2/06

    CPC分类号： A61F2/856 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2250/006

    摘要： A stent assembly comprises a second stent body and a substantially tubular first stent body defining a first lumen and containing a side branch opening. In an undeployed state, the second stent body is at least partially comprised of rings having peaks and valleys at least some of the valleys of adjacent rings being interconnected by bridges. In an expanded state, the rings of the second stent body define a second lumen opening in fluid communication with the first lumen. The second lumen has superior body vessel coverage and is flexible enough to form an oblique angle relative to the longitudinal axis of the first stent body.

    摘要翻译： 支架组件包括第二支架主体和限定第一内腔并且包含侧分支开口的基本管状的第一支架主体。 在非部署状态下，第二支架主体至少部分地由具有峰和谷的环组成，相邻环的至少一些谷通过桥互连。 在扩张状态下，第二支架主体的环限定与第一管腔流体连通的第二管腔开口。 第二内腔具有优异的体血管覆盖度并且足够灵活以相对于第一支架主体的纵向轴线形成倾斜角。

    Medical devices coated with drug carrier macromolecules
    6.
    发明授权
    Medical devices coated with drug carrier macromolecules 有权
    用药物载体大分子涂覆的医疗器械

    公开(公告)号：US07572625B2

    公开(公告)日：2009-08-11

    申请号：US11435690

    申请日：2006-05-18

    申请人： Liza J. Davis ,  Kim Robertson ,  Richard C. Tooley, Jr.

    发明人： Liza J. Davis ,  Kim Robertson ,  Richard C. Tooley, Jr.

    IPC分类号： C12M3/00

    CPC分类号： A61L31/16 ,  A61L27/227 ,  A61L27/34 ,  A61L27/54 ,  A61L31/04 ,  A61L31/10 ,  A61L2300/602

    摘要： A medical device coated with carrier macromolecules, wherein the carrier macromolecules are conjugated with a therapeutic agent. The carrier macromolecules may be antibodies which bind the therapeutic agent at the antigen binding site or by covalent bonding. The carrier macromolecules may be tethered to the surface of or dispersed within a coating on the medical device. The carrier macromolecules may release the therapeutic agent upon exposure to a trigger, which may be exposure to an aqueous environment, or a change in the pH or the ionic strength of the environment. The carrier macromolecules may also be bispecific antibodies directed to both a therapeutic agent and a target antigen. In some cases, binding of the target antigen causes the therapeutic agent to be released from the bispecific antibody. Also provided are methods of controlling the release and targeting of therapeutic agents eluted from a medical device.

    摘要翻译： 涂覆有载体大分子的医疗装置，其中载体大分子与治疗剂缀合。 载体大分子可以是在抗原结合位点或通过共价键结合治疗剂的抗体。 载体大分子可以连接到医疗装置上的涂层的表面或分散在其中。 载体大分子可能暴露于可能暴露于水性环境的触发剂或pH或环境离子强度的变化下释放治疗剂。 载体大分子也可以是针对治疗剂和靶抗原的双特异性抗体。 在一些情况下，靶抗原的结合导致治疗剂从双特异性抗体释放。 还提供了控制从医疗装置洗脱的治疗剂的释放和靶向的方法。