公开(公告)号：US06716596B2

公开(公告)日：2004-04-06

申请号：US09805726

申请日：2001-03-12

申请人： Richard H. Fish ,  John B. Kerr ,  Christine H. Lo

发明人： Richard H. Fish ,  John B. Kerr ,  Christine H. Lo

IPC分类号： C12Q126

CPC分类号： C12Q1/32 ,  C07D213/50 ,  C07D213/80 ,  C07D213/82 ,  C07D213/83 ,  C07D213/85 ,  C07F17/02 ,  C07H19/00 ,  C07H19/207 ,  C12Q1/26

摘要： Novel agents acting as co-factors for replacement of NAD(P)+/NAD(P)H co-enzyme systems in enzymatic oxido-reductive reactions. Agents mimicking the action of NAD(P)+/NAD(P)H system in enzymatic oxidation/reduction of substrates into reduced or oxidized products. A method for selection and preparation of the mimicking agents for replacement of NAD(P)+/NAD(P)H system and a device comprising co-factors for replacement of NAD(P)+/NAD(P)H system.

摘要翻译： 作为在酶促氧化还原反应中替代NAD（P）+ / NAD（P）H辅酶系统的辅因子的新型试剂。 模仿NAD（P）+ / NAD（P）H系统在底物酶促氧化/还原成还原或氧化产物的作用剂的试剂。 用于选择和制备用于替代NAD（P）+ / NAD（P）H系统的模拟剂的方法和包含用于替代NAD（P）+ / NAD（P）H系统的辅因子的装置 系统。

公开(公告)号：US5622996A

公开(公告)日：1997-04-22

申请号：US389851

申请日：1995-02-17

申请人： Richard H. Fish

发明人： Richard H. Fish

IPC分类号： C08F8/00 ,  C08F8/32 ,  C08F8/36

CPC分类号： C08F8/24

摘要： The present invention concerns the synthesis of several biomimetically important polymer-supported, sulfonated catechol (PS-CATS), sulfonated bis-catechol linear amide (PS-2-6-LICAMS) and sulfonated 3,3-linear tris-catechol amide (PS-3,3-LICAMS) ligands, which chemically bond to modified 6% crosslinked macroporous polystyrene-divinylbenzene beads (PS-DVB). These polymers are useful for the for selective removal and recovery of environmentally and economically important metal ions from aqueous solution, as a function of pH. The Fe.sup.3+ ion selectivity shown for PS-CATS, PS-2-6-LICAMS, and PS-3,3-LICAMS polymer beads in competition with a similar concentration of Cu.sup.2+, Zn.sup.2+, Mn.sup.2+, Ni.sup.2+,Mg.sup.2+, Al.sup.3+, and Cr.sup.3+ ions at pH 1-3. Further, the metal ion selectivity is changed at higher pH values in the absence of Fe.sup.3+ (for example, Hg.sup.2+ at pH 3). The rates of selective removal and recovery of the trivalent metal ions, e.g. Fe.sup.3+ Al.sup.3+ ion etc. with the PS-CATS, PS-2-6-LICAMS, and PS-3,3-LICAMS polymer beads use determined are useful as well as equilibrium selectivity coefficient (K.sub.m) values for all metal competition studies. The chelate effect for the predisposed octahedral PS-3,3-LICAMS polymer pendant ligand is the reason that this ligand has a more pronounced selectivity for Fe.sup.3+ ion in comparison to the PS-CATS polymer beads. The predisposed square planar PS-2-6-Mn.sup.2+, Ni.sup.2+, and Mg.sup.2+, than either PS-CATS or PS-3,3-LICAMS. However, Fe.sup.3+ ion still dominates in competition with other divalent and trivalent metal ions. In the absence of Fe.sup.3+, the polymer ligand is selective for Al.sup.3+, Cu.sup.2+ or Hg.sup.2+. The changing of the cavity size from two CH.sub.2 groups to six CH.sub.2 groups in the PS-2-6-LICAMS polymer pendant ligand series does not effect the order of metal ion selectivity.

公开(公告)号：US4659684A

公开(公告)日：1987-04-21

申请号：US842574

申请日：1986-03-21

申请人： Richard H. Fish

发明人： Richard H. Fish

IPC分类号： C10G25/00 ,  B01J20/34 ,  B01J38/60 ,  B01J38/64 ,  C02F1/42

CPC分类号： C10G25/003 ,  Y10S502/515 ,  Y10S502/516

摘要： Described is a process for removing arsenic, vanadium, and/or nickel from petroliferous derived liquids by contacting said liquid at an elevated temperature with a divinylbenzene-crosslinked polystyrene having catechol ligands anchored thereon. For vanadium and nickel removal an amine, preferably a diamine is included.Also, described is a process for regenerating spent catecholated polystyrene by removal of the arsenic, vanadium, and/or nickel bound to it from contacting petroliferous liquid as described above and involves:treating the spent polymer containing any vanadium and/or nickel with an aqueous acid to achieve an acid pH; and,separating the solids from the liquid; and thentreating said spent catecholated polystyrene, at a temperature in the range of about 20.degree. to 100.degree. C. with an aqueous solution of at least one carbonate and/or bicarbonate of ammonium, alkali and alkaline earth metals, said solution having a pH between about 8 and 10; and,separating the solids and liquids from each other. Preferably the regeneration treatment of arsenic containing catecholated polymer is in two steps wherein the first step is carried out with an aqueous alcoholic carbonate solution containing lower alkyl alcohol, and, the steps are repeated using a bicarbonate.

摘要翻译： 描述的是通过使升高的温度下的液体与锚定在其上的儿茶酚配体的二乙烯基苯交联的聚苯乙烯接触，从含油衍生的液体中除去砷，钒和/或镍的方法。 对于钒和镍的去除，包括胺，优选二胺。 此外，还描述了如上所述通过除去与含石油液体接触的砷，钒和/或镍结合而再生用过的儿茶酚基聚苯乙烯的方法，其涉及：用含水的钒和/或镍 酸达到酸的pH值; 并将固体与液体分离; 然后在约20-100℃的温度下用铵，碱金属和碱土金属的至少一种碳酸盐和/或碳酸氢盐的水溶液处理所述乏儿茶酚聚苯乙烯，所述溶液具有pH 约8至10; 并将固体和液体彼此分离。 优选地，含砷儿茶酚酸化聚合物的再生处理分为两个步骤，其中第一步是用含有低级烷基醇的含水醇酸水溶液进行，并且使用碳酸氢盐重复该步骤。

公开(公告)号：US4552854A

公开(公告)日：1985-11-12

申请号：US699886

申请日：1985-02-08

申请人： Richard H. Fish

发明人： Richard H. Fish

IPC分类号： C10G25/00 ,  B01J31/40

CPC分类号： C10G25/003 ,  Y10S502/514 ,  Y10S502/516

摘要： Described is a process for removing arsenic from petroliferous derived liquids by contacting said liquid at an elevated temperature with a divinylbenzene-crosslinked polystyrene having catechol ligands anchored thereon.Also, described is a process for regenerating spent catecholated polystyrene by removal of the arsenic bound to it from contacting petroliferous liquid as described above and involves:a. treating said spent catecholated polystyrene, at a temperature in the range of about 20.degree. to 100.degree. C. with an aqueous solution of at least one carbonate and/or bicarbonate of ammonium, alkali and alkaline earth metals, said solution having a pH between about 8 and 10 and,b. separating the solids and liquids from each other. Preferably the regeneration treatment is in two steps wherein step (a) is carried out with an aqueous alcoholic carbonate solution containing lower alkyl alcohol, and, steps (a) and (b) are repeated using a bicarbonate.

摘要翻译： 描述了通过使升高的温度下的所述液体与锚定在其上的儿茶酚配体的二乙烯基苯交联的聚苯乙烯接触从含石油衍生的液体中除去砷的方法。 此外，还描述了如上所述通过除去与含铁液体接触的砷结合的砷来再生乏儿茶酚聚苯乙烯的方法，并涉及：a。 在约20-100℃的温度下用铵，碱金属和碱土金属的至少一种碳酸盐和/或碳酸氢盐的水溶液处理所述废的儿茶酚基聚苯乙烯，所述溶液的pH介于约 8和10，和b。 将固体和液体彼此分离。 优选地，再生处理分两个步骤，其中步骤（a）用含有低级烷基醇的含水醇酸水溶液进行，并且使用碳酸氢盐重复步骤（a）和（b）。

公开(公告)号：US4518490A

公开(公告)日：1985-05-21

申请号：US597627

申请日：1984-04-06

申请人： Richard H. Fish

发明人： Richard H. Fish

IPC分类号： C10G25/00

CPC分类号： C10G25/003

摘要： Described is a process for removing arsenic from petroliferous derived liquids by contacting said liquid at an elevated temperature with a divinylbenzene-crosslinked polystyrene having catechol ligands anchored thereon.Also, described is a process for regenerating spent catecholated polystyrene by removal of the arsenic bound to it from contacting petroliferous liquid as described above and involves:a. treating said spent catecholated polystyrene, at a temperature in the range of about 20.degree. to 100.degree. C. with an aqueous solution of at least one carbonate and/or bicarbonate of ammonium, alkali and alkaline earth metals, said solution having a pH between about 8 and 10 and,b. separating the solids and liquids from each other. Preferably the regeneration treatment is in two steps wherein step (a) is carried out with an aqueous alcoholic carbonate solution containing lower alkyl alcohol, and, steps (a) and (b) are repeated using a bicarbonate.

摘要翻译： 描述了通过使升高的温度下的所述液体与锚定在其上的儿茶酚配体的二乙烯基苯交联的聚苯乙烯接触从含石油衍生的液体中除去砷的方法。 此外，还描述了如上所述通过除去与含铁液体接触的砷结合的砷来再生乏儿茶酚聚苯乙烯的方法，并涉及：a。 在约20-100℃的温度下用铵，碱金属和碱土金属的至少一种碳酸盐和/或碳酸氢盐的水溶液处理所述废的儿茶酚基聚苯乙烯，所述溶液的pH介于约 8和10，和b。 将固体和液体彼此分离。 优选地，再生处理分两个步骤，其中步骤（a）用含有低级烷基醇的含水醇酸水溶液进行，并且使用碳酸氢盐重复步骤（a）和（b）。

公开(公告)号：US5834525A

公开(公告)日：1998-11-10

申请号：US839359

申请日：1997-04-17

申请人： Richard H. Fish

发明人： Richard H. Fish

IPC分类号： C08F8/00 ,  C08F8/36 ,  C02F1/42 ,  C08F8/24

CPC分类号： C08F8/24

摘要： The present invention concerns the synthesis of several biomimetically important polymer-supported, sulfonated catechol (PS-CATS), sulfonated bis-catechol linear amide (PS-2-6-LICAMS) and sulfonated 3,3-linear tris-catechol amide (PS-3,3-LICAMS) ligands, which chemically bond to modified 6% crosslinked macroporous polystyrene-divinylbenzene beads (PS-DVB). These polymers are useful for the for selective removal and recovery of environmentally and economically important metal ions from aqueous solution, as a function of pH. The Fe.sup.3+ ion selectivity shown for PS-CATS, PS-2-6-LICAMS, and PS-3,3-LICAMS polymer beads in competition with a similar concentration of Cu.sup.2+, Zn.sup.2+, Mn.sup.2+, Ni.sup.2+, Mg.sup.2+, Al.sup.3+, and Cr.sup.3+ ions at pH 1-3. Further, the metal ion selectivity is changed at higher pH values in the absence of Fe.sup.3+ (for example, Hg.sup.2+ at pH 3). The rates of selective removal and recovery of the trivalent metal ions, e.g. Fe.sup.3+ Al.sup.3+ ion etc. with the PS-CATS, PS-2-6-LICAMS, and PS-3,3-LICAMS polymer beads used determined are useful as well as equilibrium selectivity coefficient (K.sub.m) values for all metal competition studies. The chelate effect for the predisposed octahedral PS-3,3-LICAMS polymer pendant ligand is the reason that this ligand has a more pronounced selectivity for Fe.sup.3+ ion in comparison to the PS-CATS polymer beads. The predisposed square planar PS-2,6-LICAMS series of polymer pendant ligands are more selective to divalent metal ions Cu.sup.2+, Zn.sup.2+, Mn.sup.2+, Ni.sup.2+, and Mg.sup.2+, than either PS-CATS or PS-3,3-LICAMS. However, Fe.sup.3+ ion still dominates in competition with other divalent and trivalent metal ions. In the absence of Fe.sup.3+, the polymer ligand is selective for Al.sup.3+, Cu.sup.2+ or Hg.sup.2+. The changing of the cavity size from two CH.sub.2 groups to six CH.sub.2 groups in the PS-2-6-LICAMS polymer pendant ligand series does not effect the order of metal ion selectivity.

公开(公告)号：US5671086A

公开(公告)日：1997-09-23

申请号：US423969

申请日：1995-04-18

申请人： Bahram A. Parvin ,  Marcos F. Maestre ,  Richard H. Fish ,  William E. Johnston

发明人： Bahram A. Parvin ,  Marcos F. Maestre ,  Richard H. Fish ,  William E. Johnston

IPC分类号： G01N27/447 ,  G01Q30/04 ,  G01Q30/08 ,  G02B21/26 ,  G01N21/01 ,  G02B21/00 ,  G02B21/36

CPC分类号： G02B21/26 ,  G01N27/447 ,  G01N27/44721

摘要： An apparatus using electrophoresis provides accurate manipulation of an object on a microscope stage for further manipulations add reactions. The present invention also provides an inexpensive and easily accessible means to move an object without damage to the object. A plurality of electrodes are coupled to the stage in an array whereby the electrode array allows for distinct manipulations of the electric field for accurate manipulations of the object. There is an electrode array control coupled to the plurality of electrodes for manipulating the electric field. In an alternative embodiment, a chamber is provided on the stage to hold the object. The plurality of electrodes are positioned in the chamber, and the chamber is filled with fluid. The system can be automated using visual servoing, which manipulates the control parameters, i.e., x, y stage, applying the field, etc., after extracting the significant features directly from image data. Visual servoing includes an imaging device and computer system to determine the location of the object. A second stage having a plurality of tubes positioned on top of the second stage, can be accurately positioned by visual servoing so that one end of one of the plurality of tubes surrounds at least part of the object on the first stage.

摘要翻译： 使用电泳的装置提供对显微镜载物台上的物体的精确操作，以进一步操作添加反应。 本发明还提供了一种便宜且易于接近的手段来移动物体而不损坏物体。 多个电极以阵列耦合到平台，由此电极阵列允许电场的不同操纵以精确地操纵物体。 耦合到多个电极的电极阵列控制用于操纵电场。 在替代实施例中，在台架上设置一个室以保持物体。 多个电极定位在腔室中，并且腔室中充满流体。 该系统可以使用视觉伺服自动化，其在从图像数据直接提取显着特征之后操纵控制参数，即x，y级，应用场等。 视觉伺服包括成像装置和计算机系统来确定物体的位置。 可以通过视觉伺服来精确地定位具有位于第二台顶部的多个管的第二台，使得多个管中的一个管的一端围绕第一台上的物体的至少一部分。

公开(公告)号：US4604191A

公开(公告)日：1986-08-05

申请号：US735228

申请日：1985-05-17

申请人： Richard H. Fish

发明人： Richard H. Fish

IPC分类号： C10G25/00

CPC分类号： C10G25/003

摘要： Described is a process for removing arsenic, vanadium, and/or nickel from petroliferous derived liquids by contacting said liquid at an elevated temperature with a divinylbenzene-crosslinked polystyrene having catechol ligands anchored thereon. For vanadium and nickel removal an amine, preferably a diamine is included.Also, described is a process for regenerating spent catecholated polystyrene by removal of the arsenic, vanadium, and/or nickel bound to it from contacting petroliferous liquid as described above and involves:treating the spent polymer containing any vanadium and/or nickel with an aqueous acid to achieve an acid pH; and,separating the solids from the liquid; and thentreating said spent catecholated polystyrene, at a temperature in the range of about 20.degree. to 100.degree. C. with an aqueous solution of at least one carbonate and/or bicarbonate of ammonium, alkali and alkaline earth metals, said solution having a pH between about 8 and 10; and,separating the solids and liquids from each other. Preferably the regeneration treatment of arsenic containing catecholated polymer is in two steps wherein the first step is carried out with an aqueous alcoholic carbonate solution containing lower alkyl alcohol, and, the steps are repeated using a bicarbonate.

摘要翻译： 描述的是通过使升高的温度下的液体与锚定在其上的儿茶酚配体的二乙烯基苯交联的聚苯乙烯接触，从含油衍生的液体中除去砷，钒和/或镍的方法。 对于钒和镍的去除，包括胺，优选二胺。 此外，还描述了如上所述通过除去与含石油液体接触的砷，钒和/或镍结合而再生用过的儿茶酚基聚苯乙烯的方法，其涉及：用含水的钒和/或镍 酸达到酸的pH值; 并将固体与液体分离; 然后在约20-100℃的温度下用铵，碱金属和碱土金属的至少一种碳酸盐和/或碳酸氢盐的水溶液处理所述乏儿茶酚聚苯乙烯，所述溶液具有pH 约8至10; 并将固体和液体彼此分离。 优选地，含砷儿茶酚酸化聚合物的再生处理分为两个步骤，其中第一步是用含有低级烷基醇的含水醇酸水溶液进行，并且使用碳酸氢盐重复该步骤。